Detailed information for compound 64645

Basic information

Technical information
  • TDR Targets ID: 64645
  • Name: 4-[4-[5-(2-oxo-3-pyridin-4-ylimidazolidin-1-y l)pentoxy]phenyl]benzonitrile
  • MW: 426.51 | Formula: C26H26N4O2
  • H donors: 0 H acceptors: 3 LogP: 4.08 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)c1ccc(cc1)OCCCCCN1CCN(C1=O)c1ccncc1
  • InChi: 1S/C26H26N4O2/c27-20-21-4-6-22(7-5-21)23-8-10-25(11-9-23)32-19-3-1-2-16-29-17-18-30(26(29)31)24-12-14-28-15-13-24/h4-15H,1-3,16-19H2
  • InChiKey: YMUKVEFALCARDF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-[5-[2-oxo-3-(4-pyridyl)imidazolidin-1-yl]pentoxy]phenyl]benzonitrile
  • 4-[4-[5-[2-oxo-3-(4-pyridyl)-1-imidazolidinyl]pentoxy]phenyl]benzonitrile
  • 4-[4-[5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)pentoxy]phenyl]benzenecarbonitrile
  • 4-[4-[5-[2-keto-3-(4-pyridyl)imidazolidin-1-yl]pentoxy]phenyl]benzonitrile
  • 4-[4-[5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)pentoxy]phenyl]benzonitrile
  • AIDS-122450
  • AIDS122450
  • [1,1'-Biphenyl]-4-carbonitrile, 4'-[[5-[2-oxo-3-(4-pyridinyl)-1-imidazolidinyl]pentyl]oxy]-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cathepsin B precursor 0.0036 0.015 0.0587
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.015
Toxoplasma gondii cathepsin CPC2 0.0036 0.015 0.0504
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0036 0.015 0.015
Leishmania major cysteine peptidase A (CPA) 0.0099 0.1418 0.4243
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0461 0.872 0.872
Echinococcus granulosus histone deacetylase 7 0.0045 0.033 0.033
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0461 0.872 0.872
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0613 0.128
Schistosoma mansoni survival motor neuron protein 0.0048 0.0393 0.0393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Brugia malayi prolyl oligopeptidase family protein 0.0176 0.2982 0.2982
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0613 1
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0042 0.0265 0.0405
Giardia lamblia Cathepsin L-like protease 0.0036 0.015 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.015 0.015
Echinococcus multilocularis cysteine protease 0.0099 0.1418 0.1418
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0176 0.2982 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0121 0.0121
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0099 0.1418 0.1418
Echinococcus granulosus acylamino acid releasing enzyme 0.0042 0.0265 0.0265
Schistosoma mansoni caspase-7 (C14 family) 0.0151 0.2461 0.2461
Leishmania major cathepsin L-like protease 0.0099 0.1418 0.4243
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0045 0.033 0.033
Leishmania major cathepsin L-like protease 0.0099 0.1418 0.4243
Echinococcus multilocularis cathepsin L cysteine protease 0.0099 0.1418 0.1418
Plasmodium vivax vivapain-2 0.0099 0.1418 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0613 0.2055
Onchocerca volvulus 0.0151 0.2461 0.2461
Plasmodium vivax vivapain-2 0.0099 0.1418 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Trypanosoma brucei cysteine peptidase C (CPC) 0.0155 0.2559 0.8508
Loa Loa (eye worm) histone deacetylase 0.0045 0.033 0.033
Onchocerca volvulus Cathepsin L homolog 0.0099 0.1418 0.1418
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0155 0.2559 0.8445
Onchocerca volvulus Prolyl endopeptidase homolog 0.0042 0.0265 0.0265
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0036 0.015 0.015
Schistosoma mansoni cathepsin B (C01 family) 0.0036 0.015 0.015
Onchocerca volvulus 0.0099 0.1418 0.1418
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0224 0.0224
Entamoeba histolytica prolyl oligopeptidase family protein 0.0042 0.0265 0.0905
Echinococcus granulosus cathepsin L 0.0036 0.015 0.015
Brugia malayi Cathepsin L-like cysteine proteinase 0.0099 0.1418 0.1418
Brugia malayi jmjC domain containing protein 0.0034 0.0121 0.0121
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.015 0.015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.015 0.015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.015 0.015
