Detailed information for compound 616616

Basic information

Technical information
  • TDR Targets ID: 616616
  • Name: 4-bromo-N-[2-(8-methylimidazo[1,2-a]pyridin-2 -yl)ethyl]benzenesulfonamide
  • MW: 394.286 | Formula: C16H16BrN3O2S
  • H donors: 1 H acceptors: 3 LogP: 3.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)S(=O)(=O)NCCc1cn2c(n1)c(C)ccc2
  • InChi: 1S/C16H16BrN3O2S/c1-12-3-2-10-20-11-14(19-16(12)20)8-9-18-23(21,22)15-6-4-13(17)5-7-15/h2-7,10-11,18H,8-9H2,1H3
  • InChiKey: AOCPJYDPVPMYEY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-bromo-N-[2-(8-methyl-2-imidazo[1,2-a]pyridinyl)ethyl]benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mitogen activated protein kinase 11 0.0305 0.8919 0.8919
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0908 0.1018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0331 0.0335
Giardia lamblia DINP protein human, muc B family 0.0019 0 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0331 0.0331
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0305 0.8919 0.9011
Onchocerca volvulus 0.0238 0.6829 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0305 0.8919 0.8919
Echinococcus granulosus hormone sensitive lipase 0.0336 0.9897 0.9897
Loa Loa (eye worm) hypothetical protein 0.005 0.0947 0.0956
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0331 0.0331
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0336 0.9897 1
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0947 0.0956
Schistosoma mansoni hypothetical protein 0.0048 0.0908 0.0918
Trichomonas vaginalis set domain proteins, putative 0.0238 0.6829 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0305 0.8919 0.8919
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.6816 0.6816
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0336 0.9897 1
Onchocerca volvulus 0.0048 0.0908 0.0888
Plasmodium vivax SET domain protein, putative 0.003 0.0331 0.5
Echinococcus multilocularis tumor protein p63 0.034 1 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0336 0.9897 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0331 0.0335
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0336 0.9897 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0305 0.8919 1
Brugia malayi Pre-SET motif family protein 0.003 0.0331 0.0371
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0297 0.0297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0331 0.0335
Mycobacterium ulcerans DNA polymerase IV 0.0019 0 0.5
Brugia malayi hypothetical protein 0.0238 0.6816 0.7643
Brugia malayi Pre-SET motif family protein 0.0209 0.5927 0.6645
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0305 0.8919 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0305 0.8919 0.8919
Loa Loa (eye worm) hypothetical protein 0.003 0.0331 0.0335
Echinococcus multilocularis mitogen activated protein kinase 14 0.0305 0.8919 0.8919
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0331 0.5
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.6816 0.6816
Echinococcus multilocularis mitogen activated protein kinase 11 0.0305 0.8919 0.8919
Echinococcus multilocularis hormone sensitive lipase 0.0336 0.9897 0.9897
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0 0.5
Onchocerca volvulus 0.005 0.0947 0.0947
Mycobacterium ulcerans DNA polymerase IV 0.0019 0 0.5
Schistosoma mansoni survival motor neuron protein 0.0048 0.0908 0.0918
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0331 0.0331
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0331 0.0335
Brugia malayi P38 map kinase family protein 2 0.0305 0.8919 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.5927 0.5988
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0305 0.8919 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.6816 0.6887
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0305 0.8919 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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