Detailed information for compound 64419

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 454.519 | Formula: C24H30N4O5
  • H donors: 3 H acceptors: 2 LogP: 1.78 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N([C@@H]1c2cc(N)ccc2O[C@@]([C@H]1O)(C)C(OC)OC)Cc1[nH]ccn1
  • InChi: 1S/C24H30N4O5/c1-24(23(31-3)32-4)22(29)21(18-13-15(25)5-10-19(18)33-24)28(14-20-26-11-12-27-20)16-6-8-17(30-2)9-7-16/h5-13,21-23,29H,14,25H2,1-4H3,(H,26,27)/t21-,22+,24-/m1/s1
  • InChiKey: GUCYQVAGPLOJSY-AOHZBQACSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax unspecified product 0.0327 0.3187 0.5083
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0128 0.1153 0.1731
Plasmodium vivax importin-beta 2, putative 0.0028 0.0135 0.0053
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0222 0.058
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0025 0.0103 0.0037
Echinococcus granulosus cathepsin l cysteine peptidase 0.0618 0.617 0.9229
Echinococcus granulosus cathepsin b 0.0669 0.6684 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0128 0.1153 0.1762
Brugia malayi G-protein coupled receptor 0.0076 0.0626 0.0929
Brugia malayi sulfakinin receptor protein 0.0076 0.0626 0.0929
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0128 0.1153 0.1726
Schistosoma mansoni alpha-1 adrenergic receptor 0.0076 0.0626 0.0936
Loa Loa (eye worm) hypothetical protein 0.0669 0.6684 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Echinococcus multilocularis smad 0.0032 0.0174 0.0197
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.018 0.0244
Loa Loa (eye worm) hypothetical protein 0.0128 0.1153 0.1719
Echinococcus granulosus fmrfamide receptor 0.0076 0.0626 0.0913
Leishmania major cathepsin L-like protease 0.0618 0.617 0.617
Onchocerca volvulus 0.0076 0.0626 0.0862
Onchocerca volvulus 0.0618 0.617 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0207 0.3541
Echinococcus multilocularis sex peptide receptor 0.0076 0.0626 0.0767
Giardia lamblia Cathepsin L precursor 0.0128 0.1153 0.3804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0324 0.0484
Onchocerca volvulus 0.0076 0.0626 0.0862
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0128 0.1153 0.1719
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0207 0.0207
Toxoplasma gondii cathepsin CPL 0.0618 0.617 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0626 0.0936
Loa Loa (eye worm) hypothetical protein 0.0103 0.09 0.134
Brugia malayi putative neuropeptide receptor NPR1 0.0076 0.0626 0.0929
Brugia malayi MH1 domain containing protein 0.0018 0.0028 0.0033
Trypanosoma cruzi major cysteine proteinase, putative 0.0128 0.1153 0.1153
Schistosoma mansoni hypothetical protein 0.0076 0.0626 0.0936
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0508 0.0752
Plasmodium falciparum serine repeat antigen 7 0.0128 0.1153 0.1731
Leishmania major hypothetical protein, conserved 0.0035 0.0207 0.0207
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0618 0.617 0.7755
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0207 0.0207
Schistosoma mansoni peroxidasin 0.0065 0.0508 0.076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.1153 0.1762
Loa Loa (eye worm) blistered cuticle protein 3 0.0065 0.0508 0.0752
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0025 0.0103 0.0154
Trypanosoma cruzi kinesin, putative 0.0029 0.0144 0.0144
Plasmodium falciparum serine repeat antigen 9 0.0128 0.1153 0.1731
Brugia malayi Cathepsin L-like precursor 0.0618 0.617 0.923
Plasmodium vivax unspecified product 0.0128 0.1153 0.1731
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.1153 0.1726
Leishmania major hypothetical protein, conserved 0.0025 0.0103 0.0103
Schistosoma mansoni opsin-like receptor 0.0076 0.0626 0.0936
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0128 0.1153 0.1731
Loa Loa (eye worm) hypothetical protein 0.0053 0.039 0.0575
Giardia lamblia Cathepsin B precursor 0.0128 0.1153 0.3804
Brugia malayi Dopamine receptor protein 1 0.0076 0.0626 0.0929
Schistosoma mansoni calpain-7 (C02 family) 0.0042 0.0272 0.0407
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0076 0.0626 0.0913
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0508 0.0752
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0626 0.0913
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0128 0.1153 0.1762
Brugia malayi Proteasome A-type and B-type family protein 0.0071 0.0574 0.0852
Giardia lamblia Cathepsin B precursor 0.0128 0.1153 0.3804
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0071 0.0574 0.1707
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Onchocerca volvulus 0.0065 0.0508 0.0667
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0272 0.0272
Echinococcus granulosus Smad4 0.0032 0.0174 0.0234
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0207 0.0302
Onchocerca volvulus Dual oxidase homolog 0.0065 0.0508 0.0667
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0626 0.0767
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0222 0.0429
Echinococcus granulosus snurportin 1 0.0301 0.2923 0.4359
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Plasmodium falciparum proteasome subunit beta type-5 0.0071 0.0574 0.0777
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0025 0.0103 0.0037
Echinococcus multilocularis cpg binding protein 0.0032 0.0174 0.0198
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0076 0.0626 0.0929
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0207 0.0207
Plasmodium vivax subtilisin-like protease 1 0.0178 0.167 0.2583
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0626 0.0936
Brugia malayi Cathepsin L-like precursor 0.042 0.4136 0.6185
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0618 0.617 1
Plasmodium falciparum serine repeat antigen 4 0.0128 0.1153 0.1731
Entamoeba histolytica cysteine proteinase, putative 0.0327 0.3187 0.5101
Giardia lamblia Cathepsin L precursor 0.0128 0.1153 0.3804
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0076 0.0626 0.0936
Echinococcus granulosus neuropeptide s receptor 0.0076 0.0626 0.0913
Brugia malayi Melatonin receptor type 1A 0.0076 0.0626 0.0929
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0769 0.1127
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0222 0.0323
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0222 0.0222
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0272 0.0272
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0076 0.0626 0.0936
Schistosoma mansoni importin beta-1 0.0028 0.0135 0.0202
Onchocerca volvulus 0.0048 0.0337 0.0386
Entamoeba histolytica cysteine protease, putative 0.0618 0.617 1
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0508 0.0752
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0071 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0128 0.1153 0.1719
Leishmania major cathepsin L-like protease 0.0993 1 1
Onchocerca volvulus 0.0076 0.0626 0.0862
