Detailed information for compound 668773

Basic information

Technical information
  • TDR Targets ID: 668773
  • Name: (E)-N-(5-methyl-1,2-oxazol-3-yl)-3-(4-nitroph enyl)prop-2-enamide
  • MW: 273.244 | Formula: C13H11N3O4
  • H donors: 1 H acceptors: 4 LogP: 2.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1noc(c1)C)C=Cc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C13H11N3O4/c1-9-8-12(15-20-9)14-13(17)7-4-10-2-5-11(6-3-10)16(18)19/h2-8H,1H3,(H,14,15,17)/b7-4+
  • InChiKey: JNIZIUKLBHOELH-QPJJXVBHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-methyl-1,2-oxazol-3-yl)-3-(4-nitrophenyl)prop-2-enamide
  • (E)-N-(5-methylisoxazol-3-yl)-3-(4-nitrophenyl)prop-2-enamide
  • N-(5-methylisoxazol-3-yl)-3-(4-nitrophenyl)prop-2-enamide
  • N-(5-methyl-3-isoxazolyl)-3-(4-nitrophenyl)prop-2-enamide
  • (E)-N-(5-methyl-3-isoxazolyl)-3-(4-nitrophenyl)prop-2-enamide
  • N-(5-methylisoxazol-3-yl)-3-(4-nitrophenyl)acrylamide
  • (E)-N-(5-methylisoxazol-3-yl)-3-(4-nitrophenyl)acrylamide
  • IVK/9088730
  • ZINC00460526

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.005 0.0058
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0119 0.0222
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0577 0.1688
Toxoplasma gondii tRNA ligases class I (M) protein 0.0105 0.115 0.3522
Brugia malayi RNA binding protein 0.0063 0.0647 0.1002
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0119 0.0165
Plasmodium vivax methionine--tRNA ligase, putative 0.0105 0.115 0.3522
Plasmodium vivax hypothetical protein, conserved 0.0105 0.115 0.3522
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1181 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0128 0.0109
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1181 0.1854
Schistosoma mansoni methionine-tRNA synthetase 0.0276 0.3174 0.5038
Echinococcus granulosus snurportin 1 0.0298 0.3436 0.6626
Onchocerca volvulus 0.0036 0.0324 0.1141
Onchocerca volvulus 0.0036 0.0324 0.1141
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0577 0.089
Toxoplasma gondii methionyl-tRNA synthetase 0.0276 0.3174 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0324 0.0487
Echinococcus granulosus dna polymerase kappa 0.0019 0.0128 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0128 0.011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0252 0.0372
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0107 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0577 0.1688
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0171 0.1924 0.3042
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0618 0.722 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0338 0.0508
Loa Loa (eye worm) glutaminase 2 0.0538 0.6281 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0338 0.0319
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0252 0.0451
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2353 0.3726
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0128 0.0109
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0105 0.115 0.1133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0134 0.0184
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0618 0.722 1
Schistosoma mansoni ap endonuclease 0.0037 0.0338 0.0508
Onchocerca volvulus Alhambra homolog 0.0057 0.0577 0.2086
Brugia malayi methionyl-tRNA synthetase 0.0276 0.3174 0.5038
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0057 0.0011
Onchocerca volvulus 0.0023 0.0177 0.0588
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0119 0.0158
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0647 0.1002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0128 0.0211
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0324 0.0487
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0128 0.0173
Brugia malayi Importin beta-1 subunit 0.0028 0.0232 0.0339
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0139
Leishmania major hypothetical protein, conserved 0.0013 0.005 0.0069
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0158
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0128 0.0126
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0128 0.011
Brugia malayi PHD-finger family protein 0.0057 0.0577 0.089
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0276 0.3174 0.841
Loa Loa (eye worm) hypothetical protein 0.0036 0.0324 0.0487
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0119 0.0097
Echinococcus granulosus muscleblind protein 0.0445 0.5176 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0128 0.0177
Giardia lamblia DINP protein human, muc B family 0.0019 0.0128 0.0252
Brugia malayi Pre-SET motif family protein 0.003 0.0252 0.0372
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.1181 0.1739
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0105 0.115 0.2864
Loa Loa (eye worm) hypothetical protein 0.0028 0.0232 0.0339
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0246 0.063
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0324 0.0441
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1181 0.1635
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0119 0.0158
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0119 0.0192
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0324 0.0625
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.1181 0.3349
Plasmodium falciparum methionine--tRNA ligase 0.0276 0.3174 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0246 0.063
Entamoeba histolytica Ran family GTPase 0.0021 0.0144 0.0837
Leishmania major DNA polymerase eta, putative 0.0019 0.0128 0.0177
Trypanosoma brucei unspecified product 0.0013 0.0057 0.0011
Leishmania major leucyl-tRNA synthetase, putative 0.0105 0.115 0.1593
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0246 0.1739
