Detailed information for compound 651315

Basic information

Technical information
  • TDR Targets ID: 651315
  • Name: (2-amino-5-methylphenyl)-phenylmethanol
  • MW: 213.275 | Formula: C14H15NO
  • H donors: 2 H acceptors: 1 LogP: 2.97 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)C(c1ccccc1)O)N
  • InChi: 1S/C14H15NO/c1-10-7-8-13(15)12(9-10)14(16)11-5-3-2-4-6-11/h2-9,14,16H,15H2,1H3
  • InChiKey: RFGHBTFPMINONZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2-Amino-5-methyl-phenyl)-phenyl-methanol
  • Oprea1_300255
  • BAS 00462567
  • ST5002802
  • IFLab1_000149
  • IDI1_008368
  • Oprea1_340720

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.1597 0.1472
Trichomonas vaginalis beta lactamase domain, putative 0.0224 1 1
Trypanosoma cruzi glyoxalase II 0.0224 1 1
Mycobacterium ulcerans hypothetical protein 0.0224 1 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0321 0.0177
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0224 1 0.5
Mycobacterium ulcerans beta lactamase-like protein 0.0224 1 0.5
Plasmodium vivax unspecified product 0.0224 1 0.5
Trichomonas vaginalis beta lactamase domain, putative 0.0224 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.1597 0.1472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0146 0.0146
Mycobacterium leprae POSSIBLE HYDROLASE 0.0224 1 0.5
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0224 1 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0224 1 1
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.115 0.115
Loa Loa (eye worm) hypothetical protein 0.0224 1 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0224 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.1152 0.1021
Treponema pallidum ribonuclease Z 0.0224 1 0.5
Entamoeba histolytica metallo-beta-lactamase family protein 0.0224 1 1
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1038 0.1038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.115 0.115
Trichomonas vaginalis conserved hypothetical protein 0.0224 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.1152 0.1021
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0224 1 1
Brugia malayi hypothetical protein 0.0224 1 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0224 1 1
Mycobacterium leprae conserved hypothetical protein 0.0224 1 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.1597 0.1472
Trichomonas vaginalis beta lactamase domain, putative 0.0224 1 1
Schistosoma mansoni hypothetical protein 0.0224 1 1
Onchocerca volvulus 0.0224 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0224 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.1597 0.1472
Trichomonas vaginalis apoptosis inducing factor, putative 0.0224 1 1
Schistosoma mansoni zinc phosphodiesterase 0.0224 1 1
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0224 1 1
Entamoeba histolytica alkyl sulfatase, putative 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0146 0.0146
Leishmania major metallo-beta-lactamase family-like protein 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0719 0.0719
Mycobacterium ulcerans hypothetical protein 0.0224 1 0.5
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.1597 0.1597
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0224 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.1597 0.1472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1038 0.1038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0878 0.0878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0146 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.1597 0.1597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1038 0.1038
Mycobacterium ulcerans hydrolase 0.0224 1 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0146 0.0146
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.1597 0.1472
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.1597 0.1472
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1038 0.1038
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.1597 0.1472
Mycobacterium ulcerans hypothetical protein 0.0224 1 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0719 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.115 0.115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0719 0.0719
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0224 1 1
Leishmania major metallo-beta-lactamase family protein-like protein 0.0224 1 1
Mycobacterium ulcerans hydrolase 0.0224 1 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0224 1 0.5
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0224 1 1
Mycobacterium tuberculosis Possible hydrolase 0.0224 1 0.5
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.1597 0.1472
Entamoeba histolytica metallo-beta-lactamase family protein 0.0224 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0224 1 1
Mycobacterium ulcerans glyoxalase II, GloB 0.0224 1 0.5
Echinococcus granulosus zinc phosphodiesterase 0.0224 1 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0224 1 1
Mycobacterium tuberculosis Possible hydrolase 0.0224 1 0.5
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0224 1 1
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0224 1 1
Mycobacterium leprae conserved hypothetical protein 0.0224 1 0.5
Mycobacterium ulcerans hypothetical protein 0.0224 1 0.5
Mycobacterium tuberculosis Conserved protein 0.0224 1 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1038 0.1038
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0224 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0591 0.0591
Echinococcus multilocularis ETHE1 protein 0.0224 1 1
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0224 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0447 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0831 0.0831
Trichomonas vaginalis beta lactamase domain, putative 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0591 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0593 0.0593
Onchocerca volvulus Putative hydrolase PNKD 0.0224 1 0.5
Entamoeba histolytica metallo-beta-lactamase family protein 0.0224 1 1
Entamoeba histolytica type A flavoprotein, putative 0.0224 1 1
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0224 1 1
Mycobacterium tuberculosis Conserved protein 0.0224 1 0.5
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0593 0.0593
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.115 0.115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1038 0.1038
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.1597 0.1472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0593 0.0593
Mycobacterium tuberculosis Conserved hypothetical protein 0.0224 1 0.5
Schistosoma mansoni hypothetical protein 0.0224 1 1
Echinococcus granulosus ETHE1 protein 0.0224 1 1
Chlamydia trachomatis ribonuclease Z 0.0224 1 0.5
Entamoeba histolytica alkyl sulfatase, putative 0.0224 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0224 1 1
Trichomonas vaginalis beta lactamase domain, putative 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0593 0.0593
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0224 1 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0224 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0224 1 1
Entamoeba histolytica type A flavoprotein, putative 0.0224 1 1
Mycobacterium tuberculosis Beta lactamase like protein 0.0224 1 0.5
Trichomonas vaginalis A-type flavoprotein 0.0224 1 1
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0224 1 0.5
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1038 0.1038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.1597 0.1597
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.1597 0.1472
Mycobacterium leprae Beta-lactamase-like protein 0.0224 1 0.5
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0224 1 1
Onchocerca volvulus 0.0224 1 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0224 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.115 0.115
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0224 1 1
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0224 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.1152 0.1021
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0224 1 1
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0224 1 1
Leishmania major hypothetical protein, conserved 0.0224 1 1
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0224 1 1
Schistosoma mansoni hypothetical protein 0.0224 1 1
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0224 1 0.5
Mycobacterium tuberculosis Conserved protein 0.0224 1 0.5
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0224 1 1
Echinococcus multilocularis zinc phosphodiesterase 0.0224 1 1
Trypanosoma brucei glyoxalase II 0.0224 1 1
Trypanosoma cruzi glyoxalase II 0.0224 1 1
Plasmodium falciparum cytosolic glyoxalase II 0.0224 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0224 1 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0224 1 1
Schistosoma mansoni zinc phosphodiesterase 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0706 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0224 1 1
Trypanosoma cruzi glyoxalase II 0.0224 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.1278 0.1278
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0224 1 0.5
Mycobacterium ulcerans hydrolase 0.0224 1 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0146 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0706 0.0706
Trichomonas vaginalis beta lactamase domain, putative 0.0224 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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