Detailed information for compound 657937

Basic information

Technical information
  • TDR Targets ID: 657937
  • Name: 5-cyclopropyl-N-[(4-fluorophenyl)methylidenea mino]-1H-pyrazole-3-carboxamide
  • MW: 272.278 | Formula: C14H13FN4O
  • H donors: 2 H acceptors: 2 LogP: 1.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C=NNC(=O)c1n[nH]c(c1)C1CC1
  • InChi: 1S/C14H13FN4O/c15-11-5-1-9(2-6-11)8-16-19-14(20)13-7-12(17-18-13)10-3-4-10/h1-2,5-8,10H,3-4H2,(H,17,18)(H,19,20)/b16-8+
  • InChiKey: BLNLRCOFSQGZKT-LZYBPNLTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-cyclopropyl-N-[(4-fluorophenyl)methyleneamino]-1H-pyrazole-3-carboxamide
  • 5-cyclopropyl-N-[(4-fluorobenzylidene)amino]-1H-pyrazole-3-carboxamide
  • BIM-0033119.P001
  • ST5053921
  • CBMicro_032983
  • ZINC00229272

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Rab geranylgeranyltransferase 0.0046 0.0772 0.1723
Echinococcus multilocularis cpg binding protein 0.003 0.0393 0.0276
Echinococcus multilocularis lamin dm0 0.0028 0.034 0.0222
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0066 0.1241 0.1135
Brugia malayi ATP synthase alpha chain, mitochondrial precursor, putative 0.0336 0.764 0.7632
Plasmodium falciparum V-type proton ATPase subunit B 0.0104 0.2143 0.2047
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0146 0.0114
Schistosoma mansoni hypothetical protein 0.0103 0.2124 0.2028
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0046 0.0772 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0114
Schistosoma mansoni intermediate filament proteins 0.0028 0.034 0.0222
Plasmodium falciparum geranylgeranyltransferase, putative 0.0034 0.0476 0.036
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.012 0.0193
Trypanosoma cruzi ATPase beta subunit, putative 0.0044 0.0732 0.157
Schistosoma mansoni ATP synthase beta subunit 0.0104 0.2143 0.2047
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0124 0.2624 0.6621
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0365 0.0248
Brugia malayi vacuolar ATP synthase catalytic subunit A, osteoclast isoform 0.0104 0.2143 0.2118
Trypanosoma cruzi ATP synthase F1 subunit gamma protein, putative 0.015 0.3246 0.802
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0183 0.0064
Onchocerca volvulus 0.0046 0.0772 0.0592
Trichomonas vaginalis ATP synthase alpha subunit mitochondrial, putative 0.0104 0.2143 0.5348
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0146 0.0042
Entamoeba histolytica hypothetical protein 0.0037 0.0551 0.1139
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0758 0.0646
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0034 0.0476 0.036
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.2089 0.3353
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0815 0.0704
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0146 0.0067
Echinococcus granulosus lamin 0.0028 0.034 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.0234
Trypanosoma brucei mitochondrial ATP synthase delta chain 0.0183 0.4018 0.645
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0476 0.0913
Echinococcus multilocularis vacuolar ATP synthase subunit b 0.0104 0.2143 0.2047
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0973 0.0863
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0034 0.0476 0.036
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.2089 0.505
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.2089 0.1992
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0235 0.0303
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0183 0.0064
Trypanosoma brucei mitochondrial ATP synthase epsilon chain 0.0148 0.3183 0.5109
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0809 0.078
Mycobacterium tuberculosis Probable ATP synthase beta chain AtpD 0.0336 0.764 1
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0046 0.0772 0.066
Echinococcus granulosus geminin 0.0342 0.7795 0.7768
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0034 0.0476 0.0941
Onchocerca volvulus 0.0029 0.0354 0.002
Leishmania major hypothetical protein, conserved 0.0102 0.2089 0.3222
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0551 0.0436
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0046 0.0772 0.1067
Leishmania major ATPase alpha subunit 0.0276 0.6229 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0973 0.0863
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0091 0.1825 0.1725
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0183 0.0152
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0178 0.3902 0.3828
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.012 0.0089
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0815 0.0704
Leishmania major ATP synthase, epsilon chain, putative 0.0183 0.4018 0.6381
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0046 0.0772 0.066
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0124 0.2624 0.2601
