Detailed information for compound 579313

Basic information

Technical information
  • TDR Targets ID: 579313
  • Name: N-[(9Z)-9-[amino(hydroxy)methylene]-7-(dimeth ylamino)-10a,12-dihydroxy-8,10,11-trioxo-5a,6 ,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(3-chlor o-1-hydroxy-piperidin-1-ium-1-yl)acetamide
  • MW: 590.045 | Formula: C28H34ClN4O8+
  • H donors: 6 H acceptors: 8 LogP: 2.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 3
  • SMILES: ClC1CCC[N+](C1)(O)CC(=O)Nc1ccc2c(c1)C(=C1C(C2)CC2C(C1=O)(O)C(=O)/C(=C(\O)/N)/C(=O)C2N(C)C)O
  • InChi: 1S/C28H33ClN4O8/c1-32(2)22-18-9-14-8-13-5-6-16(31-19(34)12-33(41)7-3-4-15(29)11-33)10-17(13)23(35)20(14)25(37)28(18,40)26(38)21(24(22)36)27(30)39/h5-6,10,14-15,18,22,40-41H,3-4,7-9,11-12H2,1-2H3,(H4-,30,31,34,35,36,37,38,39)/p+1
  • InChiKey: OCVXYJWINDBCJV-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • N-[(9Z)-9-[amino(hydroxy)methylene]-7-(dimethylamino)-10a,12-dihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(3-chloro-1-hydroxy-1-piperidin-1-iumyl)acetamide
  • N-[(9Z)-9-[azanyl(hydroxy)methylidene]-7-(dimethylamino)-10a,12-dihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(3-chloro-1-hydroxy-piperidin-1-ium-1-yl)ethanamide
  • N-[(9Z)-9-[amino(hydroxy)methylene]-7-(dimethylamino)-10a,12-dihydroxy-8,10,11-triketo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(3-chloro-1-hydroxy-piperidin-1-ium-1-yl)acetamide
  • N-[(9Z)-9-[amino(hydroxy)methylidene]-7-(dimethylamino)-10a,12-dihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(3-chloro-1-hydroxypiperidin-1-ium-1-yl)acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutaminase 0.0285 0.2174 0.2148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1294 0.1997
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0264 0.0307
Brugia malayi Cell death protein 3 precursor 0.0084 0.0584 0.0511
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0423 0.3273 0.3221
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0173 0.1294 0.2096
Loa Loa (eye worm) hypothetical protein 0.025 0.1899 0.1837
Schistosoma mansoni cathepsin F (C01 family) 0.054 0.4196 0.4177
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0402 0.065
Onchocerca volvulus 0.0108 0.0779 0.0909
Plasmodium falciparum importin beta, putative 0.003 0.0158 0.0134
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0402 0.0328
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0211 0.0342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Schistosoma mansoni DNA helicase recq5 0.002 0.0077 0.0044
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0173 0.1294 0.2096
Leishmania major cathepsin L-like protease 0.079 0.6175 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0173 0.1294 0.1997
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0402 0.0328
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0211 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0423 0.3273 0.5241
Trypanosoma brucei metacaspase 0.0043 0.0264 0.0307
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0779 0.1145
Trypanosoma cruzi metacaspase, putative 0.0043 0.0264 0.0189
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0173 0.1294 0.1997
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1294 0.1997
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0779 0.0708
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0471 0.3653 0.3604
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0779 0.1153
Loa Loa (eye worm) hypothetical protein 0.0108 0.0779 0.0708
Brugia malayi jmjC domain containing protein 0.0031 0.0166 0.009
Brugia malayi jmjC domain containing protein 0.0116 0.084 0.0769
Giardia lamblia Cathepsin B precursor 0.0513 0.3987 1
Entamoeba histolytica cysteine protease, putative 0.0173 0.1294 0.2096
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0264 0.0307
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0264 0.0307
Trypanosoma cruzi major cysteine proteinase, putative 0.0173 0.1294 0.1227
Onchocerca volvulus 0.054 0.4196 0.6666
Echinococcus multilocularis cathepsin L cysteine protease 0.079 0.6175 0.6145
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0314 0.0389
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0779 0.0708
Plasmodium falciparum cysteine proteinase falcipain 2b 0.079 0.6175 1
Trypanosoma cruzi cysteine peptidase, putative 0.079 0.6175 0.6145
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0211 0.0136
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0173 0.1294 0.3114
