Detailed information for compound 656114

Basic information

Technical information
  • TDR Targets ID: 656114
  • Name: 3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)-1,3-th iazol-2-yl]prop-2-enenitrile
  • MW: 378.361 | Formula: C18H10N4O4S
  • H donors: 0 H acceptors: 6 LogP: 4.09 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1ccccc1[N+](=O)[O-])c1scc(n1)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C18H10N4O4S/c19-10-14(9-13-3-1-2-4-17(13)22(25)26)18-20-16(11-27-18)12-5-7-15(8-6-12)21(23)24/h1-9,11H/b14-9+
  • InChiKey: CPFKIUXPWNRFIM-NTEUORMPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
  • (E)-3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)thiazol-2-yl]prop-2-enenitrile
  • 3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)thiazol-2-yl]prop-2-enenitrile
  • (E)-3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)-2-thiazolyl]prop-2-enenitrile
  • 3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)-2-thiazolyl]prop-2-enenitrile
  • (E)-3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)thiazol-2-yl]acrylonitrile
  • 3-(2-nitrophenyl)-2-[4-(4-nitrophenyl)thiazol-2-yl]acrylonitrile
  • 3-(2-Nitro-phenyl)-2-[4-(4-nitro-phenyl)-thiazol-2-yl]-acrylonitrile
  • BAS 00873900
  • ZINC04853680

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Entamoeba histolytica hypothetical protein 0.0035 0.004 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0972 0.2339 0.2339
Plasmodium vivax vivapain-2 0.1736 0.4212 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.2066 0.5022 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0452 0.1062 0.1085
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Entamoeba histolytica cysteine protease, putative 0.1736 0.4212 1
Onchocerca volvulus 0.1736 0.4212 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Onchocerca volvulus Cathepsin L homolog 0.0452 0.1062 0.2504
Brugia malayi Cathepsin L-like precursor 0.1215 0.2935 0.2996
Brugia malayi hypothetical protein 0.0035 0.004 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0452 0.1062 0.2116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1736 0.4212 0.43
Giardia lamblia Cysteine protease 0.0452 0.1062 0.2116
Entamoeba histolytica cysteine proteinase 2 0.0972 0.2339 0.5554
Echinococcus granulosus cathepsin L cysteine proteinase 0.1736 0.4212 0.43
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0452 0.1062 0.1085
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0452 0.1062 0.2116
Loa Loa (eye worm) cysteine protease 0.1736 0.4212 0.43
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Echinococcus granulosus cathepsin L 0.0452 0.1062 0.1085
Plasmodium vivax vivapain-3 0.0972 0.2339 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.4095 1 1
Giardia lamblia Cathepsin B precursor 0.0452 0.1062 0.2116
Giardia lamblia Cathepsin L-like protease 0.0452 0.1062 0.2116
Entamoeba histolytica cysteine proteinase, putative 0.0972 0.2339 0.5554
Brugia malayi Papain family cysteine protease containing protein 0.1736 0.4212 0.43
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2066 0.5022 0.5127
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0452 0.1062 0.1085
Loa Loa (eye worm) hypothetical protein 0.1215 0.2935 0.2996
Onchocerca volvulus 0.1736 0.4212 1
Echinococcus multilocularis cathepsin b 0.4012 0.9796 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Plasmodium falciparum cysteine proteinase falcipain 1 0.0972 0.2339 0.4054
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0972 0.2339 0.2339
Giardia lamblia Cathepsin B precursor 0.2066 0.5022 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.1736 0.4212 1
Giardia lamblia Cathepsin L-like protease 0.0452 0.1062 0.2116
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0452 0.1062 0.2116
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.052 0.1231 0.1256
Leishmania major cathepsin L-like protease 0.1736 0.4212 0.4212
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4012 0.9796 1
Echinococcus multilocularis cathepsin L 0.0452 0.1062 0.1085
Echinococcus granulosus cathepsin l1 0.1736 0.4212 0.43
Echinococcus multilocularis cathepsin L cysteine protease 0.1736 0.4212 0.43
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Entamoeba histolytica hypothetical protein 0.0452 0.1062 0.2523
Giardia lamblia Cysteine protease 0.0452 0.1062 0.2116