Echinococcus granulosus vacuolar H ATPase v1 sector subunit A 0.0104 0.2143 0.2047
Plasmodium vivax ATP synthase subunit beta, mitochondrial, putative 0.0104 0.2143 0.2047
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0046 0.0772 0.1672
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0146 0.0065
Entamoeba histolytica vacuolar ATP synthase subunit B, putative 0.0059 0.1087 0.2556
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0365 0.0586
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.2089 0.1992
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0046 0.0772 0.1723
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.4254 0.4184
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0183 0.0064
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0178 0.3902 0.3828
Schistosoma mansoni ran 0.0021 0.0183 0.0064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0809 0.078
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.096 0.085
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0124 0.2624 0.2535
Plasmodium vivax hypothetical protein, conserved 0.0183 0.4018 0.3945
Loa Loa (eye worm) hypothetical protein 0.0029 0.0365 0.0334
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0034 0.0476 0.036
Leishmania major GTP-binding protein, putative 0.0021 0.0183 0.0103
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0046 0.0772 0.1239
Schistosoma mansoni ATP synthase gamma subunit 0.015 0.3246 0.3164
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0809 0.0698
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0809 0.0698
Mycobacterium ulcerans transcription termination factor Rho 0.0044 0.0732 0.0814
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.0234
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0146 0.0034
Entamoeba histolytica V-type ATPase, A subunit, putative 0.0104 0.2143 0.5348
Loa Loa (eye worm) hypothetical protein 0.0034 0.0476 0.0446
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0178 0.3902 1
Plasmodium falciparum mitochondrial ATP synthase F1, epsilon subunit, putative 0.0435 1 1
Mycobacterium tuberculosis Probable ATP synthase alpha chain AtpA 0.0336 0.764 1
Trypanosoma cruzi V-type proton ATPase subunit B, putative 0.0104 0.2143 0.5188
Plasmodium falciparum ATP synthase subunit gamma, mitochondrial 0.015 0.3246 0.3164
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0034 0.0476 0.0446
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1857 0.1758
Plasmodium falciparum ATP synthase subunit delta, mitochondrial, putative 0.0183 0.4018 0.3945
Brugia malayi hypothetical protein 0.0066 0.1234 0.1206
Loa Loa (eye worm) ATP synthase subunit epsilon 0.0435 1 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0132 0.2807 0.7103
Mycobacterium tuberculosis Probable ATP synthase epsilon chain AtpC 0.0183 0.4018 0.5184
Echinococcus multilocularis ATP synthase subunit beta, mitochondrial 0.0104 0.2143 0.2047
Plasmodium vivax vacuolar ATP synthase subunit b, putative 0.0104 0.2143 0.2047
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0365 0.0586
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0809 0.0698
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0034 0.0476 0.0446
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0046 0.0772 0.066
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0178 0.3902 0.3828
Treponema pallidum V-type ATP synthase subunit B 0.0104 0.2143 1
Plasmodium falciparum ATP synthase subunit beta, mitochondrial 0.0104 0.2143 0.2047
Treponema pallidum V-type ATP synthase subunit B 0.0104 0.2143 1
Leishmania major farnesyltransferase beta subunit 0.0124 0.2624 0.4099
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0034 0.0476 0.0941
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0146 0.0114
Trypanosoma cruzi Vacuolar proton pump subunit B, putative 0.0104 0.2143 0.5188
Trypanosoma brucei Vacuolar proton pump subunit B, putative 0.0104 0.2143 0.344
Schistosoma mansoni ATP synthase gamma subunit 0.015 0.3246 0.3164
Loa Loa (eye worm) hypothetical protein 0.015 0.3246 0.3225
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0146 0.0065
Schistosoma mansoni ATP synthase gamma subunit 0.015 0.3246 0.3164
Loa Loa (eye worm) hypothetical protein 0.0178 0.3902 0.3883
Leishmania major importin beta-1 subunit, putative 0.0024 0.0235 0.0187
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0178 0.3902 1
Plasmodium falciparum ATP synthase F1, alpha subunit 0.0336 0.764 0.7611
Schistosoma mansoni ATP synthase alpha subunit mitochondrial 0.0336 0.764 0.7611
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1857 0.1758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1857 0.1758
Trypanosoma cruzi V-type ATPase, A subunit, putative 0.0104 0.2143 0.5188
Loa Loa (eye worm) hypothetical protein 0.0055 0.0973 0.0944
Echinococcus multilocularis snurportin 1 0.031 0.7027 0.699
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.0234