Giardia lamblia Cathepsin L precursor 0.0036 0.015 0.0587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Plasmodium falciparum cysteine proteinase falcipain 1 0.0036 0.015 0.1059
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0176 0.2982 1
Brugia malayi hypothetical protein 0.0135 0.2144 0.2144
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0036 0.015 0.1059
Giardia lamblia Cysteine protease 0.0036 0.015 0.0587
Leishmania major cathepsin L-like protease 0.0099 0.1418 0.4243
Giardia lamblia Cathepsin B precursor 0.0155 0.2559 1
Echinococcus granulosus histone deacetylase 0.0045 0.033 0.033
Brugia malayi Cathepsin L-like precursor 0.0099 0.1418 0.1418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.4162 0.4162
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0036 0.015 0.1059
Onchocerca volvulus 0.0048 0.0393 0.0393
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0422 0.7939 0.7939
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0525 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.015
Giardia lamblia Encystation-specific protease 0.0036 0.015 0.0587
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0099 0.1418 0.1418
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0042 0.0265 0.0147
Plasmodium falciparum serine repeat antigen 7 0.0036 0.015 0.1059
Echinococcus multilocularis cathepsin b 0.0422 0.7939 0.7939
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.015
Echinococcus multilocularis histone deacetylase 6 0.0045 0.033 0.033
Onchocerca volvulus 0.0099 0.1418 0.1418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Onchocerca volvulus Deterin homolog 0.0461 0.872 0.872
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0176 0.2982 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0099 0.1418 0.1418
Plasmodium vivax vivapain-1 0.0036 0.015 0.1059
Loa Loa (eye worm) hypothetical protein 0.0151 0.2461 0.2461
Loa Loa (eye worm) histone deacetylase 7A 0.0045 0.033 0.033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1418 0.5261
Echinococcus multilocularis histone deacetylase 0.0045 0.033 0.033
Plasmodium vivax unspecified product 0.0036 0.015 0.1059
Loa Loa (eye worm) ctsf protein 0.0099 0.1418 0.1418
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0613 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0099 0.1418 0.5261
Echinococcus multilocularis histone deacetylase 6 0.0045 0.033 0.033
Plasmodium falciparum histone deacetylase 2 0.0045 0.033 0.2327
Echinococcus multilocularis cathepsin L cysteine protease 0.0099 0.1418 0.1418
Loa Loa (eye worm) hypothetical protein 0.0461 0.872 0.872
Schistosoma mansoni histone deacetylase 4 5 0.0045 0.033 0.033
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0036 0.015 0.1059
Toxoplasma gondii hypothetical protein 0.0042 0.0265 0.0888
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0613 0.0613
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1418 0.5261
Toxoplasma gondii cathepsin B 0.0155 0.2559 0.8583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Trypanosoma cruzi oligopeptidase b 0.0042 0.0265 0.0147
Loa Loa (eye worm) hypothetical protein 0.0042 0.0265 0.0265
Plasmodium vivax serine-repeat antigen (SERA) 0.0036 0.015 0.1059
Echinococcus multilocularis caspase 2 0.0151 0.2461 0.2461
Brugia malayi Cathepsin L-like precursor 0.0099 0.1418 0.1418
Echinococcus multilocularis cathepsin L 0.0036 0.015 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1418 0.5261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.032 0.032
Plasmodium falciparum serine repeat antigen 4 0.0036 0.015 0.1059
Plasmodium vivax histone deacetylase 2, putative 0.0045 0.033 0.2327
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.015
Brugia malayi cathepsin L-like precursor 0.0099 0.1418 0.1418
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.015 0.015
Echinococcus multilocularis cathepsin b 0.0422 0.7939 0.7939
Schistosoma mansoni hypothetical protein 0.0048 0.0393 0.0393
Onchocerca volvulus 0.0099 0.1418 0.1418
Leishmania major cathepsin L-like protease 0.0099 0.1418 0.4243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1418 0.5261
Plasmodium falciparum serine repeat antigen 2 0.0036 0.015 0.1059