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1181 0.1577
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0276 0.3174 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0177 0.0245
Trypanosoma brucei unspecified product 0.0013 0.0057 0.0011
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0338 0.0374
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0577 0.089
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0086 0.0106
Loa Loa (eye worm) hypothetical protein 0.0057 0.0577 0.089
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0324 0.0353
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0324 0.0449
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0158
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2609 0.6868
Trypanosoma brucei unspecified product 0.0019 0.0128 0.011
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.005 0.0058
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1181 0.1815
Loa Loa (eye worm) beta-lactamase 0.0036 0.0324 0.0487
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0119 0.0099
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0246 0.0316
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0144 0.0199
Toxoplasma gondii ABC1 family protein 0.0036 0.0324 0.088
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0177 0.0113
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0177 0.0113
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0577 0.1081
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0128 0.0177
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1181 1
Loa Loa (eye worm) glutaminase 0.0538 0.6281 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0128 0.011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0978 0.1859
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1181 0.1854
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0338 0.0662
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0128 0.011
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0647 0.1002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.093 0.1288
Schistosoma mansoni hypothetical protein 0.0019 0.0122 0.0163
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0324 0.0383
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0276 0.3174 0.5038
Schistosoma mansoni ap endonuclease 0.0037 0.0338 0.0508
Schistosoma mansoni jumonji domain containing protein 0.0148 0.166 0.2621
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0338 0.0978
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.1181 0.1163
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0338 0.0402
Brugia malayi AF-10 protein 0.0019 0.0122 0.0163
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0246 0.0316
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0338 0.0462
Giardia lamblia PHD finger protein 15 0.0057 0.0577 0.1688
Echinococcus multilocularis leucyl tRNA synthetase 0.0105 0.115 0.1133
Schistosoma mansoni importin beta-1 0.0028 0.0232 0.0339
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0128 0.011
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0246 0.0316
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0246 0.0316
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.1181 0.2252
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0107 0.0183
Echinococcus granulosus GPCR family 2 0.0016 0.0086 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0057 0.0011
Mycobacterium ulcerans hypothetical protein 0.0036 0.0324 0.0353
Echinococcus granulosus dna polymerase eta 0.0019 0.0128 0.0211
Echinococcus multilocularis muscleblind protein 1 0.0445 0.5176 0.5166
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0324 0.0625
Schistosoma mansoni DNA polymerase eta 0.0019 0.0128 0.0173
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0119 0.0099
Loa Loa (eye worm) hypothetical protein 0.0023 0.0177 0.0251
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0647 0.0629
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0276 0.3174 0.4357
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0246 0.063
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0144 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0128 0.011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0324 0.0487
Mycobacterium tuberculosis Conserved hypothetical protein 0.0325 0.3756 1
Toxoplasma gondii exonuclease III APE 0.0037 0.0338 0.0922
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0338 0.0922
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0139
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0252 0.0372
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0139
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0128 0.0109
Entamoeba histolytica hypothetical protein 0.0023 0.0169 0.1056
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0232 0.0254
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0647 0.1002
Echinococcus multilocularis GPCR, family 2 0.0016 0.0086 0.0067
Loa Loa (eye worm) hypothetical protein 0.0098 0.106 0.1662
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0128 0.011
Schistosoma mansoni methionine-tRNA synthetase 0.0105 0.115 0.1806
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0338 0.0922
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0122 0.023
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0246 0.0316
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0719 0.1357
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0119 0.0158
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0177 0.0113
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0177 0.1123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0239 0.0426
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0338 0.0468
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0252 0.0233
