Detailed information for compound 65539

Basic information

Technical information
  • TDR Targets ID: 65539
  • Name: 4-[2,6-dichloro-4-[2-[di(propan-2-yl)amino]-2 -oxoethoxy]phenyl]benzoic acid
  • MW: 424.318 | Formula: C21H23Cl2NO4
  • H donors: 1 H acceptors: 3 LogP: 5.43 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(N(C(=O)COc1cc(Cl)c(c(c1)Cl)c1ccc(cc1)C(=O)O)C(C)C)C
  • InChi: 1S/C21H23Cl2NO4/c1-12(2)24(13(3)4)19(25)11-28-16-9-17(22)20(18(23)10-16)14-5-7-15(8-6-14)21(26)27/h5-10,12-13H,11H2,1-4H3,(H,26,27)
  • InChiKey: HDTCKUBKTCKUIN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2,6-dichloro-4-[2-(diisopropylamino)-2-oxo-ethoxy]phenyl]benzoic acid
  • 4-[2,6-dichloro-4-[2-(diisopropylamino)-2-oxoethoxy]phenyl]benzoic acid
  • 4-[2,6-dichloro-4-[2-[di(propan-2-yl)amino]-2-oxo-ethoxy]phenyl]benzoic acid
  • 4-[2,6-dichloro-4-[2-(diisopropylamino)-2-keto-ethoxy]phenyl]benzoic acid
  • 4-[2,6-dichloro-4-[2-(di(propan-2-yl)amino)-2-oxoethoxy]phenyl]benzoic acid
  • 4-[2,6-dichloro-4-[2-(di(propan-2-yl)amino)-2-oxo-ethoxy]phenyl]benzoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania infantum 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative Get druggable targets OG5_128852 All targets in OG5_128852
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128852 All targets in OG5_128852
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128852 All targets in OG5_128852
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania braziliensis 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania donovani 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Leishmania mexicana 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein Get druggable targets OG5_128852 All targets in OG5_128852
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Get druggable targets OG5_128852 All targets in OG5_128852
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Entamoeba histolytica steroid 5-alpha reductase, putative Get druggable targets OG5_128852 All targets in OG5_128852
Trypanosoma brucei gambiense 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative Get druggable targets OG5_128852 All targets in OG5_128852
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Synaptic glycoprotein SC2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 254 aa 208 aa 28.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0125 0.3893 0.9758
Echinococcus granulosus protein kinase c epsilon type 0.0126 0.399 1
Echinococcus granulosus active breakpoint cluster region 0.0125 0.3893 0.9758
Brugia malayi Copine VIII 0.0125 0.3893 0.3893
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Brugia malayi Protein kinase c protein 2 0.0126 0.399 0.399
Leishmania major hypothetical protein, conserved 0.0125 0.3893 0.3893
Echinococcus multilocularis synaptotagmin 0.0125 0.3893 0.9758
Echinococcus granulosus copine 9 0.0125 0.3893 0.9758
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Schistosoma mansoni mctp-related 0.0125 0.3893 0.9758
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Schistosoma mansoni synaptotagmin-like protein 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Schistosoma mansoni synaptotagmin 12 0.0125 0.3893 0.9758
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0125 0.3893 0.9758
Echinococcus granulosus protein piccolo 0.0125 0.3893 0.9758
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.3893 0.3893
Echinococcus multilocularis calpain 5 0.0125 0.3893 0.9758
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Schistosoma mansoni unc-13 (munc13) 0.0125 0.3893 0.9758
Trichomonas vaginalis synaptotagmin, putative 0.0125 0.3893 0.3893
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0125 0.3893 0.9758
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0125 0.3893 0.9758
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0125 0.3893 0.9758
Echinococcus granulosus synaptotagmin 15 0.0125 0.3893 0.9758
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0125 0.3893 0.9758
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0125 0.3893 0.3893
Toxoplasma gondii hypothetical protein 0.0125 0.3893 0.3893
