TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 275.344 | Formula: C19H17NO
H donors: 1 H acceptors: 1 LogP: 4.91 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)N=Cc1c(O)ccc2c1cccc2
InChi: 1S/C19H17NO/c1-2-14-7-10-16(11-8-14)20-13-18-17-6-4-3-5-15(17)9-12-19(18)21/h3-13,21H,2H2,1H3/b20-13+
InChiKey: JPZIGMWHWAOWNX-DEDYPNTBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Niemann Pick C1 protein	0.0202	0.1132	0.2602
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0228	0.1452
Onchocerca volvulus		0.0049	0.0202	0.1327
Schistosoma mansoni	hypothetical protein	0.0036	0.0126	0.0286
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0081	0.0514
Onchocerca volvulus		0.0051	0.0217	0.1492
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0273	0.1569	1
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0081	0.0181
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0044	0.0177	0.0596
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0139	0.0314
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0081	0.0274
Echinococcus multilocularis	neuropeptide s receptor	0.0465	0.2733	0.2732
Brugia malayi	intermediate filament protein	0.0029	0.0081	0.0274
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0048	0.2605
Echinococcus granulosus	expressed conserved protein	0.0189	0.1058	0.2431
Echinococcus granulosus	sterol regulatory element binding protein	0.0087	0.0433	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0228	0.1452
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0049	0.0202	1
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0044	0.0177	0.0596
Echinococcus granulosus	intermediate filament protein	0.0029	0.0081	0.0181
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0009	0.0029
Echinococcus multilocularis	protein dispatched 1	0.0099	0.0507	0.0505
Onchocerca volvulus	Glucosylceramidase homolog	0.0179	0.0997	1
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0044	0.0177	0.0403
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.1569	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0009	0.0006
Toxoplasma gondii	exonuclease III APE	0.0019	0.002	0.1033
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.002	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0049	0.0202	1
Onchocerca volvulus		0.0082	0.0407	0.3561
Schistosoma mansoni	hypothetical protein	0.0017	0.0009	0.0015
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0044	0.0177	0.0596
Mycobacterium ulcerans	acyl-CoA synthetase	0.0049	0.0202	0.0624
Onchocerca volvulus		0.016	0.0879	0.8713
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0217	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0202	0.1289
Echinococcus multilocularis	Niemann Pick C1 protein	0.0202	0.1132	0.1131
Echinococcus multilocularis	Aminotransferase class III	0.0044	0.0177	0.0175
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0997	0.631
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0009	0.0015
Schistosoma mansoni	hypothetical protein	0.0179	0.0997	0.2291
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0202	0.1289
Schistosoma mansoni	hypothetical protein	0.0083	0.0414	0.0948
Schistosoma mansoni	hypothetical protein	0.0083	0.0414	0.0948
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.0048	0.0094
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0217	0.074
Mycobacterium ulcerans	acyl-CoA synthetase	0.0049	0.0202	0.0624
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0228	0.0775
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.1569	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0002	0.0013
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0002	0.0007
Echinococcus granulosus	ornithine aminotransferase	0.0044	0.0177	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0407	0.2595
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0499	0.2937	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0128	0.0813
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0009	0.0006
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.002	0.0904
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.0407	0.0405
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0116	0.0386
Echinococcus multilocularis	geminin	0.0179	0.0997	0.0995
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.002	1
Schistosoma mansoni	ap endonuclease	0.0019	0.002	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0128	0.0813
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.1569	1
Echinococcus granulosus	lamin dm0	0.0029	0.0081	0.0181
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.1056	0.6689
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0049	0.0202	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1132	0.722
Entamoeba histolytica	hypothetical protein	0.0038	0.0139	0.1064
Leishmania major	4-coumarate:coa ligase-like protein	0.0049	0.0202	1
Schistosoma mansoni	hypothetical protein	0.0179	0.0997	0.2291
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0009	0.0054
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0036	0.0128	0.6171
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0048	1
Echinococcus granulosus	microtubule associated protein 2	0.073	0.4347	1
Echinococcus granulosus	geminin	0.0179	0.0997	0.2291
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0002	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0128	0.0813
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0049	0.0202	0.0682
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0009	0.0054
Entamoeba histolytica	hypothetical protein	0.0038	0.0139	0.1064
Schistosoma mansoni	hypothetical protein	0.0017	0.0009	0.0015
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0128	0.7168
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.002	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0128	0.0813
Trichomonas vaginalis	glucosylceramidase, putative	0.0189	0.1056	0.6689
Schistosoma mansoni	hypothetical protein	0.0017	0.0009	0.0015
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.0407	0.0932
Leishmania major	4-coumarate:coa ligase-like protein	0.0049	0.0202	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0049	0.0202	1
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0048	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0202	0.1132	0.3855
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.002	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.1569	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.002	0.0128
Schistosoma mansoni	hypothetical protein	0.0017	0.0009	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0433	0.276
Brugia malayi	hypothetical protein	0.0038	0.0139	0.0472
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0044	0.0177	0.0538
Brugia malayi	AMP-binding enzyme family protein	0.0049	0.0202	0.0688
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0126	0.043
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0997	0.631
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0044	0.0177	0.0538
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0128	0.7168
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0044	0.0177	1
Brugia malayi	hypothetical protein	0.016	0.0879	0.2993
Echinococcus multilocularis	lamin dm0	0.0029	0.0081	0.0079
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.002	0.0062