Entamoeba histolytica cysteine proteinase, putative 0.054 0.4196 0.6796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.079 0.6175 1
Plasmodium falciparum serine repeat antigen 1 0.0173 0.1294 0.1997
Leishmania major cathepsin L-like protease 0.079 0.6175 1
Brugia malayi beta-lactamase 0.0108 0.0779 0.0708
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0402 0.037
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0031 0.0166 0.0268
Echinococcus multilocularis cysteine protease 0.079 0.6175 0.6145
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.0166 0.009
Brugia malayi jmjC domain containing protein 0.0031 0.0166 0.009
Plasmodium falciparum serine repeat antigen 7 0.0173 0.1294 0.1997
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0077 0.0124
Trypanosoma cruzi cysteine proteinase, putative 0.0423 0.3273 0.3221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.054 0.4196 0.6755
Onchocerca volvulus 0.079 0.6175 1
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.084 0.081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0779 0.0749
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0173 0.1294 0.2096
Onchocerca volvulus Cathepsin F homolog 0.079 0.6175 1
Brugia malayi glutaminase DH11.1 0.0285 0.2174 0.2114
Trypanosoma brucei cysteine peptidase C (CPC) 0.0513 0.3987 0.6412
Echinococcus multilocularis cathepsin l cysteine peptidase 0.079 0.6175 0.6145
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0116 0.084 0.0769
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0173 0.1294 0.1997
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0314 0.0239
Entamoeba histolytica cysteine protease, putative 0.0173 0.1294 0.2096
Echinococcus granulosus cathepsin l1 0.054 0.4196 0.4151
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0166 0.009
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0779 0.1153
Plasmodium falciparum cysteine proteinase falcipain 1 0.0423 0.3273 0.5241
Trypanosoma cruzi cruzipain precursor, putative 0.025 0.1899 0.1837
Loa Loa (eye worm) beta-lactamase 0.0108 0.0779 0.0708
Schistosoma mansoni hypothetical protein 0.0176 0.1317 0.1289
Echinococcus multilocularis caspase 8 0.0043 0.0264 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0264 0.0307
Giardia lamblia Cathepsin B precursor 0.0513 0.3987 1
Mycobacterium tuberculosis Conserved protein 0.0108 0.0779 0.1145
Brugia malayi Cathepsin L-like precursor 0.079 0.6175 0.6145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0423 0.3273 0.5241
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0264 0.0189
Onchocerca volvulus 0.079 0.6175 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0043 0.0264 0.0232
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.024 0.0165
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0097 0.0021
Trypanosoma brucei metacaspase 5, putative 0.0043 0.0264 0.0307
Giardia lamblia Cysteine protease 0.0173 0.1294 0.3114
Plasmodium vivax JmjC domain containing protein 0.0031 0.0166 0.0268
Entamoeba histolytica cysteine protease, putative 0.079 0.6175 1
Schistosoma mansoni cathepsin S (C01 family) 0.0173 0.1294 0.1265
Plasmodium vivax vivapain-1 0.0423 0.3273 0.53
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1012 0.0942
Loa Loa (eye worm) inositol-1 0.0037 0.0211 0.0136
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0779 0.0708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Onchocerca volvulus 0.0482 0.3738 0.5894
Brugia malayi Cathepsin L-like precursor 0.079 0.6175 0.6145
Onchocerca volvulus Cathepsin L homolog 0.079 0.6175 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.079 0.6175 1
Giardia lamblia Cysteine protease 0.0173 0.1294 0.3114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1012 0.0982
Brugia malayi fibroinase precursor 0.0173 0.1294 0.1227
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0779 0.1145
Plasmodium falciparum serine repeat antigen 2 0.0173 0.1294 0.1997
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.009
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0173 0.1294 0.1997
Brugia malayi cathepsin F-like cysteine proteinase 0.025 0.1899 0.1837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.079 0.6175 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0314 0.0239
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0264 0.0307
Leishmania major cathepsin L-like protease 0.079 0.6175 1
Trichomonas vaginalis esterase, putative 0.0108 0.0779 0.1153
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.3273 0.53
Plasmodium vivax metacaspase 1, putative 0.0043 0.0264 0.0427