Trypanosoma cruzi cruzipain precursor, putative 0.4095 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.004 0.0041
Brugia malayi Cathepsin L-like cysteine proteinase 0.1215 0.2935 0.2996
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0452 0.1062 0.2523
Echinococcus granulosus cathepsin L cysteine protease 0.0972 0.2339 0.2388
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0972 0.2339 0.4658
Loa Loa (eye worm) papain family cysteine protease containing protein 0.052 0.1231 0.1256
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Brugia malayi cathepsin Z-like cysteine proteinase 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0452 0.1062 0.2116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1215 0.2935 0.5844
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0011 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0972 0.2339 0.4658
Entamoeba histolytica hypothetical protein 0.0035 0.004 0.0095
Echinococcus multilocularis cysteine protease 0.1736 0.4212 0.43
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Giardia lamblia Cysteine protease 0.0452 0.1062 0.2116
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Echinococcus granulosus cathepsin l1 0.1215 0.2935 0.2996
Echinococcus multilocularis tumor protein p63 0.033 0.0763 0.0779
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.1215 0.2935 0.2996
Leishmania major cathepsin L-like protease 0.1736 0.4212 0.4212
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Loa Loa (eye worm) hypothetical protein 0.052 0.1231 0.1256
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0972 0.2339 0.2388
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1215 0.2935 0.5844
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0452 0.1062 0.1085
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Onchocerca volvulus 0.0452 0.1062 0.2504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Leishmania major cathepsin L-like protease 0.1736 0.4212 0.4212
Schistosoma mansoni cathepsin C 0.0452 0.1062 0.1085
Giardia lamblia Cathepsin B precursor 0.2066 0.5022 1
Giardia lamblia Encystation-specific protease 0.0452 0.1062 0.2116
Brugia malayi fibroinase precursor 0.0452 0.1062 0.1085
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Giardia lamblia Cathepsin B precursor 0.0452 0.1062 0.2116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.004 0.0041
Schistosoma mansoni cathepsin B (C01 family) 0.0452 0.1062 0.1085
Plasmodium vivax unspecified product 0.052 0.1231 0.0534
Brugia malayi cathepsin F-like cysteine proteinase 0.052 0.1231 0.1256
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0452 0.1062 0.2116
Schistosoma mansoni cathepsin F (C01 family) 0.1215 0.2935 0.2996
Giardia lamblia Cathepsin B precursor 0.0452 0.1062 0.2116
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0452 0.1062 0.2116
Schistosoma mansoni cathepsin s 0.052 0.1231 0.1256
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Schistosoma mansoni cathepsin S (C01 family) 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Entamoeba histolytica cysteine proteinase, putative 0.1215 0.2935 0.6969
Leishmania major cathepsin L-like protease 0.4095 1 1
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Onchocerca volvulus 0.1736 0.4212 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0011 0.0025
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0011 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1736 0.4212 0.8386
Trypanosoma cruzi cysteine protease, putative 0.0972 0.2339 0.2339
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.0011
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0072 0.0074
Toxoplasma gondii cathepsin B 0.2066 0.5022 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0011 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1736 0.4212 0.43
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0452 0.1062 0.1085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0072 0.0074
Trypanosoma cruzi major cysteine proteinase, putative 0.2811 0.6851 0.6851
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Giardia lamblia Hypothetical protein 0.0452 0.1062 0.2116
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Brugia malayi cathepsin Z-like cysteine proteinase 0.0452 0.1062 0.1085
Trypanosoma cruzi cysteine peptidase, putative 0.4095 1 1
Echinococcus granulosus cathepsin b 0.4012 0.9796 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 1