Echinococcus granulosus cathepsin l cysteine peptidase 0.0099 0.1418 0.1418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.1418 1
Brugia malayi fibroinase precursor 0.0036 0.015 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.2559 1
Trypanosoma cruzi oligopeptidase b 0.0042 0.0265 0.0147
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0099 0.1418 0.1418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Giardia lamblia Cathepsin L precursor 0.0036 0.015 0.0587
Onchocerca volvulus 0.0099 0.1418 0.1418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1304 0.1304
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0036 0.015 0.1059
Plasmodium falciparum cysteine proteinase falcipain 3 0.0099 0.1418 1
Brugia malayi cathepsin L precursor 0.0036 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0099 0.1418 0.1418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0422 0.7939 0.7939
Trypanosoma cruzi cysteine peptidase, putative 0.0099 0.1418 0.1627
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0121 0.0121
Onchocerca volvulus Cell death protein 3 homolog 0.0151 0.2461 0.2461
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0042 0.0265 0.0265
Onchocerca volvulus 0.0036 0.015 0.015
Toxoplasma gondii prolyl endopeptidase 0.0042 0.0265 0.0888
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0121 0.0121
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0265 0.1869
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0525 1 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0036 0.015 0.0587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0036 0.015 0.015
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0036 0.015 0.1059
Toxoplasma gondii histone deacetylase HDAC1 0.0045 0.033 0.1106
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0036 0.015 0.015
Schistosoma mansoni cathepsin F (C01 family) 0.0099 0.1418 0.1418
Brugia malayi Cathepsin L-like precursor 0.0099 0.1418 0.1418
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0042 0.0265 0.0888
Brugia malayi cathepsin L-like cysteine proteinase 0.0036 0.015 0.015
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.015 0.015
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0036 0.015 0.0587
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0099 0.1418 0.1418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.032 0.032
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0265 0.0147
Giardia lamblia Cathepsin L precursor 0.0036 0.015 0.0587
Giardia lamblia Hypothetical protein 0.0036 0.015 0.0587
Giardia lamblia Cathepsin B precursor 0.0036 0.015 0.0587
Onchocerca volvulus 0.0099 0.1418 0.1418
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0042 0.0265 0.0905
Trypanosoma cruzi cysteine peptidase, putative 0.0099 0.1418 0.1627
Giardia lamblia Cathepsin L precursor 0.0036 0.015 0.0587
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0036 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0099 0.1418 0.1418
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0036 0.015 0.1059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0422 0.7939 0.7939
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0176 0.2982 0.2982
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0613 0.0613
Echinococcus granulosus cathepsin b 0.0422 0.7939 0.7939
Echinococcus granulosus cathepsin l1 0.0099 0.1418 0.1418
Loa Loa (eye worm) hypothetical protein 0.0135 0.2144 0.2144
Echinococcus granulosus prolyl endopeptidase 0.0042 0.0265 0.0265
Trypanosoma brucei oligopeptidase b 0.0042 0.0265 0.0405
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0525 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.032 0.032
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0613 0.0613
Echinococcus granulosus histone deacetylase 6 0.0045 0.033 0.033
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0393 0.0393
Plasmodium falciparum serine repeat antigen 3 0.0036 0.015 0.1059
Brugia malayi cathepsin Z-like cysteine proteinase 0.0036 0.015 0.015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.032 0.032
Loa Loa (eye worm) cysteine protease 0.0099 0.1418 0.1418
