Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glutamine synthetase, putative | 0.0659 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0135 | 0.0758 | 0.1728 |
Loa Loa (eye worm) | Gln-2 protein | 0.0341 | 0.4386 | 1 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0479 | 0.6823 | 1 |
Entamoeba histolytica | glutamine synthetase, putative | 0.016 | 0.1209 | 0.5 |
Echinococcus multilocularis | glutamine synthetase | 0.0341 | 0.4386 | 1 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0341 | 0.4386 | 0.5 |
Entamoeba histolytica | glutamine synthetase, putative | 0.016 | 0.1209 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0659 | 1 | 1 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.0659 | 1 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0109 | 0.0313 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0124 | 0.0577 | 0.0845 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0659 | 1 | 1 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.0341 | 0.4386 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0319 | 0.4 | 0.3175 |
Trichomonas vaginalis | glutamine synthetase-bacteria, putative | 0.016 | 0.1209 | 0.5 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0479 | 0.6823 | 1 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 0.0479 | 0.6823 | 0.4705 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.0479 | 0.6823 | 0.5 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0341 | 0.4386 | 0.5 |
Mycobacterium ulcerans | glutamine synthetase | 0.0659 | 1 | 1 |
Echinococcus granulosus | glutamine synthetase | 0.0341 | 0.4386 | 1 |
Trichomonas vaginalis | glutamine synthetase, putative | 0.016 | 0.1209 | 0.5 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.0341 | 0.4386 | 0.6428 |
Plasmodium vivax | glutamine synthetase, putative | 0.0659 | 1 | 0.5 |
Leishmania major | glutamine synthetase, putative | 0.0341 | 0.4386 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0758 | 0.1093 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0135 | 0.0758 | 0.1728 |
Trypanosoma brucei | glutamine synthetase, putative | 0.0341 | 0.4386 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/C (binding) | = 6.1 | Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter | ChEMBL. | 11931612 |
Log 1/C (binding) | = 6.1 | Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter | ChEMBL. | 11931612 |
pKD (binding) | = 6 | Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells | ChEMBL. | 11931612 |
pKD (binding) | = 6.17 | Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells | ChEMBL. | 11931612 |
pKD (binding) | = 6 | Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells | ChEMBL. | 11931612 |
pKD (binding) | = 6.17 | Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells | ChEMBL. | 11931612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.