Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | apocytochrome b, putative | 0.0139 | 0.4206 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.3636 | 0.402 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0648 | 0.0906 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0047 | 0.0474 | 0.067 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0383 | 0.0383 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0115 | 0.3236 | 0.5342 |
Schistosoma mansoni | lipoxygenase | 0.0115 | 0.3236 | 0.3236 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0047 | 0.0474 | 0.0474 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0474 | 0.0663 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0078 | 0.5 |
Brugia malayi | cytochrome b | 0.0139 | 0.4206 | 0.5879 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0184 | 0.599 | 1 |
Schistosoma mansoni | cytochrome b | 0.0139 | 0.4206 | 0.4206 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0383 | 0.0515 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0078 | 0.0109 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0383 | 0.0515 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0078 | 0.5 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0053 | 0.0734 | 0.1026 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0648 | 0.0906 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0047 | 0.0474 | 0.067 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0053 | 0.0734 | 0.111 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0383 | 0.0515 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0078 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0474 | 0.0663 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0474 | 0.0474 |
Toxoplasma gondii | cytochrome b | 0.0139 | 0.4206 | 0.5 |
Onchocerca volvulus | 0.0242 | 0.8338 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0383 | 0.0383 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0139 | 0.4206 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0383 | 0.0535 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0053 | 0.0734 | 0.111 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.3293 | 0.4602 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.3636 | 0.5081 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0053 | 0.0734 | 0.111 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0184 | 0.599 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0047 | 0.0474 | 0.067 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0474 | 0.0474 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.7155 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0383 | 0.0535 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.7155 | 1 |
Plasmodium vivax | cytochrome b | 0.0139 | 0.4206 | 0.5 |
Plasmodium falciparum | cytochrome b | 0.0139 | 0.4206 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.3636 | 0.5081 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0474 | 0.0663 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0648 | 0.0906 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.3293 | 0.4602 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.3636 | 0.402 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0078 | 0.0078 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0115 | 0.3236 | 0.5342 |
Brugia malayi | hypothetical protein | 0.0125 | 0.3636 | 0.5081 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0047 | 0.0474 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0734 | 0.1026 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0078 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.3293 | 0.4602 |
Schistosoma mansoni | cytochrome b | 0.0139 | 0.4206 | 0.4206 |
Echinococcus granulosus | cytochrome B | 0.0139 | 0.4206 | 0.6984 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0648 | 0.0906 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0053 | 0.0734 | 0.0734 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0047 | 0.0474 | 0.067 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.8338 | 0.5 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0053 | 0.0734 | 0.111 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0383 | 0.0515 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | cytochrome b | 0.0139 | 0.4206 | 0.5879 |
Loa Loa (eye worm) | MBCTL1 | 0.0053 | 0.0734 | 0.1026 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.1841 | 0.1841 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.