Mycobacterium ulcerans	hypothetical protein	0.0049	0.0202	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0077	0.0493
Echinococcus granulosus	neuropeptide s receptor	0.0465	0.2733	0.6286
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.1569	1
Echinococcus multilocularis	protein patched	0.0087	0.0433	0.0431
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0128	0.0428
Echinococcus multilocularis	microtubule associated protein 2	0.073	0.4347	0.4345
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0081	0.0514
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.002	0.1033
Mycobacterium ulcerans	L-lysine aminotransferase	0.0499	0.2937	1
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0177	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0551	0.3514
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0997	0.631
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0499	0.2937	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0049	0.0202	0.0682
Brugia malayi	AMP-binding enzyme family protein	0.0049	0.0202	0.0688
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.002	0.0018
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0049	0.0202	0.0624
Schistosoma mansoni	microtubule-associated protein tau	0.073	0.4347	1
Echinococcus granulosus	Protein patched homolog 1	0.0087	0.0433	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0128	0.0813
Brugia malayi	AMP-binding enzyme family protein	0.0049	0.0202	0.0688
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0116	0.0386
Echinococcus multilocularis	survival motor neuron protein 1	0.025	0.1428	0.1427
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.002	0.1033
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0081	0.0514
Mycobacterium leprae	PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)	0.0044	0.0177	0.838
Schistosoma mansoni	hypothetical protein	0.0083	0.0414	0.0948
Echinococcus granulosus	Aminotransferase class III	0.0044	0.0177	0.0403
Echinococcus granulosus	lamin	0.0029	0.0081	0.0181
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0139	0.0136
Entamoeba histolytica	hypothetical protein	0.0038	0.0139	0.1064
Brugia malayi	CHE-14 protein	0.0087	0.0433	0.1474
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0139	0.0314
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0044	0.0177	0.0538
Mycobacterium leprae	Probable Acetylornithine aminotransferase ArgD	0.0044	0.0177	0.838
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0116	0.0386
Mycobacterium leprae	Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM	0.0044	0.0177	0.838
Schistosoma mansoni	hypothetical protein	0.0038	0.0139	0.0314
Schistosoma mansoni	patched 1	0.0087	0.0433	0.0992
Echinococcus multilocularis	ornithine aminotransferase	0.0044	0.0177	0.0175
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0044	0.0177	0.0538
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.002	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0126	0.0805
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.0433	0.2666
Schistosoma mansoni	ap endonuclease	0.0019	0.002	0.0042
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0997	0.631
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0049	0.0202	0.0624
Schistosoma mansoni	hypothetical protein	0.0051	0.0217	0.0496
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0273	0.1569	0.534
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0036	0.0128	0.0368
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0205	0.1151	0.2645
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0202	0.1132	1
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0044	0.0177	0.0596
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0997	0.631
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0044	0.0177	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0997	0.631
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.0048	0.0094
Echinococcus granulosus	GPCR family 2	0.0017	0.0009	0.0015
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0049	0.0202	0.0624
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0009	0.0029
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0087	0.0433	0.276
Entamoeba histolytica	acyl-coA synthetase, putative	0.0049	0.0202	0.1636
Brugia malayi	hypothetical protein	0.025	0.1428	0.4863
Mycobacterium tuberculosis	Probable aminotransferase	0.0044	0.0177	0.0596
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0009	0.0006
Echinococcus granulosus	Niemann Pick C1 protein	0.0288	0.1658	0.3812
Entamoeba histolytica	hypothetical protein	0.0023	0.0048	0.0247
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0048	0.2605
Echinococcus multilocularis	sterol regulatory element binding protein	0.0087	0.0433	0.0431
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0116	0.0386
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.0407	0.0932
Trichomonas vaginalis	glucosylceramidase, putative	0.0179	0.0997	0.631
Echinococcus multilocularis	ornithine aminotransferase	0.0044	0.0177	0.0175
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0048	0.2605
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0009	0.0015
Echinococcus multilocularis	expressed conserved protein	0.0189	0.1058	0.1056
Echinococcus multilocularis	Niemann Pick C1 protein	0.0288	0.1658	0.1657
Loa Loa (eye worm)	hypothetical protein	0.025	0.1428	0.9106
Echinococcus granulosus	neuropeptide receptor A26	0.0465	0.2733	0.6286
Mycobacterium ulcerans	acyl-CoA synthetase	0.0049	0.0202	0.0624
Echinococcus multilocularis	musashi	0.0029	0.0081	0.0079
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0044	0.0177	0.838
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0048	0.2279
Schistosoma mansoni	hypothetical protein	0.0083	0.0414	0.0948
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0044	0.0177	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.0879	0.5605
Plasmodium vivax	ornithine aminotransferase, putative	0.0044	0.0177	1
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0048	0.2605
Echinococcus multilocularis	lamin	0.0029	0.0081	0.0079
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.0407	0.1386
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.002	0.0069
Echinococcus granulosus	survival motor neuron protein 1	0.025	0.1428	0.3283
Trichomonas vaginalis	glucosylceramidase, putative	0.0273	0.1569	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0139	0.1064
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.0048	0.1753
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0049	0.0202	0.1636
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0044	0.0177	0.0538
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0048	0.0155
Echinococcus multilocularis	neuropeptide receptor A26	0.0465	0.2733	0.2732
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0044	0.0177	0.0538
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0044	0.0177	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0202	0.1289
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0228	0.0775
Plasmodium falciparum	ornithine aminotransferase	0.0044	0.0177	1
Schistosoma mansoni	lamin	0.0029	0.0081	0.0181
Schistosoma mansoni	lamin	0.0029	0.0081	0.0181
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0049	0.0202	0.1636

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 658419