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0128 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0057 0.0011
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0119 0.0158
Brugia malayi jmjC domain containing protein 0.0018 0.0119 0.0158
Onchocerca volvulus 0.0235 0.2691 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0177 0.0251
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0086 0.0106
Brugia malayi Bromodomain containing protein 0.0057 0.0577 0.089
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0324 0.0441
Schistosoma mansoni ran 0.0021 0.0144 0.0199
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0338 0.0468
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0324 0.0625
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0122 0.01
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0128 0.011
Loa Loa (eye worm) hypothetical protein 0.0105 0.115 0.1806
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0302 0.0451
Echinococcus multilocularis snurportin 1 0.0298 0.3436 0.3423
Plasmodium falciparum importin beta, putative 0.0028 0.0232 0.0583
Loa Loa (eye worm) hypothetical protein 0.0445 0.5176 0.8234
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0144 0.0125
Onchocerca volvulus 0.0011 0.0026 0.0024
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0128 0.0035
Mycobacterium ulcerans hypothetical protein 0.0023 0.0177 0.0113
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0324 0.0487
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0246 0.1337
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0276 0.3174 0.4396
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0324 0.088
Brugia malayi beta-lactamase 0.0036 0.0324 0.0487
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0128 0.0126
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1181 0.1854
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0139
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0324 0.0441
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0978 0.096
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0246 0.0316
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.1297 0.204
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0719 0.0701
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0647 0.1002
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0232 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.005 0.0069
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0119 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0324 0.0441
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0276 0.3174 1
Brugia malayi PHD-finger family protein 0.0019 0.0122 0.0163
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0324 0.0591
Echinococcus granulosus importin subunit beta 1 0.0028 0.0232 0.0411
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0122 0.023
Brugia malayi phosphofructokinase 0.0108 0.1181 0.1854
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0324 0.0487
Leishmania major hypothetical protein, conserved 0.0036 0.0324 0.0449
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0128 0.0173
Giardia lamblia Methionyl-tRNA synthetase 0.0276 0.3174 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0128 0.011
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.093 0.1227
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0144 0.0242
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0128 0.0173
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0246 0.063
Chlamydia trachomatis methionine--tRNA ligase 0.0105 0.115 1
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0324 0.0493
Schistosoma mansoni hypothetical protein 0.0012 0.0048 0.0045
Mycobacterium tuberculosis Conserved protein 0.0036 0.0324 0.0625
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0232 0.0583
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0119 0.0222
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0119 0.0099
Echinococcus multilocularis peregrin 0.0057 0.0577 0.0558
Leishmania major importin beta-1 subunit, putative 0.0023 0.0169 0.0234
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0618 0.722 1
Brugia malayi 6-phosphofructokinase 0.0108 0.1181 0.1854
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.3365 0.466
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0488 0.0747
Brugia malayi methionyl-tRNA synthetase 0.0105 0.115 0.1806
Mycobacterium tuberculosis Conserved protein 0.0036 0.0324 0.0625
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0177 0.0113
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0187 0.2116 0.4066
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0324 0.0625
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0105 0.115 0.169
Leishmania major mitochondrial DNA polymerase beta 0.0618 0.722 1
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2691 0.4239
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0488 0.0747
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0324 0.0487
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0842 0.0824
Loa Loa (eye worm) hypothetical protein 0.0019 0.0122 0.0163
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0177 0.1123
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0246 0.1337
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1181 0.1815
Loa Loa (eye worm) RNA binding protein 0.0063 0.0647 0.1002
Loa Loa (eye worm) hypothetical protein 0.005 0.0488 0.0747
Brugia malayi TAR-binding protein 0.0063 0.0647 0.1002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.093 0.1288
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0144 0.02
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0647 0.1002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0128 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0128 0.011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0324 0.0487
