Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0171 | 0.4088 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0171 | 0.4088 | 0.063 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0171 | 0.4088 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0171 | 0.4088 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.4088 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0171 | 0.4088 | 0.4088 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0171 | 0.4088 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0171 | 0.4088 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0164 | 0.3761 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0306 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.3761 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.0306 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0171 | 0.4088 | 0.4088 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0282 | 0.8951 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0171 | 0.4088 | 0.4088 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0164 | 0.3761 | 0.7772 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0171 | 0.4088 | 0.4088 |
Schistosoma mansoni | inositol transporter | 0.0306 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0171 | 0.4088 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0171 | 0.4088 | 0.4088 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0306 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.0306 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.3761 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0171 | 0.4088 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0306 | 1 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0171 | 0.4088 | 0.5 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0306 | 1 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0171 | 0.4088 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0282 | 0.8951 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0164 | 0.3761 | 0.7772 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0171 | 0.4088 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0171 | 0.4088 | 0.5 |
Echinococcus multilocularis | solute carrier family 5 | 0.0306 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0171 | 0.4088 | 0.4088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 58 % | Antagonistic blocking activity at alpha adrenergic receptor by NE induced contractions of the epididymal portion of isolated rat vas deferens at the dose of 20 microM | ChEMBL. | 2999398 |
Activity (functional) | = 58 % | Antagonistic blocking activity at alpha adrenergic receptor by NE induced contractions of the epididymal portion of isolated rat vas deferens at the dose of 20 microM | ChEMBL. | 2999398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.