Detailed information for compound 663840

Basic information

Technical information
  • TDR Targets ID: 663840
  • Name: 2-(4-chloro-3,5-dimethylphenoxy)-N-(5-chloro- 2-hydroxyphenyl)acetamide
  • MW: 340.201 | Formula: C16H15Cl2NO3
  • H donors: 2 H acceptors: 2 LogP: 4.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(Cl)ccc1O)COc1cc(C)c(c(c1)C)Cl
  • InChi: 1S/C16H15Cl2NO3/c1-9-5-12(6-10(2)16(9)18)22-8-15(21)19-13-7-11(17)3-4-14(13)20/h3-7,20H,8H2,1-2H3,(H,19,21)
  • InChiKey: DXQBZKIRLKRBGR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chloro-3,5-dimethyl-phenoxy)-N-(5-chloro-2-hydroxy-phenyl)acetamide
  • 2-(4-chloro-3,5-dimethyl-phenoxy)-N-(5-chloro-2-hydroxy-phenyl)ethanamide
  • STK276828
  • ZINC00466999

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0276 0.1254 0.1254
Schistosoma mansoni lipoxygenase 0.0081 0.0262 0.0262
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0032 0.0032
Brugia malayi topoisomerase 0.0031 0.0008 0.0008
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Onchocerca volvulus 0.0131 0.0521 0.0521
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0038 0.0046 0.0893
Echinococcus multilocularis aldo keto reductase 0.0131 0.0521 0.0521
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0041 0.0063 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0095 0.0287
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1998 1 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0043 0.0072 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0034 0.0033
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0072 0.021
Schistosoma mansoni tyrosine kinase 0.0405 0.1911 0.1911
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.048 0.2289 0.2289
Entamoeba histolytica hypothetical protein 0.0035 0.0032 0.018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0034 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0095 0.0095
Onchocerca volvulus 0.0048 0.0095 0.0095
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0289 0.1322 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Schistosoma mansoni amine oxidase 0.0043 0.0072 0.0072
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0131 0.0521 1
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0629 0.3047 1
Brugia malayi DKFZp564C0469 protein 0.0031 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.004 0.0055 0.0055
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1998 1 1
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0509 0.2436 0.2436
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0349 0.0349
Brugia malayi Blistered cuticle protein 3 0.0077 0.0244 0.0244
Onchocerca volvulus Chorion peroxidase homolog 0.0077 0.0244 0.0244
Schistosoma mansoni high-affinity choline transporter 0.0381 0.1789 0.1789
Brugia malayi amine oxidase, flavin-containing family protein 0.0043 0.0072 0.0072
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0072 1
Entamoeba histolytica hypothetical protein 0.0035 0.0032 0.018
Echinococcus multilocularis peroxidasin 0.0077 0.0244 0.0244
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0038 0.0046 0.0046
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Schistosoma mansoni hypothetical protein 0.004 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0008
Brugia malayi hypothetical protein 0.0031 0.0008 0.0008
Brugia malayi GH02984p 0.0381 0.1789 0.1789
Brugia malayi hypothetical protein 0.0077 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521
Schistosoma mansoni tyrosine kinase 0.0181 0.0773 0.0773
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0167 0.0167
Onchocerca volvulus 0.0038 0.0046 0.0046
Brugia malayi Common central domain of tyrosinase family protein 0.0095 0.0336 0.0336
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0042 0.0067 0.1281
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0095 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Schistosoma mansoni tyrosine kinase 0.0184 0.0789 0.0789
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0043 0.0072 0.0072
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0031 0.0008 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0244 0.0244
Onchocerca volvulus 0.0077 0.0244 0.0244
Echinococcus granulosus aldehyde reductase 0.0093 0.0327 0.0327
Brugia malayi Furin-like cysteine rich region family protein 0.0184 0.0789 0.0789
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0289 0.1322 1
Schistosoma mansoni hypothetical protein 0.004 0.0055 0.0055
Entamoeba histolytica aldose reductase, putative 0.0131 0.0521 0.39
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0289 0.1322 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0095 0.0095
Echinococcus multilocularis protein dispatched 1 0.0047 0.0092 0.0092
Mycobacterium ulcerans hypothetical protein 0.0048 0.0095 0.0287
Schistosoma mansoni peroxidasin 0.0077 0.0244 0.0244
Schistosoma mansoni potassium channel beta 0.0038 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0276 0.1254 0.1254