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0107 0.0183
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0177 0.0245
Mycobacterium ulcerans beta-lactamase 0.0036 0.0324 0.0353
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0324 0.0625
Plasmodium falciparum phd finger protein, putative 0.0057 0.0577 0.1688
Plasmodium vivax importin-beta 2, putative 0.0028 0.0232 0.0583
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0177 0.1123
Trichomonas vaginalis esterase, putative 0.0036 0.0324 0.0441
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0177 0.0221
Mycobacterium ulcerans hypothetical protein 0.0325 0.3756 0.591
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0128 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0324 0.0449
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0978 0.1531
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0338 0.0468
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0276 0.3174 0.5014
Schistosoma mansoni hypothetical protein 0.0057 0.0577 0.089
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0842 0.1595
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0086 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0252 0.0372
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0128 0.0089
Schistosoma mansoni hypothetical protein 0.0034 0.0302 0.0451
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0324 0.0306
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0128 0.0177
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0105 0.115 0.2193
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0086 0.0067
Brugia malayi protein ZK524.3 0.0105 0.115 0.1806
Plasmodium vivax methionine--tRNA ligase, putative 0.0276 0.3174 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0122 0.023
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0276 0.3174 0.4968
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0119 0.0192
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0169 0.0192
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0577 0.1688
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0169 0.0234
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0324 0.0441
Plasmodium vivax SET domain protein, putative 0.003 0.0252 0.0649
Plasmodium falciparum methionine--tRNA ligase, putative 0.0105 0.115 0.3522
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0106
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0144 0.0303
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1181 0.1854
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0232 0.0254
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.1155 0.1599
Echinococcus granulosus methionine tRNA synthetase 0.0276 0.3174 0.6118
Mycobacterium leprae Probable lipase LipE 0.0036 0.0324 0.0493
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0187 0.2116 0.21
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0978 0.096
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0719 0.1117
Loa Loa (eye worm) hypothetical protein 0.0105 0.115 0.1806
Echinococcus multilocularis muscleblind protein 0.0445 0.5176 0.5166
Leishmania major DNA polymerase kappa, putative 0.0019 0.0128 0.0177
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0128 0.0695
Brugia malayi jmjC domain containing protein 0.0018 0.0119 0.0158
Trichomonas vaginalis ran, putative 0.0021 0.0144 0.0152
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0144 0.0303
Onchocerca volvulus 0.0036 0.0324 0.1141
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0139
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0045
Schistosoma mansoni ran 0.0021 0.0144 0.0199
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0128 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0128 0.0177
Brugia malayi jmjC domain containing protein 0.0069 0.0719 0.1117
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.005 0.003
Chlamydia trachomatis leucine--tRNA ligase 0.0105 0.115 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0169 0.0192
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.005 0.0048
Leishmania major GTP-binding protein, putative 0.0021 0.0144 0.02
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0119 0.0192
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0338 0.0617
Mycobacterium ulcerans glutaminase 0.0538 0.6281 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0177 0.0113
Schistosoma mansoni hypothetical protein 0.0298 0.3436 0.5456
Loa Loa (eye worm) hypothetical protein 0.0036 0.0324 0.0487
Brugia malayi 6-phosphofructokinase 0.0108 0.1181 0.1854
Leishmania major methionyl-tRNA synthetase, putative 0.0276 0.3174 0.4396
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.005 0.0048
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0324 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0128 0.011
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0177 0.0113
Loa Loa (eye worm) hypothetical protein 0.0036 0.0324 0.0487
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0169 0.0192
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0122 0.023
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0105 0.115 0.973
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0122 0.01
Echinococcus multilocularis 0.0013 0.005 0.003
Mycobacterium tuberculosis Conserved protein 0.0036 0.0324 0.0625
Brugia malayi jmjC domain containing protein 0.0018 0.0119 0.0158
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0086 0.0129
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0128 0.0089
Onchocerca volvulus 0.0171 0.1924 0.7129
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0177 0.0245
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0324 0.0625
