TDR Targets

Basic information

Technical information

TDR Targets ID: 676891
Name: ethyl 2-[(5E)-5-[[5-(4-chloro-2-nitrophenyl)f uran-2-yl]methylidene]-2,4-dioxo-1,3-thiazoli din-3-yl]acetate
MW: 436.823 | Formula: C18H13ClN2O7S
H donors: 0 H acceptors: 5 LogP: 3.89 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)CN1C(=O)S/C(=C/c2ccc(o2)c2ccc(cc2[N+](=O)[O-])Cl)/C1=O
InChi: 1S/C18H13ClN2O7S/c1-2-27-16(22)9-20-17(23)15(29-18(20)24)8-11-4-6-14(28-11)12-5-3-10(19)7-13(12)21(25)26/h3-8H,2,9H2,1H3/b15-8+
InChiKey: VJENEWYIPMWWFJ-OVCLIPMQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 2-[(5E)-5-[[5-(4-chloro-2-nitro-phenyl)-2-furyl]methylene]-2,4-dioxo-thiazolidin-3-yl]acetate
2-[(5E)-5-[[5-(4-chloro-2-nitrophenyl)-2-furyl]methylene]-2,4-dioxo-3-thiazolidinyl]acetic acid ethyl ester
2-[(5E)-5-[[5-(4-chloro-2-nitro-phenyl)-2-furyl]methylene]-2,4-diketo-thiazolidin-3-yl]acetic acid ethyl ester
ethyl 2-[(5E)-5-[[5-(4-chloro-2-nitro-phenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethanoate
ZINC08383920
AH-487/40935463

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0335	0.1913	0.4781
Giardia lamblia	Kinase, PLK	0.0104	0.0527	0.9877
Mycobacterium tuberculosis	Probable lipase LipD	0.0117	0.0605	0.0793
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0117	0.0605	0.0793
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0527	0.8673
Mycobacterium tuberculosis	Probable esterase LipL	0.0117	0.0605	0.0793
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0052	0.0591
Schistosoma mansoni	hypothetical protein	0.004	0.0147	0.0365
Echinococcus multilocularis	microtubule associated protein 2	0.0683	0.4	0.3999
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0104	0.0527	0.8673
Trichomonas vaginalis	CAMK family protein kinase	0.0052	0.0216	0.3385
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0605	0.1395
Schistosoma mansoni	ap endonuclease	0.0019	0.0017	0.004
Giardia lamblia	PHD finger protein 15	0.003	0.0083	0.1286
Schistosoma mansoni	survival motor neuron protein	0.0151	0.0809	0.2019
Trypanosoma cruzi	hypothetical protein, conserved	0.0117	0.0605	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0498	0.1243
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0052	0.0591
Echinococcus granulosus	expressed conserved protein	0.0091	0.0454	0.1045
Echinococcus multilocularis	mitogen activated protein kinase	0.0105	0.0534	0.0533
Trypanosoma brucei	hypothetical protein, conserved	0.0117	0.0605	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0105	0.0534	0.878
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0104	0.0527	0.612
Echinococcus multilocularis	protein patched	0.0042	0.0156	0.0155
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.012	0.0139
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.0488	0.1125
Schistosoma mansoni	microtubule-associated protein tau	0.0683	0.4	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0105	0.0534	0.878
Echinococcus granulosus	mitogen activated protein kinase 3	0.0105	0.0534	0.1229
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.0527	0.1316
Echinococcus granulosus	survival motor neuron protein 1	0.0739	0.4333	1
Schistosoma mansoni	ran	0.0023	0.0044	0.0107
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0044	0.0457
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0044	0.3514
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0156	0.2363
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0121	0.03
Mycobacterium tuberculosis	Conserved protein	0.0117	0.0605	0.0793
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0527	0.8673
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0052	0.4545
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0489	0.1127
Schistosoma mansoni	hypothetical protein	0.003	0.0083	0.0206
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0527	0.8673
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0058	0.0697
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0052	0.0591
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.0489	0.0488
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0083	0.1129
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0332	0.0765
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0144	0.0768	0.1772
Schistosoma mansoni	hypothetical protein	0.0151	0.0809	0.2019
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0527	0.8673
Onchocerca volvulus		0.0117	0.0605	0.7196
Mycobacterium ulcerans	hypothetical protein	0.0117	0.0605	0.0793
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.012	0.1749
Brugia malayi	hypothetical protein	0.0071	0.0332	0.0767
Loa Loa (eye worm)	MH2 domain-containing protein	0.0234	0.1307	0.3015
Trichomonas vaginalis	ran, putative	0.0023	0.0044	0.0457
Schistosoma mansoni	hypothetical protein	0.0181	0.0989	0.2471
