Detailed information for compound 662370

Basic information

Technical information
  • TDR Targets ID: 662370
  • Name: 2-(4-bromophenyl)-N-pyridin-4-ylquinoline-4-c arboxamide
  • MW: 404.259 | Formula: C21H14BrN3O
  • H donors: 1 H acceptors: 3 LogP: 4.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)c1nc2ccccc2c(c1)C(=O)Nc1ccncc1
  • InChi: 1S/C21H14BrN3O/c22-15-7-5-14(6-8-15)20-13-18(17-3-1-2-4-19(17)25-20)21(26)24-16-9-11-23-12-10-16/h1-13H,(H,23,24,26)
  • InChiKey: SHWHYTVYXQOEMT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-bromophenyl)-N-(4-pyridyl)quinoline-4-carboxamide
  • 2-(4-bromophenyl)-N-(4-pyridyl)-4-quinolinecarboxamide
  • 2-(4-bromophenyl)-N-(4-pyridyl)cinchoninamide
  • 2-(4-bromophenyl)-N-pyridin-4-yl-quinoline-4-carboxamide
  • Oprea1_298682
  • AK-968/13408018
  • IVK/9020344
  • ZINC00998552

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0329 0.073
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Entamoeba histolytica acetyltransferase, GNAT family 0.0082 0.0836 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0329 0.073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0329 0.073
Giardia lamblia Histone acetyltransferase GCN5 0.0082 0.0836 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Brugia malayi PHD-finger family protein 0.0009 0.0025 0.0059
Plasmodium falciparum histone acetyltransferase GCN5 0.0082 0.0836 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0008 0.0003
Echinococcus granulosus muscleblind protein 0.0147 0.1558 0.2742
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0029 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0005 0.0016
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0495 0.1102
Echinococcus multilocularis muscleblind protein 0.0147 0.1558 0.1554
Mycobacterium ulcerans lipase LipD 0.0037 0.0329 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3132 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0327 0.0724
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.044 0.0768
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0327 0.0724
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.068 0.204
Echinococcus multilocularis neuropeptide receptor A26 0.0517 0.5669 0.5667
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.00000077734
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Echinococcus granulosus neuropeptide receptor A26 0.0517 0.5669 1
Entamoeba histolytica hypothetical protein 0.004 0.0369 0.4379
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1558 0.1554
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.0919 1
Plasmodium vivax SET domain containing protein 0.0008 0.0012 0.0082
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0005 0.0016
Brugia malayi Bromodomain containing protein 0.0009 0.0025 0.0059
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni hypothetical protein 0.0068 0.068 0.1519
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0327 0.0973
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0329 0.1052
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0005 0.0016
Onchocerca volvulus 0.0037 0.0329 0.1604
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0329 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0327 0.3872
Schistosoma mansoni cpg binding protein 0.0033 0.0286 0.0633
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni cpg binding protein 0.0033 0.0286 0.0633
Loa Loa (eye worm) hypothetical protein 0.0032 0.0273 0.0603
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3132 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0008 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Brugia malayi beta-lactamase family protein 0.0037 0.0329 0.0981
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis hypothetical protein 0.0007 0.0005 0.0016
Toxoplasma gondii ABC1 family protein 0.0037 0.0329 0.3549
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.044 0.0978
Echinococcus granulosus cpg binding protein 0.0033 0.0286 0.0497
Loa Loa (eye worm) hypothetical protein 0.0037 0.0329 0.073
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0005 0.0016
Echinococcus granulosus GPCR family 2 0.0032 0.0273 0.0473
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0327 0.0724
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1031 0.3101
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0029 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Onchocerca volvulus 0.0031 0.0267 0.1294
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Brugia malayi hypothetical protein 0.004 0.0369 0.11
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3132 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2028 0.6475
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0007 0.0005 0.00000034568
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0009 0.0017 0.0054
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0305 0.3314 0.3311
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Echinococcus granulosus zinc finger protein 0.0009 0.0025 0.0035
Brugia malayi mbt repeat family protein 0.0051 0.0495 0.148
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0658 0.7146
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0305 0.3314 0.7445
Loa Loa (eye worm) hypothetical protein 0.0051 0.0495 0.1102
Entamoeba histolytica hypothetical protein 0.004 0.0369 0.4379
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0495 0.1102
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2141 0.6838
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0369 0.0819
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2028 0.6475
Schistosoma mansoni bromodomain containing protein 0.0009 0.0025 0.0044
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0044
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1031 0.3101
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0327 0.3872
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0273 0.0268
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0327 0.0568
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0005 0.0016
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0327 0.0322
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0574 0.172
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0407 0.445 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Brugia malayi ATPase, AAA family protein 0.0007 0.0005 0.0000010441
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0574 0.0569
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0273 0.0809
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.0919 1
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2028 0.6475
Schistosoma mansoni hypothetical protein 0.0032 0.0273 0.0603
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0329 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0329 0.073
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0273 0.0809
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0495 0.049
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0329 0.5
Schistosoma mansoni hypothetical protein 0.0032 0.0273 0.0603
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0329 0.0325
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0327 0.9918
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni hypothetical protein 0.0032 0.0273 0.0603
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0495 0.1102
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0574 0.128
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0008 0.0006
Brugia malayi acetyltransferase, GNAT family protein 0.0305 0.3314 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0329 0.5
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0147 0.1558 0.3494
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0653 0.1459
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.2179 0.2175
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0289 0.3132 0.9448