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0144 0.02
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.3365 0.466
Loa Loa (eye worm) phosphofructokinase 0.0108 0.1181 0.1854
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0719 0.1117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0177 0.0251
Brugia malayi jmjC domain containing protein 0.0187 0.2116 0.3348
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0177 0.0221
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0246 0.063
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.1181 0.1635
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0978 0.1531
Leishmania major hypothetical protein, conserved 0.0018 0.0119 0.0165
Giardia lamblia Leucyl-tRNA synthetase 0.0105 0.115 0.3522
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0338 0.2548
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0338 0.0922
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0134 0.0184
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0647 0.1002
Schistosoma mansoni glutaminase 0.0538 0.6281 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0119 0.0158
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0252 0.0649
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0086 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0647 0.1002
Toxoplasma gondii hypothetical protein 0.01 0.1081 0.3301
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0119 0.0158
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.005 0.0048
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1181 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1181 0.1815
Brugia malayi Muscleblind-like protein 0.0445 0.5176 0.8234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0978 0.1531
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0119 0.0165
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.1181 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0128 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0252 0.0372
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0338 0.0462
Trichomonas vaginalis glutaminase, putative 0.0538 0.6281 1
Brugia malayi RNA, U transporter 1 0.0079 0.0842 0.1314
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0106
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0488 0.0747
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0128 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0978 0.1531
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0119 0.0158
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0119 0.0099
Mycobacterium ulcerans lipase LipD 0.0036 0.0324 0.0353
Echinococcus granulosus tar DNA binding protein 0.0063 0.0647 0.1217
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0144 0.0199
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0128 0.0177
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0577 0.0558
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0119 0.0192
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0252 0.0233
Onchocerca volvulus 0.003 0.0252 0.0871
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0144 0.0303
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0144 0.0303
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0119 0.0099
Echinococcus granulosus phd:f box containing protein 0.0018 0.0119 0.0192
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.0048
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0246 0.063
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0119 0.0158
Treponema pallidum methionyl-tRNA synthetase 0.0105 0.115 0.9674
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.3436 0.5456
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0177 0.0113
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0128 0.0173
Schistosoma mansoni leucyl-tRNA synthetase 0.0105 0.115 0.1806
Echinococcus multilocularis methionine tRNA synthetase 0.0276 0.3174 0.3161
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0292 0.3365 0.4623
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0177 0.0251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0978 0.1531
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1181 0.1815
Brugia malayi Pre-SET motif family protein 0.0207 0.2353 0.3726
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0324 0.0625
Echinococcus granulosus peregrin 0.0057 0.0577 0.1081
Loa Loa (eye worm) hypothetical protein 0.0445 0.5176 0.8234
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0246 0.063
Brugia malayi jmjC domain containing protein 0.0018 0.0119 0.0158
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0246 0.0316
Loa Loa (eye worm) hypothetical protein 0.0023 0.0177 0.0251
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0338 0.0508
Plasmodium vivax JmjC domain containing protein 0.0018 0.0119 0.0222
Brugia malayi beta-lactamase family protein 0.0036 0.0324 0.0487
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0086 0.0067
Loa Loa (eye worm) hypothetical protein 0.0105 0.115 0.1806
Treponema pallidum leucyl-tRNA synthetase 0.0105 0.115 0.9674
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0177 0.0251
Brugia malayi glutaminase DH11.1 0.0538 0.6281 1
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.093 0.1288
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0246 0.063
Loa Loa (eye worm) hypothetical protein 0.003 0.0252 0.0372
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0647 0.1002
Brugia malayi beta-lactamase family protein 0.0036 0.0324 0.0487
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0978 0.1859
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.1181 0.2964
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0719 0.1117

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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