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0034 0.4074
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0146 0.0594 0.0594
Echinococcus multilocularis epidermal growth factor receptor 0.0184 0.0789 0.0789
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0095 0.0287
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0289 0.1322 0.1322
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521
Echinococcus multilocularis aldehyde reductase 0.0093 0.0327 0.0327
Echinococcus multilocularis epidermal growth factor receptor 0.0184 0.0789 0.0789
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0095 0.0663
Brugia malayi CHE-14 protein 0.0041 0.0063 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0167 0.0167
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0521 0.0521
Schistosoma mansoni sodium/solute symporter 0.0042 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0048 0.0095 0.0095
Echinococcus granulosus hypothetical protein 0.0131 0.0521 0.0521
Onchocerca volvulus 0.0095 0.0336 0.0336
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1998 1 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0042 0.0067 0.0067
Echinococcus granulosus dual specificity 0.0289 0.1322 0.1322
Trypanosoma cruzi aldo/keto reductase, putative 0.0131 0.0521 0.39
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Onchocerca volvulus Dual oxidase homolog 0.0077 0.0244 0.0244
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0551 0.0551
Loa Loa (eye worm) blistered cuticle protein 3 0.0077 0.0244 0.0244
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0095 0.0287
Echinococcus granulosus solute carrier family 5 0.0042 0.0067 0.0067
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Schistosoma mansoni tyrosine kinase 0.0184 0.0789 0.0789
Schistosoma mansoni aldo-keto reductase 0.0131 0.0521 0.0521
Schistosoma mansoni hypothetical protein 0.0063 0.0175 0.0175
Echinococcus multilocularis solute carrier family 5 0.0042 0.0067 0.0067
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0034 0.474
Echinococcus multilocularis nibrin 0.0031 0.0008 0.0008
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0551 0.0551
Loa Loa (eye worm) TK/EGFR protein kinase 0.0184 0.0789 0.0789
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0336 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0167 0.0167
Echinococcus granulosus voltage gated potassium channel subunit 0.0038 0.0046 0.0046
Echinococcus granulosus tar DNA binding protein 0.0062 0.0167 0.0167
Brugia malayi ShTK domain containing protein 0.0095 0.0336 0.0336
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0042 0.0067 0.0067
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0072 1
Loa Loa (eye worm) oxidoreductase 0.0131 0.0521 0.0521
Loa Loa (eye worm) oxidoreductase 0.0131 0.0521 0.0521
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0072 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0095 0.0095
Onchocerca volvulus 0.0077 0.0244 0.0244
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0008 0.0008
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0095 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0063 0.1068
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1998 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0521 0.0521
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0072 0.0158
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0038 0.0046 0.0046
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Echinococcus multilocularis protein patched 0.0041 0.0063 0.0063
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0204 0.0889 0.0889
Schistosoma mansoni hypothetical protein 0.004 0.0055 0.0055
Schistosoma mansoni DNA ligase IV 0.0031 0.0008 0.0008
Onchocerca volvulus 0.0095 0.0336 0.0336
Mycobacterium ulcerans hypothetical protein 0.0038 0.0046 0.0126
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.0175 0.0175
Echinococcus multilocularis aldo keto reductase 0.0131 0.0521 0.0521
Trypanosoma brucei aldo/keto reductase, putative 0.0038 0.0046 0.0292
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0038 0.0046 0.0046
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0131 0.0521 1
Mycobacterium ulcerans dehydrogenase 0.0043 0.0072 0.021
Echinococcus multilocularis 0.0043 0.0072 0.0072
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0032 0.0032
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521
Echinococcus granulosus sodium:myo inositol cotransporter 0.0042 0.0067 0.0067
Onchocerca volvulus 0.0077 0.0244 0.0244
Schistosoma mansoni tyrosine kinase 0.0405 0.1911 0.1911
Leishmania major prostaglandin f synthase, putative 0.0131 0.0521 0.3937
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0244 0.0244
Loa Loa (eye worm) TK/INSR protein kinase 0.0405 0.1911 0.1911
Echinococcus granulosus epidermal growth factor receptor 0.0184 0.0789 0.0789
Entamoeba histolytica hypothetical protein 0.0289 0.1322 1
Echinococcus multilocularis expressed conserved protein 0.009 0.0312 0.0312
