Detailed information for compound 575943

Basic information

Technical information
  • TDR Targets ID: 575943
  • Name: 1-(2-chlorophenyl)sulfonyl-3-(4-methoxy-6-met hyl-1,3,5-triazin-2-yl)urea
  • MW: 357.773 | Formula: C12H12ClN5O4S
  • H donors: 2 H acceptors: 6 LogP: 2.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1nc(nc(n1)C)NC(=O)NS(=O)(=O)c1ccccc1Cl
  • InChi: 1S/C12H12ClN5O4S/c1-7-14-10(17-12(15-7)22-2)16-11(19)18-23(20,21)9-6-4-3-5-8(9)13/h3-6H,1-2H3,(H2,14,15,16,17,18,19)
  • InChiKey: VJYIFXVZLXQVHO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(2-chlorophenyl)sulfonyl-3-(4-methoxy-6-methyl-s-triazin-2-yl)urea
  • chlorsulfuron
  • finesse
  • 112143-77-8
  • 79793-04-7
  • 64902-72-3
  • Benzenesulfonamide, 2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]-
  • 2-Chloro-N-(((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbony- l)benzenesulphonamide
  • 1-((o-Chlorophenyl)sulfonyl)-3-(4-methoxy-6-methyl-s-triazin-2-yl)urea
  • 1-(2-Chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea
  • 1-(2-Chlorophenylsulphonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea
  • 2-Chloro-N-(((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)benzenesulfonamide
  • 2-Chloro-N-(((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)benzenesulphonamide
  • 2-Chloro-N-((4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl)-benzenesulfonamide
  • 2-Chlorsulfuron
  • 5-26-09-00405 (Beilstein Handbook Reference)
  • BRN 0577255
  • Benzenesulfonamide, 2-chloro-N-(((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)-
  • Caswell No. 194AA
  • Chlorsulfon
  • Chlorsulfuron [ANSI:BSI:ISO]
  • DPX 4189
  • EINECS 265-268-5
  • EPA Pesticide Chemical Code 118601
  • Glean
  • Glean 20DF
  • Glean C
  • HSDB 6847
  • Telar
  • Trilixon
  • Urea, 1-((o-chlorophenyl)sulfonyl)-3-(4-methoxy-6-methyl-s-triazin-2-yl)-
  • 1-(2-CHLOROPHENYLSULFONYL)-3-(4-METHOXY-6-METHYL-L,3,5-TRIAZIN-2-YL)UREA
  • PS1065_SUPELCO
  • 1CS
  • 1-(2-Chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-urea
  • Chlorosulfuron
  • MLS001066361
  • SMR000471866
  • Chlorsulphuron
  • 2-chloro-N-{[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}benzenesulfonamide
  • NCGC00164267-01
  • Khardin
  • 34322_RIEDEL
  • C05071
  • AIDS-082317
  • ChemDiv1_004813
  • AIDS082317

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Lolium rigidum Acetolactate synthase Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Saccharomyces cerevisiae acetolactate synthase catalytic subunit Starlite/ChEMBL References
Raphanus raphanistrum Acetolactate synthase Starlite/ChEMBL References
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) ILVBL protein Get druggable targets OG5_126899 All targets in OG5_126899
Mycobacterium leprae Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) Get druggable targets OG5_126899 All targets in OG5_126899
Mycobacterium leprae PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) Get druggable targets OG5_126899 All targets in OG5_126899
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans Acetolactate synthase Get druggable targets OG5_126899 All targets in OG5_126899
Mycobacterium tuberculosis Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) Get druggable targets OG5_126899 All targets in OG5_126899
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126899 All targets in OG5_126899
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium ulcerans putative oxalyl-CoA decarboxylase Get druggable targets OG5_126899 All targets in OG5_126899
Schistosoma mansoni acetolactate synthase Get druggable targets OG5_126899 All targets in OG5_126899
Schistosoma mansoni acetolactate synthase Get druggable targets OG5_126899 All targets in OG5_126899
Mycobacterium tuberculosis Probable oxalyl-CoA decarboxylase OxcA Get druggable targets OG5_126899 All targets in OG5_126899
Brugia malayi Thiamine pyrophosphate enzyme, central domain containing protein Get druggable targets OG5_126899 All targets in OG5_126899
Loa Loa (eye worm) thiamine pyrophosphate enzyme Get druggable targets OG5_126899 All targets in OG5_126899
Schistosoma japonicum ko:K01651 acetolactate synthase [EC2.2.1.6], putative Get druggable targets OG5_126899 All targets in OG5_126899
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium ulcerans acetolactate synthase 1 catalytic subunit Get druggable targets OG5_126899 All targets in OG5_126899
Schistosoma japonicum ko:K01651 acetolactate synthase [EC2.2.1.6], putative Get druggable targets OG5_126899 All targets in OG5_126899
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans Acetolactate synthase Get druggable targets OG5_126899 All targets in OG5_126899
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium tuberculosis Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) Get druggable targets OG5_126899 All targets in OG5_126899
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae PROBABLE PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC Acetolactate synthase   516 aa 447 aa 23.7 %
Leishmania braziliensis putative pyruvate/indole-pyruvate carboxylase, putative Acetolactate synthase   516 aa 457 aa 22.3 %
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Leishmania mexicana putative pyruvate/indole-pyruvate carboxylase, putative Acetolactate synthase   516 aa 459 aa 22.4 %