Echinococcus multilocularis protein kinase c epsilon type 0.0126 0.399 1
Trypanosoma brucei predicted C2 domain protein 0.0125 0.3893 0.3893
Brugia malayi WW domain containing protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) C2 domain-containing protein 0.0125 0.3893 0.3893
Trypanosoma cruzi cAMP binding protein, putative 0.0125 0.3893 0.3893
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) copine family protein 0.0125 0.3893 0.3893
Onchocerca volvulus 0.0125 0.3893 1
Schistosoma mansoni hypothetical protein 0.0125 0.3893 0.9758
Onchocerca volvulus 0.0125 0.3893 1
Trypanosoma brucei C2 domain containing protein, putative 0.0125 0.3893 0.3893
Schistosoma mansoni hypothetical protein 0.0125 0.3893 0.9758
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Schistosoma mansoni rho gtpase activating protein 0.0125 0.3893 0.9758
Trichomonas vaginalis copine, putative 0.0125 0.3893 0.3893
Echinococcus granulosus unc 13 munc13 0.0125 0.3893 0.9758
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.3893 0.3893
Schistosoma mansoni hypothetical protein 0.0125 0.3893 0.9758
Toxoplasma gondii Elicitor-responsive protein, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0189 1 1
Echinococcus multilocularis myoferlin 0.0125 0.3893 0.9758
Echinococcus granulosus synaptotagmin 0.0125 0.3893 0.9758
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.0125 0.3893 0.3893
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Echinococcus granulosus synaptotagmin 0.0125 0.3893 0.9758
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0126 0.399 0.399
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0125 0.3893 0.9758
Onchocerca volvulus 0.0125 0.3893 1
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Trichomonas vaginalis Proline-rich protein, putative 0.0125 0.3893 0.3893
Echinococcus granulosus synaptotagmin 2 0.0125 0.3893 0.9758
Trypanosoma brucei predicted C2 domain protein 0.0125 0.3893 0.3893
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0125 0.3893 0.3893
Brugia malayi Copine family protein 0.0125 0.3893 0.3893
Echinococcus granulosus Immunoglobulin E set 0.0125 0.3893 0.9758
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Trypanosoma brucei cAMP binding protein, putative 0.0125 0.3893 0.3893
Leishmania major c2 domain protein, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis synaptotagmin, putative 0.0125 0.3893 0.3893
Toxoplasma gondii Sma protein 0.0125 0.3893 0.3893
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) C2 domain-containing protein 0.0125 0.3893 0.3893
Onchocerca volvulus 0.0125 0.3893 1
Echinococcus granulosus UNCoordinated family member unc 13 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Echinococcus multilocularis synaptotagmin 0.0125 0.3893 0.9758
Echinococcus granulosus extended synaptotagmin 2 0.0125 0.3893 0.9758
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Trichomonas vaginalis annexin VII, putative 0.0125 0.3893 0.3893
Trypanosoma brucei hypothetical protein, conserved 0.0125 0.3893 0.3893
Loa Loa (eye worm) C2 domain-containing protein 0.0125 0.3893 0.3893
Entamoeba histolytica hypothetical protein 0.0125 0.3893 0.3893
Echinococcus granulosus myoferlin 0.0125 0.3893 0.9758
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 1 1
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Trypanosoma cruzi C2 domain containing protein, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) Nedd4-PD 0.0125 0.3893 0.3893
Echinococcus multilocularis synaptotagmin 0.0125 0.3893 0.9758
Schistosoma mansoni hypothetical protein 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Trypanosoma brucei C2 domain containing protein, putative 0.0125 0.3893 0.3893
Loa Loa (eye worm) C2 domain-containing protein 0.0125 0.3893 0.3893
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 1 1
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0189 1 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.3893 0.3893
Trypanosoma cruzi synaptotagmin, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Entamoeba histolytica hypothetical protein 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0125 0.3893 0.3893
