Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alcohol dehydrogenase 1B (class I), beta polypeptide | Starlite/ChEMBL | References |
Homo sapiens | alcohol dehydrogenase 1A (class I), alpha polypeptide | Starlite/ChEMBL | References |
Equus caballus | Alcohol dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Possible dehydrogenase | alcohol dehydrogenase 1A (class I), alpha polypeptide | 375 aa | 356 aa | 27.0 % |
Trypanosoma cruzi | oxidoreductase, putative | Alcohol dehydrogenase | 374 aa | 318 aa | 20.1 % |
Onchocerca volvulus | Putative ATP-dependent RNA helicase DDX52 | Alcohol dehydrogenase | 374 aa | 337 aa | 21.4 % |
Mycobacterium tuberculosis | Possible dehydrogenase | alcohol dehydrogenase 1B (class I), beta polypeptide | 375 aa | 352 aa | 26.4 % |
Onchocerca volvulus | Alcohol dehydrogenase | 374 aa | 376 aa | 48.9 % | |
Toxoplasma gondii | quinone oxidoreductase, putative | Alcohol dehydrogenase | 374 aa | 323 aa | 23.8 % |
Mycobacterium tuberculosis | Possible dehydrogenase | Alcohol dehydrogenase | 374 aa | 350 aa | 26.0 % |
Candida albicans | likely Zinc-binding dehydrogenase, one of two genes similar to S. cerevisiae YAL060W and BDH1 (YAL060W) butanediol dehydrogenase | Alcohol dehydrogenase | 374 aa | 366 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0265 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 0.0511 | 0.0511 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0031 | 0.0031 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 0.5 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0032 | 0.0511 | 1 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0233 | 0.8682 | 0.8612 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0032 | 0.0511 | 0.5 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0032 | 0.0511 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0032 | 0.0511 | 1 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0265 | 1 | 1 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0032 | 0.0511 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0511 | 0.0511 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0265 | 1 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0265 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0511 | 0.0511 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0265 | 1 | 1 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0265 | 1 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0032 | 0.0511 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0032 | 0.0511 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium ulcerans | oxidoreductase | 0.0032 | 0.0511 | 0.0481 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0021 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | acyl carrier protein | 0.0021 | 0.0031 | 0.0031 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0032 | 0.0511 | 0.0481 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0032 | 0.0511 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0032 | 0.0511 | 0.0511 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 1 |
Leishmania major | d-xylulose reductase, putative | 0.0032 | 0.0511 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0511 | 0.0511 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0021 | 0.0031 | 0.0031 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 0.5 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0265 | 1 | 1 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0032 | 0.0511 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0265 | 1 | 1 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 1 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0265 | 1 | 1 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0265 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0032 | 0.0511 | 0.5 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0032 | 0.0511 | 0.0481 |
Leishmania major | oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Schistosoma mansoni | zinc binding dehydrogenase | 0.0032 | 0.0511 | 0.0511 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0032 | 0.0511 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0233 | 0.8682 | 0.8612 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0265 | 1 | 1 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0032 | 0.0511 | 0.0481 |
Leishmania major | quinone oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0032 | 0.0511 | 0.0481 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0032 | 0.0511 | 1 |
Onchocerca volvulus | 0.0021 | 0.0031 | 0.0031 | |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0021 | 0.0031 | 0.0031 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0032 | 0.0511 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0032 | 0.0511 | 0.0511 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0032 | 0.0511 | 0.0481 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0032 | 0.0511 | 0.0481 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0032 | 0.0511 | 1 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0032 | 0.0511 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 7.2 uM | Inhibition of human alcohol dehydrogenase alpha activity | ChEMBL. | 9572895 |
Ki (binding) | = 7.2 uM | Inhibition of human alcohol dehydrogenase alpha activity | ChEMBL. | 9572895 |
Ki (binding) | = 11 uM | Inhibition of human alcohol dehydrogenase beta 1 activity | ChEMBL. | 9572895 |
Ki (binding) | = 11 uM | Inhibition of human alcohol dehydrogenase beta 1 activity | ChEMBL. | 9572895 |
Ki (binding) | = 16 uM | Inhibition of horse liver alcohol dehydrogenase activity | ChEMBL. | 9572895 |
Ki (binding) | = 16 uM | Inhibition of horse liver alcohol dehydrogenase activity | ChEMBL. | 9572895 |
Ki (binding) | = 30 uM | Inhibition of human alcohol dehydrogenase sigma activity | ChEMBL. | 9572895 |
Ki (binding) | = 30 uM | Inhibition of human alcohol dehydrogenase sigma activity | ChEMBL. | 9572895 |
Ki (binding) | = 100 uM | Inhibition of human alcohol dehydrogenase gamma2 activity | ChEMBL. | 9572895 |
Ki (binding) | = 100 uM | Inhibition of human alcohol dehydrogenase gamma2 activity | ChEMBL. | 9572895 |
Ki (binding) | = 110 uM | Inhibition of human alcohol dehydrogenase pi activity | ChEMBL. | 9572895 |
Ki (binding) | = 110 uM | Inhibition of human alcohol dehydrogenase pi activity | ChEMBL. | 9572895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.