Brugia malayi Papain family cysteine protease containing protein 0.0452 0.1062 0.1085
Echinococcus multilocularis cathepsin b 0.4012 0.9796 1
Schistosoma mansoni cathepsin F (C01 family) 0.1736 0.4212 0.43
Trypanosoma cruzi cysteine peptidase, putative 0.0972 0.2339 0.2339
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0011 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 1
Toxoplasma gondii cathepsin CPL 0.1736 0.4212 0.7953
Echinococcus multilocularis cathepsin L cysteine protease 0.1736 0.4212 0.43
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Leishmania major cathepsin L-like protease 0.4095 1 1
Giardia lamblia Cathepsin B precursor 0.0452 0.1062 0.2116
Onchocerca volvulus 0.1736 0.4212 1
Brugia malayi Papain family cysteine protease containing protein 0.0452 0.1062 0.1085
Loa Loa (eye worm) cathepsin B 0.2066 0.5022 0.5127
Echinococcus granulosus cathepsin b 0.4012 0.9796 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0011 1
Plasmodium vivax vivapain-2 0.1736 0.4212 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4012 0.9796 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0452 0.1062 0.2116
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4012 0.9796 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Echinococcus granulosus tumor protein p63 0.033 0.0763 0.0779
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0452 0.1062 0.1085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0011 1
Brugia malayi Papain family cysteine protease containing protein 0.0972 0.2339 0.2388
Brugia malayi cathepsin L precursor 0.0452 0.1062 0.1085
Entamoeba histolytica cysteine proteinase, putative 0.1736 0.4212 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0452 0.1062 0.2116
Giardia lamblia Cysteine protease 0.0452 0.1062 0.2116
Giardia lamblia Cathepsin L precursor 0.0452 0.1062 0.2116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Brugia malayi Cathepsin L-like precursor 0.052 0.1231 0.1256
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1736 0.4212 1
Brugia malayi Cathepsin L-like precursor 0.1215 0.2935 0.2996
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0452 0.1062 0.1085
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0011 1
Entamoeba histolytica cysteine protease, putative 0.0452 0.1062 0.2523
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0972 0.2339 0.2388
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0452 0.1062 0.2116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0452 0.1062 0.1085
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0035 0.004 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0011 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0972 0.2339 0.2388
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Loa Loa (eye worm) ctsf protein 0.1736 0.4212 0.43
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1736 0.4212 0.8386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Echinococcus granulosus cathepsin l cysteine peptidase 0.1736 0.4212 0.43
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0011 0.5
Onchocerca volvulus 0.1736 0.4212 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Brugia malayi Papain family cysteine protease containing protein 0.0972 0.2339 0.2388
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Loa Loa (eye worm) hypothetical protein 0.052 0.1231 0.1256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0011 0.5
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.3574 0.8723 0.8723
Trypanosoma cruzi cysteine peptidase, putative 0.1736 0.4212 0.4212
Trypanosoma cruzi cysteine proteinase, putative 0.0972 0.2339 0.2339
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Onchocerca volvulus 0.0048 0.0072 0.0147
Loa Loa (eye worm) hypothetical protein 0.1215 0.2935 0.2996
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Onchocerca volvulus 0.1736 0.4212 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1736 0.4212 0.43
Onchocerca volvulus Cathepsin L homolog 0.1736 0.4212 1
Giardia lamblia Hypothetical protein 0.0452 0.1062 0.2116
Giardia lamblia Cathepsin B precursor 0.0452 0.1062 0.2116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Entamoeba histolytica cysteine proteinase, putative 0.0972 0.2339 0.5554
Entamoeba histolytica cysteine proteinase, putative 0.1736 0.4212 1
Entamoeba histolytica cysteine proteinase, putative 0.0972 0.2339 0.5554