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0131 0.0521 0.3937
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0046 0.0292
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0521 0.0521
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0146 0.0594 0.0594
Echinococcus granulosus sodium:glucose cotransporter 2 0.0042 0.0067 0.0067
Echinococcus multilocularis aldo keto reductase 0.0131 0.0521 0.0521
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0167 0.0167
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0063 0.0063
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0521 0.0521
Mycobacterium ulcerans oxidoreductase 0.0131 0.0521 0.1686
Echinococcus granulosus peroxidasin 0.0077 0.0244 0.0244
Treponema pallidum DNA ligase (lig) 0.0031 0.0008 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.0032 0.018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0095 0.1701
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0521 0.0521
Entamoeba histolytica alcohol dehydrogenase, putative 0.0038 0.0046 0.0292
Schistosoma mansoni pol-related 0.0131 0.0521 0.0521
Echinococcus multilocularis high affinity choline transporter 1 0.0381 0.1789 0.1789
Schistosoma mansoni amine oxidase 0.0043 0.0072 0.0072
Trypanosoma brucei aldo-keto reductase, putative 0.0131 0.0521 0.39
Mycobacterium ulcerans oxidoreductase 0.0043 0.0072 0.021
Onchocerca volvulus 0.0095 0.0336 0.0336
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0521 0.0521
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0072 1
Entamoeba histolytica aldose reductase, putative 0.0131 0.0521 0.39
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0342 0.0342
Mycobacterium leprae Conserved hypothetical protein 0.0093 0.0327 0.6228
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0167 0.0167
Echinococcus granulosus nibrin 0.0031 0.0008 0.0008
Echinococcus granulosus aldo keto reductase 0.0131 0.0521 0.0521
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0072 0.0072
Giardia lamblia Aldose reductase 0.0131 0.0521 1
Loa Loa (eye worm) oxidoreductase 0.0131 0.0521 0.0521
Onchocerca volvulus Peroxidasin homolog 0.0077 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0221 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0184 0.0789 0.0789
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0244 0.0244
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0042 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0095 0.0336 0.0336
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0405 0.1911 0.1911
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Loa Loa (eye worm) oxidoreductase 0.0131 0.0521 0.0521
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.0175 0.0175
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0095 0.072
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521
Toxoplasma gondii aldo-keto reductase 0.0038 0.0046 0.0893
Brugia malayi Peroxidasin 0.0077 0.0244 0.0244
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0167 0.0167
Onchocerca volvulus 0.0131 0.0521 0.0521
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0521 0.0521
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0167 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0046 0.0749
Echinococcus multilocularis insulin receptor 0.0405 0.1911 0.1911
Echinococcus multilocularis voltage gated potassium channel subunit 0.0038 0.0046 0.0046
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.0336 0.0336
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0568 0.2739 0.8982
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0521 0.0521
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0336 0.0336
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0072 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Schistosoma mansoni inositol transporter 0.0042 0.0067 0.0067
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0072 0.0485
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0008 0.0008
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521
Trypanosoma cruzi aldo-keto reductase 0.0131 0.0521 0.39
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Schistosoma mansoni tyrosinase precursor 0.0095 0.0336 0.0336
Schistosoma mansoni inositol transporter 0.0042 0.0067 0.0067
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0008 0.0155
Onchocerca volvulus 0.0031 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0204 0.0889 0.0889
Entamoeba histolytica protein kinase domain containing protein 0.0289 0.1322 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0405 0.1911 0.1911
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0072 1
Giardia lamblia Aldose reductase 0.0131 0.0521 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0095 0.072
Plasmodium falciparum aldo-keto reductase, putative 0.0038 0.0046 0.6473
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0131 0.0521 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.0035 0.0032 0.0032
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0167 0.0167