Echinococcus granulosus GPCR family 2 0.0033 0.018 0.0244
Loa Loa (eye worm) hypothetical protein 0.042 0.4136 0.6185
Echinococcus multilocularis calpain family protein 1, d 0.0081 0.0677 0.0831
Schistosoma mansoni neuropeptide receptor 0.0076 0.0626 0.0936
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0076 0.0626 0.0929
Brugia malayi cathepsin Z-like cysteine proteinase 0.0128 0.1153 0.1719
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0327 0.3187 0.4768
Echinococcus granulosus smad 0.0032 0.0174 0.0234
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0207 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.1153 0.1762
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0626 0.0767
Entamoeba histolytica cysteine protease, putative 0.0128 0.1153 0.1762
Schistosoma mansoni smad1 5 8 and 0.0032 0.0174 0.026
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Brugia malayi hypothetical protein 0.0076 0.0626 0.0929
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0262
Brugia malayi AKH receptor 0.0076 0.0626 0.0929
Plasmodium vivax vivapain-2 0.0618 0.617 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0128 0.1153 0.1719
Schistosoma mansoni opsin-like receptor 0.0076 0.0626 0.0936
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0626 0.0936
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0128 0.1153 0.1726
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0272 0.0272
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0626 0.0913
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0207 0.0284
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0222 0.0195
Brugia malayi mbt repeat family protein 0.0047 0.0324 0.0477
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.018 0.0205
Entamoeba histolytica cysteine protease, putative 0.0128 0.1153 0.1762
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0626 0.0767
Entamoeba histolytica cysteine proteinase, putative 0.042 0.4136 0.666
Onchocerca volvulus 0.0076 0.0626 0.0862
Trypanosoma cruzi major cysteine proteinase, putative 0.0502 0.4983 0.4983
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0128 0.1153 0.1731
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0222 0.0222
Trypanosoma cruzi cysteine proteinase, putative 0.0327 0.3187 0.3187
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0222 0.0306
Brugia malayi follicle stimulating hormone receptor 0.0076 0.0626 0.0929
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0076 0.0626 0.0767
Onchocerca volvulus 0.0076 0.0626 0.0862
Onchocerca volvulus 0.0076 0.0626 0.0862
Leishmania major importin beta-1 subunit, putative 0.0023 0.0081 0.0081
Echinococcus multilocularis zinc finger protein 0.0021 0.0059 0.0053
Brugia malayi hypothetical protein 0.0076 0.0626 0.0929
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0128 0.1153 0.1719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.042 0.4136 0.666
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0626 0.0767
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0626 0.0913
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0302
Schistosoma mansoni neuropeptide f receptor 76f 0.0076 0.0626 0.0936
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0128 0.1153 0.1731
Schistosoma mansoni cpg binding protein 0.0029 0.0139 0.0208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.1153 0.1762
Echinococcus multilocularis orexin receptor type 2 0.0076 0.0626 0.0767
Echinococcus multilocularis Smad4 0.0032 0.0174 0.0197
Echinococcus granulosus g protein coupled receptor 0.0076 0.0626 0.0913
Brugia malayi beta-lactamase family protein 0.0035 0.0207 0.0302
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.3187 0.4764
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0626 0.0936
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0025 0.0103 0.0103
Echinococcus multilocularis dro:myosuppressin receptor 0.0076 0.0626 0.0767
Echinococcus multilocularis cathepsin L 0.0327 0.3187 0.3995
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0128 0.1153 0.1762
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Giardia lamblia Encystation-specific protease 0.0128 0.1153 0.3804
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0076 0.0626 0.0929
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0076 0.0626 0.0929
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Schistosoma mansoni ap endonuclease 0.0037 0.0222 0.0331
Echinococcus multilocularis serotonin receptor 0.0076 0.0626 0.0767
Onchocerca volvulus 0.0076 0.0626 0.0862
Giardia lamblia Cathepsin L precursor 0.0128 0.1153 0.3804
Onchocerca volvulus 0.0065 0.0508 0.0667
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0076 0.0626 0.0936
Loa Loa (eye worm) beta-lactamase 0.0035 0.0207 0.0302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0769 0.0947
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0025 0.0103 0.0037
Echinococcus multilocularis GPCR, family 2 0.0033 0.018 0.0205
Plasmodium falciparum serine repeat antigen 6 0.0128 0.1153 0.1731
Echinococcus granulosus calpain A 0.0042 0.0272 0.0382
Brugia malayi Serotonin receptor 0.0076 0.0626 0.0929
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0508 0.0752
Trypanosoma brucei kinesin, putative 0.0029 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Giardia lamblia Cathepsin L-like protease 0.0128 0.1153 0.3804
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0272 0.0272
Entamoeba histolytica cysteine proteinase 1, putative 0.0327 0.3187 0.5101
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0324 0.0484
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0025 0.0103 0.0108
Brugia malayi Cathepsin L-like precursor 0.0618 0.617 0.923
Schistosoma mansoni hypothetical protein 0.0033 0.018 0.027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0626 0.0936
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0199 0.1881 0.2808
Echinococcus multilocularis neuropeptide s receptor 0.0076 0.0626 0.0767
Toxoplasma gondii cathepsin CPC2 0.0128 0.1153 0.1731
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0115 0.1025 0.1534
Toxoplasma gondii ABC1 family protein 0.0035 0.0207 0.0171
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0508 0.0752
Echinococcus multilocularis calpain 5 0.0042 0.0272 0.0321
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.1801 0.2676
Loa Loa (eye worm) hypothetical protein 0.0069 0.0554 0.0821
Trypanosoma cruzi cysteine peptidase, putative 0.0993 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0024 0.0036
Onchocerca volvulus 0.0618 0.617 1
Loa Loa (eye worm) cathepsin B 0.0295 0.2864 0.428
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0207 0.0508
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0626 0.0936
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0626 0.0936
Echinococcus granulosus cysteine protease 0.0327 0.3187 0.4755
