Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0339 | 0.0652 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0339 | 0.0339 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0339 | 0.0664 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0339 | 0.0339 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0102 | 0.2379 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0014 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.004 | 0.071 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.041 | 0.041 |
Loa Loa (eye worm) | glutathione reductase | 0.004 | 0.071 | 0.1379 |
Brugia malayi | Thioredoxin reductase | 0.004 | 0.071 | 0.139 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0339 | 0.0339 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.041 | 0.041 |
Trypanosoma brucei | trypanothione reductase | 0.004 | 0.071 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0092 | 0.2102 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0102 | 0.2379 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.5107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0326 | 0.0626 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0092 | 0.2102 | 0.8837 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.041 | 0.0806 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.041 | 0.041 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0041 | 0.0725 | 0.0725 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0041 | 0.0725 | 0.0725 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1142 | 0.2226 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0203 | 0.5091 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0339 | 0.0652 |
Plasmodium falciparum | glutathione reductase | 0.004 | 0.071 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0385 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0339 | 0.0666 |
Treponema pallidum | NADH oxidase | 0.0014 | 0 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.5107 | 1 |
Onchocerca volvulus | 0.0029 | 0.041 | 0.0128 | |
Echinococcus granulosus | hormone sensitive lipase | 0.0203 | 0.5091 | 0.5091 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0007 | 0.0014 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.041 | 0.0806 |
Brugia malayi | glutathione reductase | 0.004 | 0.071 | 0.139 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0092 | 0.2102 | 0.8837 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0339 | 0.0666 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0102 | 0.2379 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.041 | 0.0803 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.041 | 0.5775 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0339 | 0.0339 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0339 | 0.0664 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.004 | 0.071 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0092 | 0.2102 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0339 | 0.0652 |
Onchocerca volvulus | 0.0056 | 0.1142 | 0.1453 | |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0092 | 0.2102 | 0.8837 |
Plasmodium vivax | glutathione reductase, putative | 0.004 | 0.071 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.041 | 0.0806 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0092 | 0.2102 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.5091 | 0.9967 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0203 | 0.5091 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.5865 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0381 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.041 | 0.079 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.041 | 0.0806 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0339 | 0.0339 |
Schistosoma mansoni | lamin | 0.0027 | 0.0339 | 0.0666 |
Loa Loa (eye worm) | thioredoxin reductase | 0.004 | 0.071 | 0.1379 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.041 | 0.5775 |
Onchocerca volvulus | 0.0232 | 0.5865 | 1 | |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.004 | 0.071 | 0.2985 |
Plasmodium vivax | thioredoxin reductase, putative | 0.004 | 0.071 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0203 | 0.5091 | 0.5091 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0203 | 0.5091 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0056 | 0.1142 | 0.2244 |
Echinococcus granulosus | lamin | 0.0027 | 0.0339 | 0.0339 |
Plasmodium falciparum | thioredoxin reductase | 0.004 | 0.071 | 1 |
Leishmania major | trypanothione reductase | 0.004 | 0.071 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0102 | 0.2379 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.