Detailed information for compound 574122

Basic information

Technical information
  • TDR Targets ID: 574122
  • Name: 2-[(2-aminocyclopentanecarbonyl)amino]-2-[6-( 2-aminopurin-9-yl)-4-(1,2-dihydroxyethyl)-4,5 -dihydroxy-tetrahydropyran-2-yl]acetic acid
  • MW: 495.486 | Formula: C20H29N7O8
  • H donors: 8 H acceptors: 10 LogP: -4.64 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCC(C1(O)CC(OC(C1O)n1cnc2c1nc(N)nc2)C(C(=O)O)NC(=O)C1CCCC1N)O
  • InChi: 1S/C20H29N7O8/c21-9-3-1-2-8(9)16(31)25-13(18(32)33)11-4-20(34,12(29)6-28)14(30)17(35-11)27-7-24-10-5-23-19(22)26-15(10)27/h5,7-9,11-14,17,28-30,34H,1-4,6,21H2,(H,25,31)(H,32,33)(H2,22,23,26)
  • InChiKey: BHAUQSKSOITMND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[(2-aminocyclopentyl)-oxomethyl]amino]-2-[6-(2-amino-9-purinyl)-4-(1,2-dihydroxyethyl)-4,5-dihydroxy-2-tetrahydropyranyl]acetic acid
  • 2-[(2-azanylcyclopentyl)carbonylamino]-2-[6-(2-azanylpurin-9-yl)-4-(1,2-dihydroxyethyl)-4,5-dihydroxy-oxan-2-yl]ethanoic acid
  • 2-[(2-aminocyclopentanecarbonyl)amino]-2-[6-(2-aminopurin-9-yl)-4-(1,2-dihydroxyethyl)-4,5-dihydroxyoxan-2-yl]acetic acid
  • amipurimycin
  • 2-[(2-aminocyclopentyl)carbonylamino]-2-[6-(2-aminopurin-9-yl)-4-(1,2-dihydroxyethyl)-4,5-dihydroxy-oxan-2-yl]ethanoic acid
  • 61991-08-0
  • 9H-Purin-2-amine, 9-[6-[[(2-aminocyclopentyl)carbonyl]amino]-4,6-dideoxy-3-C-(1,2-dihydroxyethyl)heptopyranuronosyl]-
  • AIDS-166731
  • AIDS166731
  • Ampurimycin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.066 0.3051 1
Trypanosoma cruzi trypanothione reductase, putative 0.0116 0.0436 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0175 0.0723 0.0706
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.0808 0.0792
Toxoplasma gondii thioredoxin reductase 0.0116 0.0436 0.1429
Loa Loa (eye worm) jmjC domain-containing protein 0.0184 0.0765 0.1926
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.004 0.0072 0.005
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0148 0.013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.0435 0.0418
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.002 0.0064
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0205 0.471
Wolbachia endosymbiont of Brugia malayi 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.066 0.3051 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0056 0.0039
Mycobacterium tuberculosis Probable reductase 0.0264 0.1149 0.3648
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.0072 0.1657
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.1323 1
Leishmania major hypothetical protein, conserved 0.0047 0.0107 0.245
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0057 0.0002
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0056 0.0039
Loa Loa (eye worm) hypothetical protein 0.0149 0.0595 0.1496
Brugia malayi Bromodomain containing protein 0.0097 0.0344 0.0865
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.0072 0.0237
Plasmodium vivax glutathione reductase, putative 0.0116 0.0436 0.1429
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0308 0.1011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0205 0.0672
Echinococcus granulosus muscleblind protein 0.0149 0.0595 0.0578
Brugia malayi glutathione reductase 0.0116 0.0436 0.1097
Onchocerca volvulus 0.0123 0.0469 0.0992
Brugia malayi hypothetical protein 0.0036 0.0052 0.013
Brugia malayi PHD-finger family protein 0.0089 0.0308 0.0776
Mycobacterium ulcerans 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.066 0.3051 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0148 0.013
Loa Loa (eye worm) jmjC domain-containing protein 0.0116 0.0435 0.1095
Echinococcus multilocularis jumonji domain containing protein 0.0124 0.0477 0.046
Schistosoma mansoni cpg binding protein 0.0037 0.0058 0.004
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.0072 0.0055
Brugia malayi Thioredoxin reductase 0.0116 0.0436 0.1097
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0851 0.3974 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0205 0.0188
Brugia malayi beta-lactamase 0.0037 0.0057 0.0144
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0072 0.1657
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0131 0.0167
Echinococcus multilocularis lysine specific demethylase 5A 0.0108 0.0399 0.0382
Echinococcus granulosus histone lysine methyltransferase setb 0.0175 0.0723 0.0706
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0076 0.0059
Plasmodium falciparum glutathione reductase 0.0116 0.0436 0.1429
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.0308 0.0291
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0057 0.0039
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.0072 0.0237
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0056 0.0039
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.0072 0.0125
Schistosoma mansoni hypothetical protein 0.0085 0.0288 0.0271
Toxoplasma gondii ABC1 family protein 0.0037 0.0057 0.0187
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Brugia malayi mbt repeat family protein 0.0049 0.0115 0.0289
Plasmodium falciparum phd finger protein, putative 0.0089 0.0308 0.1011
Loa Loa (eye worm) glutathione reductase 0.0116 0.0436 0.1097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Loa Loa (eye worm) beta-lactamase 0.0037 0.0057 0.0144
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0288 0.0725
Mycobacterium leprae Probable 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) (MECDP-synthase ) 0.0529 0.2422 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.0585 0.1762
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0131 0.3005
Mycobacterium tuberculosis Probable dehydrogenase 0.0264 0.1149 0.3648