Mycobacterium ulcerans glutaminase 0.0285 0.2174 1
Giardia lamblia Cathepsin B precursor 0.0173 0.1294 0.3114
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.079 0.6175 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0173 0.1294 0.1227
Trypanosoma cruzi cysteine proteinase, putative 0.0423 0.3273 0.3221
Echinococcus granulosus caspase 0.0115 0.0828 0.0758
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0211 0.0221
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0779 0.2895
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0779 0.1153
Loa Loa (eye worm) hypothetical protein 0.025 0.1899 0.1837
Leishmania major cathepsin L-like protease 0.079 0.6175 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0423 0.3273 0.53
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0264 0.0307
Leishmania major cathepsin L-like protease 0.079 0.6175 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Trypanosoma brucei metacaspase MCA2 0.0043 0.0264 0.0307
Plasmodium falciparum JmjC domain-containing protein, putative 0.0031 0.0166 0.0146
Brugia malayi Pre-SET motif family protein 0.0061 0.0402 0.0328
Brugia malayi cathepsin L-like precursor 0.054 0.4196 0.4151
Schistosoma mansoni hypothetical protein 0.004 0.024 0.0208
Brugia malayi Cathepsin L-like precursor 0.079 0.6175 0.6145
Onchocerca volvulus Cathepsin L homolog 0.0173 0.1294 0.1776
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0779 0.1145
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.079 0.6175 1
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.3273 0.53
Plasmodium vivax vivapain-2 0.079 0.6175 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0424 0.3275 0.3223
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0715 0.0685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Brugia malayi Papain family cysteine protease containing protein 0.0423 0.3273 0.3221
Loa Loa (eye worm) hypothetical protein 0.0173 0.1294 0.1227
Brugia malayi Cathepsin L-like precursor 0.079 0.6175 0.6145
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Brugia malayi Melibiase family protein 0.0067 0.0451 0.0377
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0173 0.1294 0.3114
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0173 0.1294 0.1997
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0211 0.0136
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1742 0.1678
Loa Loa (eye worm) hypothetical protein 0.0173 0.1294 0.1227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0173 0.1294 0.3114
Echinococcus granulosus cathepsin b 0.1273 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0423 0.3273 0.3251
Schistosoma mansoni cathepsin C 0.0173 0.1294 0.1265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0402 0.037
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0264 0.0307
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0211 0.0221
Brugia malayi Papain family cysteine protease containing protein 0.079 0.6175 0.6145
Trypanosoma cruzi cruzipain precursor, putative 0.079 0.6175 0.6145
Echinococcus granulosus cysteine protease 0.0423 0.3273 0.3221
Entamoeba histolytica cysteine protease, putative 0.0173 0.1294 0.2096
Trypanosoma cruzi metacaspase, putative 0.0043 0.0264 0.0189
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0211 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0513 0.3987 0.6412
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1273 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0113 0.006
Loa Loa (eye worm) hypothetical protein 0.0108 0.0779 0.0708
Schistosoma mansoni caspase-3 (C14 family) 0.0115 0.0828 0.0798
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0264 0.0307
Onchocerca volvulus 0.0047 0.0292 0.0087
Loa Loa (eye worm) fibroinase 0.079 0.6175 0.6145
Schistosoma mansoni caspase-7 (C14 family) 0.0084 0.0584 0.0552
Schistosoma mansoni hypothetical protein 0.0022 0.0097 0.0064
Plasmodium falciparum serine repeat antigen 3 0.0173 0.1294 0.1997
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.054 0.4196 0.6755
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0173 0.1294 0.2096
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0264 0.0307
Onchocerca volvulus 0.079 0.6175 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0402 0.0328
Loa Loa (eye worm) cathepsin B 0.0513 0.3987 0.394
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.1294 0.1265
Giardia lamblia Cathepsin B precursor 0.0173 0.1294 0.3114
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0779 0.1145