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0324 0.0459
Onchocerca volvulus 0.0076 0.0626 0.0862
Echinococcus granulosus g protein coupled receptor 0.0076 0.0626 0.0913
Echinococcus multilocularis neuropeptide receptor A26 0.0076 0.0626 0.0767
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0222 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.3187 0.5101
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0207 0.0207
Entamoeba histolytica cysteine proteinase, putative 0.0618 0.617 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0076 0.0626 0.0929
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0222 0.0257
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0669 0.6684 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0272 0.0272
Onchocerca volvulus 0.042 0.4136 0.6648
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.1153 0.1719
Schistosoma mansoni cathepsin F (C01 family) 0.0618 0.617 0.9231
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0146
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0626 0.0936
Brugia malayi neuropeptide F receptor 0.0076 0.0626 0.0929
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0626 0.0767
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0076 0.0626 0.0929
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0626 0.0913
Echinococcus multilocularis proteasome (prosome, macropain) 0.0071 0.0574 0.0702
Onchocerca volvulus 0.0076 0.0626 0.0862
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.039 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0128 0.1153 0.1762
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0618 0.617 0.7755
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.1153 0.1762
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Brugia malayi ORL1-like opioid receptor 0.0076 0.0626 0.0929
Mycobacterium tuberculosis Conserved protein 0.0035 0.0207 0.0508
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0174 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.039 0.0575
Giardia lamblia Cathepsin B precursor 0.0128 0.1153 0.3804
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0626 0.0767
Loa Loa (eye worm) hypothetical protein 0.0048 0.0337 0.0497
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0324 0.0484
Brugia malayi Serotonin receptor 0.0076 0.0626 0.0929
Entamoeba histolytica cysteine protease, putative 0.0128 0.1153 0.1762
Echinococcus granulosus somatostatin receptor 0.0076 0.0626 0.0913
Loa Loa (eye worm) hypothetical protein 0.042 0.4136 0.6185
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0076 0.0626 0.0936
Brugia malayi PHD-finger family protein 0.0026 0.0113 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.1153 0.1762
Mycobacterium ulcerans lipase LipD 0.0035 0.0207 0.3541
Echinococcus granulosus orexin receptor type 2 0.0076 0.0626 0.0913
Loa Loa (eye worm) melatonin receptor type 1A 0.0076 0.0626 0.0929
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0222 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0128 0.1153 0.1731
Onchocerca volvulus 0.0618 0.617 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0024 0.0008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.2923 0.4369
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0128 0.1153 0.1731
Onchocerca volvulus 0.0128 0.1153 0.1731
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.018 0.0244
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0626 0.0767
Brugia malayi MH1 domain containing protein 0.0032 0.0174 0.0252
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0272 0.0272
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0626 0.0767
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0626 0.0929
Schistosoma mansoni hypothetical protein 0.0033 0.018 0.027
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Trypanosoma brucei antigen, putative 0.0042 0.0272 0.0272
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0626 0.0767
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0626 0.0936
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.018 0.0205
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0207 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0076 0.0626 0.0936
Trypanosoma cruzi cruzipain precursor, putative 0.0199 0.1881 0.1881
Brugia malayi Papain family cysteine protease containing protein 0.0618 0.617 0.923
Brugia malayi Cathepsin L-like cysteine proteinase 0.042 0.4136 0.6185
Loa Loa (eye worm) nuclear factor I 0.0018 0.0028 0.0033
Echinococcus granulosus proteasome prosome macropain 0.0071 0.0574 0.0835
Brugia malayi eukaryotic initiation factor 4A 0.0025 0.0103 0.0146
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0135 0.0148
Trypanosoma cruzi kinesin, putative 0.0029 0.0144 0.0144
Brugia malayi putative neuropeptide receptor 0.0076 0.0626 0.0929
Brugia malayi calpain 5 0.0029 0.0144 0.0208
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0626 0.0913
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0626 0.0767
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0076 0.0626 0.0862
Echinococcus granulosus geminin 0.0331 0.3234 0.4825
Schistosoma mansoni hypothetical protein 0.0406 0.4001 0.5986
Trypanosoma cruzi Aph-1 protein, putative 0.0226 0.2161 0.2161
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0222 0.3797
Echinococcus granulosus calpain A 0.0115 0.1025 0.1512
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0018 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0626 0.0767
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0272 0.0272
Brugia malayi cathepsin L precursor 0.0128 0.1153 0.1719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.3187 0.5101
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0626 0.0913
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0272 0.0272
Schistosoma mansoni neuropeptide receptor 0.0076 0.0626 0.0936
Plasmodium falciparum serine repeat antigen 1 0.0128 0.1153 0.1731
Entamoeba histolytica cysteine proteinase, putative 0.0618 0.617 1
Loa Loa (eye worm) calpain 5 0.0029 0.0144 0.0208
Echinococcus multilocularis calpain 0.0042 0.0272 0.0321
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0115 0.1025 0.127
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Brugia malayi Tachykinin-like peptides receptor 99D 0.0076 0.0626 0.0929
Echinococcus granulosus tachykinin peptides receptor 99D 0.0076 0.0626 0.0913
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0115 0.1025 0.1534
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0618 0.617 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Brugia malayi hypothetical protein 0.0076 0.0626 0.0929
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0128 0.1153 0.1719
Onchocerca volvulus Peroxidasin homolog 0.0065 0.0508 0.0667
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0626 0.0936
Brugia malayi hypothetical protein 0.0076 0.0626 0.0929