Schistosoma mansoni hypothetical protein 0.042 0.19 0.1886
Loa Loa (eye worm) hypothetical protein 0.0126 0.0485 0.1221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0469 0.0452
Echinococcus granulosus cpg binding protein 0.0037 0.0058 0.004
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0054 0.0037
Brugia malayi hypothetical protein 0.0126 0.0485 0.1219
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.1323 1
Onchocerca volvulus 0.0037 0.0057 0.008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.0469 0.0452
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0018 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0409
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0072 0.1657
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0289
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0054 0.0037
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0445 0.0428
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0057 0.0039
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0288 0.0725
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.0072 0.0182
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0131 0.0113
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0288 0.0271
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.1293
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0056 0.0039
Echinococcus multilocularis cpg binding protein 0.0037 0.0058 0.004
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0115 0.0289
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0308 0.1011
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0131 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0131 0.0113
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0053 0.0133 0.0115
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0148 0.013
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0131 0.3005
Plasmodium vivax thioredoxin reductase, putative 0.0116 0.0436 0.1429
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0288 0.0271
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0116 0.0436 0.1266
Mycobacterium tuberculosis Probable oxidoreductase 0.0294 0.1291 0.4122
Echinococcus granulosus neuropeptide s receptor 0.0482 0.2196 0.2183
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0018 0.0058
Schistosoma mansoni cpg binding protein 0.0037 0.0058 0.004
Echinococcus granulosus neuropeptide receptor A26 0.0482 0.2196 0.2183
Echinococcus multilocularis muscleblind protein 0.0149 0.0595 0.0578
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.0072 0.0055
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.1323 0.4199
Brugia malayi MH2 domain containing protein 0.0123 0.0469 0.118
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0056 0.0039
Echinococcus multilocularis zinc finger protein 0.0062 0.0179 0.0161
Brugia malayi Pre-SET motif family protein 0.0851 0.3974 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0057 0.0002
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0131 0.0429
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0021 0.0053
Brugia malayi follicle stimulating hormone receptor 0.024 0.1035 0.2605
Leishmania major hypothetical protein, conserved 0.0037 0.0057 0.1311
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0056 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0131 0.0167
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.002 0.0449
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0057 0.0002
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0131 0.3005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.0469 0.1538
Loa Loa (eye worm) hypothetical protein 0.0126 0.0485 0.1219
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0294 0.1291 0.5217
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0131 0.0589
Echinococcus multilocularis peregrin 0.0097 0.0344 0.0326
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0469 0.118
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0264 0.1149 0.3648
Brugia malayi jmjC domain containing protein 0.0116 0.0435 0.1095
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0056 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0057 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0175 0.0723 0.0706
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0045
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0131 0.0113
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0045
Echinococcus granulosus peregrin 0.0097 0.0344 0.0326
Leishmania major hypothetical protein, conserved 0.0029 0.0018 0.0409
Plasmodium vivax 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, putative 0.066 0.3051 1
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0056 0.0039
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0057 0.0187
Loa Loa (eye worm) bromodomain containing protein 0.0055 0.0142 0.0357
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Loa Loa (eye worm) hypothetical protein 0.0056 0.0148 0.0371
Onchocerca volvulus 0.0049 0.0115 0.0208
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.002 0.0064
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0264 0.1149 0.3648
Trichomonas vaginalis esterase, putative 0.0037 0.0057 0.0002
Echinococcus granulosus fetal alzheimer antigen falz 0.0071 0.0223 0.0205
Schistosoma mansoni cpg binding protein 0.003 0.0021 0.0003
Plasmodium falciparum 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.066 0.3051 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Plasmodium falciparum thioredoxin reductase 0.004 0.0072 0.0237
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0115 0.0208
Echinococcus granulosus methyl CpG binding domain protein 2 0.0053 0.0133 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0057 0.1311