Leishmania infantum putative pyruvate/indole-pyruvate carboxylase, putative Acetolactate synthase   516 aa 450 aa 22.2 %
Onchocerca volvulus UPF0553 protein C9orf64 homolog Acetolactate synthase   604 aa 534 aa 25.3 %
Mycobacterium tuberculosis Probable acetolactate synthase (large subunit) IlvB2 (AHAS) (acetohydroxy-acid synthase large subunit) (ALS) Acetolactate synthase   516 aa 520 aa 28.3 %
Mycobacterium ulcerans acetolactate synthase large subunit IlvB Acetolactate synthase   516 aa 525 aa 28.8 %
Leishmania donovani Alpha-keto-acid decarboxylase, putative Acetolactate synthase   516 aa 449 aa 22.0 %
Candida albicans putative indole-3-pyruvate decarboxylase Acetolactate synthase   604 aa 529 aa 22.3 %
Leishmania major putative pyruvate/indole-pyruvate carboxylase, putative Acetolactate synthase   516 aa 463 aa 23.1 %
Candida albicans putative indole-3-pyruvate decarboxylase Acetolactate synthase   604 aa 529 aa 22.3 %
Mycobacterium ulcerans pyruvate or indole-3-pyruvate decarboxylase Pdc Acetolactate synthase   516 aa 461 aa 25.2 %
Cryptosporidium parvum pyruvate decarboxylase Acetolactate synthase   516 aa 508 aa 19.7 %
Mycobacterium tuberculosis Probable pyruvate or indole-3-pyruvate decarboxylase Pdc Acetolactate synthase   516 aa 454 aa 25.6 %
Mycobacterium ulcerans acetolactate synthase Acetolactate synthase   516 aa 522 aa 27.4 %
Cryptosporidium hominis TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Acetolactate synthase   516 aa 508 aa 19.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni acetolactate synthase 0.0341 0.3761 0.3761
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0016 0.0016
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0072 0.0072
Leishmania major phosphonopyruvate decarboxylase-like protein 0.0129 0.1341 0.5311
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.037
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0067 0.0067
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0147 0.0333
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0261
Onchocerca volvulus 0.0041 0.0334 0.5753
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0097 0.0323
Echinococcus multilocularis thyroid hormone receptor alpha 0.0176 0.1885 0.1885
Brugia malayi hypothetical protein 0.0013 0.0016 0.0036
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0147 0.0147
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0147 0.0147
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0147 0.0147
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0045 0.0045
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.1332 0.301
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0561
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0067 0.0254
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0056 0.0126
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0072 0.0072
Trypanosoma brucei unspecified product 0.002 0.0097 0.054
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0147 0.0147
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0431 0.0974
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0147 0.0561
Mycobacterium ulcerans beta-lactamase 0.0041 0.0334 0.0546
Leishmania major hypothetical protein, conserved 0.0041 0.0334 0.1149
Echinococcus multilocularis GPCR, family 2 0.0018 0.0072 0.0072
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0067 0.0067
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0056 0.0056
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0334 0.0636
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0016 0.0016
Loa Loa (eye worm) thiamine pyrophosphate enzyme 0.0228 0.248 0.944
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0147 0.0147
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0097 0.1347
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0097 0.0323
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0147 0.0561
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0309 0.0698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0147 0.0561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0147 0.0561
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0016 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0334 0.6061
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0056 0.0056
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0147 0.0333
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0334 0.1149
Leishmania major DNA polymerase eta, putative 0.002 0.0097 0.0171
Echinococcus multilocularis Ankyrin 0.0018 0.0069 0.0069
Schistosoma mansoni cpg binding protein 0.0066 0.062 0.062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0147 0.0561
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0045 0.0045
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0334 0.0636
Mycobacterium leprae Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) 0.0398 0.4424 1
Echinococcus granulosus tar DNA binding protein 0.0128 0.1332 0.1332
Brugia malayi hypothetical protein 0.0091 0.0913 0.2063
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0147 0.2543
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0275
Schistosoma mansoni thyroid hormone receptor 0.0176 0.1885 0.1885
