Detailed information for compound 645615

Basic information

Technical information
  • TDR Targets ID: 645615
  • Name: N'-(2-methylphenyl)-N-(2-phenylethyl)oxamide
  • MW: 282.337 | Formula: C17H18N2O2
  • H donors: 2 H acceptors: 2 LogP: 3.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)NCCc1ccccc1)Nc1ccccc1C
  • InChi: 1S/C17H18N2O2/c1-13-7-5-6-10-15(13)19-17(21)16(20)18-12-11-14-8-3-2-4-9-14/h2-10H,11-12H2,1H3,(H,18,20)(H,19,21)
  • InChiKey: WNRIDHIWKLNGQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N'-(2-methylphenyl)-N-(2-phenylethyl)ethanediamide
  • CDS1_003593
  • DivK1c_004633
  • MLS000666670
  • N-(2-methylphenyl)-N'-(2-phenylethyl)ethanediamide
  • SMR000268602
  • BIM-0010938.P001
  • ZINC02964211
  • ST073082
  • CBMicro_011017

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glycosyl hydrolase-like protein 0.0027 0.011 0.0144
Brugia malayi Glycosyl hydrolases family 31 protein 0.0328 0.3233 0.5012
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.011 0.0144
Leishmania major hypothetical protein, conserved 0.0076 0.0618 0.0934
Loa Loa (eye worm) hypothetical protein 0.0036 0.0199 0.0308
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0017 0.0027
Giardia lamblia Hypothetical protein 0.0076 0.0618 1
Brugia malayi hypothetical protein 0.0247 0.2397 0.3716
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.011 0.0144
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0076 0.0618 0.0934
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0076 0.0618 0.0934
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0584 0.0881
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0017 0.0027
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.011 0.0144
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.011 0.0144
Loa Loa (eye worm) hypothetical protein 0.0247 0.2397 0.3716
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.011 0.0144
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0638 0.645 1
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0076 0.0618 0.0958
Onchocerca volvulus 0.005 0.0353 0.1223
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0584 0.0881
Echinococcus multilocularis dna polymerase eta 0.0019 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0638 0.645 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Echinococcus granulosus geminin 0.0167 0.1563 0.2424
Schistosoma mansoni survival motor neuron protein 0.005 0.0353 0.0547
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0022 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 1
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0076 0.0618 0.0934
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0022 0.0022
Onchocerca volvulus 0.019 0.1798 0.851
Trichomonas vaginalis hypothetical protein 0.0076 0.0618 0.0934
Brugia malayi N-terminal motif family protein 0.0218 0.2093 0.3245
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0022 0.0008
Echinococcus multilocularis neutral alpha glucosidase AB 0.0073 0.0584 0.0584
Schistosoma mansoni alpha-glucosidase 0.0282 0.2759 0.4277
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0076 0.0618 0.0934
Entamoeba histolytica hypothetical protein 0.0076 0.0618 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0618 0.0934
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0073 0.0584 0.0906
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0076 0.0618 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0022 0.0008
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0638 0.645 1
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0076 0.0618 0.0958
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Entamoeba histolytica translation initiation factor 4e, putative 0.0076 0.0618 0.0934
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0618 1
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0076 0.0618 0.0958
Giardia lamblia Hypothetical protein 0.0076 0.0618 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0022 0.0035
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0022 0.0008
Toxoplasma gondii hypothetical protein 0.0047 0.0317 0.0466
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0638 0.645 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0584 0.0881
Trypanosoma brucei unspecified product 0.0019 0.0022 0.0008
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.011 0.0171
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0255 0.0369
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0638 0.645 1
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0022 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0022 0.0008
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1263 0.1936
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.019 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0618 0.0934
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0328 0.0509
Schistosoma mansoni alpha-glucosidase 0.0282 0.2759 0.4277
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0076 0.0618 0.0934
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.2397 0.3716
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0638 0.645 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0022 0.0035
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0255 0.0369
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2093 1
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0076 0.0618 0.0934
Entamoeba histolytica hypothetical protein 0.0035 0.019 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Schistosoma mansoni hypothetical protein 0.0167 0.1563 0.2424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0328 0.0509
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.2397 0.2397
Echinococcus granulosus dna polymerase eta 0.0019 0.0022 0.0035
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0022 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0199 0.0308
Schistosoma mansoni hypothetical protein 0.0036 0.0199 0.0308
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0022 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0052 0.037 0.0574
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0076 0.0618 0.0934
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0328 0.0328
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0076 0.0618 0.0934
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0022 0.0035
Schistosoma mansoni DNA polymerase eta 0.0019 0.0022 0.0035
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.2859 0.4418
Echinococcus granulosus lysosomal alpha glucosidase 0.0328 0.3233 0.5012
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0022 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0618 0.0934
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0076 0.0618 0.0934
Toxoplasma gondii hypothetical protein 0.0076 0.0618 0.0934
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.011 0.0144
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0076 0.0618 0.0934
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.011 0.0171
Schistosoma mansoni hypothetical protein 0.0101 0.0883 0.1368
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0584 0.0881
