Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0102 | 0.1708 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.2185 | 0.2185 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0038 | 0.0176 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0102 | 0.1708 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0347 | 0.782 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0896 | 0.4099 |
Mycobacterium ulcerans | hypothetical protein | 0.0347 | 0.782 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0347 | 0.782 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0347 | 0.782 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.004 | 0.0172 | 0.0785 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0102 | 0.1708 | 0.7816 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0102 | 0.1708 | 0.7816 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0119 | 0.2134 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0121 | 0.2185 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0102 | 0.1708 | 0.1108 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0105 | 0.0616 |
Plasmodium vivax | RNA helicase-1, putative | 0.0102 | 0.1708 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.1708 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0121 | 0.2185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1708 | 0.7816 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.2134 | 0.9767 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0119 | 0.2134 | 0.9706 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Onchocerca volvulus | 0.0121 | 0.2185 | 1 | |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0102 | 0.1708 | 0.7816 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.004 | 0.0172 | 0.0785 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.1708 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.1708 | 0.7245 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.004 | 0.0172 | 0.1004 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0119 | 0.2134 | 0.9706 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0264 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.2185 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 0.7816 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0347 | 0.782 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0105 | 0.0616 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0119 | 0.2134 | 0.9706 |
Mycobacterium tuberculosis | Conserved protein | 0.0347 | 0.782 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.1708 | 0.7245 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0264 | 0.0264 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 0.7816 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.004 | 0.0172 | 0.0785 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | 0 uM | Inhibition of dihydrosterculate synthesis in Crithidia fasciculata; No inhibition | ChEMBL. | 3398003 |
I50 (functional) | > 100 uM | The compound was tested for 50% growth inhibition against Crithidia fasciculata | ChEMBL. | 3398003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.