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0147 0.0333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0431 0.0431
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0147 0.0147
Brugia malayi Death domain containing protein 0.0017 0.0067 0.0151
Echinococcus multilocularis dnaJ subfamily B 0.0886 1 1
Mycobacterium ulcerans 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase 0.0071 0.0678 0.1343
Loa Loa (eye worm) TAR-binding protein 0.0128 0.1332 0.5069
Loa Loa (eye worm) beta-lactamase 0.0041 0.0334 0.127
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0512 0.1158
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0072 0.0163
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0885 0.0885
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.054
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0097 0.054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0147 0.0147
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0147 0.0147
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1332 0.1332
Mycobacterium leprae PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SH 0.0071 0.0678 0.0843
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0097 0.0097
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0147 0.0147
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0072
Onchocerca volvulus 0.0041 0.0334 0.5753
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0885 0.0885
Echinococcus granulosus Ankyrin 0.0018 0.0069 0.0069
Brugia malayi beta-lactamase family protein 0.0041 0.0334 0.0754
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0334 0.2162
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0147 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.054
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.1332 0.5069
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0067 0.1153
Schistosoma mansoni hypothetical protein 0.0039 0.0309 0.0309
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0097 0.054
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0072
Schistosoma mansoni coup transcription factor 0.0024 0.0147 0.0147
Schistosoma mansoni hypothetical protein 0.0886 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0147 0.0561
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1332 0.1332
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0334 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0147 0.0561
Echinococcus granulosus dna polymerase eta 0.002 0.0097 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1332 0.1332
Mycobacterium ulcerans hypothetical protein 0.0398 0.4424 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0147 0.0333
Loa Loa (eye worm) hypothetical protein 0.0091 0.0913 0.3474
Mycobacterium tuberculosis Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) 0.0398 0.4424 1
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0129 0.1341 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0097 0.0095
Echinococcus granulosus dna polymerase kappa 0.002 0.0097 0.0097
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0147 0.0147
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0147 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0147 0.0333
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0431 0.164
Brugia malayi beta-lactamase family protein 0.0041 0.0334 0.0754
Echinococcus granulosus cpg binding protein 0.0066 0.062 0.062
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0147 0.2543
Plasmodium vivax acyl-CoA synthetase, putative 0.0228 0.2475 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.1606 0.1606
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0431 0.0431
Onchocerca volvulus 0.0062 0.058 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0431 0.0431
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0147 0.0147
Loa Loa (eye worm) ILVBL protein 0.0241 0.2627 1
Brugia malayi TAR-binding protein 0.0128 0.1332 0.301
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0334 0.2162
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0097 0.0171
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0097 0.0323
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0097 0.037
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0097 0.1347
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0058 0.0531 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0561
Loa Loa (eye worm) hypothetical protein 0.0056 0.0512 0.1951
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0147 0.0333
Loa Loa (eye worm) hypothetical protein 0.0041 0.0334 0.127
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0072 0.0163
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0147 0.0147
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0147 0.0333
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0058 0.0531 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0334 0.0334
Echinococcus multilocularis dna polymerase kappa 0.002 0.0097 0.0097
Schistosoma mansoni eyes absent homolog 0.0091 0.0913 0.0913
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0147 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0147 0.0333
Mycobacterium ulcerans hypothetical protein 0.0129 0.1341 0.2874
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0334 0.0334