Mycobacterium tuberculosis	Conserved protein	0.0117	0.0605	0.0793
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0534	0.878
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0117	0.0605	0.0793
Echinococcus granulosus	mitogen activated protein kinase	0.0105	0.0534	0.1229
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.0768	0.1919
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0144	0.0768	0.0768
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0052	0.0591
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0058	0.0697
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0094	0.1301
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0105	0.0534	0.0533
Entamoeba histolytica	hypothetical protein	0.0071	0.0332	0.618
Schistosoma mansoni	importin beta-1	0.0031	0.0094	0.0231
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0052	0.0591
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0057	0.0246	0.0568
Brugia malayi	MH2 domain containing protein	0.0016	0.0001	0.0002
Brugia malayi	Importin beta-1 subunit	0.0031	0.0094	0.0216
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.0368	0.0919
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0121	0.012
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0094	0.1301
Loa Loa (eye worm)	inositol-1	0.0036	0.012	0.0275
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0121	0.03
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0105	0.0534	0.878
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0153	0.0351
Loa Loa (eye worm)	beta-lactamase	0.0117	0.0605	0.1395
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.0527	0.8673
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.0332	0.0331
Echinococcus granulosus	geminin	0.0181	0.0989	0.2281
Echinococcus multilocularis	geminin	0.0181	0.0989	0.0988
Trichomonas vaginalis	D-aminoacylase, putative	0.0117	0.0605	1
Entamoeba histolytica	hypothetical protein	0.0025	0.0058	0.0803
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0144	0.0768	0.1772
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0534	0.878
Brugia malayi	CHE-14 protein	0.0042	0.0156	0.036
Loa Loa (eye worm)	hypothetical protein	0.0739	0.4333	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.012	0.1749
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0117	0.0605	0.1395
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0094	0.1301
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.012	0.0275
Trypanosoma brucei	protein kinase, putative	0.0105	0.0534	0.878
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0605	0.1395
Brugia malayi	beta-lactamase	0.0117	0.0605	0.1397
Plasmodium falciparum	importin beta, putative	0.0031	0.0094	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0605	0.1395
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0527	0.8673
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0104	0.0527	0.1215
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0105	0.0534	0.878
Mycobacterium tuberculosis	Probable hydrolase	0.0117	0.0605	0.0793
Schistosoma mansoni	inositol monophosphatase	0.0036	0.012	0.0297
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0104	0.0527	1
Echinococcus multilocularis	snurportin 1	0.0335	0.1913	0.1912
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0094	0.0214
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.012	0.0119
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0121	0.0277
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0117	0.0605	0.1511
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0057	0.0246	0.0612
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0335	0.1913	0.4414
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0121	0.0277
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.0768	0.1919
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0044	0.0099
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0094	0.1301
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0058	0.0697
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0534	0.878
Onchocerca volvulus		0.0151	0.0809	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0017	0.0016
Brugia malayi	MH2 domain containing protein	0.0016	0.0001	0.0002
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.0489	0.9255
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0044	0.0457
Brugia malayi	MH2 domain containing protein	0.0234	0.1307	0.3016
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.012	0.1749
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0212	0.0488
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0153	0.0152
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0052	0.4545
Schistosoma mansoni	ap endonuclease	0.0019	0.0017	0.004
Schistosoma mansoni	hypothetical protein	0.004	0.0147	0.0365