Giardia lamblia Cathepsin B precursor 0.0155 0.2559 1
Echinococcus multilocularis cathepsin L 0.0036 0.015 0.015
Brugia malayi cathepsin B-like cysteine proteinase 0.0422 0.7939 0.7939
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.032 0.032
Echinococcus granulosus cathepsin b 0.0422 0.7939 0.7939
Echinococcus granulosus apoptotic protease activating factor 1 0.0151 0.2461 0.2461
Leishmania major cathepsin L-like protease 0.0099 0.1418 0.4243
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.015 0.015
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.015 0.015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.2559 0.2559
Schistosoma mansoni cathepsin S (C01 family) 0.0036 0.015 0.015
Onchocerca volvulus 0.0099 0.1418 0.1418
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0036 0.015 0.1059
Schistosoma mansoni inhibitor of apoptosis protein 0.0461 0.872 0.872
Onchocerca volvulus Cathepsin F homolog 0.0099 0.1418 0.1418
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0176 0.2982 0.3635
Echinococcus multilocularis prolyl endopeptidase 0.0042 0.0265 0.0265
Brugia malayi cathepsin Z-like cysteine proteinase 0.0036 0.015 0.015
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0042 0.0265 0.0265
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.1418 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0036 0.015 0.1059
Loa Loa (eye worm) hypothetical protein 0.0422 0.7939 0.7939
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.015 0.015
Toxoplasma gondii cathepsin CPL 0.0099 0.1418 0.4754
Brugia malayi Cell death protein 3 precursor 0.0151 0.2461 0.2461
Giardia lamblia Cathepsin L precursor 0.0036 0.015 0.0587
Giardia lamblia Cathepsin L precursor 0.0036 0.015 0.0587
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0265 0.0905
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.015
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0176 0.2982 0.3635
Giardia lamblia Cathepsin B precursor 0.0036 0.015 0.0587
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0155 0.2559 0.3093
Plasmodium falciparum serine repeat antigen 8 0.0036 0.015 0.1059
Schistosoma mansoni hypothetical protein 0.0461 0.872 0.872
Schistosoma mansoni hypothetical protein 0.0151 0.2461 0.2461
Loa Loa (eye worm) hypothetical protein 0.0042 0.0265 0.0265
Brugia malayi Histone deacetylase family protein 0.0045 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0461 0.872 0.872
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0036 0.015 0.1059
Echinococcus multilocularis histone deacetylase 7 0.0045 0.033 0.033
Entamoeba histolytica prolyl oligopeptidase family protein 0.0042 0.0265 0.0905
Loa Loa (eye worm) prolyl oligopeptidase 0.0042 0.0265 0.0265
Brugia malayi hypothetical protein 0.0235 0.4162 0.4162
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0036 0.015 0.1059
Giardia lamblia Hypothetical protein 0.0036 0.015 0.0587
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0036 0.015 0.015
Brugia malayi prolyl oligopeptidase family protein 0.0042 0.0265 0.0265
Onchocerca volvulus 0.0461 0.872 0.872
Plasmodium falciparum histone deacetylase, putative 0.0045 0.033 0.2327
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0042 0.0265 0.0147
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0036 0.015 0.1059
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0042 0.0265 0.0905
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0613 0.0613
Trypanosoma brucei histone deacetylase 3 0.0045 0.033 0.0635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0036 0.015 0.0587
Plasmodium falciparum peptidase, putative 0.0042 0.0265 0.1869
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0099 0.1418 1
Echinococcus granulosus histone deacetylase 6 0.0045 0.033 0.033
Giardia lamblia Cysteine protease 0.0036 0.015 0.0587
Plasmodium falciparum serine repeat antigen 1 0.0036 0.015 0.1059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.015 0.015
Echinococcus multilocularis acylamino acid releasing enzyme 0.0042 0.0265 0.0265
Brugia malayi Papain family cysteine protease containing protein 0.0099 0.1418 0.1418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.032 0.032