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0334 0.6061
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0088 0.0088
Entamoeba histolytica pyruvate:ferredoxin oxidoreductase 0.0058 0.0531 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0097 0.054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0561
Mycobacterium leprae PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) 0.0398 0.4424 1
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0058 0.0531 1
Brugia malayi hypothetical protein 0.0013 0.0016 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0067 0.0254
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0067 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0147 0.0333
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0561
Brugia malayi isocitrate dehydrogenase 0.0016 0.0056 0.0126
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0147 0.0147
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0147 0.0147
Loa Loa (eye worm) RNA binding protein 0.0128 0.1332 0.5069
Brugia malayi nuclear hormone receptor 0.0024 0.0147 0.0333
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0129 0.1341 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0072 0.0072
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0058 0.0531 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.1377 0.1377
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0072 0.0275
Mycobacterium ulcerans hypothetical protein 0.0041 0.0334 0.0546
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.054
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0097 0.0219
Mycobacterium ulcerans acetolactate synthase 0.0228 0.2475 0.5496
Loa Loa (eye worm) hypothetical protein 0.0041 0.0334 0.127
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0058 0.0531 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0097 0.0097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0147 0.0147
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0058 0.0531 1
Echinococcus multilocularis cpg binding protein 0.0066 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0334 0.127
Schistosoma mansoni cpg binding protein 0.0062 0.058 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.054
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0147 0.0147
Mycobacterium ulcerans lipase LipD 0.0041 0.0334 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0147 0.0333
Mycobacterium ulcerans putative oxalyl-CoA decarboxylase 0.0398 0.4424 1
Schistosoma mansoni acetolactate synthase 0.0341 0.3761 0.3761
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0334 0.127
Giardia lamblia Pyruvate-flavodoxin oxidoreductase 0.0058 0.0531 1
Schistosoma mansoni cpg binding protein 0.0066 0.062 0.062
Schistosoma mansoni DNA polymerase eta 0.002 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0334 0.127
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0334 0.0636
Brugia malayi nuclear receptor NHR-88 0.0024 0.0147 0.0333
Mycobacterium ulcerans 2-oxoglutarate ferredoxin oxidoreductase subunit beta 0.0058 0.0531 0.1003
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0334 0.0636
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0334 0.6061
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0334 0.2338
Mycobacterium tuberculosis Probable oxalyl-CoA decarboxylase OxcA 0.0398 0.4424 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0147 0.0147
Brugia malayi Uncoordinated protein 44 0.0017 0.0067 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1332 0.1332
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0072
Schistosoma mansoni thyroid hormone receptor 0.0176 0.1885 0.1885
Leishmania major DNA polymerase kappa, putative 0.002 0.0097 0.0171
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0016 0.006
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0045 0.0045
Treponema pallidum pyruvate oxidoreductase 0.0058 0.0531 0.5
Mycobacterium tuberculosis Conserved protein 0.0041 0.0334 0.0636
Mycobacterium tuberculosis Conserved protein 0.0041 0.0334 0.0636
Brugia malayi CXXC zinc finger family protein 0.0062 0.058 0.131
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0097 0.0219
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0097 0.0323
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0334 0.6061
Brugia malayi beta-lactamase 0.0041 0.0334 0.0754
Loa Loa (eye worm) hypothetical protein 0.0041 0.0334 0.127
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0056 0.0212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0431 0.0431
Echinococcus granulosus GPCR family 2 0.0018 0.0072 0.0072
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0334 0.6061
Mycobacterium ulcerans acetolactate synthase 1 catalytic subunit 0.0398 0.4424 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0086 0.0194
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0561
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0067 0.0151
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0072 0.0072
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0147 0.0147
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0334 0.0546
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.1606 0.1606
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0056 0.0056
Mycobacterium tuberculosis Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) 0.017 0.1817 0.4032
