Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | putative regulatory protein | 0.0128 | 0.6741 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0056 | 0.2035 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.1917 | 0.2313 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0056 | 0.2035 | 1 |
Brugia malayi | glutathione reductase | 0.0056 | 0.2035 | 0.2456 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0128 | 0.6741 | 0.5 |
Mycobacterium tuberculosis | Possible nitrate/nitrite response transcriptional regulatory protein NarL | 0.0128 | 0.6741 | 0.8422 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0141 | 0.7623 | 1 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0128 | 0.6741 | 0.0483 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.0128 | 0.6741 | 0.8422 |
Loa Loa (eye worm) | glutathione reductase | 0.0056 | 0.2035 | 0.2456 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0056 | 0.2035 | 0.2456 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.1917 | 0.2313 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 0.8288 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.1917 | 0.2313 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 0.8288 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0127 | 0.6696 | 0.8342 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.1917 | 0.2313 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.8288 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0151 | 0.8288 | 1 |
Leishmania major | trypanothione reductase | 0.0056 | 0.2035 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0056 | 0.2035 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0141 | 0.7623 | 1 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0127 | 0.6696 | 0.8342 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0127 | 0.6696 | 0.8342 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0127 | 0.6696 | 0.8342 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.1917 | 0.1917 |
Brugia malayi | Thioredoxin reductase | 0.0056 | 0.2035 | 0.2456 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0056 | 0.2035 | 0.2456 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.1917 | 0.2313 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.8288 | 1 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0128 | 0.6741 | 0.5 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 0.8288 | 1 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.0128 | 0.6741 | 0.8422 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0128 | 0.6741 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0056 | 0.2035 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0141 | 0.7623 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.1917 | 0.2313 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0141 | 0.7623 | 1 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.0128 | 0.6741 | 0.8422 |
Plasmodium vivax | glutathione reductase, putative | 0.0056 | 0.2035 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.1917 | 0.1917 |
Trypanosoma brucei | trypanothione reductase | 0.0056 | 0.2035 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0056 | 0.2035 | 0.2456 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.1917 | 0.1917 |
Plasmodium falciparum | thioredoxin reductase | 0.0056 | 0.2035 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0128 | 0.6741 | 0.5 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.0128 | 0.6741 | 0.8422 |
Mycobacterium tuberculosis | Probable reductase | 0.0127 | 0.6696 | 0.8342 |
Trichomonas vaginalis | chaperonin, putative | 0.0025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0128 | 0.6741 | 0.8422 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0127 | 0.6696 | 0.8342 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.