Loa Loa (eye worm) hypothetical protein 0.0027 0.0328 0.0297
Schistosoma mansoni hypothetical protein 0.0048 0.0809 0.0698
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.0234
Giardia lamblia Vacuolar ATP synthase catalytic subunit A 0.0104 0.2143 0.5348
Brugia malayi ATP synthase delta chain, mitochondrial precursor, putative 0.0183 0.4018 0.3999
Schistosoma mansoni hypothetical protein 0.0435 1 1
Trypanosoma brucei V-type ATPase, A subunit, putative 0.0104 0.2143 0.344
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.9328 0.932
Plasmodium falciparum V-type proton ATPase catalytic subunit A 0.0104 0.2143 0.2047
Mycobacterium leprae PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC 0.0183 0.4018 0.4757
Brugia malayi mbt repeat family protein 0.0048 0.0815 0.0786
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.034 0.0309
Leishmania major hypothetical protein, conserved 0.0148 0.3183 0.5013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0354 0.0323
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.2089 0.1992
Echinococcus granulosus mitochondrial F1F0 ATP synthase subunit epsilon 0.0435 1 1
Leishmania major ATPase beta subunit, putative 0.0104 0.2143 0.3311
Trypanosoma brucei ATP synthase F1, alpha subunit 0.0276 0.6229 1
Brugia malayi hypothetical protein 0.0037 0.0551 0.0521
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.0234
Echinococcus granulosus ATP synthase subunit beta mitochondrial 0.0104 0.2143 0.2047
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0183 0.0166
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0815 0.0651
Loa Loa (eye worm) hypothetical protein 0.0044 0.0732 0.0703
Plasmodium falciparum importin beta, putative 0.0029 0.0365 0.0248
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0146 0.0034
Echinococcus multilocularis dna polymerase eta 0.002 0.0146 0.0026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0183 0.0161
Loa Loa (eye worm) vacuolar H ATPase family member 0.0104 0.2143 0.2118
Loa Loa (eye worm) intermediate filament protein 0.0028 0.034 0.0309
Toxoplasma gondii ATP synthase, putative 0.0183 0.4018 0.3945
Loa Loa (eye worm) hypothetical protein 0.0048 0.0815 0.0786
Giardia lamblia DINP protein human, muc B family 0.002 0.0146 0.0067
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0183 0.0152
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0365 0.0248
Mycobacterium leprae PROBABLE ATP SYNTHASE BETA CHAIN ATPD 0.0336 0.764 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0758 0.0646
Brugia malayi ATP synthase gamma chain, mitochondrial precursor, putative 0.015 0.3246 0.3225
Toxoplasma gondii hypothetical protein 0.0132 0.2807 0.2719
Treponema pallidum transcription termination factor Rho 0.0044 0.0732 0.3027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0809 0.0698
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0046 0.0772 0.1239
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0146 0.0026
Giardia lamblia Rab geranylgeranyltransferase 0.0178 0.3902 1
Schistosoma mansoni ATP synthase gamma subunit 0.015 0.3246 0.3164
Leishmania major DNA polymerase kappa, putative 0.002 0.0146 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.2089 0.505
Leishmania major ATPase alpha subunit 0.0276 0.6229 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.034 0.0309
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0772 0.1672
Schistosoma mansoni cpg binding protein 0.003 0.0393 0.0276
Giardia lamblia Prenyltransferase 0.0124 0.2624 0.6621
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0772 0.1672
Trypanosoma cruzi ATP synthase F1 subunit gamma protein, putative 0.015 0.3246 0.802
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.7027 0.7017
Trypanosoma cruzi lanosterol synthase, putative 0.0034 0.0476 0.0913
Schistosoma mansoni ATP synthase subunit beta vacuolar 0.0104 0.2143 0.2047
Brugia malayi ATP synthase beta chain, mitochondrial precursor, putative 0.0104 0.2143 0.2118
Mycobacterium ulcerans F0F1 ATP synthase subunit beta 0.0104 0.2143 0.269
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1857 0.1831
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.1278 0.125
Mycobacterium ulcerans F0F1 ATP synthase subunit epsilon 0.0183 0.4018 0.5184
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0146 0.0234
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.3257 0.3235
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0183 0.0294
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0815 0.0704
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.0234
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0046 0.0772 0.1239
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0034 0.0476 0.036
Entamoeba histolytica hypothetical protein 0.0037 0.0551 0.1139
Echinococcus multilocularis GPCR, family 2 0.0048 0.0809 0.0698
Entamoeba histolytica hypothetical protein 0.0037 0.0551 0.1139