Loa Loa (eye worm) glutaminase 2 0.0285 0.2174 0.2114
Entamoeba histolytica cysteine proteinase 2 0.0423 0.3273 0.53
Loa Loa (eye worm) hypothetical protein 0.0108 0.0779 0.0708
Onchocerca volvulus 0.079 0.6175 1
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0314 0.0509
Loa Loa (eye worm) hypothetical protein 0.0084 0.0584 0.0511
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0779 0.1153
Mycobacterium leprae Probable lipase LipE 0.0108 0.0779 1
Echinococcus multilocularis caspase 0.0115 0.0828 0.0758
Plasmodium vivax SET domain protein, putative 0.0061 0.0402 0.065
Echinococcus multilocularis geminin 0.0176 0.1317 0.125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1294 0.1997
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0173 0.1294 0.1227
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.3273 0.53
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.2458 0.24
Schistosoma mansoni importin beta-1 0.003 0.0158 0.0126
Echinococcus multilocularis cysteine protease 0.079 0.6175 0.6145
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.025 0.1899 0.1837
Loa Loa (eye worm) glutaminase 0.0285 0.2174 0.2114
Leishmania major importin beta-1 subunit, putative 0.0024 0.0113 0.006
Entamoeba histolytica cysteine protease, putative 0.0173 0.1294 0.2096
Giardia lamblia Cathepsin L precursor 0.0173 0.1294 0.3114
Plasmodium falciparum metacaspase-like protein 0.0043 0.0264 0.0307
Brugia malayi jmjC domain containing protein 0.0031 0.0166 0.009
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0715 0.0685
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0865 0.0795
Schistosoma mansoni cathepsin B (C01 family) 0.0173 0.1294 0.1265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Echinococcus granulosus phd:f box containing protein 0.0031 0.0166 0.009
Echinococcus multilocularis cathepsin b 0.1273 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0173 0.1294 0.1997
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0314 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0173 0.1294 0.1997
Echinococcus multilocularis cathepsin L 0.0173 0.1294 0.1227
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0173 0.1294 0.1265
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.009
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0779 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0173 0.1294 0.3114
Toxoplasma gondii cathepsin B 0.0513 0.3987 0.6456
Loa Loa (eye worm) hypothetical protein 0.0173 0.1294 0.1227
Trypanosoma cruzi cysteine peptidase, putative 0.0423 0.3273 0.3221
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0211 0.0136
Giardia lamblia Cathepsin L precursor 0.0173 0.1294 0.3114
Brugia malayi jmjC domain containing protein 0.0031 0.0166 0.009
Echinococcus multilocularis cathepsin b 0.1273 1 1
Schistosoma mansoni jumonji domain containing protein 0.0031 0.0166 0.0133
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0115 0.0828 0.0758
Schistosoma mansoni cathepsin s 0.025 0.1899 0.1872
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.0715 0.0644
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1273 1 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0264 0.0427
Echinococcus granulosus geminin 0.0176 0.1317 0.125
Brugia malayi beta-lactamase family protein 0.0108 0.0779 0.0708
Loa Loa (eye worm) hypothetical protein 0.0173 0.1294 0.1227
Echinococcus granulosus lysine specific demethylase 5A 0.0116 0.084 0.0769
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.0715 0.0644
Toxoplasma gondii melibiase subfamily protein 0.01 0.0715 0.1159
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0173 0.1294 0.1227
Schistosoma mansoni phosphatidylserine receptor 0.0031 0.0166 0.0133
Entamoeba histolytica cysteine proteinase, putative 0.0423 0.3273 0.53
Brugia malayi Inositol-1 0.0037 0.0211 0.0136
Schistosoma mansoni cathepsin F (C01 family) 0.079 0.6175 0.6162
Schistosoma mansoni caspase-7 (C14 family) 0.0115 0.0828 0.0798
Brugia malayi Cathepsin L-like precursor 0.079 0.6175 0.6145
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0116 0.084 0.0769
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0158 0.0256
Leishmania major metacaspase, putative 0.0043 0.0264 0.0307
Onchocerca volvulus 0.079 0.6175 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0314 0.0239
Echinococcus granulosus caspase 8 0.0043 0.0264 0.0189
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0779 0.1153
Loa Loa (eye worm) hypothetical protein 0.079 0.6175 0.6145
