Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.0195 | 0.3447 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.3447 | 0.7482 |
Leishmania major | glutamine synthetase, putative | 0.0226 | 0.443 | 1 |
Mycobacterium ulcerans | glutamine synthetase | 0.0402 | 1 | 1 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0089 | 0.0093 | 0.5 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.0226 | 0.443 | 0.7823 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.3447 | 0.778 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.0402 | 1 | 1 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0226 | 0.443 | 1 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.0265 | 0.5663 | 0.5 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0265 | 0.5663 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0.0221 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.2863 | 0.2795 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0102 | 0.0524 | 0.0942 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0126 | 0.1271 | 0.2869 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II) | 0.0176 | 0.2863 | 0.2702 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0226 | 0.443 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.3447 | 0.0818 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.0226 | 0.443 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.3447 | 0.778 |
Trypanosoma brucei | glutamine synthetase, putative | 0.0226 | 0.443 | 1 |
Loa Loa (eye worm) | Gln-2 protein | 0.0226 | 0.443 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1271 | 0.1912 |
Echinococcus granulosus | glutamine synthetase | 0.0226 | 0.443 | 1 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0089 | 0.0093 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.3447 | 0.3299 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0265 | 0.5663 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 0.3447 | 0.3385 |
Echinococcus multilocularis | glutamine synthetase | 0.0226 | 0.443 | 1 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0402 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3447 | 0.6086 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0402 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0176 | 0.2863 | 0.2702 |
Mycobacterium tuberculosis | Glutamine synthetase GlnA1 (glutamine synthase) (GS-I) | 0.0176 | 0.2863 | 0.2702 |
Plasmodium vivax | glutamine synthetase, putative | 0.0402 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.3447 | 0.7664 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0126 | 0.1271 | 0.2869 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 0.0265 | 0.5663 | 0.5565 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0116 | 0.0967 | 0.1708 |
Plasmodium falciparum | glutamine synthetase, putative | 0.0402 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.008 uM | In vitro inhibition of L1210 cell growth in culture. | ChEMBL. | 2033585 |
IC50 (functional) | = 0.008 uM | In vitro inhibition of L1210 cell growth in culture. | ChEMBL. | 2033585 |
IC50 (binding) | = 0.23 uM | In vitro inhibition of partially purified L1210 thymidylate synthase (TS). | ChEMBL. | 2033585 |
IC50 (binding) | = 0.23 uM | In vitro inhibition of partially purified L1210 thymidylate synthase (TS). | ChEMBL. | 2033585 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2033585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.