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.044 0.0978
Loa Loa (eye worm) hypothetical protein 0.0059 0.0574 0.128
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0495 0.1102
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0327 0.0568
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.044 0.0978
Brugia malayi beta-lactamase 0.0037 0.0329 0.0981
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2028 0.6475
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0009 0.0025 0.002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0327 0.9918
Echinococcus multilocularis hormone sensitive lipase 0.0407 0.445 0.4447
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0273 0.0268
Echinococcus granulosus neuropeptide s receptor 0.0517 0.5669 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0327 0.9918
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.0919 0.2936
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Entamoeba histolytica hypothetical protein 0.004 0.0369 0.4379
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0273 0.0473
Loa Loa (eye worm) hypothetical protein 0.01 0.1031 0.2309
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Onchocerca volvulus Glucosylceramidase homolog 0.0189 0.2028 1
Brugia malayi CXXC zinc finger family protein 0.0031 0.0267 0.0791
Echinococcus multilocularis neuropeptide s receptor 0.0517 0.5669 0.5667
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0327 0.0322
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0007 0.0005 0.00000060999
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0329 0.3549
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0147 0.1558 0.3494
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0327 0.0568
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0327 0.1044
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0329 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0369 0.0364
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3132 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0495 0.2421
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0327 0.1044
Echinococcus granulosus histone acetyltransferase KAT2B 0.0296 0.3219 0.5674
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0495 0.049
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0008 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1031 0.2309
Onchocerca volvulus 0.0037 0.0329 0.1604
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.2179 0.3839
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.2526 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0009 0.0025 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni hypothetical protein 0.0032 0.0273 0.0603
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0407 0.445 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0329 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0329 0.1052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.044 0.1314
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0329 0.073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0329 0.073
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0329 0.073
Loa Loa (eye worm) MBCTL1 0.0059 0.0574 0.128
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0495 0.0865
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0329 0.0573
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3132 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.0919 1
Trichomonas vaginalis hypothetical protein 0.0007 0.0005 0.0016
Brugia malayi beta-lactamase family protein 0.0037 0.0329 0.0981
Echinococcus granulosus hormone sensitive lipase 0.0407 0.445 0.7847
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0267 0.0589
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0273 0.0603
Brugia malayi mbt repeat family protein 0.0051 0.0495 0.148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.044 0.0435
Loa Loa (eye worm) beta-lactamase 0.0037 0.0329 0.073
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0329 0.1052
Leishmania major hypothetical protein, conserved 0.0037 0.0329 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0574 0.0569
Loa Loa (eye worm) hypothetical protein 0.0068 0.068 0.1519
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0329 0.5
Schistosoma mansoni hypothetical protein 0.0313 0.3404 0.7648
Trichomonas vaginalis esterase, putative 0.0037 0.0329 0.1052
Echinococcus multilocularis cpg binding protein 0.0033 0.0286 0.0282
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0407 0.445 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0574 0.1005
Schistosoma mansoni cpg binding protein 0.0031 0.0267 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0329 0.1052
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0574 0.1005
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0329 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.044 0.0435
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.0919 0.2936
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0329 0.1052
Onchocerca volvulus 0.0051 0.0495 0.2421
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2028 0.6475
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0008 0.0005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Loa Loa (eye worm) acetyltransferase 0.0305 0.3314 0.7445
Onchocerca volvulus 0.0037 0.0329 0.1604
Schistosoma mansoni zinc finger protein 0.0009 0.0025 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0273 0.0473
Loa Loa (eye worm) hypothetical protein 0.0407 0.445 1
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0005 0.0016
Entamoeba histolytica hypothetical protein 0.004 0.0369 0.4379
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0007 0.0005 0.0016
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0495 0.0865
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2028 0.6475
Trichomonas vaginalis lymphoid specific helicase, putative 0.0007 0.0005 0.0016
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0289 0.3132 0.7034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.044 0.0768
Echinococcus multilocularis zinc finger protein 0.0009 0.0025 0.002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.0919 0.1614
Schistosoma mansoni bromodomain containing protein 0.0009 0.0025 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0027 0.0067
Loa Loa (eye worm) histone methyltransferase 0.001 0.0029 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0329 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0327 0.9918
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3132 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0327 0.0322
Loa Loa (eye worm) hypothetical protein 0.0037 0.0329 0.073
Brugia malayi Muscleblind-like protein 0.0147 0.1558 0.4693
Echinococcus multilocularis GPCR, family 2 0.0032 0.0273 0.0268
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0009 0.0017 0.0054
Mycobacterium ulcerans hypothetical protein 0.0037 0.0329 0.5
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2141 0.6838
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Schistosoma mansoni hypothetical protein 0.004 0.0369 0.0819
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2028 0.6475
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.044 0.0978
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0005 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0005 0.0016
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0327 0.1044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0369 0.0643

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 35.7 % Potentiation of ATRA-induced human NB4 cell differentiation at 1 uM after 96 hrs by nitroblue tetrazolium assay (Rvb = 29.93 +/- 0.73%) ChEMBL. 23601821

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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