Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.207 | 0.495 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0168 | 0.207 | 0.6542 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0058 | 0.0174 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.335 | 1 |
Plasmodium falciparum | phd finger protein, putative | 0.003 | 0.0058 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0149 | 0.0582 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0144 | 0.1713 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0097 | 0.104 | 0.5947 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0714 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0144 | 0.1713 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0144 | 0.1713 | 0.5115 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.335 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.2707 | 0.8082 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0477 | 0.6556 | 0.6348 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0118 | 0.0353 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.207 | 0.495 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0346 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0118 | 0.0353 |
Trichomonas vaginalis | set domain proteins, putative | 0.0241 | 0.3133 | 0.9144 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.207 | 0.495 |
Brugia malayi | Bromodomain containing protein | 0.003 | 0.0058 | 0.0174 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0069 | 0.0062 |
Loa Loa (eye worm) | PHD-finger family protein | 0.003 | 0.0058 | 0.0174 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0069 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.2201 | 0.5469 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0256 | 0.335 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0144 | 0.1713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0367 | 0.1095 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0256 | 0.335 | 1 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0319 | 0.4259 | 0.3809 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0319 | 0.4259 | 0.375 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0704 | 0.9858 | 1 |
Onchocerca volvulus | 0.003 | 0.0069 | 0.0034 | |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0227 | 0.1021 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0704 | 0.9858 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0097 | 0.104 | 0.5932 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0069 | 0.0062 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0346 | 0.1032 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0477 | 0.6556 | 0.6348 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.207 | 0.495 |
Onchocerca volvulus | 0.0241 | 0.3133 | 1 | |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.0058 | 0.8498 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0069 | 0.0098 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.2201 | 0.5469 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0144 | 0.1713 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0227 | 0.1053 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0477 | 0.6556 | 0.6348 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0149 | 0.0445 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0714 | 1 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0069 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.335 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0144 | 0.1713 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0346 | 0.1032 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.0058 | 0.0036 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0069 | 0.0062 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0149 | 0.0549 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0069 | 0.0205 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.207 | 0.495 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0346 | 0.1032 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0069 | 0.0062 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0144 | 0.1713 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0144 | 0.1713 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0.0058 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0058 | 0.8498 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0149 | 0.0445 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0118 | 0.0361 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0149 | 0.0549 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.335 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0058 | 0.8498 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.335 | 1 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0704 | 0.9858 | 1 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0058 | 0.0174 |
Echinococcus granulosus | peregrin | 0.003 | 0.0058 | 0.0036 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0069 | 0.0062 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.0518 | 0.1546 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0069 | 0.0205 |
Brugia malayi | jmjC domain containing protein | 0.0097 | 0.104 | 0.3105 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.207 | 0.495 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0168 | 0.207 | 0.495 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0149 | 0.0549 |
Schistosoma mansoni | jumonji domain containing protein | 0.0077 | 0.075 | 0.4177 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0144 | 0.1713 | 0.5115 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0069 | 0.0062 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0256 | 0.335 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.2707 | 0.8082 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.