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0561
Mycobacterium ulcerans pyruvate or indole-3-pyruvate decarboxylase Pdc 0.0228 0.2475 0.5496
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0512 0.1951
Echinococcus multilocularis tar DNA binding protein 0.0128 0.1332 0.1332
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0147 0.0147
Plasmodium falciparum acyl-CoA synthetase 0.0228 0.2475 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0431 0.0431
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0088 0.0337
Onchocerca volvulus 0.0041 0.0334 0.5753
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.006
Echinococcus multilocularis dna polymerase eta 0.002 0.0097 0.0097
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0097 0.0097
Brugia malayi nuclear receptor RXR 0.0013 0.0016 0.0036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0147 0.0333
Toxoplasma gondii ABC1 family protein 0.0041 0.0334 0.2395
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.054
Loa Loa (eye worm) hypothetical protein 0.0041 0.0334 0.127
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0147 0.0333
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0097 0.0097
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0147 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0431 0.0431
Schistosoma mansoni hypothetical protein 0.0152 0.1606 0.1606
Schistosoma mansoni netrin receptor unc5 0.0017 0.0067 0.0067
Mycobacterium tuberculosis Conserved protein 0.0041 0.0334 0.0636
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0129 0.1341 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.054
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0097 0.054
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0097 0.0095
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0147 0.0561
Onchocerca volvulus 0.0024 0.0147 0.2543
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0334 0.0546
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0334 0.0636
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0147 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1332 0.1332
Leishmania major putative pyruvate/indole-pyruvate carboxylase, putative 0.0228 0.2475 1
Brugia malayi steroid hormone receptor 0.0024 0.0147 0.0333
Schistosoma mansoni hypothetical protein 0.0017 0.0067 0.0067
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0309 0.1175
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0147 0.0147
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0147 0.0333
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0147 0.0147
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0056 0.0224
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0091 0.0913 0.3474
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0067 0.0067
Brugia malayi Protein kinase domain containing protein 0.0017 0.0067 0.0151
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0147 0.2543
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0334 0.0334
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0045 0.0045
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0147 0.0147
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0056 0.0056
Mycobacterium ulcerans acetolactate synthase large subunit IlvB 0.0228 0.2475 0.5496
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0097 0.0323
Mycobacterium tuberculosis Probable oxidoreductase (beta subunit) 0.0058 0.0531 0.1088
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0129 0.1341 1
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0334 0.0636
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0056 0.0224
Brugia malayi Thiamine pyrophosphate enzyme, central domain containing protein 0.0398 0.4424 1
Brugia malayi ecdysteroid receptor 0.0024 0.0147 0.0333
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0016 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0334 0.0636
Mycobacterium tuberculosis Possible penicillin-binding protein 0.026 0.284 0.6374
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.006
Brugia malayi RNA binding protein 0.0128 0.1332 0.301
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0512 0.1158
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0147 0.0147
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0334 0.0754
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0431 0.0431
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.1216 1
Trichomonas vaginalis esterase, putative 0.0041 0.0334 0.6061
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.006
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.058 0.2207
Echinococcus granulosus death domain containing protein 0.0017 0.0067 0.0067

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.007 uM Inhibition of ALS in ALS-herbicide-susceptible Raphanus raphanistrum WARR33 (wild radish) ChEMBL. 22431132
IC50 (binding) = 0.007 uM Inhibition of ALS in ALS-herbicide-susceptible Raphanus raphanistrum WARR7 (wild radish) ChEMBL. 22431132