Onchocerca volvulus 0.0131 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Mycobacterium ulcerans hypothetical protein 0.0339 0.1573 0.5149
Echinococcus multilocularis muscleblind protein 0.0146 0.0594 0.0594
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0095 0.1701
Toxoplasma gondii aldose reductase, putative 0.0131 0.0521 1
Echinococcus granulosus insulin receptor 0.0405 0.1911 0.1911
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0095 0.0235
Trichomonas vaginalis aldo/keto reductase, putative 0.0131 0.0521 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0032 0.0032
Schistosoma mansoni lipoxygenase 0.0115 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0008
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0342 0.0342
Brugia malayi Protein kinase domain containing protein 0.0405 0.1911 0.1911
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0521 0.0521
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0244 0.0244
Schistosoma mansoni tyrosinase precursor 0.0095 0.0336 0.0336
Schistosoma mansoni tyrosine kinase 0.0184 0.0789 0.0789
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Entamoeba histolytica hypothetical protein 0.0035 0.0032 0.018
Onchocerca volvulus 0.0131 0.0521 0.0521
Echinococcus granulosus muscleblind protein 0.0146 0.0594 0.0594
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0072 0.1379
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0289 0.1322 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0611 0.2958 0.9706
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.048 0.2289 0.2289
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521
Leishmania major aldo-keto reductase-like protein 0.0131 0.0521 0.3937
Brugia malayi hypothetical protein 0.0043 0.0072 0.0072
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0008 0.1124
Onchocerca volvulus 0.0043 0.0072 0.0072
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0594 0.0594
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0008 0.0155
Echinococcus granulosus aldo keto reductase 0.0131 0.0521 0.0521
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0046 0.0749
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0131 0.0521 0.3937
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0008 0.0008
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0342 0.2539
Schistosoma mansoni topbp1 0.0031 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0008
Brugia malayi RNA binding protein 0.0062 0.0167 0.0167
Brugia malayi hypothetical protein 0.0035 0.0032 0.0032
Brugia malayi Muscleblind-like protein 0.0146 0.0594 0.0594
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0043 0.0072 0.0072
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521
Brugia malayi Sodium:solute symporter family protein 0.0042 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0046 0.0749
Echinococcus granulosus expressed conserved protein 0.009 0.0312 0.0312
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0095 0.0663
Echinococcus multilocularis aldo keto reductase 0.0131 0.0521 0.0521
Mycobacterium leprae Possible oxidoreductase 0.0038 0.0046 0.0749
Loa Loa (eye worm) hypothetical protein 0.0042 0.0067 0.0067
Onchocerca volvulus 0.0131 0.0521 0.0521
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0072 0.1243
Echinococcus granulosus high affinity choline transporter 1 0.0381 0.1789 0.1789
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0038 0.0046 0.0893
Schistosoma mansoni hypothetical protein 0.0509 0.2436 0.2436
Schistosoma mansoni tyrosine kinase 0.0181 0.0773 0.0773
Schistosoma mansoni aldo-keto reductase 0.0131 0.0521 0.0521
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0095 0.0287
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Brugia malayi Protein kinase domain containing protein 0.0224 0.0992 0.0992
Brugia malayi TAR-binding protein 0.0062 0.0167 0.0167
Onchocerca volvulus 0.0042 0.0067 0.0067
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1998 1 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.0521 0.0521
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0046 0.0749
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Plasmodium falciparum aldehyde reductase, putative 0.0038 0.0046 0.6473
Loa Loa (eye worm) oxidoreductase 0.0131 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0095 0.0336 0.0336
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0131 0.0521 0.0521
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521
Trichomonas vaginalis aldo/keto reductase, putative 0.0131 0.0521 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0043 0.0072 0.1379
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0072 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0521 0.0521
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0095 0.0287
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0008
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0042 0.0067 0.0067