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0618 0.617 0.923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0626 0.0767
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0115 0.1025 0.1512
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0626 0.0767
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0128 0.1153 0.1731
Brugia malayi Cathepsin L-like precursor 0.042 0.4136 0.6185
Echinococcus granulosus cathepsin L cysteine protease 0.0327 0.3187 0.4755
Brugia malayi calpain family protein 1 0.011 0.0974 0.1451
Mycobacterium ulcerans proteasome PrcB 0.0071 0.0574 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0071 0.0574 0.0574
Schistosoma mansoni hypothetical protein 0.0291 0.2821 0.422
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0174 0.0252
Onchocerca volvulus 0.0035 0.0207 0.0171
Schistosoma mansoni adenoreceptor 0.0076 0.0626 0.0936
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0071 0.0574 0.2307
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.046 0.0558
Loa Loa (eye worm) hypothetical protein 0.0199 0.1881 0.2808
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0508 0.0752
Echinococcus granulosus cpg binding protein 0.0032 0.0174 0.0235
Trypanosoma cruzi cysteine peptidase, putative 0.0618 0.617 0.617
Loa Loa (eye worm) calpain family protein 1 0.011 0.0974 0.1451
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0272 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0207 0.0508
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0626 0.0767
Trypanosoma cruzi cysteine peptidase, putative 0.0199 0.1881 0.1881
Echinococcus multilocularis cathepsin b 0.0669 0.6684 0.8403
Echinococcus multilocularis cathepsin L 0.0128 0.1153 0.1432
Echinococcus multilocularis geminin 0.0331 0.3234 0.4054
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.1801 0.2248
Trypanosoma cruzi cruzipain precursor, putative 0.0993 1 1
Schistosoma mansoni cathepsin s 0.0199 0.1881 0.2814
Brugia malayi beta-lactamase 0.0035 0.0207 0.0302
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0295 0.2864 0.2864
Echinococcus granulosus g protein coupled receptor 0.0076 0.0626 0.0913
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0508 0.0752
Brugia malayi beta-lactamase family protein 0.0035 0.0207 0.0302
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0109 0.0154
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0128 0.1153 0.1719
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.007 0.0567 0.0848
Schistosoma mansoni amine GPCR 0.0076 0.0626 0.0936
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0626 0.0913
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0174 0.0234
Loa Loa (eye worm) ctsf protein 0.0618 0.617 0.923
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0076 0.0626 0.0929
Brugia malayi hypothetical protein 0.0076 0.0626 0.0929
Echinococcus multilocularis hypothetical protein 0.0042 0.0272 0.0321
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0128 0.1153 0.1731
Leishmania major kinesin, putative 0.0029 0.0144 0.0144
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0567 0.0841
Schistosoma mansoni smad 0.0032 0.0174 0.026
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0272 0.0272
Trypanosoma cruzi Aph-1 protein, putative 0.0226 0.2161 0.2161
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.7951 1
Onchocerca volvulus 0.0035 0.0207 0.0171
Echinococcus multilocularis calpain 7 (C02 family) 0.0042 0.0272 0.0321
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0174 0.026
Onchocerca volvulus 0.0029 0.0139 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0128 0.1153 0.1762
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0128 0.1153 0.1731
Plasmodium falciparum cysteine proteinase falcipain 3 0.0618 0.617 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0327 0.3187 0.4768
Brugia malayi neuropeptide F receptor 0.0076 0.0626 0.0929
Schistosoma mansoni hypothetical protein 0.0331 0.3234 0.4838
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0327 0.3187 0.4768
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0581 0.5785 0.8654
Entamoeba histolytica cysteine proteinase, putative 0.0327 0.3187 0.5101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.1153 0.1726
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0626 0.0913
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Leishmania major cathepsin L-like protease 0.0618 0.617 0.617
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0618 0.617 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0135 0.0053
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0207 0.0302
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0207 0.0239
Brugia malayi calpain 7 0.0042 0.0272 0.04
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0302
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0033
Echinococcus granulosus hypothetical protein 0.0076 0.0626 0.0913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0327 0.3187 0.3187
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0076 0.0626 0.0913
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0626 0.0767
Plasmodium vivax serine-repeat antigen (SERA) 0.0128 0.1153 0.1731
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.1153 0.1726
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0128 0.1153 0.1731
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Schistosoma mansoni hypothetical protein 0.0076 0.0626 0.0936
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.018 0.0262
Echinococcus multilocularis serotonin receptor 0.0076 0.0626 0.0767
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0128 0.1153 0.1762
Onchocerca volvulus 0.0076 0.0626 0.0862
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0174 0.0252
Toxoplasma gondii cathepsin CPC1 0.0128 0.1153 0.1731
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0324 0.0386
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0222 0.0323
Echinococcus granulosus cathepsin l1 0.0618 0.617 0.9229
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0139 0.02
Brugia malayi Dopamine receptor protein 2 0.0076 0.0626 0.0929
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.09 0.134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0769 0.0947
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0025 0.0103 0.0154
Loa Loa (eye worm) hypothetical protein 0.007 0.0567 0.0841
Giardia lamblia Cysteine protease 0.0128 0.1153 0.3804
Echinococcus granulosus cathepsin L 0.0128 0.1153 0.1704
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0135 0.0135
Brugia malayi cathepsin F-like cysteine proteinase 0.0128 0.1153 0.1719
Giardia lamblia Cathepsin B precursor 0.0128 0.1153 0.3804
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0206 0.0283
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0076 0.0626 0.0936
Brugia malayi GnHR receptor homolog 0.0076 0.0626 0.0929