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0255 0.0369
Brugia malayi Glycosyl hydrolases family 31 protein 0.0073 0.0584 0.0906
Echinococcus multilocularis geminin 0.0167 0.1563 0.1563
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0638 0.645 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.011 0.0144
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0255 0.0369
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0638 0.645 0.645
Leishmania major eukaryotic translation initiation factor-like 0.0638 0.645 1
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0076 0.0618 0.0934
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0022 0.0035
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0076 0.0618 0.0958
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0638 0.645 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1425 1
Giardia lamblia hypothetical protein 0.0076 0.0618 1
Brugia malayi translation initiation factor 4E 0.0638 0.645 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0584 0.0881
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0022 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.011 0.0144
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0022 0.0008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0328 0.3233 0.3233
Entamoeba histolytica hypothetical protein 0.0035 0.019 0.0268
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0076 0.0618 0.0934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0328 0.0509
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0638 0.645 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0328 0.0509
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0328 0.0509
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.019 0.0294
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0073 0.0584 0.0881
Plasmodium vivax translation initiation factor 4E, putative 0.0076 0.0618 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0073 0.0584 0.0881
Entamoeba histolytica hypothetical protein 0.0035 0.019 0.0268
Schistosoma mansoni ap endonuclease 0.0018 0.0017 0.0027
Trypanosoma brucei glucosidase, putative 0.0073 0.0584 0.0881
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0017 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0584 0.0881
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0348 0.0514
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0076 0.0618 0.0934
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0017 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0328 0.0509
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0022 0.0008
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0022 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.037 0.0574
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0584 0.0881
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0076 0.0618 0.0934
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0353 0.0547
Schistosoma mansoni alpha glucosidase 0.0073 0.0584 0.0906
Leishmania major alpha glucosidase II subunit, putative 0.0073 0.0584 0.0881
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0584 0.0881
Mycobacterium ulcerans hypothetical protein 0.0154 0.1425 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2859 0.4418
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2859 0.4418
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0328 0.0509
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0017 0.5
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0638 0.645 1
Entamoeba histolytica hypothetical protein 0.0076 0.0618 0.0934
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1263 0.1936
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0022 0.0035
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0076 0.0618 0.0934
Echinococcus multilocularis lysosomal alpha glucosidase 0.0328 0.3233 0.3233
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Schistosoma mansoni ap endonuclease 0.0018 0.0017 0.0027
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0076 0.0618 0.0934
Leishmania major DNA polymerase eta, putative 0.0019 0.0022 0.0008
Giardia lamblia DINP protein human, muc B family 0.0019 0.0022 0.0082
Schistosoma mansoni hypothetical protein 0.0167 0.1563 0.2424
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0022 0.0035
Echinococcus granulosus dna polymerase kappa 0.0019 0.0022 0.0035
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0638 0.645 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Trichomonas vaginalis maltase-glucoamylase, putative 0.0073 0.0584 0.0881
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1263 0.1936
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0076 0.0618 0.0934
Entamoeba histolytica hypothetical protein 0.0035 0.019 0.0268
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0076 0.0618 0.0958
Loa Loa (eye worm) translation initiation factor 4E 0.0638 0.645 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.2093 0.3245
Leishmania major DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0584 0.0881
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0076 0.0618 0.2562
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0584 0.0881
Schistosoma mansoni hypothetical protein 0.0035 0.019 0.0294
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0076 0.0618 0.0934
Leishmania major eukaryotic translation initiation factor-like protein 0.0638 0.645 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0328 0.3233 0.5012
Trypanosoma brucei RNA helicase, putative 0.0101 0.0883 0.1345
Schistosoma mansoni hypothetical protein 0.005 0.0353 0.0547
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0638 0.645 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0035
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.2859 0.4418
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0017 0.0027
Giardia lamblia Translation elongation factor 0.0076 0.0618 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.011 0.0144
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.011 0.0144
Echinococcus granulosus neutral alpha glucosidase AB 0.0073 0.0584 0.0906
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0076 0.0618 0.0934
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.011 0.0144
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0328 0.0328
Leishmania major eukaryotic translation initiation factor, putative 0.0076 0.0618 0.0934
Brugia malayi hypothetical protein 0.0035 0.019 0.0294
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.011 0.0144
Leishmania major hypothetical protein, conserved 0.0076 0.0618 0.0934
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0076 0.0618 0.0934
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0584 0.0881
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0076 0.0618 0.0934
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.037 0.0574
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0638 0.645 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0022 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.037 0.0574

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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