Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2C | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3B | References | |
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | References | |
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glutamate receptor 1 precursor | 0.0196 | 0.3392 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0092 | 0.0247 | 0.0262 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0223 | 0.4228 | 0.4473 |
Echinococcus multilocularis | glutamate receptor 2 | 0.014 | 0.1692 | 0.179 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0223 | 0.4228 | 0.4473 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0188 | 0.316 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0223 | 0.4228 | 0.4473 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0196 | 0.3392 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0396 | 0.9453 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0098 | 0.0427 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0218 | 0.4071 | 0.4307 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.032 | 0.7165 | 0.758 |
Echinococcus granulosus | glutamate receptor 2 | 0.014 | 0.1692 | 0.179 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.2483 | 0.2483 |
Echinococcus granulosus | geminin | 0.0166 | 0.2483 | 0.2627 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.013 | 0.1393 | 0.1474 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0196 | 0.3392 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0196 | 0.3392 | 0.3392 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0196 | 0.3392 | 0.3392 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0196 | 0.3392 | 0.3392 |
Echinococcus multilocularis | expressed conserved protein | 0.0092 | 0.0247 | 0.0262 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0218 | 0.4071 | 0.4307 |
Schistosoma mansoni | glutamate receptor kainate | 0.0196 | 0.3392 | 0.3392 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0223 | 0.4228 | 0.4473 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.019 | 0.3235 | 0.3423 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0098 | 0.0427 | 0.0452 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0188 | 0.316 | 1 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0188 | 0.316 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.0473 | 0.0473 |
Leishmania major | sterol 24-c-methyltransferase, putative | 0.0188 | 0.316 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0196 | 0.3392 | 0.3589 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0223 | 0.4228 | 0.4473 |
Echinococcus granulosus | glutamate receptor 2 | 0.0223 | 0.4228 | 0.4473 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0188 | 0.316 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.2483 | 0.2483 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0098 | 0.0427 | 0.0452 |
Echinococcus multilocularis | geminin | 0.0166 | 0.2483 | 0.2627 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0223 | 0.4228 | 0.4473 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0196 | 0.3392 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0427 | 0.0595 |
Trypanosoma brucei | Sterol methyltransferase, putative | 0.0188 | 0.316 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0223 | 0.4228 | 0.4473 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0188 | 0.316 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0396 | 0.9453 | 0.9453 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0396 | 0.9453 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.014 | 0.1699 | 0.1797 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0196 | 0.3392 | 0.3392 |
Echinococcus granulosus | nmda type glutamate receptor | 0.032 | 0.7165 | 0.758 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.014 | 0.1699 | 0.1797 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0098 | 0.0427 | 0.0595 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0223 | 0.4228 | 0.4473 |
Echinococcus granulosus | glutamate receptor NMDA | 0.019 | 0.3235 | 0.3423 |
Leishmania major | sterol 24-c-methyltransferase, putative | 0.0188 | 0.316 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.0196 | 0.3392 | 0.3392 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0223 | 0.4228 | 0.4473 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.15 | Compound was tested for inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | = 1.4 uM | Inhibition of [3H]-DCKA binding to NMDA receptor of rat brain membranes. | ChEMBL. | 8917657 |
IC50 (binding) | = 1.4 uM | Inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | = 1.4 uM | Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | ChEMBL. | 8765507 |
IC50 (binding) | = 1.4 uM | Inhibition of [3H]-DCKA binding to NMDA receptor of rat brain membranes. | ChEMBL. | 8917657 |
IC50 (binding) | = 1.4 uM | Inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | = 1.4 uM | Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | ChEMBL. | 8765507 |
Log (binding) | = -0.15 1/IC50 | Compound was tested for inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.