Leishmania major vacuolar ATP synthase catalytic subunit A, putative 0.0104 0.2143 0.3311
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0178 0.3902 0.3828
Toxoplasma gondii atp synthase F1, epsilon subunit, putative 0.0435 1 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0365 0.0248
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0124 0.2624 0.6621
Onchocerca volvulus ATP synthase subunit gamma, mitochondrial homolog 0.015 0.3246 0.3982
Brugia malayi CXXC zinc finger family protein 0.0029 0.0354 0.0323
Toxoplasma gondii vacuolar ATP synthase subunit A, putative 0.0104 0.2143 0.2047
Schistosoma mansoni importin beta-1 0.0029 0.0365 0.0248
Treponema pallidum V-type ATP synthase subunit A 0.0104 0.2143 1
Trypanosoma cruzi protein farnesyltransferase, putative 0.0124 0.2624 0.6424
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0815 0.0704
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0146 0.0065
Trypanosoma cruzi ATP synthase, epsilon chain, putative 0.0183 0.4018 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.2124 0.2099
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit beta 0.0104 0.2143 0.269
Trypanosoma brucei ATP synthase F1, alpha subunit 0.0276 0.6229 1
Schistosoma mansoni ATP synthase gamma subunit 0.015 0.3246 0.3164
Toxoplasma gondii vacuolar ATP synthase subunit b, putative 0.0104 0.2143 0.2047
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0235 0.0303
Schistosoma mansoni hypothetical protein 0.0046 0.0758 0.0646
Brugia malayi vacuolar ATP synthase subunit B 0.0104 0.2143 0.2118
Trypanosoma cruzi ATP synthase F1, alpha subunit, putative 0.0044 0.0732 0.157
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0124 0.2624 0.2535
Leishmania major vacuolar ATP synthase subunit b, putative 0.0104 0.2143 0.3311
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0815 0.0704
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0235 0.0294
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0046 0.0772 0.1723
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0046 0.0772 0.0743
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.3257 0.3235
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0146 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.0234
Loa Loa (eye worm) hypothetical protein 0.0048 0.0809 0.078
Echinococcus multilocularis geminin 0.0342 0.7795 0.7768
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1114 0.1006
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0146 0.0065
Schistosoma mansoni ran 0.0021 0.0183 0.0064
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0034 0.0476 0.036
Plasmodium vivax vacuolar ATP synthase catalytic subunit A, putative 0.0104 0.2143 0.2047
Schistosoma mansoni ATP synthase delta chain mitochondrial 0.0183 0.4018 0.3945
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0034 0.0476 0.036
Schistosoma mansoni hypothetical protein 0.0048 0.0809 0.0698
Mycobacterium leprae PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA 0.0336 0.764 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.3257 0.3235
Chlamydia trachomatis type III secretion system ATP synthase 0.0104 0.2143 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0476 0.0446
Echinococcus granulosus 5'partial|ATP synthase subunit delta mitochondrial 0.0183 0.4018 0.3945
Leishmania major geranylgeranyltransferase, putative 0.0034 0.0476 0.0583
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0046 0.0772 0.066
Mycobacterium leprae PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG 0.015 0.3246 0.364
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0124 0.2624 0.6621
Mycobacterium tuberculosis Probable ATP synthase gamma chain AtpG 0.015 0.3246 0.4157
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0146 0.0026
Trypanosoma cruzi ATP synthase subunit beta, mitochondrial, putative 0.0104 0.2143 0.5188
Loa Loa (eye worm) hypothetical protein 0.0102 0.2089 0.2063
Echinococcus granulosus cpg binding protein 0.003 0.0393 0.0276
Chlamydia trachomatis type III secretion system ATPase 0.0104 0.2143 1
Echinococcus granulosus dnaJ subfamily B 0.0407 0.9328 0.932
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0046 0.0772 0.066
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.0234
Treponema pallidum V-type ATP synthase subunit A 0.0104 0.2143 1
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0124 0.2624 0.2535
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0146 0.0114
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0178 0.3902 0.3883
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0178 0.3902 0.3883
Schistosoma mansoni hypothetical protein 0.0342 0.7795 0.7768
Trypanosoma cruzi protein farnesyltransferase, putative 0.0124 0.2624 0.6424
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0146 0.0234
Echinococcus granulosus lamin dm0 0.0028 0.034 0.0222
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0178 0.3902 1