Plasmodium falciparum serine repeat antigen 8 0.0173 0.1294 0.1997
Loa Loa (eye worm) hypothetical protein 0.0173 0.1294 0.1227
Giardia lamblia Cathepsin B precursor 0.0173 0.1294 0.3114
Giardia lamblia Cysteine protease 0.0173 0.1294 0.3114
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1273 1 1
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0451 0.0613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Plasmodium vivax vivapain-2 0.079 0.6175 1
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.1294 0.1997
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0173 0.1294 0.1997
Loa Loa (eye worm) cysteine protease 0.079 0.6175 0.6145
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.079 0.6175 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0116 0.084 0.0769
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0384 0.031
Trypanosoma cruzi cysteine peptidase, putative 0.079 0.6175 0.6145
Trichomonas vaginalis glutaminase, putative 0.0285 0.2174 0.3439
Plasmodium falciparum serine repeat antigen 9 0.0173 0.1294 0.1997
Brugia malayi cathepsin L-like cysteine proteinase 0.0173 0.1294 0.1227
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0173 0.1294 0.2096
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0173 0.1294 0.1997
Echinococcus granulosus cathepsin l cysteine peptidase 0.079 0.6175 0.6145
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0031 0.0166 0.009
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Mycobacterium ulcerans hypothetical protein 0.0108 0.0779 0.2895
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.084 0.081
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0779 0.2895
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0264 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1294 0.1997
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.1012 0.0942
Brugia malayi cathepsin Z-like cysteine proteinase 0.0173 0.1294 0.1227
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0173 0.1294 0.1997
Plasmodium vivax serine-repeat antigen (SERA) 0.0173 0.1294 0.2096
Echinococcus multilocularis caspase 2 0.0084 0.0584 0.0511
Brugia malayi Importin beta-1 subunit 0.003 0.0158 0.0082
Onchocerca volvulus 0.079 0.6175 1
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Mycobacterium tuberculosis Conserved protein 0.0108 0.0779 0.1145
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0173 0.1294 0.2096
Echinococcus granulosus cathepsin l1 0.079 0.6175 0.6145
Trypanosoma cruzi metacaspase, putative 0.0043 0.0264 0.0189
Brugia malayi hypothetical protein 0.005 0.0314 0.0239
Echinococcus granulosus cathepsin L cysteine proteinase 0.079 0.6175 0.6145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0423 0.3273 0.5241
Brugia malayi Cathepsin L-like cysteine proteinase 0.054 0.4196 0.4151
Giardia lamblia Cathepsin L-like protease 0.0173 0.1294 0.3114
Toxoplasma gondii preprocathepsin c precursor, putative 0.0173 0.1294 0.2096
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0314 0.0509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Echinococcus multilocularis cathepsin L 0.0423 0.3273 0.3221
Loa Loa (eye worm) hypothetical protein 0.0043 0.0264 0.0189
Trichomonas vaginalis set domain proteins, putative 0.0482 0.3738 0.6004
Loa Loa (eye worm) hypothetical protein 0.025 0.1899 0.1837
Schistosoma mansoni cathepsin F (C01 family) 0.079 0.6175 0.6162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Leishmania major hypothetical protein, conserved 0.0031 0.0166 0.0146
Giardia lamblia Cathepsin B precursor 0.0173 0.1294 0.3114
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0031 0.0166 0.0133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1012 0.0982
Entamoeba histolytica cysteine protease, putative 0.0173 0.1294 0.2096
Entamoeba histolytica cysteine proteinase, putative 0.079 0.6175 1
Brugia malayi Pre-SET motif family protein 0.0424 0.3275 0.3223
Loa Loa (eye worm) hypothetical protein 0.023 0.1742 0.1678
Brugia malayi Cathepsin L-like precursor 0.025 0.1899 0.1837
Schistosoma mansoni inositol monophosphatase 0.0037 0.0211 0.0179
Leishmania major cathepsin L-like protease 0.079 0.6175 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0779 0.1145
Schistosoma mansoni hypothetical protein 0.0176 0.1317 0.1289
Loa Loa (eye worm) papain family cysteine protease containing protein 0.079 0.6175 0.6145
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0173 0.1294 0.1265
Brugia malayi hypothetical protein 0.023 0.1742 0.1678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0116 0.084 0.0769