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0068 0.005
Plasmodium vivax SET domain protein, putative 0.0123 0.0469 0.1538
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0072 0.1657
Echinococcus multilocularis dnaJ subfamily B 0.042 0.19 0.1886
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.1293
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0142
Onchocerca volvulus Alhambra homolog 0.0089 0.0308 0.0636
Brugia malayi AF-10 protein 0.0029 0.002 0.0049
Brugia malayi beta-lactamase family protein 0.0037 0.0057 0.0144
Echinococcus multilocularis neuropeptide s receptor 0.0482 0.2196 0.2183
Brugia malayi MAP kinase sur-1 0.0052 0.0131 0.033
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.0072 0.0055
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.004 0.0072 0.005
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0409
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0205 0.471
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0148 0.013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0057 0.0039
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0057 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0148 0.013
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0028 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0469 0.118
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0205 0.0188
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0021 0.0053
Loa Loa (eye worm) thioredoxin reductase 0.0116 0.0436 0.1097
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0072 0.1657
Giardia lamblia PHD finger protein 15 0.0089 0.0308 0.199
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0056 0.0038
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0131 0.3005
Loa Loa (eye worm) hypothetical protein 0.0119 0.045 0.1132
Onchocerca volvulus 0.0969 0.4539 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0292 0.1285 0.1269
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0264 0.1149 0.4618
Trypanosoma brucei protein kinase, putative 0.0052 0.0131 0.3005
Brugia malayi mbt repeat family protein 0.0049 0.0115 0.0289
Brugia malayi beta-lactamase family protein 0.0037 0.0057 0.0144
Echinococcus granulosus dnaJ subfamily B 0.042 0.19 0.1886
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0205 0.0517
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.0469 0.0452
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.1293
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0288 0.0271
Schistosoma mansoni bromodomain containing protein 0.0197 0.0829 0.0812
Schistosoma mansoni microtubule-associated protein tau 0.2105 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0308 0.0776
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0288 0.0271
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0205 0.121
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0057 0.0002
Trypanosoma brucei trypanothione reductase 0.0116 0.0436 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0205 0.0188
Brugia malayi CXXC zinc finger family protein 0.003 0.0021 0.0053
Schistosoma mansoni hypothetical protein 0.0047 0.0107 0.0089
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0111 0.0414 0.0397
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.0072 0.1657
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.0808 0.0792
Loa Loa (eye worm) hypothetical protein 0.0219 0.0931 0.2343
Trypanosoma cruzi ISWI complex protein 0.0047 0.0107 0.245
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0131 0.033
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.0072 0.0237
Plasmodium falciparum glutathione reductase 0.004 0.0072 0.0237
Brugia malayi Bromodomain containing protein 0.0234 0.1003 0.2523
Plasmodium falciparum thioredoxin reductase 0.0116 0.0436 0.1429
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0111 0.0414 0.0397
Schistosoma mansoni hypothetical protein 0.0089 0.0308 0.0291
Brugia malayi jmjC domain containing protein 0.0292 0.1285 0.3233
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0031 0.0028 0.0093
Leishmania major trypanothione reductase 0.0116 0.0436 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0057 0.0144
Trypanosoma brucei ISWI complex protein 0.0047 0.0107 0.245
Trichomonas vaginalis glutathione reductase, putative 0.004 0.0072 0.0035
Loa Loa (eye worm) hypothetical protein 0.0126 0.0485 0.1219
Schistosoma mansoni jumonji domain containing protein 0.0232 0.0996 0.098
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0115 0.0097
Schistosoma mansoni zinc finger protein 0.0047 0.0107 0.0089
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0131 0.3005
Plasmodium vivax JmjC domain containing protein 0.0029 0.0018 0.0058
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0068 0.005
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0294 0.1291 0.4122
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0133 0.0115
Onchocerca volvulus 0.0037 0.0057 0.008
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0308 0.1011
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0113 0.0284
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0057 0.1311
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.002 0.0449
Echinococcus multilocularis microtubule associated protein 2 0.2105 1 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0148 0.0371
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0288 0.0271
Schistosoma mansoni hypothetical protein 0.0298 0.1312 0.1296
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0071 0.0223 0.0205
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0018 0.0058
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0115 0.0097
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0294 0.1291 0.4122
