Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0088 | 0.228 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0179 | 0.0733 | 1 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0102 | 0.0387 | 1 |
Trypanosoma cruzi | carbohydrate kinase, thermoresistant glucokinase, putative | 0.0102 | 0.0387 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0088 | 0.0088 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0088 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0088 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0427 | 0.1844 | 0.1844 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0088 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0088 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0226 | 0.0943 | 0.2575 |
Mycobacterium ulcerans | shikimate kinase | 0.0775 | 0.3409 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0088 | 0.0259 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0197 | 0.0816 | 0.0816 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0197 | 0.0816 | 0.0816 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0088 | 0.0259 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0046 | 0.0046 |
Echinococcus granulosus | carbohydrate kinase thermoresistant glucokinase | 0.0102 | 0.0387 | 0.0373 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0088 | 0.0259 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0088 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0427 | 0.1844 | 0.6173 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.0816 | 0.2558 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0733 | 0.0733 |
Chlamydia trachomatis | shikimate kinase | 0.0775 | 0.3409 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0088 | 0.228 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0088 | 0.0259 |
Mycobacterium tuberculosis | Shikimate kinase AroK (SK) | 0.0775 | 0.3409 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.0816 | 0.2558 |
Loa Loa (eye worm) | hypothetical protein | 0.2244 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0088 | 0.5 |
Mycobacterium leprae | Shikimate kinase AroK (SK) | 0.0775 | 0.3409 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0088 | 0.5 |
Mycobacterium ulcerans | gluconate kinase | 0.0102 | 0.0387 | 0.1135 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.0816 | 0.2558 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0088 | 0.0088 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.1844 | 0.1844 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0046 | 0.0046 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0088 | 0.0088 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0088 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0179 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0816 | 0.0816 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0197 | 0.0816 | 0.0816 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0088 | 0.0088 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0197 | 0.0816 | 0.0909 |
Echinococcus granulosus | GPCR family 2 | 0.0197 | 0.0816 | 0.0909 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0088 | 0.0088 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0088 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0669 | 0.2932 | 0.3556 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0669 | 0.2932 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0197 | 0.0816 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0088 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.1818 | 0.8086 | 1 |
Echinococcus granulosus | thermoresistant glucokinase family carbohydrate | 0.0102 | 0.0387 | 0.0373 |
Echinococcus multilocularis | GPCR, family 2 | 0.0197 | 0.0816 | 0.0909 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0624 | 0.273 | 0.273 |
Echinococcus multilocularis | carbohydrate kinase, thermoresistant glucokinase | 0.0102 | 0.0387 | 0.0373 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0088 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0088 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0088 | 0.0259 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.1818 | 0.8086 | 1 |
Schistosoma mansoni | shikimate-kinase | 0.0102 | 0.0387 | 0.105 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0102 | 0.0387 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0624 | 0.273 | 0.273 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0669 | 0.2932 | 0.3556 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.0816 | 0.2558 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0088 | 0.0088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | ND 0 nM | In vitro inhibitory activity against Angiotensin I converting enzyme | ChEMBL. | 2999394 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.