Plasmodium vivax unspecified product 0.025 0.1899 0.3076
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0211 0.0221
Schistosoma mansoni hypothetical protein 0.0047 0.0292 0.026
Schistosoma mansoni jumonji domain containing protein 0.0116 0.084 0.081
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0423 0.3273 0.3251
Leishmania major hypothetical protein, conserved 0.0108 0.0779 0.1153
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1273 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0158 0.0134
Brugia malayi hypothetical protein 0.004 0.024 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.079 0.6175 1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.0715 0.0644
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0779 0.0708
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.1294 0.1265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1012 0.0982
Loa Loa (eye worm) hypothetical protein 0.054 0.4196 0.4151
Echinococcus granulosus caspase 2 0.0084 0.0584 0.0511
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0865 0.0795
Leishmania major cathepsin L-like protease 0.079 0.6175 1
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0779 0.1153
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0211 0.0342
Echinococcus granulosus cathepsin L 0.0173 0.1294 0.1227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1012 0.0942
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0292 0.0217
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0264 0.0307
Schistosoma mansoni survival motor neuron protein 0.0047 0.0292 0.026
Plasmodium falciparum serine repeat antigen 6 0.0173 0.1294 0.1997
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Echinococcus granulosus importin subunit beta 1 0.003 0.0158 0.0082
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.1294 0.1265
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0158 0.0134
Echinococcus multilocularis cathepsin l cysteine peptidase 0.079 0.6175 0.6145
Echinococcus granulosus cathepsin L 0.0423 0.3273 0.3221
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0451 0.0419
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0097 0.0021
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0715 0.0685
Brugia malayi follicle stimulating hormone receptor 0.0471 0.3653 0.3604
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0264 0.0307
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0513 0.3987 0.394
Loa Loa (eye worm) papain family cysteine protease containing protein 0.025 0.1899 0.1837
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1012 0.0942
Onchocerca volvulus 0.0173 0.1294 0.1776
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0513 0.3987 0.6412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0158 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0779 0.1262
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0402 0.0328
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0166 0.009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0779 0.1145
Onchocerca volvulus 0.0108 0.0779 0.0909
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0451 0.0419
Echinococcus granulosus snurportin 1 0.032 0.2458 0.24
Plasmodium vivax serine-repeat antigen (SERA) 0.0173 0.1294 0.2096
Entamoeba histolytica hypothetical protein 0.0173 0.1294 0.2096
Entamoeba histolytica cysteine protease, putative 0.0173 0.1294 0.2096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0402 0.037
Echinococcus granulosus cathepsin b 0.1273 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0173 0.1294 0.1265
Leishmania major cathepsin L-like protease 0.079 0.6175 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Schistosoma mansoni phd/f-box containing protein 0.0031 0.0166 0.0133
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0264 0.0189
Giardia lamblia Cathepsin L precursor 0.0173 0.1294 0.3114
Toxoplasma gondii Alpha-galactosidase 0.0014 0.0033 0.0053
Toxoplasma gondii cathepsin CPC2 0.0173 0.1294 0.2096
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0113 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0513 0.3987 0.3967
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.0166 0.009
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0314 0.0389
Giardia lamblia Cysteine protease 0.0173 0.1294 0.3114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.079 0.6175 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.1294 0.1265
Echinococcus granulosus caspase 3 0.0071 0.0485 0.0412
