Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0531 | 1 | 1 |
Echinococcus granulosus | glutamine synthetase | 0.0269 | 0.0226 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 0.0395 | 0.4914 | 0.4914 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.0269 | 0.0226 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.0395 | 0.4914 | 0.5 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0395 | 0.4914 | 1 |
Loa Loa (eye worm) | Gln-2 protein | 0.0269 | 0.0226 | 0.5 |
Leishmania major | glutamine synthetase, putative | 0.0269 | 0.0226 | 0.5 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.0531 | 1 | 0.5 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0269 | 0.0226 | 0.5 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0269 | 0.0226 | 0.5 |
Mycobacterium ulcerans | glutamine synthetase | 0.0531 | 1 | 1 |
Trypanosoma brucei | glutamine synthetase, putative | 0.0269 | 0.0226 | 0.5 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0395 | 0.4914 | 1 |
Plasmodium falciparum | glutamine synthetase, putative | 0.0531 | 1 | 0.5 |
Echinococcus multilocularis | glutamine synthetase | 0.0269 | 0.0226 | 0.5 |
Plasmodium vivax | glutamine synthetase, putative | 0.0531 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0531 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 15 ug ml-1 | In vitro inhibition against Caenorhabditis elegans motility for anthelmintic activity was measured | ChEMBL. | No reference |
IC50 (functional) | = 15 ug ml-1 | In vitro inhibition against Caenorhabditis elegans motility for anthelmintic activity was measured | ChEMBL. | No reference |
Reduction (functional) | < 50 % | Evaluated for the anthelmintic activity against Oesophagostomum columbianum in sheep at dose of 0.5 mg/kg | ChEMBL. | No reference |
Reduction (functional) | = 51 % | Evaluated for the anthelmintic activity against Oesophagostomum columbianum in sheep at dose of 2 mg/kg; value ranges from 51-75% | ChEMBL. | No reference |
Reduction (functional) | = 91 % | Evaluated for the anthelmintic activity against Haemonchus contortus in sheep at dose of 2 mg/kg; value ranges from 91-100% | ChEMBL. | No reference |
Reduction (functional) | = 91 % | Evaluated for the anthelmintic activity against Haemonchus contortus in sheep at dose of 0.5 mg/kg; value ranges from 91-100% | ChEMBL. | No reference |
Reduction (functional) | = 91 % | Evaluated for the anthelmintic activity against Ostertagia circumcincta in sheep at dose of 2 mg/kg; value ranges from 91-100% | ChEMBL. | No reference |
Reduction (functional) | = 91 % | Evaluated for the anthelmintic activity against Ostertagia circumcincta in sheep at dose of 0.5 mg/kg; value ranges from 91-100% | ChEMBL. | No reference |
Reduction (functional) | = 91 % | Evaluated for the anthelmintic activity against Trichostrongylus axei in sheep at dose of 2 mg/kg; value ranges from 91-100% | ChEMBL. | No reference |
Reduction (functional) | = 91 % | Evaluated for the anthelmintic activity against Trichostrongylus axei in sheep at dose of 0.5 mg/kg; value ranges from 91-100% | ChEMBL. | No reference |
Reduction (functional) | = 91 % | Evaluated for the anthelmintic activity against Trichostrongylus colubriformis in sheep at dose of 2 mg/kg; value ranges from 91-100% | ChEMBL. | No reference |
Reduction (functional) | = 91 % | Evaluated for the anthelmintic activity against Trichostrongylus colubriformis in sheep at dose of 0.5 mg/kg; value ranges from 91-100% | ChEMBL. | No reference |
Reduction (functional) | = 91 % | Evaluated for the anthelmintic activity against Cooperia species in sheep at dose of 2 mg/kg; value ranges from 91-100% | ChEMBL. | No reference |
Reduction (functional) | = 91 % | Evaluated for the anthelmintic activity against Cooperia species in sheep at dose of 0.5 mg/kg; value ranges from 91-100% | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.