Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0121 | 0.2185 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.1708 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0105 | 0.0616 |
Plasmodium vivax | RNA helicase-1, putative | 0.0102 | 0.1708 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 1 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.0121 | 0.2185 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0102 | 0.1708 | 0.1108 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0119 | 0.2134 | 0.9706 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0102 | 0.1708 | 0.7816 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0102 | 0.1708 | 0.7816 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.004 | 0.0172 | 0.0785 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0347 | 0.782 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0347 | 0.782 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0896 | 0.4099 |
Mycobacterium ulcerans | hypothetical protein | 0.0347 | 0.782 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0102 | 0.1708 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0347 | 0.782 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0038 | 0.0176 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0121 | 0.2185 | 0.2185 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0102 | 0.1708 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.004 | 0.0172 | 0.0785 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 0.7816 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.1708 | 0.7245 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0264 | 0.0264 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0119 | 0.2134 | 0.9706 |
Mycobacterium tuberculosis | Conserved protein | 0.0347 | 0.782 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0105 | 0.0616 |
Mycobacterium leprae | conserved hypothetical protein | 0.0347 | 0.782 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0102 | 0.1708 | 0.7816 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 0.1708 | 0.7245 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0121 | 0.2185 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0264 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.2185 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0119 | 0.2134 | 0.9706 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 0.1708 | 0.7245 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.004 | 0.0172 | 0.1004 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.1708 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0102 | 0.1708 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.004 | 0.0172 | 0.0785 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0102 | 0.1708 | 0.7816 |
Onchocerca volvulus | 0.0121 | 0.2185 | 1 | |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0119 | 0.2134 | 0.9706 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 0.1708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.2134 | 0.9767 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1708 | 0.7816 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | 0 uM | Inhibition of dihydrosterculate synthesis in Crithidia fasciculata; No inhibition | ChEMBL. | 3398003 |
I50 (functional) | > 100 uM | The compound was tested for 50% growth inhibition against Crithidia fasciculata | ChEMBL. | 3398003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.