Detailed information for compound 652250

Basic information

Technical information
  • TDR Targets ID: 652250
  • Name: 8-amino-1,3,7-trimethylbenzo[g]pteridine-2,4- dione
  • MW: 271.275 | Formula: C13H13N5O2
  • H donors: 1 H acceptors: 4 LogP: 0.45 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc2nc3c(nc2cc1N)n(C)c(=O)n(c3=O)C
  • InChi: 1S/C13H13N5O2/c1-6-4-8-9(5-7(6)14)16-11-10(15-8)12(19)18(3)13(20)17(11)2/h4-5H,14H2,1-3H3
  • InChiKey: MQZPSLQSYHKJHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-amino-1,3,7-trimethyl-benzo[g]pteridine-2,4-dione
  • 8-amino-1,3,7-trimethyl-benzo[g]pteridine-2,4-quinone
  • Oprea1_217403
  • ZINC00235641
  • AG-670/33699014
  • ChemDiv1_019587
  • STOCK1N-07076

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi fatty acid elongation protein 3 0.0079 0.009 0.0257
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.0392 0.3495 1
Echinococcus granulosus hormone sensitive lipase 0.041 0.3691 0.3634
Trypanosoma cruzi fatty acid elongase, putative 0.0079 0.009 0.0127
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0152 0.0879 0.2514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1294 0.1294
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0079 0.009 0.009
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.1294 0.1294
Leishmania major fatty acid elongase, putative 0.0079 0.009 0.0127
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0392 0.3495 0.3495
Echinococcus granulosus beta LACTamase domain containing family member 0.0152 0.0879 0.0796
Loa Loa (eye worm) hypothetical protein 0.0152 0.0879 0.0879
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1294 0.1215
Mycobacterium ulcerans hypothetical protein 0.0152 0.0879 0.5
Echinococcus multilocularis snurportin 1 0.0989 1 1
Trypanosoma brucei RNA helicase, putative 0.0282 0.2294 0.6473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1294 0.1294
Loa Loa (eye worm) ELO-9 protein 0.0079 0.009 0.009
Trypanosoma cruzi fatty acid elongase, putative 0.0079 0.009 0.0127
Plasmodium falciparum importin beta, putative 0.0093 0.0237 0.0432
Leishmania major fatty acid elongase, putative 0.0392 0.3495 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.041 0.3691 0.3691
Trypanosoma cruzi fatty acid elongase, putative 0.0392 0.3495 1
Entamoeba histolytica hypothetical protein 0.0075 0.0046 0.5
Echinococcus multilocularis hormone sensitive lipase 0.041 0.3691 0.3634
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0989 1 1
Brugia malayi Importin beta-1 subunit 0.0093 0.0237 0.0678
Trichomonas vaginalis penicillin-binding protein, putative 0.0152 0.0879 1
Schistosoma mansoni elongation of fatty acids protein 1 0.0079 0.009 0.009
Trypanosoma brucei importin beta-1 subunit, putative 0.0093 0.0237 0.0432
Leishmania major fatty acid elongase, putative 0.0079 0.009 0.0127
Loa Loa (eye worm) hypothetical protein 0.0152 0.0879 0.0879
Leishmania major fatty acid elongase, putative 0.0079 0.009 0.0127
Loa Loa (eye worm) fatty acid elongation protein 3 0.0079 0.009 0.009
Onchocerca volvulus 0.0152 0.0879 1
Trypanosoma cruzi fatty acid elongase, putative 0.0079 0.009 0.0127
Leishmania major fatty acid elongase, putative 0.0079 0.009 0.0127
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0152 0.0879 0.5
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.0392 0.3495 1
Trypanosoma cruzi fatty acid elongase, putative 0.0392 0.3495 1
Mycobacterium ulcerans esterase/lipase LipP 0.0152 0.0879 0.5
Loa Loa (eye worm) hypothetical protein 0.0152 0.0879 0.0879
Schistosoma mansoni elongation of fatty acids protein 1 0.0079 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0104 0.0357 0.0357
Echinococcus multilocularis importin subunit beta 1 0.0093 0.0237 0.0149
Brugia malayi beta-lactamase family protein 0.0152 0.0879 0.2514
Toxoplasma gondii HEAT repeat-containing protein 0.0093 0.0237 0.0432
Brugia malayi Fatty acid elongation protein 3 0.0392 0.3495 1
Trypanosoma cruzi fatty acid elongase, putative 0.0392 0.3495 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.1294 0.3701
Echinococcus multilocularis beta LACTamase domain containing family member 0.0152 0.0879 0.0796
Schistosoma mansoni elongation of fatty acids protein 1 0.0079 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0152 0.0879 0.0879
Mycobacterium ulcerans lipase LipD 0.0152 0.0879 0.5
Schistosoma mansoni importin beta-1 0.0093 0.0237 0.0237
Brugia malayi GNS1/SUR4 family protein 0.0079 0.009 0.0257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0152 0.0879 0.0879