Leishmania major cathepsin L-like protease 0.1736 0.4212 0.4212
Brugia malayi cathepsin L-like cysteine proteinase 0.0452 0.1062 0.1085
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0452 0.1062 0.2523
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4012 0.9796 1
Schistosoma mansoni cathepsin F (C01 family) 0.1736 0.4212 0.43
Entamoeba histolytica cysteine proteinase, putative 0.0972 0.2339 0.5554
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4012 0.9796 0.9796
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0452 0.1062 0.2116
Echinococcus granulosus cysteine protease 0.0972 0.2339 0.2388
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.2066 0.5022 0.5022
Trypanosoma cruzi cysteine peptidase, putative 0.4095 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1736 0.4212 0.43
Brugia malayi cathepsin L-like precursor 0.1215 0.2935 0.2996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Onchocerca volvulus Cathepsin F homolog 0.1736 0.4212 1
Trichomonas vaginalis conserved hypothetical protein 0.0452 0.1062 0.2116
Trypanosoma cruzi cruzipain precursor, putative 0.052 0.1231 0.1231
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0452 0.1062 0.2116
Onchocerca volvulus Cathepsin L homolog 0.1736 0.4212 1
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0452 0.1062 0.2116
Brugia malayi cathepsin F-like cysteine proteinase 0.0452 0.1062 0.1085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Onchocerca volvulus 0.1736 0.4212 1
Loa Loa (eye worm) fibroinase 0.1736 0.4212 0.43
Giardia lamblia Cathepsin B precursor 0.2066 0.5022 1
Trypanosoma cruzi cysteine proteinase, putative 0.0972 0.2339 0.2339
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1736 0.4212 0.8386
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0452 0.1062 0.1085
Entamoeba histolytica cysteine proteinase 1, putative 0.0972 0.2339 0.5554
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2066 0.5022 0.5022
Leishmania major cathepsin L-like protease 0.1736 0.4212 0.4212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0452 0.1062 0.2116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Loa Loa (eye worm) hypothetical protein 0.4012 0.9796 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0972 0.2339 0.2339
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0452 0.1062 0.2116
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0452 0.1062 0.2116
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Echinococcus granulosus cathepsin L 0.0972 0.2339 0.2388
Loa Loa (eye worm) hypothetical protein 0.0452 0.1062 0.1085
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1736 0.4212 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0452 0.1062 0.1085
Echinococcus multilocularis cysteine protease 0.1736 0.4212 0.43
Onchocerca volvulus 0.1215 0.2935 0.6961
Brugia malayi Cathepsin L-like precursor 0.1736 0.4212 0.43
Trypanosoma cruzi major cysteine proteinase, putative 0.0452 0.1062 0.1062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.004 0.0041
Plasmodium vivax unspecified product 0.0972 0.2339 0.4054
Entamoeba histolytica hypothetical protein 0.0035 0.004 0.0095
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0011 0.0025
Brugia malayi cathepsin B-like cysteine proteinase 0.4012 0.9796 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.4095 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0452 0.1062 0.1085
Entamoeba histolytica cysteine protease, putative 0.0972 0.2339 0.5554
Mycobacterium ulcerans hypothetical protein 0.0023 0.0011 1
Loa Loa (eye worm) hypothetical protein 0.052 0.1231 0.1256
Leishmania major cysteine peptidase A (CPA) 0.1736 0.4212 0.4212
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0452 0.1062 0.2116
Trichomonas vaginalis conserved hypothetical protein 0.0452 0.1062 0.2116
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0452 0.1062 0.1085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1736 0.4212 0.8386
Echinococcus multilocularis cathepsin L 0.0972 0.2339 0.2388
Trypanosoma cruzi cysteine peptidase, putative 0.052 0.1231 0.1231
Plasmodium vivax vivapain-1 0.0972 0.2339 0.4054
Trypanosoma brucei cysteine peptidase C (CPC) 0.2066 0.5022 0.5022
Loa Loa (eye worm) hypothetical protein 0.1736 0.4212 0.43
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.004 0.0041

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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