Giardia lamblia Cathepsin B precursor 0.0295 0.2864 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0669 0.6684 0.6684
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0302
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0071 0.0574 0.0859
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0222 0.0222
Brugia malayi cathepsin B-like cysteine proteinase 0.0669 0.6684 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.011 0.0974 0.1458
Schistosoma mansoni cpg binding protein 0.0032 0.0174 0.0261
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0207 0.031
Echinococcus multilocularis cathepsin L cysteine protease 0.0618 0.617 0.7755
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0128 0.1153 0.1719
Brugia malayi hypothetical protein 0.0025 0.0103 0.0146
Onchocerca volvulus Cathepsin L homolog 0.0128 0.1153 0.1731
Schistosoma mansoni ap endonuclease 0.0037 0.0222 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0128 0.1153 0.1762
Mycobacterium ulcerans hypothetical protein 0.0035 0.0207 0.3541
Echinococcus granulosus peroxidasin 0.0065 0.0508 0.0735
Giardia lamblia Cathepsin L precursor 0.0128 0.1153 0.3804
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0128 0.1153 0.3804
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0206 0.0238
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0618 0.617 0.9231
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0324 0.0364
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0222 0.0231
Schistosoma mansoni zinc finger protein 0.0021 0.0059 0.0089
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0207 0.0508
Schistosoma mansoni hypothetical protein 0.002 0.0053 0.008
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Brugia malayi larval opioid receptor 0.0076 0.0626 0.0929
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0071 0.0574 0.0852
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0207 0.0207
Echinococcus granulosus cathepsin b 0.0669 0.6684 1
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.1153 0.1762
Loa Loa (eye worm) TYRA-2 protein 0.0076 0.0626 0.0929
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0618 0.617 1
Schistosoma mansoni amine GPCR 0.0076 0.0626 0.0936
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.039 0.0583
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0769 0.1127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0626 0.0936
Brugia malayi Cathepsin L-like precursor 0.0618 0.617 0.923
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.09 0.134
Leishmania major cathepsin L-like protease 0.0618 0.617 0.617
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0025 0.0103 0.0037
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0626 0.0913
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0626 0.0767
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0076 0.0626 0.0767
Onchocerca volvulus 0.0047 0.0324 0.0364
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0626 0.0913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.1153 0.1762
Plasmodium falciparum cysteine proteinase falcipain 1 0.0327 0.3187 0.5083
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0626 0.0767
Loa Loa (eye worm) hypothetical protein 0.0199 0.1881 0.2808
Trypanosoma cruzi cysteine peptidase, putative 0.0993 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0769 0.115
Giardia lamblia Cathepsin B precursor 0.0128 0.1153 0.3804
Brugia malayi MH2 domain containing protein 0.0032 0.0174 0.0252
Loa Loa (eye worm) hypothetical protein 0.011 0.0974 0.1451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0669 0.6684 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0076 0.0626 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.1153 0.1762
Brugia malayi hypothetical protein 0.0076 0.0626 0.0929
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0025 0.0103 0.0128
Brugia malayi G-protein coupled receptor 0.0076 0.0626 0.0929
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0769 0.115
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2146 1
Echinococcus granulosus dnaJ subfamily B 0.0406 0.4001 0.5975
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0128 0.1153 0.1731
Entamoeba histolytica calpain large subunit domain III containing protein 0.0029 0.0144 0.0105
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0025 0.0103 0.0103
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Brugia malayi Cytochrome P450 family protein 0.0026 0.0109 0.0154
Entamoeba histolytica hypothetical protein 0.0128 0.1153 0.1762
Loa Loa (eye worm) hypothetical protein 0.0038 0.0231 0.0337
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0626 0.0913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.1153 0.1762
Brugia malayi hypothetical protein 0.0076 0.0626 0.0929
Giardia lamblia Cysteine protease 0.0128 0.1153 0.3804
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0626 0.0913
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0272 0.0272
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0626 0.0936
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0618 0.617 1
Leishmania major cathepsin L-like protease 0.0993 1 1
Onchocerca volvulus Peroxidase homolog 0.0065 0.0508 0.0667
Entamoeba histolytica cysteine protease, putative 0.0128 0.1153 0.1762
Brugia malayi Importin beta-1 subunit 0.0028 0.0135 0.0194
Giardia lamblia Cathepsin L precursor 0.0128 0.1153 0.3804
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.039 0.0558
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0071 0.0574 0.0811
Echinococcus multilocularis peroxidasin 0.0065 0.0508 0.0618
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0626 0.0936
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0626 0.0929
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Echinococcus multilocularis calpain A 0.0115 0.1025 0.127
Plasmodium vivax serine-repeat antigen (SERA) 0.0128 0.1153 0.1731
Echinococcus granulosus peptide allatostatin:somatostatin 0.0076 0.0626 0.0913
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0076 0.0626 0.0936
Onchocerca volvulus 0.0618 0.617 1
Schistosoma mansoni hypothetical protein 0.0033 0.018 0.027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0207 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0295 0.2864 0.4571
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0128 0.1153 0.3804
Brugia malayi Cathepsin L-like precursor 0.0199 0.1881 0.2808
Trypanosoma brucei cysteine peptidase C (CPC) 0.0295 0.2864 0.2864
Echinococcus granulosus neuropeptide receptor 0.0076 0.0626 0.0913
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0025 0.0103 0.0108
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0128 0.1153 0.1762
Entamoeba histolytica cysteine proteinase, putative 0.0327 0.3187 0.5101
Schistosoma mansoni hypothetical protein 0.0301 0.2923 0.4374
Brugia malayi cathepsin F-like cysteine proteinase 0.0199 0.1881 0.2808