Onchocerca volvulus Peroxidasin homolog 0.0077 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0008
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0438 0.0438
Schistosoma mansoni topbp1 0.0031 0.0008 0.0008
Brugia malayi Protein kinase domain containing protein 0.0289 0.1322 0.1322
Trichomonas vaginalis aldo/keto reductase, putative 0.0131 0.0521 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Onchocerca volvulus Peroxidase homolog 0.0077 0.0244 0.0244
Schistosoma mansoni tyrosine kinase 0.0181 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0051 0.011 0.011
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0131 0.0521 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0072 0.0485
Mycobacterium tuberculosis Conserved protein 0.0038 0.0046 0.0074
Onchocerca volvulus 0.0131 0.0521 0.0521
Brugia malayi SWIRM domain containing protein 0.0043 0.0072 0.0072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0095 0.0235
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0095 0.0287
Plasmodium vivax aldehyde reductase, putative 0.0038 0.0046 0.6473
Loa Loa (eye worm) hypothetical protein 0.0096 0.0342 0.0342
Loa Loa (eye worm) tyrosinase 1 0.0095 0.0336 0.0336
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0063 0.0063
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0038 0.0046 0.0749
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.1322 0.1322
Loa Loa (eye worm) animal heme peroxidase 0.0077 0.0244 0.0244
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1998 1 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0342 0.0342
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0521 0.1642
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0008 0.1124
Trichomonas vaginalis aldo-keto reductase, putative 0.0131 0.0521 1
Echinococcus multilocularis dual specificity 0.0289 0.1322 0.1322
Onchocerca volvulus 0.0095 0.0336 0.0336
Schistosoma mansoni peroxidasin 0.0077 0.0244 0.0244
Entamoeba histolytica aldose reductase, putative 0.0131 0.0521 0.39
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0244 0.0244
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0038 0.0046 0.0351
Onchocerca volvulus 0.0204 0.0889 0.0889
Trypanosoma brucei prostaglandin f synthase 0.0131 0.0521 0.39
Entamoeba histolytica alcohol dehydrogenase, putative 0.0038 0.0046 0.0292
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0095 0.0663
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0038 0.0046 0.6473
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0034 0.474
Schistosoma mansoni serine/threonine protein kinase 0.1998 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0381 0.1789 0.1789
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0095 0.072
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0008
Loa Loa (eye worm) RNA binding protein 0.0062 0.0167 0.0167
Echinococcus granulosus sodium:glucose cotransporter 0.0042 0.0067 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0048 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0077 0.0244 0.0244
Brugia malayi hypothetical protein 0.0031 0.0008 0.0008
Echinococcus multilocularis 0.0053 0.0122 0.0122
Schistosoma mansoni patched 1 0.0041 0.0063 0.0063
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0244 0.0244
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0072 0.0072
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0072 0.0072
Echinococcus granulosus epidermal growth factor receptor 0.0184 0.0789 0.0789
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0072 1
Brugia malayi NADH-dependent xylose reductase 0.0038 0.0046 0.0046
Leishmania major UDP-galactopyranose mutase 0.0043 0.0072 0.0543
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0008 0.0008
Entamoeba histolytica protein kinase, putative 0.0289 0.1322 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0072 0.021
Entamoeba histolytica protein kinase, putative 0.0289 0.1322 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521
Brugia malayi DnaJ domain containing protein 0.0063 0.0175 0.0175
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0611 0.2958 0.9706
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0629 0.3047 1
Brugia malayi Animal haem peroxidase family protein 0.0077 0.0244 0.0244
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.0336 0.0336
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0063 0.0063
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0072 0.0158
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0131 0.0521 0.0521
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0167 0.0167
Onchocerca volvulus Peroxidase homolog 0.0077 0.0244 0.0244
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0438 0.0438
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.0175 0.325
Echinococcus granulosus aldo keto reductase 0.0131 0.0521 0.0521
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0131 0.0521 0.0521

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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