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.0879 1
Trypanosoma cruzi fatty acid elongase, putative 0.0392 0.3495 1
Brugia malayi fatty acid elongation protein 3 0.0079 0.009 0.0257
Brugia malayi fatty acid elongation protein 3 0.0079 0.009 0.0257
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.0879 0.2414
Plasmodium vivax importin-beta 2, putative 0.0093 0.0237 0.0432
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1294 0.1215
Loa Loa (eye worm) hypothetical protein 0.041 0.3691 0.3691
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.0879 1
Trypanosoma brucei Fatty acid elongase 0.0392 0.3495 1
Schistosoma mansoni hypothetical protein 0.0989 1 1
Brugia malayi fatty acid elongation protein 3 0.0079 0.009 0.0257
Onchocerca volvulus 0.0152 0.0879 1
Loa Loa (eye worm) fatty acid elongation protein 3 0.0079 0.009 0.009
Trypanosoma cruzi fatty acid elongase, putative 0.0079 0.009 0.0127
Mycobacterium leprae Probable lipase LipE 0.0152 0.0879 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.0879 1
Leishmania major fatty acid elongase, putative 0.0079 0.009 0.0127
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0969 0.9775 1
Leishmania major fatty acid elongase, putative 0.0079 0.009 0.0127
Brugia malayi RNA, U transporter 1 0.0264 0.2097 0.6
Loa Loa (eye worm) hypothetical protein 0.0152 0.0879 0.0879
Brugia malayi Hypothetical 34.1 kDa protein C40H1.4 in chromosome III 0.0079 0.009 0.0257
Trichomonas vaginalis penicillin-binding protein, putative 0.0152 0.0879 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.041 0.3691 0.3691
Leishmania major fatty acid elongase, putative 0.0392 0.3495 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0093 0.0237 0.0432
Leishmania major fatty acid elongase, putative 0.0079 0.009 0.0127
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0357 0.0357
Trypanosoma cruzi fatty acid elongase, putative 0.0079 0.009 0.0127
Mycobacterium ulcerans beta-lactamase 0.0152 0.0879 0.5
Trichomonas vaginalis esterase, putative 0.0152 0.0879 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1294 0.1215
Loa Loa (eye worm) hypothetical protein 0.0093 0.0237 0.0237
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.0392 0.3495 1
Brugia malayi GNS1/SUR4 family protein 0.0392 0.3495 1
Brugia malayi beta-lactamase 0.0152 0.0879 0.2514
Toxoplasma gondii GNS1/SUR4 family protein 0.0392 0.3495 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.041 0.3691 0.3691
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0357 0.1022
Loa Loa (eye worm) fatty acid elongation protein 3 0.0079 0.009 0.009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0152 0.0879 0.0879
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.0879 0.2414
Leishmania major fatty acid elongase, putative 0.0079 0.009 0.0127
Leishmania major fatty acid elongase, putative 0.0392 0.3495 1
Loa Loa (eye worm) fatty acid elongation protein 3 0.0392 0.3495 0.3495
Loa Loa (eye worm) beta-lactamase 0.0152 0.0879 0.0879
Schistosoma mansoni elongation of fatty acids protein 1 0.0079 0.009 0.009
Brugia malayi beta-lactamase family protein 0.0152 0.0879 0.2514
Loa Loa (eye worm) hypothetical protein 0.0152 0.0879 0.0879
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0152 0.0879 0.0879
Plasmodium vivax hypothetical protein, conserved 0.0152 0.0879 0.2317
Loa Loa (eye worm) hypothetical protein 0.0079 0.009 0.009
Trypanosoma brucei hypothetical protein, conserved 0.0152 0.0879 0.2317
Schistosoma mansoni fatty acid acyl transferase-related 0.0079 0.009 0.009
Onchocerca volvulus 0.0152 0.0879 1
Leishmania major long chain polyunsaturated fatty acid elongation enzyme-like protein 0.0079 0.009 0.0127
Mycobacterium leprae conserved hypothetical protein 0.0152 0.0879 0.5
Plasmodium vivax GNS1/SUR4 domain containing protein 0.0392 0.3495 1
Echinococcus granulosus importin subunit beta 1 0.0093 0.0237 0.0149
Toxoplasma gondii ABC1 family protein 0.0152 0.0879 0.2317
Schistosoma mansoni hypothetical protein 0.0282 0.2294 0.2294
Trypanosoma cruzi fatty acid elongase, putative 0.0079 0.009 0.0127
Leishmania major fatty acid elongase, putative 0.0079 0.009 0.0127
Leishmania major fatty acid elongase, putative 0.0079 0.009 0.0127
Leishmania major hypothetical protein, conserved 0.0152 0.0879 0.2414
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1294 0.1215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0357 0.1022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1294 0.1294

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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