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0222 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0128 0.1153 0.1719
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0272 0.0272
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0626 0.0913
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0207 0.0508
Schistosoma mansoni smad1 5 8 and 0.0032 0.0174 0.026
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0135 0.0135
Brugia malayi Bromodomain containing protein 0.0075 0.0613 0.091
Brugia malayi CXXC zinc finger family protein 0.0029 0.0139 0.02
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0076 0.0626 0.0767
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0626 0.0929
Schistosoma mansoni amine GPCR 0.0076 0.0626 0.0936
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0769 0.1143
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0076 0.0626 0.0767
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.046 0.0664
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0618 0.617 1
Plasmodium falciparum importin beta, putative 0.0028 0.0135 0.0053
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0302
Echinococcus multilocularis snurportin 1 0.0301 0.2923 0.3663
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0194
Brugia malayi hypothetical protein 0.0016 0.0012 0.001
Schistosoma mansoni smad1 5 8 and 0.0032 0.0174 0.026
Trypanosoma cruzi cysteine peptidase, putative 0.0327 0.3187 0.3187
Onchocerca volvulus 0.0076 0.0626 0.0862
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0618 0.617 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Schistosoma mansoni Mername-AA248 (C02 family) 0.0042 0.0272 0.0407
Schistosoma mansoni cathepsin F (C01 family) 0.042 0.4136 0.6188
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.1153 0.1719
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0466 0.0697
Plasmodium falciparum serine repeat antigen 2 0.0128 0.1153 0.1731
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0626 0.0767
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0128 0.1153 0.1731
Brugia malayi hypothetical protein 0.0065 0.0508 0.0752
Brugia malayi G protein-coupled receptor 0.0076 0.0626 0.0929
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0272 0.0272
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0207 0.0508
Brugia malayi hypothetical protein 0.0076 0.0626 0.0929
Echinococcus granulosus calpain 7 C02 family 0.0042 0.0272 0.0382
Echinococcus granulosus gamma secretase subunit aph 1 0.0581 0.5785 0.8651
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0128 0.1153 0.1726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0174 0.0234
Brugia malayi MH2 domain containing protein 0.0032 0.0174 0.0252
Schistosoma mansoni hypothetical protein 0.0033 0.018 0.027
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0626 0.0767
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0626 0.0936
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.018 0.0262
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0302
Loa Loa (eye worm) cysteine protease 0.0618 0.617 0.923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0769 0.115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0024 0.0036
Schistosoma mansoni histamine h1 receptor 0.0076 0.0626 0.0936
Echinococcus granulosus calpain 0.0042 0.0272 0.0382
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Entamoeba histolytica cysteine proteinase 2 0.0327 0.3187 0.5101
Toxoplasma gondii subtilisin SUB1 0.0178 0.167 0.2583
Loa Loa (eye worm) MBCTL1 0.0053 0.039 0.0575
Schistosoma mansoni hypothetical protein 0.0076 0.0626 0.0936
Echinococcus granulosus g-protein coupled receptor 0.0076 0.0626 0.0913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.042 0.4136 0.666
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0076 0.0626 0.0913
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0076 0.0626 0.0929
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0128 0.1153 0.1762
Brugia malayi Smad1 0.0032 0.0174 0.0252
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Onchocerca volvulus 0.0076 0.0626 0.0862
Brugia malayi hypothetical protein 0.0076 0.0626 0.0929
Brugia malayi Cathepsin L-like precursor 0.0618 0.617 0.923
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0669 0.6684 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0076 0.0626 0.0913
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.039 0.0558
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0626 0.0913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0327 0.3187 0.3187
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0302
Loa Loa (eye worm) hypothetical protein 0.0199 0.1881 0.2808
Schistosoma mansoni cathepsin C 0.0128 0.1153 0.1726
Onchocerca volvulus 0.0618 0.617 1
Plasmodium falciparum serine repeat antigen 8 0.0128 0.1153 0.1731
Echinococcus granulosus sex peptide receptor 0.0076 0.0626 0.0913
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0626 0.0913
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0146
Brugia malayi Blistered cuticle protein 3 0.0065 0.0508 0.0752
Leishmania major eukaryotic initiation factor 4a, putative 0.0025 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0047 0.0324 0.0477
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0128 0.1153 0.1762
Onchocerca volvulus 0.0618 0.617 1
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.3187 0.4764
Loa Loa (eye worm) hypothetical protein 0.0069 0.0549 0.0814
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0272 0.0272
Onchocerca volvulus 0.0076 0.0626 0.0862
Giardia lamblia Cathepsin L precursor 0.0128 0.1153 0.3804
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0128 0.1153 0.3804
Echinococcus granulosus serotonin receptor 0.0076 0.0626 0.0913
Toxoplasma gondii proteasome subunit beta type, putative 0.0071 0.0574 0.0777
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0626 0.0767
Onchocerca volvulus Cathepsin F homolog 0.0618 0.617 1
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0626 0.0913
Brugia malayi Peroxidasin 0.0065 0.0508 0.0752
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0337 0.0505
Plasmodium vivax vivapain-2 0.0618 0.617 1
Echinococcus multilocularis allatostatin A receptor 0.0076 0.0626 0.0767
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Brugia malayi Cathepsin L-like precursor 0.0618 0.617 0.923
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0626 0.0913
Echinococcus granulosus tumor protein p63 0.0328 0.3197 0.477
Schistosoma mansoni opsin-like receptor 0.0076 0.0626 0.0936
Brugia malayi gamma-secretase subunit aph-1 0.0581 0.5785 0.8654
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Entamoeba histolytica protein kinase, putative 0.0029 0.0144 0.0105
Plasmodium falciparum subtilisin-like protease 1 0.0178 0.167 0.2583
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0071 0.0574 1
Leishmania major cytochrome p450-like protein 0.0015 0.0005 0.0005