Brugia malayi prolyl oligopeptidase family protein 0.0042 0.0265 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1418 0.5261
Trypanosoma brucei prolyl endopeptidase 0.0042 0.0265 0.0405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Trypanosoma cruzi histone deacetylase, putative 0.0045 0.033 0.0231
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0525 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.015 0.015
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0918 0.0918
Leishmania major cathepsin L-like protease 0.0099 0.1418 0.4243
Brugia malayi Cathepsin L-like precursor 0.0099 0.1418 0.1418
Echinococcus granulosus cysteine protease 0.0036 0.015 0.015
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.015 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0461 0.872 0.872
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0613 1
Echinococcus granulosus histone deacetylase 6 0.0045 0.033 0.033
Toxoplasma gondii preprocathepsin c precursor, putative 0.0036 0.015 0.0504
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0265 0.0147
Loa Loa (eye worm) hypothetical protein 0.0049 0.0409 0.0409
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1418 0.5261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Schistosoma mansoni cathepsin C 0.0036 0.015 0.015
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0036 0.015 0.1059
Giardia lamblia Cathepsin B precursor 0.0036 0.015 0.0587
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.032 0.032
Plasmodium vivax unspecified product 0.0036 0.015 0.1059
Loa Loa (eye worm) hypothetical protein 0.0235 0.4162 0.4162
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0042 0.0265 0.0476
Leishmania major histone deacetylase, putative 0.0045 0.033 0.0239
Brugia malayi Histone deacetylase family protein 0.0045 0.033 0.033
Echinococcus multilocularis histone deacetylase 6 0.0045 0.033 0.033
Leishmania major cathepsin L-like protease 0.0099 0.1418 0.4243
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.032 0.032
Onchocerca volvulus Cathepsin L homolog 0.0099 0.1418 0.1418
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1304 0.1304
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.061 0.061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0036 0.015 0.0587
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.015 0.015
Giardia lamblia Cysteine protease 0.0036 0.015 0.0587
Entamoeba histolytica cysteine protease, putative 0.0099 0.1418 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0042 0.0265 0.0265
Leishmania major cathepsin L-like protease 0.0099 0.1418 0.4243
Brugia malayi Cathepsin L-like precursor 0.0099 0.1418 0.1418
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0099 0.1418 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0265 0.0265
Plasmodium falciparum serine repeat antigen 5 0.0036 0.015 0.1059
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0042 0.0265 0.0405
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0121 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1418 0.5261
Giardia lamblia Alanyl dipeptidyl peptidase 0.0042 0.0265 0.1035
Schistosoma mansoni cathepsin F (C01 family) 0.0099 0.1418 0.1418
Echinococcus granulosus cathepsin L 0.0036 0.015 0.015
Giardia lamblia Cathepsin B precursor 0.0036 0.015 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0099 0.1418 0.5261
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.015 0.015
Trypanosoma cruzi cysteine peptidase, putative 0.0099 0.1418 0.1627
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0176 0.2982 0.2982
Plasmodium falciparum serine repeat antigen 6 0.0036 0.015 0.1059
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0265 0.0476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0042 0.0265 0.0265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Brugia malayi jmjC domain containing protein 0.0093 0.1304 0.1304
Trypanosoma brucei histone deacetylase, putative 0.0045 0.033 0.0635
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0422 0.7939 0.7939
Plasmodium vivax vivapain-3 0.0036 0.015 0.1059
Onchocerca volvulus Cathepsin L homolog 0.0036 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0151 0.2461 0.2461
