Detailed information for compound 662679

Basic information

Technical information
  • TDR Targets ID: 662679
  • Name: ZINC01145574
  • MW: 398.303 | Formula: C18H17Cl2NO3S
  • H donors: 1 H acceptors: 2 LogP: 4.75 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=O)CSCc1c(Cl)cccc1Cl
  • InChi: 1S/C18H17Cl2NO3S/c1-2-24-18(23)12-6-8-13(9-7-12)21-17(22)11-25-10-14-15(19)4-3-5-16(14)20/h3-9H,2,10-11H2,1H3,(H,21,22)
  • InChiKey: KZEFPMVLVDTGMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STK170047

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0079 0.301 1
Mycobacterium ulcerans hypothetical protein 0.0079 0.301 0.5
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0079 0.301 0.5
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0079 0.301 0.5
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0079 0.301 0.5
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0079 0.301 0.5
Brugia malayi metallo-beta-lactamase superfamily protein 0.0079 0.301 0.3447
Loa Loa (eye worm) hypothetical protein 0.0016 0.025 0.0286
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0079 0.301 0.3447
Mycobacterium tuberculosis Conserved protein 0.0079 0.301 0.5
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0079 0.301 1
Schistosoma mansoni hypothetical protein 0.0079 0.301 1
Mycobacterium leprae POSSIBLE HYDROLASE 0.0079 0.301 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.025 0.083
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0871 0.2893
Echinococcus multilocularis zinc phosphodiesterase 0.0079 0.301 1
Loa Loa (eye worm) hypothetical protein 0.005 0.1753 0.2007
Mycobacterium ulcerans hypothetical protein 0.0079 0.301 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0871 0.2893
Onchocerca volvulus Heat shock factor protein 2 homolog 0.01 0.3927 0.3927
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0079 0.301 1
Chlamydia trachomatis ribonuclease Z 0.0079 0.301 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.8732 1
Mycobacterium leprae Beta-lactamase-like protein 0.0079 0.301 0.5
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0079 0.301 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.025 0.0286
Mycobacterium ulcerans hypothetical protein 0.0079 0.301 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0871 0.2893
Mycobacterium tuberculosis Conserved protein 0.0079 0.301 0.5
Schistosoma mansoni hypothetical protein 0.0079 0.301 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0079 0.301 1
Schistosoma mansoni hypothetical protein 0.0016 0.025 0.083
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0079 0.301 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.301 0.3447
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0079 0.301 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0079 0.301 0.5
Brugia malayi ethe1-prov protein 0.0079 0.301 0.3447
Mycobacterium tuberculosis Possible hydrolase 0.0079 0.301 0.5
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0079 0.301 0.3447
Brugia malayi Pre-SET motif family protein 0.0209 0.8732 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.301 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0871 0.2893
Onchocerca volvulus Putative hydrolase PNKD 0.0079 0.301 0.301
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1057 0.1211
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0079 0.301 0.3447
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.025 0.083
Treponema pallidum ribonuclease Z 0.0079 0.301 0.5
Entamoeba histolytica heat shock transcription factor, putative 0.01 0.3927 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1753 0.2007
Trypanosoma cruzi glyoxalase II 0.0079 0.301 0.5
Brugia malayi metallo-beta-lactamase superfamily protein 0.0079 0.301 0.3447
Loa Loa (eye worm) hypothetical protein 0.0079 0.301 0.3447
Trypanosoma brucei glyoxalase II 0.0079 0.301 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.025 0.083
Schistosoma mansoni hypothetical protein 0.0034 0.1057 0.3512
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0871 0.2893
Mycobacterium ulcerans hydrolase 0.0079 0.301 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.301 0.5
Leishmania major metallo-beta-lactamase family-like protein 0.0079 0.301 0.5
Onchocerca volvulus 0.0079 0.301 0.301
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0079 0.301 0.5
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0079 0.301 0.5
Echinococcus multilocularis GPCR, family 2 0.0016 0.025 0.083
Trypanosoma cruzi glyoxalase II 0.0079 0.301 0.5
Schistosoma mansoni hypothetical protein 0.0079 0.301 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0871 0.0997
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0079 0.301 0.5
Mycobacterium tuberculosis Possible hydrolase 0.0079 0.301 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.1057 0.1211
Schistosoma mansoni zinc phosphodiesterase 0.0079 0.301 1
Leishmania major metallo-beta-lactamase family protein-like protein 0.0079 0.301 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0.301 0.3447
Loa Loa (eye worm) hypothetical protein 0.01 0.3927 0.4497
Plasmodium falciparum cytosolic glyoxalase II 0.0079 0.301 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.025 0.0286
Mycobacterium ulcerans hypothetical protein 0.0079 0.301 0.5
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0079 0.301 0.5
Onchocerca volvulus 0.003 0.0871 0.0871
Plasmodium vivax unspecified product 0.0079 0.301 1
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0079 0.301 0.5
Echinococcus granulosus GPCR family 2 0.0016 0.025 0.083
Leishmania major hypothetical protein, conserved 0.0079 0.301 0.5
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0079 0.301 0.5
Mycobacterium leprae conserved hypothetical protein 0.0079 0.301 0.5
Mycobacterium ulcerans glyoxalase II, GloB 0.0079 0.301 0.5
Mycobacterium tuberculosis Beta lactamase like protein 0.0079 0.301 0.5
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0079 0.301 0.301
Loa Loa (eye worm) hypothetical protein 0.0079 0.301 0.3447
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0079 0.301 0.5
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0079 0.301 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0871 0.2893
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0079 0.301 0.3447
Brugia malayi HSF-type DNA-binding domain containing protein 0.01 0.3927 0.4497
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1753 0.2007
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0079 0.301 1
Mycobacterium ulcerans hydrolase 0.0079 0.301 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.301 0.5
Brugia malayi Latrophilin receptor protein 2 0.0016 0.025 0.0286
Entamoeba histolytica heat shock transcription factor, putative 0.01 0.3927 1
Mycobacterium leprae conserved hypothetical protein 0.0079 0.301 0.5
Echinococcus granulosus zinc phosphodiesterase 0.0079 0.301 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0871 0.2893
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0079 0.301 0.5
Entamoeba histolytica heat shock transcription factor, putative 0.01 0.3927 1
Brugia malayi hypothetical protein 0.0079 0.301 0.3447
Onchocerca volvulus 0.0079 0.301 0.301
Echinococcus multilocularis ETHE1 protein 0.0079 0.301 1
Echinococcus granulosus ETHE1 protein 0.0079 0.301 1
Trichomonas vaginalis set domain proteins, putative 0.0238 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.025 0.083
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0079 0.301 0.5
Mycobacterium tuberculosis Conserved protein 0.0079 0.301 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1753 0.2007
Brugia malayi Pre-SET motif family protein 0.003 0.0871 0.0997
Mycobacterium ulcerans hydrolase 0.0079 0.301 0.5
Mycobacterium ulcerans beta lactamase-like protein 0.0079 0.301 0.5
Schistosoma mansoni zinc phosphodiesterase 0.0079 0.301 1
Schistosoma mansoni hypothetical protein 0.0016 0.025 0.083
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.025 0.083
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0079 0.301 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0822 0.2732
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0079 0.301 1
Trypanosoma cruzi glyoxalase II 0.0079 0.301 0.5
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0079 0.301 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.025 0.083

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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