Brugia malayi protein kinase C II. 0.0126 0.399 0.399
Plasmodium vivax ferlin, putative 0.0125 0.3893 1
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Leishmania major hypothetical protein, conserved 0.0125 0.3893 0.3893
Schistosoma mansoni synaptotagmin 12 0.0125 0.3893 0.9758
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0125 0.3893 0.3893
Echinococcus multilocularis neural cell expressed, developmentally 0.0125 0.3893 0.9758
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0126 0.399 0.399
Brugia malayi Synaptotagmin I 0.0125 0.3893 0.3893
Leishmania major hypothetical protein, conserved 0.0125 0.3893 0.3893
Leishmania major hypothetical protein, conserved 0.0125 0.3893 0.3893
Entamoeba histolytica hypothetical protein 0.0125 0.3893 0.3893
Leishmania major c2 domain protein, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Entamoeba histolytica DENN domain protein 0.0125 0.3893 0.3893
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0125 0.3893 0.9758
Trypanosoma brucei hypothetical protein, conserved 0.0125 0.3893 0.3893
Echinococcus multilocularis synaptotagmin 0.0125 0.3893 0.9758
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Giardia lamblia Kinase, CK1 Casein kinase 0.0084 0 0.5
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0125 0.3893 0.3893
Echinococcus multilocularis extended synaptotagmin 2 0.0125 0.3893 0.9758
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Schistosoma mansoni synaptotagmin 0.0125 0.3893 0.9758
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0125 0.3893 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Trichomonas vaginalis vab10 spectraplakin, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis copine, putative 0.0125 0.3893 0.3893
Brugia malayi LD23056p 0.0125 0.3893 0.3893
Loa Loa (eye worm) C2 domain-containing protein 0.0125 0.3893 0.3893
Trypanosoma brucei C2 domain containing protein, putative 0.0125 0.3893 0.3893
Leishmania major hypothetical protein, conserved 0.0125 0.3893 0.3893
Entamoeba histolytica C2 domain containing protein 0.0125 0.3893 0.3893
Plasmodium vivax double C2-like domain-containing protein, putative 0.0125 0.3893 1
Echinococcus granulosus synaptotagmin 0.0125 0.3893 0.9758
Leishmania major hypothetical protein, conserved 0.0125 0.3893 0.3893
Entamoeba histolytica calcium-binding protein, putative 0.0125 0.3893 0.3893
Schistosoma mansoni fer-1-related 0.0125 0.3893 0.9758
Entamoeba histolytica C2 domain containing protein 0.0125 0.3893 0.3893
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0189 1 1
Schistosoma mansoni rabphilin-3a 0.0125 0.3893 0.9758
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Echinococcus granulosus intersectin 2 0.0125 0.3893 0.9758
Trichomonas vaginalis synaptotagmin, putative 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Entamoeba histolytica hypothetical protein, conserved 0.0125 0.3893 0.3893
Brugia malayi calpain 5 0.0125 0.3893 0.3893
Toxoplasma gondii hypothetical protein 0.0125 0.3893 0.3893
Trichomonas vaginalis synaptotagmin, putative 0.0125 0.3893 0.3893
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0125 0.3893 0.9758
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0125 0.3893 0.9758
Trypanosoma brucei predicted C2 domain protein 0.0125 0.3893 0.3893
Trichomonas vaginalis synaptotagmin, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Echinococcus granulosus copine 9 0.0125 0.3893 0.9758
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0125 0.3893 0.3893
Echinococcus multilocularis intersectin 2 0.0125 0.3893 0.9758
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.3893 0.3893
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.399 1
Schistosoma mansoni synaptotagmin 0.0125 0.3893 0.9758
Leishmania major hypothetical protein, conserved 0.0125 0.3893 0.3893
Leishmania major phospholipase c-like protein 0.0125 0.3893 0.3893
Entamoeba histolytica C2 domain containing protein 0.0125 0.3893 0.3893
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0125 0.3893 1
