Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0644 | 0.3112 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1031 | 1 | 0.5 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.019 | 0.1627 | 0.7902 |
Plasmodium vivax | calcium-transporting ATPase, putative | 0.0044 | 0.0182 | 0.5 |
Mycobacterium leprae | Isocitrate lyase | 0.0483 | 0.4549 | 0.4138 |
Echinococcus granulosus | calcium transporting atpase | 0.0044 | 0.0182 | 0.0218 |
Echinococcus multilocularis | nervana 2 | 0.0229 | 0.2021 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0141 | 0.06 |
Plasmodium falciparum | calcium-transporting ATPase | 0.0044 | 0.0182 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0904 | 0.4412 |
Toxoplasma gondii | P-type ATPase4, putative | 0.0044 | 0.0182 | 1 |
Echinococcus granulosus | nervana 2 | 0.0229 | 0.2021 | 1 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.004 | 0.0141 | 0.7755 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.019 | 0.1627 | 0.7902 |
Trypanosoma brucei | calcium-translocating P-type ATPase | 0.0044 | 0.0182 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1031 | 1 | 0.5 |
Echinococcus granulosus | calcium transporting ATPase type 2C member | 0.0044 | 0.0182 | 0.0218 |
Toxoplasma gondii | plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 | 0.0044 | 0.0182 | 1 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha chain, putative | 0.0101 | 0.0743 | 0.822 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0229 | 0.2021 | 1 |
Trypanosoma brucei | calcium motive p-type ATPase, putative | 0.0044 | 0.0182 | 1 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.004 | 0.0141 | 0.7455 |
Echinococcus multilocularis | plasma membrane calcium transporting ATPase | 0.0044 | 0.0182 | 0.0218 |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | 0.0044 | 0.0182 | 0.0218 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.004 | 0.0141 | 0.7455 |
Entamoeba histolytica | calcium-transporting P-type ATPase, putative | 0.0044 | 0.0182 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.019 | 0.1627 | 0.7902 |
Echinococcus multilocularis | Ca2+ transporting ATPase plasma membrane | 0.0044 | 0.0182 | 0.0218 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.0117 | 0.0904 | 1 |
Echinococcus multilocularis | Na+:K+ ATPase alpha subunit | 0.0117 | 0.0904 | 0.4056 |
Plasmodium falciparum | non-SERCA-type Ca2+ -transporting P-ATPase | 0.0044 | 0.0182 | 0.5 |
Leishmania major | calcium-transporting ATPase, putative | 0.0044 | 0.0182 | 1 |
Schistosoma mansoni | calcium-transporting atpase 2 (atpase 2) | 0.0044 | 0.0182 | 0.0218 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0044 | 0.0182 | 1 |
Brugia malayi | Membrane calcium atpase protein 3 | 0.0044 | 0.0182 | 0.2018 |
Echinococcus multilocularis | calcium transporting ATPase type 2C member | 0.0044 | 0.0182 | 0.0218 |
Echinococcus granulosus | Ca2 transporting ATPase plasma membrane | 0.0044 | 0.0182 | 0.0218 |
Schistosoma mansoni | transmemberane protein | 0.0229 | 0.2021 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1031 | 1 | 0.5 |
Plasmodium vivax | P-type ATPase4, putative | 0.0044 | 0.0182 | 0.5 |
Onchocerca volvulus | 0.0229 | 0.2021 | 1 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0055 | 0.0285 | 0.0765 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0044 | 0.0182 | 1 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase 2 | 0.0044 | 0.0182 | 0.0218 |
Echinococcus granulosus | nervana 2 | 0.019 | 0.1627 | 0.7902 |
Echinococcus multilocularis | nervana 2 | 0.019 | 0.1627 | 0.7902 |
Schistosoma mansoni | calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) | 0.0044 | 0.0182 | 0.0218 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0101 | 0.0743 | 0.3608 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0461 | 0.22 |
Brugia malayi | Probable calcium-transporting ATPase KIAA0703 | 0.0028 | 0.0022 | 0.0238 |
Brugia malayi | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0044 | 0.0182 | 0.2018 |
Echinococcus granulosus | Na:K ATPase alpha subunit | 0.0117 | 0.0904 | 0.4056 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0229 | 0.2021 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0229 | 0.2021 | 1 |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | 0.0044 | 0.0182 | 0.0218 |
Echinococcus granulosus | nervana 2 | 0.019 | 0.1627 | 0.7902 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0117 | 0.0904 | 1 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 1 | 0.004 | 0.0141 | 0.7455 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0229 | 0.2021 | 1 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 2 | 0.004 | 0.0141 | 0.7455 |
Echinococcus multilocularis | Tetracycline resistance leader peptide, TetL | 0.0044 | 0.0182 | 0.0218 |
Echinococcus multilocularis | calcium transporting atpase | 0.0044 | 0.0182 | 0.0218 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.0117 | 0.0904 | 0.4412 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.052 | 0.2491 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0117 | 0.0904 | 0.4056 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0117 | 0.0904 | 0.4056 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0229 | 0.2021 | 1 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0229 | 0.2021 | 1 |
Echinococcus granulosus | nervana 2 | 0.0229 | 0.2021 | 1 |
Leishmania major | P-type ATPase, putative | 0.0044 | 0.0182 | 1 |
Onchocerca volvulus | 0.019 | 0.1627 | 0.6596 | |
Schistosoma mansoni | lipoxygenase | 0.0055 | 0.0285 | 0.0765 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0229 | 0.2021 | 1 |
Echinococcus multilocularis | nervana 2 | 0.019 | 0.1627 | 0.7902 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0044 | 0.0182 | 1 |
Leishmania major | calcium motive p-type ATPase, putative | 0.0044 | 0.0182 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0044 | 0.0182 | 1 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase | 0.0044 | 0.0182 | 0.0218 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase, putative | 0.004 | 0.0141 | 0.7455 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.019 | 0.1627 | 0.7902 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0229 | 0.2021 | 1 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.004 | 0.0141 | 0.7755 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.0113 | 0.0863 | 0.0693 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0055 | 0.0285 | 0.0765 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.2021 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0229 | 0.2021 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.2021 | 1 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1031 | 1 | 1 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.004 | 0.0141 | 0.7755 |
Toxoplasma gondii | sarco/endoplasmic reticulum Ca2+-ATPase | 0.0044 | 0.0182 | 1 |
Trypanosoma cruzi | Calcium ATPase SERCA-like | 0.004 | 0.0141 | 0.7455 |
Schistosoma mansoni | calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) | 0.0044 | 0.0182 | 0.0218 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 2 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 3.46 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.62 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.75 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 14 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 86 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 14 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 86 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 104 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.47 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.33592 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.