Brugia malayi hypothetical protein 0.0102 0.2089 0.2063
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0815 0.0704
Schistosoma mansoni hypothetical protein 0.0407 0.9328 0.932
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0124 0.2624 0.6621
Echinococcus multilocularis vacuolar H+ ATPase v1 sector subunit A 0.0104 0.2143 0.2047
Entamoeba histolytica hypothetical protein 0.0024 0.0235 0.0303
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0124 0.2624 0.4213
Trypanosoma brucei unspecified product 0.002 0.0146 0.0234
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0146 0.0026
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0815 0.0786
Trichomonas vaginalis ATP synthase beta subunit, putative 0.0104 0.2143 0.5348
Trichomonas vaginalis ATP synthase, putative 0.0104 0.2143 0.5348
Schistosoma mansoni lamin 0.0028 0.034 0.0222
Schistosoma mansoni cpg binding protein 0.003 0.0393 0.0276
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.0234
Brugia malayi mbt repeat family protein 0.0048 0.0815 0.0786
Schistosoma mansoni hypothetical protein 0.0048 0.0809 0.0698
Giardia lamblia Rab geranylgeranyltransferase 0.0034 0.0476 0.0941
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0034 0.0476 0.0941
Schistosoma mansoni DNA polymerase eta 0.002 0.0146 0.0026
Echinococcus granulosus dna polymerase kappa 0.002 0.0146 0.0026
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0046 0.0772 0.1672
Echinococcus multilocularis ATP synthase subunit alpha, mitochondrial 0.0336 0.764 0.7611
Echinococcus multilocularis dna polymerase kappa 0.002 0.0146 0.0026
Mycobacterium ulcerans F0F1 ATP synthase subunit gamma 0.015 0.3246 0.4157
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0034 0.0476 0.036
Schistosoma mansoni cpg binding protein 0.0029 0.0354 0.0237
Echinococcus granulosus dna polymerase eta 0.002 0.0146 0.0026
Trypanosoma cruzi Mitochondrial ATP synthase epsilon chain, putative 0.0148 0.3183 0.7856
Plasmodium vivax ATP synthase alpha chain, putative 0.0336 0.764 0.7611
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0034 0.0476 0.036
Echinococcus granulosus ATP synthase subunit alpha mitochondrial 0.0336 0.764 0.7611
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.2624 0.6621
Echinococcus granulosus ATP synthase gamma subunit 0.015 0.3246 0.3164
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit epsilon 0.0183 0.4018 0.5184
Brugia malayi Cytochrome P450 family protein 0.0068 0.1278 0.125
Schistosoma mansoni ATP synthase alpha subunit vacuolar 0.0104 0.2143 0.2047
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit alpha 0.0336 0.764 1
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0046 0.0772 0.066
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0146 0.0067
Toxoplasma gondii hypothetical protein 0.0046 0.0772 0.066
Trypanosoma cruzi V-type ATPase, A subunit, putative 0.0104 0.2143 0.5188
Entamoeba histolytica hypothetical protein 0.0037 0.0551 0.1139
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0146 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1857 0.1758
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0124 0.2624 0.2601
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0034 0.0476 0.0913
Toxoplasma gondii ATP synthase F1 gamma subunit 0.015 0.3246 0.3164
Plasmodium vivax ATP synthase epsilon chain, mitochondrial , putative 0.0435 1 1
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0124 0.2624 0.2535
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0046 0.0772 0.1672
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0809 0.078
Treponema pallidum flagellum-specific ATP synthase (fliI) 0.0104 0.2143 1
Onchocerca volvulus 0.0048 0.0815 0.0651
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0124 0.2624 0.2535
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0178 0.3902 1
Loa Loa (eye worm) vacuolar ATP synthase subunit B 0.0104 0.2143 0.2118
Leishmania major ATPase beta subunit, putative 0.0104 0.2143 0.3311
Trichomonas vaginalis ran, putative 0.0021 0.0183 0.0166
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0183 0.0161
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0034 0.0476 0.0446
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.2089 0.1992
Leishmania major DNA polymerase eta, putative 0.002 0.0146 0.0042
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0973 0.0863
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1857 0.1831
Echinococcus granulosus vacuolar ATP synthase subunit b 0.0104 0.2143 0.2047
Mycobacterium tuberculosis Probable transcription termination factor Rho homolog 0.0044 0.0732 0.0814
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0476 0.0913
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0973 0.0863
Schistosoma mansoni hypothetical protein 0.0037 0.0551 0.0436
Onchocerca volvulus ATP synthase subunit alpha, mitochondrial homolog 0.0336 0.764 1
Schistosoma mansoni lamin 0.0028 0.034 0.0222