Trichomonas vaginalis ion channel nompc, putative 0.0125 0.3893 0.3893
Brugia malayi phospholipase C homolog 0.0125 0.3893 0.3893
Echinococcus multilocularis synaptotagmin 2 0.0125 0.3893 0.9758
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.3893 0.3893
Brugia malayi Synapse defective protein 1 0.0125 0.3893 0.3893
Entamoeba histolytica hypothetical protein 0.0125 0.3893 0.3893
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 1 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Onchocerca volvulus 0.0125 0.3893 1
Mycobacterium ulcerans hypothetical protein 0.0189 1 0.5
Echinococcus multilocularis active breakpoint cluster region 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Entamoeba histolytica hypothetical protein, conserved 0.0125 0.3893 0.3893
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0125 0.3893 0.9758
Echinococcus multilocularis unc 13 (munc13) 0.0125 0.3893 0.9758
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0125 0.3893 0.3893
Entamoeba histolytica C2 domain containing protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0125 0.3893 0.3893
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0189 1 1
Echinococcus multilocularis synaptotagmin 15 0.0125 0.3893 0.9758
Schistosoma mansoni synaptotagmin 0.0125 0.3893 0.9758
Trichomonas vaginalis copine, putative 0.0125 0.3893 0.3893
Echinococcus granulosus otoferlin 0.0125 0.3893 0.9758
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0125 0.3893 0.9758
Trypanosoma brucei synaptotagmin, putative 0.0125 0.3893 0.3893
Schistosoma mansoni synaptotagmin 0.0125 0.3893 0.9758
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.399 1
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0125 0.3893 0.9758
Entamoeba histolytica C2 domain containing protein 0.0125 0.3893 0.3893
Schistosoma mansoni otoferlin 0.0125 0.3893 0.9758
Entamoeba histolytica C2 domain containing protein 0.0125 0.3893 0.3893
Onchocerca volvulus 0.0125 0.3893 1
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.3893 0.3893
Echinococcus multilocularis copine 9 0.0125 0.3893 0.9758
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0125 0.3893 0.9758
Plasmodium falciparum double C2-like domain-containing protein 0.0125 0.3893 1
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Toxoplasma gondii C2 domain-containing protein 0.0125 0.3893 0.3893
Echinococcus multilocularis protein piccolo 0.0125 0.3893 0.9758
Onchocerca volvulus 0.0125 0.3893 1
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0189 1 1
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0125 0.3893 0.9758
Echinococcus granulosus synaptotagmin protein 4 0.0125 0.3893 0.9758
Entamoeba histolytica C2 domain containing protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Plasmodium falciparum ferlin, putative 0.0125 0.3893 1
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Echinococcus granulosus Protein kinase C brain isozyme 0.0126 0.399 1
Entamoeba histolytica protein kinase, putative 0.0126 0.399 0.399
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0125 0.3893 0.9758
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0125 0.3893 0.9758
Trichomonas vaginalis synaptotagmin, putative 0.0125 0.3893 0.3893
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Entamoeba histolytica protein kinase, putative 0.0126 0.399 0.399
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Leishmania major hypothetical protein, conserved 0.0125 0.3893 0.3893
Echinococcus granulosus protein kinase C gamma type 0.0126 0.399 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0125 0.3893 0.3893
Echinococcus granulosus calpain 5 0.0125 0.3893 0.9758
Plasmodium vivax ferlin, putative 0.0125 0.3893 1
Onchocerca volvulus Putative cc2d1b protein 0.0125 0.3893 1
Schistosoma mansoni hypothetical protein 0.0125 0.3893 0.9758
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0125 0.3893 0.3893
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.3893 0.3893
Schistosoma mansoni unc-13 (munc13) 0.0125 0.3893 0.9758
Echinococcus multilocularis copine 9 0.0125 0.3893 0.9758
Trypanosoma brucei C2 domain containing protein, putative 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0125 0.3893 0.9758