Trypanosoma cruzi cruzipain precursor, putative 0.0099 0.1418 0.1627
Giardia lamblia Cathepsin B precursor 0.0155 0.2559 1
Trypanosoma brucei prolyl oligopeptidase, putative 0.0042 0.0265 0.0405
Trypanosoma cruzi histone deacetylase, putative 0.0045 0.033 0.0231
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0036 0.015 0.1059
Plasmodium vivax serine-repeat antigen (SERA) 0.0036 0.015 0.1059
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0461 0.872 0.872
Brugia malayi prolyl oligopeptidase family protein 0.0042 0.0265 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1418 0.5261
Brugia malayi Cathepsin L-like precursor 0.0099 0.1418 0.1418
Giardia lamblia Cathepsin L-like protease 0.0036 0.015 0.0587
Schistosoma mansoni histone deacetylase 4 5 0.0045 0.033 0.033
Giardia lamblia Alanyl dipeptidyl peptidase 0.0042 0.0265 0.1035
Echinococcus multilocularis cysteine protease 0.0099 0.1418 0.1418
Schistosoma mansoni cathepsin F (C01 family) 0.0099 0.1418 0.1418
Trypanosoma cruzi cysteine peptidase, putative 0.0099 0.1418 0.1627
Schistosoma mansoni histone deacetylase hda2 0.0045 0.033 0.033
Onchocerca volvulus 0.0099 0.1418 0.1418
Loa Loa (eye worm) hypothetical protein 0.0045 0.033 0.033
Brugia malayi hypothetical protein 0.0151 0.2461 0.2461
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0613 1
Echinococcus multilocularis inhibitor of apoptosis protein 0.0461 0.872 0.872
Leishmania major histone deacetylase, putative 0.0045 0.033 0.0239
Echinococcus granulosus inhibitor of apoptosis protein 0.0461 0.872 0.872
Loa Loa (eye worm) hypothetical protein 0.0099 0.1418 0.1418
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0042 0.0265 0.5
Trypanosoma cruzi prolyl endopeptidase 0.0042 0.0265 0.0147
Giardia lamblia Cysteine protease 0.0036 0.015 0.0587
Toxoplasma gondii cathepsin CPC1 0.0036 0.015 0.0504
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0099 0.1418 0.1627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Echinococcus granulosus cathepsin L cysteine protease 0.0036 0.015 0.015
Trypanosoma brucei histone deacetylase 4 0.0045 0.033 0.0635
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.4162 0.4162
Onchocerca volvulus 0.0099 0.1418 0.1418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.1418 0.4476
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.1418 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0422 0.7939 1
Loa Loa (eye worm) fibroinase 0.0099 0.1418 0.1418
Brugia malayi Cathepsin L-like precursor 0.0099 0.1418 0.1418
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0121 0.0121
Echinococcus granulosus Dipeptidyl peptidase 9 0.0176 0.2982 0.2982
Echinococcus granulosus caspase 2 0.0151 0.2461 0.2461
Echinococcus granulosus jumonji domain containing protein 0.004 0.0224 0.0224
Brugia malayi Cathepsin L-like precursor 0.0099 0.1418 0.1418
Loa Loa (eye worm) cathepsin B 0.0155 0.2559 0.2559
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0099 0.1418 0.1418
Echinococcus multilocularis apoptotic protease activating factor 1 0.0151 0.2461 0.2461
Plasmodium falciparum serine repeat antigen 9 0.0036 0.015 0.1059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0099 0.1418 0.5261
Loa Loa (eye worm) prolyl oligopeptidase 0.0525 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0045 0.033 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.1418 0.5261
Entamoeba histolytica prolyl oligopeptidase family protein 0.0042 0.0265 0.0905
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0042 0.0265 0.0476
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0461 0.872 0.872
Plasmodium vivax histone deacetylase, putative 0.0045 0.033 0.2327
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0176 0.2982 1
Echinococcus granulosus cathepsin l1 0.0099 0.1418 0.1418

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 25 uM Cytotoxicity against human rhabdomyosarcoma (RD) cells ChEMBL. 11931618
IC50 (functional) = 2.66 uM Inhibition concentration against EV-71 ChEMBL. 11931618

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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