Onchocerca volvulus Peroxidase homolog 0.0065 0.0508 0.0667
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Brugia malayi MH1 domain containing protein 0.0018 0.0028 0.0033
Brugia malayi MH1 domain containing protein 0.0032 0.0174 0.0252
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0028
Schistosoma mansoni biogenic amine receptor 0.0076 0.0626 0.0936
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0508 0.0752
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Schistosoma mansoni calpain-7 (C02 family) 0.0042 0.0272 0.0407
Trypanosoma brucei Aph-1 protein, putative 0.0226 0.2161 0.2161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0618 0.617 1
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0324 0.0477
Brugia malayi Latrophilin receptor protein 2 0.0033 0.018 0.0262
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0327 0.3187 0.3187
Schistosoma mansoni hypothetical protein 0.0076 0.0626 0.0936
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0794 0.7966 0.7966
Trypanosoma cruzi cysteine peptidase, putative 0.0993 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0076 0.0626 0.0767
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0076 0.0626 0.0767
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Echinococcus granulosus 7TM GPCR rhodopsin 0.0076 0.0626 0.0913
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0272 0.0272
Echinococcus multilocularis cysteine protease 0.0618 0.617 0.7755
Schistosoma mansoni cathepsin B (C01 family) 0.0128 0.1153 0.1726
Schistosoma mansoni peroxidasin 0.0065 0.0508 0.076
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0174 0.0197
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0769 0.1143
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0626 0.0913
Loa Loa (eye worm) hypothetical protein 0.0081 0.0677 0.1005
Onchocerca volvulus 0.0076 0.0626 0.0862
Trypanosoma cruzi cysteine protease, putative 0.0327 0.3187 0.3187
Giardia lamblia Cathepsin L-like protease 0.0128 0.1153 0.3804
Toxoplasma gondii cathepsin B 0.0295 0.2864 0.4551
Onchocerca volvulus 0.0076 0.0626 0.0862
Schistosoma mansoni Smad4 0.0032 0.0174 0.026
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0626 0.0913
Echinococcus granulosus cathepsin L cysteine proteinase 0.0618 0.617 0.9229
Schistosoma mansoni bromodomain containing protein 0.0063 0.0496 0.0742
Giardia lamblia Cathepsin B precursor 0.0295 0.2864 1
Loa Loa (eye worm) hypothetical protein 0.0618 0.617 0.923
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0053 0.0072
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0076 0.0626 0.0767
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.1153 0.1762
Schistosoma mansoni cathepsin S (C01 family) 0.0128 0.1153 0.1726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0626 0.0936
Loa Loa (eye worm) hypothetical protein 0.0128 0.1153 0.1719
Echinococcus granulosus zinc finger protein 0.0021 0.0059 0.0063
Onchocerca volvulus Cathepsin L homolog 0.0618 0.617 1
Loa Loa (eye worm) fibroinase 0.0618 0.617 0.923
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0128 0.1153 0.3804
Loa Loa (eye worm) hypothetical protein 0.0128 0.1153 0.1719
Echinococcus granulosus calpain 5 0.0042 0.0272 0.0382
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0618 0.617 0.923
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.4001 0.5021
Echinococcus multilocularis cathepsin L cysteine protease 0.0618 0.617 0.7755
Giardia lamblia Hypothetical protein 0.0128 0.1153 0.3804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0327 0.3187 0.3187
Brugia malayi fibroinase precursor 0.0128 0.1153 0.1719
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0076 0.0626 0.0929
Trichomonas vaginalis esterase, putative 0.0035 0.0207 0.0207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0626 0.0767
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0222 0.0231
Onchocerca volvulus Peroxidasin homolog 0.0065 0.0508 0.0667
Giardia lamblia Hypothetical protein 0.0128 0.1153 0.3804
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0324 0.0459
Loa Loa (eye worm) hypothetical protein 0.0043 0.029 0.0426
Brugia malayi Bromodomain containing protein 0.0037 0.023 0.0336
Brugia malayi RE15519p 0.0076 0.0626 0.0929
Echinococcus multilocularis cathepsin b 0.0669 0.6684 0.8403
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0089 0.009
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0005 0.0005
Brugia malayi mbt repeat family protein 0.0047 0.0324 0.0477
Echinococcus granulosus allatostatin A receptor 0.0076 0.0626 0.0913
Schistosoma mansoni calpain C (C02 family) 0.0042 0.0272 0.0407
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Toxoplasma gondii exonuclease III APE 0.0037 0.0222 0.0195
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0089 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0618 0.617 1
Onchocerca volvulus 0.0069 0.0549 0.0735
Onchocerca volvulus 0.0076 0.0626 0.0862
Schistosoma mansoni myosin xvIII 0.0076 0.0626 0.0936
Loa Loa (eye worm) hypothetical protein 0.042 0.4136 0.6185
Loa Loa (eye worm) calpain 0.0042 0.0272 0.04
Echinococcus granulosus neuropeptide receptor A26 0.0076 0.0626 0.0913
Leishmania major cathepsin L-like protease 0.0618 0.617 0.617
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0626 0.0767
Entamoeba histolytica cysteine proteinase, putative 0.0327 0.3187 0.5101
Schistosoma mansoni amine GPCR 0.0076 0.0626 0.0936
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0207 0.0207
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0626 0.0767
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0199 0.1881 0.2808
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0618 0.617 1
Onchocerca volvulus 0.0076 0.0626 0.0862
Echinococcus multilocularis g-protein coupled receptor 0.0076 0.0626 0.0767
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0222 0.0231
Schistosoma mansoni biogenic amine receptor 0.0076 0.0626 0.0936
Echinococcus granulosus cathepsin L 0.0327 0.3187 0.4755
Plasmodium vivax unspecified product 0.0199 0.1881 0.293
Loa Loa (eye worm) hypothetical protein 0.004 0.0254 0.0372
Brugia malayi calpain family protein 1 0.011 0.0974 0.1451
Echinococcus multilocularis cysteine protease 0.0618 0.617 0.7755
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.1153 0.1726
Schistosoma mansoni neuropeptide receptor 0.0076 0.0626 0.0936
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0423 0.0528
Giardia lamblia Cysteine protease 0.0128 0.1153 0.3804
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Brugia malayi MH2 domain containing protein 0.0469 0.4639 0.6939
Onchocerca volvulus 0.0618 0.617 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0295 0.2864 0.2864
Brugia malayi cathepsin L-like precursor 0.042 0.4136 0.6185
Plasmodium vivax proteasome subunit beta type-5, putative 0.0071 0.0574 0.0777
