Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0149 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1916 | 0.1916 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1916 | 0.1916 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.0989 | 0.0852 |
Toxoplasma gondii | apocytochrome b, putative | 0.0203 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2513 | 0.2513 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.0989 | 0.0989 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0149 | 0.5 |
Plasmodium vivax | cytochrome b | 0.0203 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2513 | 0.2513 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2513 | 0.2513 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0149 | 0.5 |
Loa Loa (eye worm) | cytochrome b | 0.0203 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0149 | 0.0149 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0149 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2513 | 0.2513 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.0989 | 0.0852 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2513 | 0.2513 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.0989 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0149 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.0989 | 1 |
Brugia malayi | Augmenter of liver regeneration | 0.0035 | 0.0989 | 0.0989 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1029 | 0.1029 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1916 | 0.1916 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2513 | 0.2513 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2513 | 0.2513 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2513 | 0.2513 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1029 | 0.1029 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0149 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2513 | 0.2513 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0149 | 0.0149 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.0989 | 0.0852 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.0989 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2513 | 0.2513 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.0989 | 0.0852 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2513 | 1 |
Schistosoma mansoni | cytochrome b | 0.0203 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2513 | 0.2513 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2513 | 0.2513 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0149 | 0.0149 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1029 | 0.1029 |
Toxoplasma gondii | cytochrome b | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0035 | 0.0989 | 0.0989 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.0989 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0203 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0149 | 0.0149 |
Echinococcus granulosus | cytochrome B | 0.0203 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0149 | 0.0593 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0989 | 1 |
Plasmodium falciparum | cytochrome b | 0.0203 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1916 | 0.1916 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.0989 | 0.3933 |
Schistosoma mansoni | cytochrome b | 0.0203 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.