Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | 0.067 | 0.4242 | 0.4242 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.1455 | 0.1455 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0007 | 0.0007 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0037 | 0.0086 |
Brugia malayi | hypothetical protein | 0.0026 | 0.01 | 0.01 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0054 | 0.0281 | 0.0281 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0062 | 0.0062 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0062 | 0.0062 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0134 | 0.0134 |
Toxoplasma gondii | cytochrome b | 0.1565 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.1886 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0062 | 0.0062 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0062 | 0.0062 |
Echinococcus granulosus | microtubule associated protein 2 | 0.067 | 0.4242 | 0.4242 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0037 | 0.0037 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.0099 | 0.0063 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0419 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0264 | 0.0264 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | MBCTL1 | 0.0054 | 0.0281 | 0.0281 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.01 | 0.0063 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0062 | 0.0145 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0062 | 0.0062 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0238 | 0.9809 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0062 | 0.0062 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.01 | 0.01 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.0251 | 0.2526 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0159 | 0.0159 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.01 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0062 | 0.0062 |
Plasmodium vivax | cytochrome b | 0.1565 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0062 | 0.0062 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0062 | 0.0062 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0419 | 0.0989 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0062 | 0.0145 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0036 | 0.0086 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.1886 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.2123 | 0.2123 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.0251 | 0.2526 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0062 | 0.0062 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0062 | 0.0062 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0062 | 0.0145 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0062 | 0.0062 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0062 | 0.0062 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0054 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0062 | 0.0062 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0062 | 0.0062 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.01 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0062 | 0.0145 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0054 | 0.0281 | 0.0281 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0026 | 0.0099 | 0.0063 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0037 | 0.0037 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0242 | 0.0242 |
Schistosoma mansoni | cytochrome b | 0.1565 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0134 | 0.0134 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0419 | 0.0384 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.1565 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0062 | 0.0062 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0419 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0037 | 0.0086 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0062 | 0.0062 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.1886 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0037 | 0.0086 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0062 | 0.0062 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0238 | 0.0562 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0062 | 0.0062 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0054 | 0.0281 | 0.0281 |
Plasmodium falciparum | cytochrome b | 0.1565 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.01 | 0.0063 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.01 | 0.0063 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0419 | 0.0384 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.1886 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.1886 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0062 | 0.0062 |
Echinococcus multilocularis | geminin | 0.0341 | 0.2123 | 0.5005 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0238 | 0.0238 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0238 | 0.0238 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0036 | 0.0086 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0419 | 0.1792 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0238 | 0.0238 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.1886 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.0338 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0159 | 0.0159 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0037 | 0.0037 |
Brugia malayi | hypothetical protein | 0.0017 | 0.004 | 0.004 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0188 | 0.1142 | 0.2693 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0057 | 0.0295 | 0.0259 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0036 | 0.0036 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0062 | 0.0062 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.01 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0419 | 0.0419 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0062 | 0.0062 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0123 | 0.0123 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0062 | 0.0062 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0148 | 0.0886 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0062 | 0.0145 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0238 | 0.0238 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.0062 | 0.0145 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0304 | 0.1886 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0159 | 0.0159 |
Schistosoma mansoni | hypothetical protein | 0.029 | 0.18 | 0.18 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | cytochrome b | 0.1565 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0062 | 0.0062 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0007 | 0.0015 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0237 | 0.1455 | 0.343 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0062 | 0.0062 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0134 | 0.0134 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0036 | 0.0036 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0062 | 0.0062 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0419 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.01 | 0.0063 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0062 | 0.0062 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0062 | 0.0145 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0148 | 0.0886 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0062 | 0.0062 |
Toxoplasma gondii | apocytochrome b, putative | 0.1565 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0419 | 0.0419 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.2123 | 0.2123 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.067 | 0.4242 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.1886 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0062 | 0.0062 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0062 | 0.0062 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0007 | 0.0007 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0062 | 0.0062 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0062 | 0.0062 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0238 | 0.0238 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0062 | 0.0062 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0054 | 0.0281 | 0.0662 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0036 | 0.0036 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0304 | 0.1886 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0036 | 0.0036 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0037 | 0.0037 |
Echinococcus granulosus | geminin | 0.0341 | 0.2123 | 0.2123 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0238 | 0.0238 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0062 | 0.0062 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0264 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0238 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0036 | 0.0036 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0425 | 0.2667 | 0.6288 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0036 | 0.0086 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0419 | 0.0384 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0062 | 0.0062 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0148 | 0.0886 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0036 | 0.0036 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0264 | 0.0264 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0238 | 0.0238 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0037 | 0.0086 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0062 | 0.0062 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.1886 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0242 | 0.0242 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0062 | 0.0062 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0123 | 0.0123 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0251 | 0.0251 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0304 | 0.1886 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0062 | 0.0062 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0134 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0242 | 0.0242 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.01 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0062 | 0.0062 |
Echinococcus granulosus | cytochrome B | 0.1565 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0237 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0062 | 0.0062 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0419 | 0.0419 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0062 | 0.0062 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0062 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0062 | 0.0062 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.0251 | 0.1931 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0037 | 0.0086 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0062 | 0.0145 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0264 | 0.0264 |
Schistosoma mansoni | cytochrome b | 0.1565 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0062 | 0.0062 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0062 | 0.0062 |
Schistosoma mansoni | hypothetical protein | 0.0425 | 0.2667 | 0.2667 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0062 | 0.0062 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0036 | 0.0036 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0036 | 0.0036 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.0419 | 0.0419 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0062 | 0.0062 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0238 | 0.0238 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0188 | 0.1142 | 0.1142 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0036 | 0.0036 |
Brugia malayi | hypothetical protein | 0.0237 | 0.1455 | 0.1455 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0062 | 0.0062 |
Onchocerca volvulus | 0.0048 | 0.0242 | 1 | |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0238 | 0.0562 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0304 | 0.1886 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0419 | 0.407 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0123 | 0.0123 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.0099 | 0.0063 |
Echinococcus granulosus | dnaJ subfamily B | 0.0425 | 0.2667 | 0.2667 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0251 | 0.0592 |
Onchocerca volvulus | 0.003 | 0.0123 | 0.3408 | |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0036 | 0.0036 |
Onchocerca volvulus | 0.0048 | 0.0238 | 0.9809 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0281 | 0.0281 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0054 | 0.0281 | 0.0662 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.