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1857 0.1758
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.2624 0.6621
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.2124 0.2099
Loa Loa (eye worm) ATP synthase subunit delta 0.0183 0.4018 0.3999
Giardia lamblia Vacuolar ATP synthase subunit B 0.0104 0.2143 0.5348
Chlamydia trachomatis V-type ATP synthase subunit A 0.0104 0.2143 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.012 0.0089
Schistosoma mansoni hypothetical protein 0.0048 0.0809 0.0698
Echinococcus multilocularis musashi 0.0028 0.034 0.0222
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0815 0.0704
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0973 0.0944
Brugia malayi Importin beta-1 subunit 0.0029 0.0365 0.0334
Echinococcus multilocularis ATP synthase gamma subunit 0.015 0.3246 0.3164
Leishmania major ATP synthase F1 subunit gamma protein, putative 0.015 0.3246 0.5117
Schistosoma mansoni hypothetical protein 0.0296 0.669 0.665
Brugia malayi intermediate filament protein 0.0028 0.034 0.0309
Echinococcus granulosus snurportin 1 0.031 0.7027 0.699
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0146 0.0234
Wolbachia endosymbiont of Brugia malayi transcription termination factor Rho 0.0044 0.0732 0.0814
Entamoeba histolytica V-type ATPase, B subunit, putative 0.0104 0.2143 0.5348
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0034 0.0476 0.0473
Loa Loa (eye worm) MBCTL1 0.0055 0.0973 0.0944
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0772 0.1239
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.2624 0.6621
Trypanosoma brucei lanosterol synthase 0.0034 0.0476 0.0764
Loa Loa (eye worm) ATP synthase subunit beta 0.0044 0.0732 0.0703
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0178 0.3902 0.3828
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.4254 0.4184
Plasmodium vivax ATP synthase subunit gamma, mitochondrial, putative 0.015 0.3246 0.3164
Trichomonas vaginalis ATP synthase, putative 0.0059 0.1087 0.2556
Echinococcus multilocularis ATP synthase subunit delta, mitochondrial 0.0183 0.4018 0.3945
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0124 0.2624 0.2535
Chlamydia trachomatis V-type ATP synthase subunit B 0.0104 0.2143 1
Trypanosoma brucei ATP synthase F1 subunit gamma protein, putative 0.015 0.3246 0.5211
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0235 0.0303
Schistosoma mansoni hypothetical protein 0.0342 0.7795 0.7768
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0183 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0146 0.0234
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0034 0.0476 0.036
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0034 0.0476 0.0764
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1857 0.1758
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0146 0.0034
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0034 0.0476 0.0941
Plasmodium vivax importin-beta 2, putative 0.0029 0.0365 0.0248
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.034 0.0309
Toxoplasma gondii ATP synthase beta subunit ATP-B 0.0104 0.2143 0.2047
Trypanosoma cruzi Mitochondrial ATP synthase epsilon chain, putative 0.0148 0.3183 0.7856
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0034 0.0476 0.036
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0034 0.0476 0.0941
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0146 0.0034
Echinococcus multilocularis mitochondrial F1F0 ATP synthase subunit epsilon 0.0435 1 1
Trypanosoma brucei ATP synthase subunit beta, mitochondrial 0.0104 0.2143 0.344
Trypanosoma cruzi lanosterol synthase, putative 0.0034 0.0476 0.0913
Mycobacterium ulcerans F0F1 ATP synthase subunit alpha 0.0336 0.764 1
Echinococcus granulosus GPCR family 2 0.0048 0.0809 0.0698
Loa Loa (eye worm) hypothetical protein 0.0151 0.3257 0.3235
Schistosoma mansoni hypothetical protein 0.031 0.7027 0.699
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0973 0.0863
Echinococcus granulosus intermediate filament protein 0.0028 0.034 0.0222
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0551 0.0436
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1857 0.1758
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0183 0.0064
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit gamma 0.015 0.3246 0.4157
Plasmodium vivax geranylgeranyltransferase, putative 0.0034 0.0476 0.036
Entamoeba histolytica Ran family GTPase 0.0021 0.0183 0.0166
Brugia malayi RNA, U transporter 1 0.0083 0.1634 0.1608
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0146 0.0234
Echinococcus multilocularis lamin 0.0028 0.034 0.0222
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0551 0.0436
Onchocerca volvulus ATP synthase subunit delta, mitochondrial homolog 0.0183 0.4018 0.5039

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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