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0076 0.0626 0.0913
Loa Loa (eye worm) MH2 domain-containing protein 0.0469 0.4639 0.6939
Echinococcus granulosus neuropeptide receptor 0.0076 0.0626 0.0913
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0024 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Echinococcus granulosus eukaryotic initiation factor 4A 0.0025 0.0103 0.0128
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0089 0.0133
Echinococcus multilocularis tumor protein p63 0.0328 0.3197 0.4008
Loa Loa (eye worm) hypothetical protein 0.0098 0.0846 0.1259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.1153 0.1762
Echinococcus multilocularis G-protein coupled receptor, putative 0.0076 0.0626 0.0767
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Schistosoma mansoni amine GPCR 0.0076 0.0626 0.0936
Onchocerca volvulus Cathepsin L homolog 0.0618 0.617 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0042 0.0272 0.0272
Schistosoma mansoni neuropeptide receptor 0.0076 0.0626 0.0936
Schistosoma mansoni biogenic amine receptor 0.0076 0.0626 0.0936
Leishmania major eukaryotic initiation factor 4a, putative 0.0025 0.0103 0.0103
Brugia malayi hypothetical protein 0.0076 0.0626 0.0929
Brugia malayi cathepsin L-like cysteine proteinase 0.0128 0.1153 0.1719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0618 0.617 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0042 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Schistosoma mansoni calpain (C02 family) 0.0042 0.0272 0.0407
Brugia malayi Dopamine receptor 0.0076 0.0626 0.0929
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0626 0.0767
Loa Loa (eye worm) Smad1 0.0032 0.0174 0.0252
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0508 0.0752
Plasmodium falciparum serine repeat antigen 3 0.0128 0.1153 0.1731
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0207 0.0207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0626 0.0936
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0626 0.0936
Loa Loa (eye worm) transcription factor SMAD2 0.0469 0.4639 0.6939
Brugia malayi Cathepsin L-like precursor 0.0618 0.617 0.923
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0128 0.1153 0.1731
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0618 0.617 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0207 0.0207
Mycobacterium tuberculosis Conserved protein 0.0035 0.0207 0.0508
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0324 0.0386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0618 0.617 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0076 0.0626 0.0929
Plasmodium vivax vivapain-1 0.0327 0.3187 0.5083
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0076 0.0626 0.0767
Leishmania major cysteine peptidase A (CPA) 0.0618 0.617 0.617
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0669 0.6684 1
Plasmodium vivax calpain, putative 0.0042 0.0272 0.0279
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0207 0.0171
Leishmania major proteasome beta 5 subunit, putative 0.0071 0.0574 0.0574
Toxoplasma gondii preprocathepsin c precursor, putative 0.0128 0.1153 0.1731
Echinococcus multilocularis gamma secretase subunit aph 1 0.0581 0.5785 0.727
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0024 0.001
Brugia malayi RNA, U transporter 1 0.008 0.0667 0.099
Schistosoma mansoni hypothetical protein 0.0331 0.3234 0.4838
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0272 0.0272
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0626 0.0936
Onchocerca volvulus Neuropeptide F receptor homolog 0.0076 0.0626 0.0862
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0103 0.0103
Loa Loa (eye worm) calpain family protein 1 0.0081 0.0677 0.1005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.09 0.134
Echinococcus granulosus cathepsin l1 0.042 0.4136 0.6178
Entamoeba histolytica cysteine protease, putative 0.0128 0.1153 0.1762
Echinococcus multilocularis neuropeptide FF receptor 2 0.0076 0.0626 0.0767
Schistosoma mansoni cpg binding protein 0.0032 0.0174 0.0261
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0076 0.0626 0.0767
Plasmodium vivax vivapain-3 0.0327 0.3187 0.5083
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Echinococcus multilocularis somatostatin receptor 0.0076 0.0626 0.0767
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0993 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0222 0.0195
Onchocerca volvulus Chorion peroxidase homolog 0.0065 0.0508 0.0667
Plasmodium falciparum serine repeat antigen 5 0.0128 0.1153 0.1731
Entamoeba histolytica cysteine protease, putative 0.0128 0.1153 0.1762
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0071 0.0574 0.0574
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0076 0.0626 0.0936
Echinococcus granulosus 7tm_1 domain containing protein 0.0076 0.0626 0.0913
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0618 0.617 1
Echinococcus granulosus G protein coupled receptor 139 0.0076 0.0626 0.0913
Mycobacterium ulcerans beta-lactamase 0.0035 0.0207 0.3541
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.1153 0.1719
Leishmania major cathepsin L-like protease 0.0618 0.617 0.617
Giardia lamblia Cysteine protease 0.0128 0.1153 0.3804
Schistosoma mansoni gamma-secretase subunit aph-1 0.0581 0.5785 0.8655
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0207 0.3541
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0626 0.0767
Schistosoma mansoni growth hormone secretagogue receptor 0.0076 0.0626 0.0936
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929
Onchocerca volvulus 0.0065 0.0508 0.0667
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0025 0.0103 0.0103
Entamoeba histolytica cysteine protease, putative 0.0327 0.3187 0.5101
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0128 0.1153 0.1726
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0295 0.2864 0.4285
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.1153 0.1726
Giardia lamblia Cathepsin B precursor 0.0295 0.2864 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.0752
Onchocerca volvulus 0.0035 0.0207 0.0171
Echinococcus granulosus dro:myosuppressin receptor 0.0076 0.0626 0.0913
Echinococcus granulosus importin subunit beta 1 0.0028 0.0135 0.0177
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0207 0.0508
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0071 0.0574 0.0811
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.039 0.0469
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0626 0.0929
Loa Loa (eye worm) hypothetical protein 0.0076 0.0626 0.0929

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) 0 Inhibitory effect of the compound on (HUVEC) human umbilical vein endothelial cell tube formation at a microM; + inhibition ChEMBL. 12729636

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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