IC50 (binding) = 0.03 uM Inhibition of acetolactate synthase Pro-197/Pro-197 mutant in Lolium rigidum accession A11 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 0.03 uM Inhibition of acetolactate synthase Pro-197/Pro-197 mutant in Lolium rigidum accession A09 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 0.03 uM Inhibition of acetolactate synthase in Lolium rigidum accession A01 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 0.04 uM Inhibition of acetolactate synthase Pro-197/Pro-197 mutant in Lolium rigidum accession A10 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 0.87 uM Inhibition of acetolactate synthase Pro-197/Arg-197 or Pro-197/Ser-197 or Pro/Val or Ala/Leu mutant in Lolium rigidum accession A17 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 1.09 uM Inhibition of acetolactate synthase Ala-197/Ala-197 mutant in Lolium rigidum accession A20 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 1.58 uM Inhibition of acetolactate synthase Ser-197/Ser-197 mutant in Lolium rigidum accession A21 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 1.62 uM Inhibition of acetolactate synthase Leu-197/Leu-197 mutant in Lolium rigidum accession A18 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 1.82 uM Inhibition of acetolactate synthase Pro-197/Leu-197 mutant in Lolium rigidum accession A07 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 4.89 uM Inhibition of acetolactate synthase Ala-197/Ala-197 mutant in Lolium rigidum accession A05 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 7.71 uM Inhibition of acetolactate synthase Ala-197/Ala-197 mutant in Lolium rigidum accession A16 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 14.09 uM Inhibition of acetolactate synthase Ala-197/Ala-197 mutant in Lolium rigidum accession A06 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 16.93 uM Inhibition of acetolactate synthase Leu-197/Leu-197 mutant in Lolium rigidum accession A08 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (binding) = 18.6 uM Inhibition of acetolactate synthase Ala-197/Ala-197 mutant in Lolium rigidum accession A19 leaves extracts by acetolactate production assay ChEMBL. No reference
IC50 (functional) = 44.97 uM DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. ChEMBL. No reference
IC50 (binding) > 100 uM Inhibition of ALS Ala122Tyr mutant in ALS-herbicide-resistant Raphanus raphanistrum WARR30 (wild radish) expressing ALS Ala122Tyr mutant ChEMBL. 22431132
IC90 (functional) = 100 uM DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. ChEMBL. No reference
Ki (binding) = 127 nM Inhibition of Saccharomyces cerevisiae acetohydroxyacid synthase by colorimetric assay ChEMBL. 23237384
MIC50 (functional) = 117 uM Antifungal activity against Saccharomyces cerevisiae after 72 hrs by broth microdilution assay ChEMBL. 23237384
MIC50 (functional) = 156 uM Antifungal activity against Candida albicans after 72 hrs by broth microdilution method ChEMBL. 23237384
Potency (functional) 0.003 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2421 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Ratio (binding) = 1 Resistance index, ratio of I50 for acetolactate synthase Pro-197/Pro-197 mutant in Lolium rigidum accession A11 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 1 Resistance index, ratio of I50 for acetolactate synthase Pro-197/Pro-197 mutant in Lolium rigidum accession A10 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 1 Resistance index, ratio of I50 for acetolactate synthase Pro-197/Pro-197 mutant in Lolium rigidum accession A09 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 29 Resistance index, ratio of I50 for acetolactate synthase Pro-197/Arg-197 or Pro-197/Ser-197 or Pro/Val or Ala/Leu mutant in Lolium rigidum accession A17 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 36 Resistance index, ratio of I50 for acetolactate synthase Ala-197/Ala-197 mutant in Lolium rigidum accession A20 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 53 Resistance index, ratio of I50 for acetolactate synthase Ser-197/Ser-197 mutant in Lolium rigidum accession A21 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 54 Resistance index, ratio of I50 for acetolactate synthase PLeu-197/Leu-197 mutant in Lolium rigidum accession A18 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 61 Resistance index, ratio of I50 for acetolactate synthase Pro-197/Leu-197 mutant in Lolium rigidum accession A07 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 163 Resistance index, ratio of I50 for acetolactate synthase Ala-197/Ala-197 mutant in Lolium rigidum accession A05 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 257 Resistance index, ratio of I50 for acetolactate synthase Ala-197/Ala-197 mutant in Lolium rigidum accession A16 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 470 Resistance index, ratio of I50 for acetolactate synthase Ala-197/Ala-197 mutant in Lolium rigidum accession A06 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 564 Resistance index, ratio of I50 for acetolactate synthase Leu-197/Leu-197 mutant in Lolium rigidum accession A08 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference
Ratio (binding) = 620 Resistance index, ratio of I50 for acetolactate synthase Ala-197/Ala-197 mutant in Lolium rigidum accession A19 leaves extracts to I50 for acetolactate synthase in Lolium rigidum accession A01 leaves extracts ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.