Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.052 | 0.0979 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0375 | 0.5485 | 0.9802 |
Echinococcus granulosus | ectonucleotide | 0.0142 | 0.1821 | 0.8134 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0169 | 0.2239 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2239 | 0.4211 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0256 | 0.3604 | 0.6211 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0662 | 0.1245 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0365 | 0.5317 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0043 | 0.0254 | 0.1134 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0086 | 0.0942 | 0.1772 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0382 | 0.5596 | 0.2188 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.4363 | 0.7691 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0169 | 0.2239 | 0.4211 |
Echinococcus granulosus | dna polymerase kappa | 0.0043 | 0.0254 | 0.1134 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0142 | 0.1821 | 0.8134 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0254 | 0.2154 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0304 | 0.4363 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.4363 | 0.7691 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.0662 | 0.5618 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0.0146 | 0.1238 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0254 | 0.2154 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0375 | 0.5485 | 0.5506 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0254 | 0.2154 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0102 | 0.1178 | 1 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0136 | 0.1723 | 0.3079 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0662 | 0.5618 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0102 | 0.1178 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.052 | 0.0522 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0086 | 0.0942 | 0.4208 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.066 | 0.9962 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0169 | 0.2239 | 0.4211 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0254 | 0.2154 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0382 | 0.5596 | 0.5617 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0662 | 0.2956 |
Trypanosoma cruzi | endonuclease G, putative | 0.0102 | 0.1178 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.4363 | 0.7691 |
Echinococcus granulosus | Endonuclease G | 0.0102 | 0.1178 | 0.5262 |
Onchocerca volvulus | 0.0031 | 0.007 | 0.0132 | |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0663 | 1 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0169 | 0.2239 | 0.4211 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0254 | 0.2154 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0149 | 0.1917 | 0.1925 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.0457 | 0.086 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.0091 | 0.0769 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.0091 | 0.0769 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.052 | 0.0522 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0207 | 0.0925 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0169 | 0.2239 | 0.4211 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0254 | 0.2154 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.052 | 0.2325 |
Onchocerca volvulus | 0.0169 | 0.2239 | 0.4211 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0254 | 0.2154 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0207 | 0.0925 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.007 | 0.0314 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.0254 | 0.0255 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.007 | 0.0132 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.4363 | 0.7691 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0123 | 0.1511 | 0.675 |
Trypanosoma brucei | endonuclease G, putative | 0.0102 | 0.1178 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.0662 | 0.1517 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.052 | 0.2325 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.4363 | 0.7691 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.4363 | 0.7691 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Onchocerca volvulus | 0.0086 | 0.0942 | 0.1772 | |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0237 | 0.3307 | 0.5909 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.4363 | 0.7691 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0102 | 0.1178 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0284 | 0.4053 | 0.7623 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0086 | 0.0942 | 0.1772 |
Mycobacterium ulcerans | glutaminase | 0.0284 | 0.4053 | 0.4069 |
Trypanosoma cruzi | endonuclease G, putative | 0.0102 | 0.1178 | 1 |
Brugia malayi | polk-prov protein | 0.0032 | 0.0091 | 0.017 |
Onchocerca volvulus | 0.0246 | 0.3457 | 0.6501 | |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0663 | 1 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.007 | 0.5 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0237 | 0.3307 | 0.5612 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0662 | 0.4414 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.007 | 0.0132 |
Trichomonas vaginalis | glutaminase, putative | 0.0284 | 0.4053 | 0.7113 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.007 | 0.0314 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0052 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2239 | 0.4211 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.4363 | 0.7691 |
Loa Loa (eye worm) | glutaminase 2 | 0.0284 | 0.4053 | 0.7623 |
Schistosoma mansoni | endonuclease related | 0.0102 | 0.1178 | 0.2216 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0149 | 0.1917 | 0.2814 |
Trypanosoma brucei | endonuclease G, putative | 0.0102 | 0.1178 | 1 |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0027 | 0 | 0.5 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0102 | 0.1178 | 0.2216 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0254 | 0.2154 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0091 | 0.017 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0254 | 0.2154 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.007 | 0.0314 |
Brugia malayi | Pre-SET motif family protein | 0.0217 | 0.2986 | 0.5616 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.0931 | 0.175 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0662 | 0.2956 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0304 | 0.4363 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0375 | 0.5485 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.066 | 0.9962 | 0.9933 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.007 | 0.0132 |
Onchocerca volvulus | 0.0169 | 0.2239 | 0.4211 | |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.007 | 0.0132 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.0662 | 0.1245 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0136 | 0.1723 | 0.1729 |
Schistosoma mansoni | glutaminase | 0.0284 | 0.4053 | 0.7623 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0304 | 0.4363 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0102 | 0.1178 | 1 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0382 | 0.5596 | 1 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0256 | 0.3604 | 0.3618 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.0146 | 0.1238 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.006 | 0.052 | 0.0979 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0127 | 0.1574 | 0.2122 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.006 | 0.052 | 0.4418 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0942 | 0.1772 |
Schistosoma mansoni | hypothetical protein | 0.0365 | 0.5317 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0217 | 0.2986 | 0.5616 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.0254 | 0.0255 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0142 | 0.1821 | 0.8134 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0102 | 0.1178 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0254 | 0.2154 |
Loa Loa (eye worm) | glutaminase | 0.0284 | 0.4053 | 0.7623 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0123 | 0.1511 | 0.675 |
Leishmania major | endonuclease G, putative | 0.0102 | 0.1178 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0662 | 0.1245 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0662 | 0.4414 |
Trichomonas vaginalis | set domain proteins, putative | 0.0246 | 0.3457 | 0.5995 |
Echinococcus multilocularis | Endonuclease G | 0.0102 | 0.1178 | 0.5262 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0256 | 0.3604 | 0.644 |
Schistosoma mansoni | lipoxygenase | 0.0123 | 0.1511 | 0.2842 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0149 | 0.1917 | 0.3427 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2239 | 0.4211 |
Onchocerca volvulus | 0.0365 | 0.5317 | 1 | |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0136 | 0.1723 | 0.2422 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0086 | 0.0942 | 0.4208 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.007 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1821 | 0.3425 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0382 | 0.5596 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0254 | 0.2154 |
Echinococcus multilocularis | ectonucleotide | 0.0142 | 0.1821 | 0.8134 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0169 | 0.2239 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0365 | 0.5317 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.007 | 0.0132 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.