Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0007 | 0.0024 | 0.003 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0007 | 0.0024 | 0.003 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0097 | 0.1159 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.006 | 0.0043 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0232 | 0.1998 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0533 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.1178 | 0.1386 |
Loa Loa (eye worm) | acetyltransferase | 0.0143 | 0.1736 | 0.4174 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0462 | 0.0517 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0536 | 0.0513 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Trichomonas vaginalis | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0024 | 0.017 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0096 | 0.1049 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0466 | 0.1208 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0024 | 0.017 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0681 | 0.8501 | 0.8497 |
Toxoplasma gondii | cytochrome b | 0.0312 | 0.3861 | 1 |
Brugia malayi | cytochrome b | 0.0312 | 0.3861 | 0.9317 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0232 | 0.1998 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0097 | 0.1159 | 0.2778 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0232 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0097 | 0.1159 | 0.1339 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0024 | 0.017 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0681 | 0.8501 | 1 |
Plasmodium falciparum | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 0.1834 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0007 | 0.0024 | 0.0205 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 0.619 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0062 | 0.0717 | 0.0844 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase | 0.0062 | 0.0717 | 0.0844 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0533 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0157 | 0.6421 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0466 | 0.0522 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0235 | 0.0542 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.2996 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0097 | 0.1159 | 0.1138 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.001 | 0.006 | 0.0127 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0232 | 0.3115 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0235 | 0.3049 |
Schistosoma mansoni | cytochrome b | 0.0312 | 0.3861 | 0.4542 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0462 | 0.0439 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0232 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.0422 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0096 | 0.1049 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0422 | 0.1067 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.0334 | 0.4143 | 1 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Plasmodium vivax | cytochrome b | 0.0312 | 0.3861 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Toxoplasma gondii | hypothetical protein | 0.0006 | 0.0011 | 0.003 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0.0024 | 0.0061 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB1 | 0.0062 | 0.0717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0533 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0143 | 0.1736 | 0.4174 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0007 | 0.0024 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1159 | 0.2778 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0235 | 0.0212 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0199 | 0.0487 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0157 | 0.2061 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0235 | 0.0542 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0533 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.0024 | 0.0028 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0157 | 0.5 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0118 |
Brugia malayi | Pre-B cell enhancing factor precursor | 0.0334 | 0.4143 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0024 | 0.017 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0462 | 0.109 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.1085 | 0.1252 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0462 | 0.0517 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.006 | 0.0071 |
Trypanosoma brucei | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Plasmodium falciparum | cytochrome b | 0.0312 | 0.3861 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0422 | 0.3642 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0533 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0462 | 0.0543 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.006 | 0.0037 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0139 | 0.1685 | 0.196 |
Schistosoma mansoni | cytochrome b | 0.0312 | 0.3861 | 0.4542 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0118 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0024 | 0.017 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0235 | 0.025 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.006 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0235 | 0.3049 |
Loa Loa (eye worm) | oxidoreductase | 0.0007 | 0.0024 | 0.003 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0024 | 0.017 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.2996 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0156 |
Toxoplasma gondii | apocytochrome b, putative | 0.0312 | 0.3861 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.006 | 0.0043 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0312 | 0.3861 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Leishmania major | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0462 | 0.0439 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Echinococcus granulosus | cytochrome B | 0.0312 | 0.3861 | 0.4527 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.1085 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0462 | 0.109 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.0334 | 0.4143 | 0.486 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0143 | 0.1736 | 0.2042 |
Onchocerca volvulus | 0.0023 | 0.0232 | 1 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0136 | 0.0353 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0156 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0007 | 0.0024 | 0.0032 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0466 | 0.6379 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0096 | 0.0832 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.006 | 0.0071 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0157 | 0.0379 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0466 | 0.6379 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1437 | 0.345 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0139 | 0.1683 | 0.1958 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | 0.0062 | 0.0717 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0157 | 0.0379 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.058 | 0.1375 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0312 | 0.3861 | 0.9317 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0143 | 0.1736 | 0.1716 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0232 | 1 |
Trypanosoma cruzi | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0533 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0462 | 0.6312 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0232 | 0.3115 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0173 | 0.0203 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0139 | 0.0331 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.0334 | 0.4143 | 0.4129 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0466 | 0.1182 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.0062 | 0.0717 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.2996 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0334 | 0.4143 | 0.4874 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0024 | 0.003 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0462 | 0.109 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0681 | 0.8501 | 1 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0024 | 0.017 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0232 | 0.1998 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0.0024 | 0.0061 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0139 | 0.1683 | 0.1664 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0024 | 0.003 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.006 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0096 | 0.1049 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0096 | 0.1049 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0.0024 | 0.0061 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0466 | 0.1208 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.006 | 0.0118 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 6.06 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 6.32 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 10.69 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 19 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 77 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 20 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 19 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 77 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 100 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.18 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.65554 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.