Giardia lamblia Cathepsin B precursor 0.0513 0.3987 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1012 0.0942
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0693 0.5408 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.0082
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0211 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0779 0.0708
Loa Loa (eye worm) hypothetical protein 0.0108 0.0779 0.0708
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0264 0.0427
Entamoeba histolytica recQ family helicase, putative 0.002 0.0077 0.0124
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0264 0.0427
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0423 0.3273 0.3251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Trypanosoma cruzi cysteine peptidase, putative 0.079 0.6175 0.6145
Loa Loa (eye worm) ctsf protein 0.079 0.6175 0.6145
Echinococcus multilocularis phd:f box containing protein 0.0031 0.0166 0.009
Trypanosoma cruzi cysteine peptidase, putative 0.025 0.1899 0.1837
Onchocerca volvulus Cathepsin L homolog 0.079 0.6175 1
Loa Loa (eye worm) hypothetical protein 0.004 0.024 0.0165
Leishmania major cysteine peptidase A (CPA) 0.079 0.6175 1
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Entamoeba histolytica hypothetical protein 0.0024 0.0113 0.0183
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0173 0.1294 0.1227
Brugia malayi Cathepsin L-like precursor 0.079 0.6175 0.6145
Giardia lamblia Cathepsin L precursor 0.0173 0.1294 0.3114
Echinococcus granulosus cathepsin L cysteine protease 0.0423 0.3273 0.3221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.079 0.6175 1
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1742 0.1678
Brugia malayi MH2 domain containing protein 0.0119 0.0865 0.0795
Loa Loa (eye worm) hypothetical protein 0.0108 0.0779 0.0708
Plasmodium falciparum serine repeat antigen 5 0.0173 0.1294 0.1997
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0779 0.0708
Brugia malayi cathepsin Z-like cysteine proteinase 0.0173 0.1294 0.1227
Mycobacterium ulcerans beta-lactamase 0.0108 0.0779 0.2895
Echinococcus multilocularis caspase 3 0.0071 0.0485 0.0412
Onchocerca volvulus Cell death protein 3 homolog 0.0084 0.0584 0.0579
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0779 0.1145
Plasmodium vivax unspecified product 0.0173 0.1294 0.2096
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.0166 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0264 0.0307
Onchocerca volvulus 0.0108 0.0779 0.0909
Schistosoma mansoni hypothetical protein 0.032 0.2458 0.2433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1294 0.1997
Trypanosoma brucei Metacaspase-4 0.0043 0.0264 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0173 0.1294 0.1997
Schistosoma mansoni inositol monophosphatase 0.0037 0.0211 0.0179
Giardia lamblia Hypothetical protein 0.0173 0.1294 0.3114
Trypanosoma cruzi metacaspase, putative 0.0043 0.0264 0.0189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0173 0.1294 0.1997
Plasmodium vivax vivapain-3 0.0423 0.3273 0.53
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.0166 0.009
Entamoeba histolytica cysteine protease, putative 0.0423 0.3273 0.53
Toxoplasma gondii ABC1 family protein 0.0108 0.0779 0.1262
Loa Loa (eye worm) hypothetical protein 0.0067 0.0451 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0264 0.0307
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.0166 0.009
Brugia malayi Papain family cysteine protease containing protein 0.0173 0.1294 0.1227
Loa Loa (eye worm) hypothetical protein 0.054 0.4196 0.4151
Mycobacterium tuberculosis Conserved protein 0.0108 0.0779 0.1145
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0264 0.0427
Brugia malayi Cathepsin L-like precursor 0.054 0.4196 0.4151
Giardia lamblia Cathepsin L precursor 0.0173 0.1294 0.3114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0423 0.3273 0.5241
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0166 0.0268
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0173 0.1294 0.2096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0779 0.0749
Brugia malayi Cathepsin L-like precursor 0.054 0.4196 0.4151
Schistosoma mansoni DNA helicase recq1 0.002 0.0077 0.0044
Giardia lamblia Cathepsin L-like protease 0.0173 0.1294 0.3114
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0031 0.0166 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0173 0.1294 0.1997
Plasmodium falciparum metacaspase 1 0.0043 0.0264 0.0307
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0173 0.1294 0.1227