Echinococcus multilocularis synaptotagmin 0.0125 0.3893 0.9758
Loa Loa (eye worm) synaptotagmin-1 0.0125 0.3893 0.3893
Schistosoma mansoni Mername-AA248 (C02 family) 0.0125 0.3893 0.9758
Brugia malayi Variant SH3 domain containing protein 0.0125 0.3893 0.3893
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis copine, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.0125 0.3893 0.3893
Entamoeba histolytica C2 domain protein, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0125 0.3893 0.3893
Trypanosoma cruzi synaptotagmin, putative 0.0125 0.3893 0.3893
Leishmania major copine i-like protein 0.0125 0.3893 0.3893
Schistosoma mansoni synaptotagmin 0.0125 0.3893 0.9758
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0125 0.3893 0.3893
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0125 0.3893 0.9758
Brugia malayi Synapse defective protein 1 0.0125 0.3893 0.3893
Brugia malayi NEDD4.2 0.0125 0.3893 0.3893
Trichomonas vaginalis copine, putative 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Onchocerca volvulus 0.0125 0.3893 1
Echinococcus multilocularis serine threonine protein kinase 0.0126 0.399 1
Loa Loa (eye worm) C2 domain-containing protein 0.0125 0.3893 0.3893
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0125 0.3893 0.3893
Echinococcus granulosus synaptotagmin 0.0125 0.3893 0.9758
Schistosoma mansoni unc-13 (munc13) 0.0125 0.3893 0.9758
Entamoeba histolytica C2 domain containing protein 0.0125 0.3893 0.3893
Loa Loa (eye worm) hypothetical protein 0.0125 0.3893 0.3893
Schistosoma mansoni glut4 vesicle protein-related 0.0125 0.3893 0.9758
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Toxoplasma gondii ferlin family protein 0.0125 0.3893 0.3893
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Toxoplasma gondii hypothetical protein 0.0125 0.3893 0.3893
Echinococcus granulosus synaptotagmin 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Brugia malayi Synaptotagmin protein 3 0.0125 0.3893 0.3893
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0125 0.3893 0.9758
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0126 0.399 1
Echinococcus granulosus neural cell expressed developmentally 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Entamoeba histolytica hypothetical protein 0.0125 0.3893 0.3893
Plasmodium falciparum ferlin, putative 0.0125 0.3893 1
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0125 0.3893 0.9758
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0125 0.3893 0.9758
Schistosoma mansoni copine 0.0125 0.3893 0.9758
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0189 1 1
Plasmodium vivax hypothetical protein, conserved 0.0125 0.3893 1
Schistosoma mansoni synaptotagmin 0.0125 0.3893 0.9758
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Echinococcus multilocularis 0.0125 0.3893 0.9758
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.399 1
Schistosoma mansoni protein kinase C 0.0125 0.3893 0.9758
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0125 0.3893 0.9758
Brugia malayi C2 domain containing protein 0.0125 0.3893 0.3893
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0125 0.3893 0.3893
Trichomonas vaginalis synaptotagmin, putative 0.0125 0.3893 0.3893
Echinococcus multilocularis synaptotagmin protein 4 0.0125 0.3893 0.9758
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.3893 0.3893
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0125 0.3893 0.9758
Entamoeba histolytica C2 domain containing protein 0.0125 0.3893 0.3893
Entamoeba histolytica hypothetical protein 0.0125 0.3893 0.3893
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0125 0.3893 0.9758

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Compound was tested for the inhibition of Steroid 5-alpha-reductase type 2 of human prostates ChEMBL. 11425544
IC50 (binding) > 10 uM Compound was tested for the inhibition of Steroid 5-alpha-reductase type 2 of human prostates ChEMBL. 11425544

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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