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0115 0.0097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0072 0.1657
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0409
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0131 0.3005
Brugia malayi PHD-finger family protein 0.0079 0.0258 0.0649
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0071 0.0223 0.0205
Echinococcus granulosus jumonji domain containing protein 0.0124 0.0477 0.046
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0308 0.0776
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0186 0.0775 0.0759
Echinococcus multilocularis neuropeptide receptor A26 0.0482 0.2196 0.2183
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0131 0.3005
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.1323 1
Onchocerca volvulus Huntingtin homolog 0.0126 0.0485 0.1026
Loa Loa (eye worm) hypothetical protein 0.0175 0.0723 0.1819
Onchocerca volvulus Huntingtin homolog 0.0126 0.0485 0.1026
Schistosoma mansoni hypothetical protein 0.0029 0.002 0.0002
Brugia malayi Pre-SET motif family protein 0.0123 0.0469 0.1181
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0205 0.471
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.0072 0.0237
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0264 0.1149 0.3648
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0052 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.164 0.7768 0.7764
Schistosoma mansoni zinc finger protein 0.0062 0.0179 0.0161
Schistosoma mansoni hypothetical protein 0.0085 0.0288 0.0271
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.1035 0.2605
Toxoplasma gondii 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase domain-containing protein 0.066 0.3051 1
Loa Loa (eye worm) PHD-finger family protein 0.0064 0.0186 0.0468
Loa Loa (eye worm) hypothetical protein 0.0134 0.0522 0.1313
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0202 0.0184
Echinococcus multilocularis thioredoxin glutathione reductase 0.0117 0.0444 0.0426
Loa Loa (eye worm) hypothetical protein 0.0085 0.0288 0.0725
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0057 0.1311
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.0072 0.1657
Schistosoma mansoni hypothetical protein 0.0036 0.0052 0.0034
Schistosoma mansoni hypothetical protein 0.0064 0.0186 0.0169
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0021 0.0053
Echinococcus granulosus lysine specific demethylase 5A 0.0116 0.0435 0.0418
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0595 0.0578
Trypanosoma cruzi ISWI complex protein 0.0047 0.0107 0.245
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0205 0.471
Loa Loa (eye worm) MBCTL1 0.0056 0.0148 0.0371
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1016 0.3202
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.0308 0.0291
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.0435 0.0418
Treponema pallidum hypothetical protein 0.066 0.3051 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0131 0.0113
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0292 0.1285 0.1269
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.0308 0.0291
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0115 0.0097
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.0072 0.0237
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.0072 0.0237
Loa Loa (eye worm) hypothetical protein 0.0153 0.0615 0.1548
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.004 0.0072 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.0585 0.223
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.0072 0.1657
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0141
Echinococcus granulosus thioredoxin glutathione reductase 0.0117 0.0444 0.0426
Brugia malayi PHD-finger family protein 0.0037 0.0056 0.0141
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0115 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0052 0.0034
Mycobacterium tuberculosis Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) 0.0529 0.2422 0.79
Brugia malayi Muscleblind-like protein 0.0149 0.0595 0.1496
Mycobacterium ulcerans flavoprotein disulfide reductase 0.004 0.0072 0.005
Brugia malayi Bromodomain containing protein 0.0118 0.0449 0.113
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.0585 0.1762
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0133 0.0115
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0186 0.0775 0.0759
Trichomonas vaginalis mercuric reductase, putative 0.004 0.0072 0.0035
Loa Loa (eye worm) hypothetical protein 0.0149 0.0595 0.1496
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0115 0.0097
Schistosoma mansoni hypothetical protein 0.0085 0.0288 0.0271
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0175 0.0723 0.0706
Trichomonas vaginalis set domain proteins, putative 0.0969 0.4539 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0052 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0057 0.0002
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0115 0.0097
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0056 0.1293
Onchocerca volvulus 0.0037 0.0057 0.008
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0288 0.0271
Echinococcus granulosus zinc finger protein 0.0062 0.0179 0.0161
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0056 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0131 0.0167
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0131 0.0113
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0264 0.1149 0.3648
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0205 0.0517

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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