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.0166 0.009
Toxoplasma gondii cathepsin CPL 0.079 0.6175 1
Plasmodium falciparum serine repeat antigen 4 0.0173 0.1294 0.1997
Entamoeba histolytica cysteine proteinase, putative 0.079 0.6175 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0402 0.037
Loa Loa (eye worm) hypothetical protein 0.054 0.4196 0.4151
Loa Loa (eye worm) hypothetical protein 0.0108 0.0779 0.0708
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0166 0.009
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0166 0.009
Plasmodium vivax unspecified product 0.0423 0.3273 0.53
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0173 0.1294 0.1265
Echinococcus multilocularis cathepsin L cysteine protease 0.079 0.6175 0.6145
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.1012 0.0942
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0115 0.0828 0.0758
Onchocerca volvulus 0.0061 0.0402 0.0272
Schistosoma mansoni protein phosphatase 2C 0.0031 0.0166 0.0133
Loa Loa (eye worm) hypothetical protein 0.0173 0.1294 0.1227
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0031 0.0166 0.0146
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.054 0.4196 0.4151
Trypanosoma cruzi cysteine protease, putative 0.0423 0.3273 0.3221
Plasmodium falciparum cysteine proteinase falcipain 3 0.079 0.6175 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0173 0.1294 0.1997
Giardia lamblia Hypothetical protein 0.0173 0.1294 0.3114
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0715 0.0685
Echinococcus multilocularis snurportin 1 0.032 0.2458 0.24
Leishmania major hypothetical protein, conserved 0.005 0.0314 0.0389
Trypanosoma brucei metacaspase MCA3 0.0043 0.0264 0.0307
Brugia malayi hypothetical protein 0.0032 0.0175 0.0099
Giardia lamblia Cathepsin B precursor 0.0173 0.1294 0.3114
Mycobacterium ulcerans lipase LipD 0.0108 0.0779 0.2895
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0077 0.0124
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0113 0.006
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0173 0.1294 0.2096
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0166 0.009
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0173 0.1294 0.2096
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0173 0.1294 0.1997
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.1294 0.1265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.079 0.6175 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0173 0.1294 0.1227
Brugia malayi cathepsin L precursor 0.0173 0.1294 0.1227
Giardia lamblia Encystation-specific protease 0.0173 0.1294 0.3114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.079 0.6175 1
Brugia malayi Papain family cysteine protease containing protein 0.0173 0.1294 0.1227
Loa Loa (eye worm) hypothetical protein 0.1273 1 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0043 0.0264 0.0189
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.6167 0.6138
Brugia malayi Papain family cysteine protease containing protein 0.0173 0.1294 0.1227
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.024 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.079 0.6175 1
Brugia malayi jmjC domain containing protein 0.0116 0.084 0.0769
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0173 0.1294 0.2096
Brugia malayi RNA, U transporter 1 0.0085 0.0596 0.0524
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0173 0.1294 0.2096
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0113 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.079 0.6175 1
Giardia lamblia Cathepsin L precursor 0.0173 0.1294 0.3114
Onchocerca volvulus 0.079 0.6175 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0264 0.0307
Brugia malayi beta-lactamase family protein 0.0108 0.0779 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.1294 0.1997
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0211 0.0136
Plasmodium vivax importin-beta 2, putative 0.003 0.0158 0.0256
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0173 0.1294 0.2096
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.079 0.6175 0.6145
Toxoplasma gondii cathepsin CPC1 0.0173 0.1294 0.2096
Brugia malayi Papain family cysteine protease containing protein 0.0423 0.3273 0.3221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.079 0.6175 1
Trypanosoma cruzi cysteine peptidase, putative 0.079 0.6175 0.6145

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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