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0058	0.0697
Trichomonas vaginalis	CMGC family protein kinase	0.0105	0.0534	0.878
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0105	0.0534	0.878
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0211	0.0484
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0044	0.0457
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.0489	0.1129
Schistosoma mansoni	inositol monophosphatase	0.0036	0.012	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0605	0.1395
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.012	0.1749
Echinococcus multilocularis	survival motor neuron protein 1	0.0739	0.4333	0.4332
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0105	0.0534	0.878
Trichomonas vaginalis	esterase, putative	0.0117	0.0605	1
Brugia malayi	PHD-finger family protein	0.003	0.0083	0.0193
Brugia malayi	Smad1	0.0016	0.0001	0.0002
Entamoeba histolytica	hypothetical protein	0.0071	0.0332	0.618
Mycobacterium ulcerans	lipase LipD	0.0117	0.0605	0.0793
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	0.1256	0.7434	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0151	0.0809	0.1866
Schistosoma mansoni	kinase	0.0053	0.0224	0.0558
Schistosoma mansoni	serine/threonine protein kinase	0.0105	0.0534	0.1332
Entamoeba histolytica	hypothetical protein	0.0071	0.0332	0.618
Trichomonas vaginalis	CAMK family protein kinase	0.0052	0.0216	0.3385
Brugia malayi	RNA, U transporter 1	0.0089	0.044	0.1016
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.0527	0.8673
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0053	0.0223	0.0512
Echinococcus granulosus	peregrin	0.003	0.0083	0.019
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0527	0.8673
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0044	0.0521
Mycobacterium ulcerans	beta-lactamase	0.0117	0.0605	0.0793
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.012	0.2017
Toxoplasma gondii	ABC1 family protein	0.0117	0.0605	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0083	0.019
Mycobacterium ulcerans	esterase/lipase LipP	0.0117	0.0605	0.0793
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0044	0.0457
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0104	0.0527	0.0526
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.0488	0.0487
Trypanosoma brucei	polo-like protein kinase	0.0104	0.0527	0.8673
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0017	0.0037
Brugia malayi	serine/threonine-protein kinase plk-2	0.0104	0.0527	0.1217
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0117	0.0605	0.1397
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0044	0.0099
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0117	0.0605	0.0793
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0083	0.019
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0097	0.0108
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0017	0.5
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.012	0.1749
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0605	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0605	0.1395
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0094	0.0093
Loa Loa (eye worm)	hypothetical protein	0.003	0.0083	0.019
Entamoeba histolytica	hypothetical protein	0.0071	0.0332	0.618
Brugia malayi	Bromodomain containing protein	0.003	0.0083	0.0193
Brugia malayi	MH1 domain containing protein	0.0016	0.0001	0.0002
Schistosoma mansoni	hypothetical protein	0.004	0.0147	0.0365
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	0.1256	0.7434	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0273	0.0628
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.074	0.0739
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0057	0.0246	0.0245
Brugia malayi	beta-lactamase family protein	0.0117	0.0605	0.1397
Echinococcus multilocularis	peregrin	0.003	0.0083	0.0082
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.012	0.1749
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0057	0.0246	0.0309
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0144	0.0768	0.0768
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0094	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0052	0.0117
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0057	0.0246	0.0309
Brugia malayi	jmjC domain containing protein	0.0097	0.0488	0.1127
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0105	0.0534	0.1229
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0117	0.0605	0.0604
Trichomonas vaginalis	penicillin-binding protein, putative	0.0117	0.0605	1
Leishmania major	hypothetical protein, conserved	0.0117	0.0605	1
Mycobacterium leprae	conserved hypothetical protein	0.0117	0.0605	1
Schistosoma mansoni	hypothetical protein	0.0181	0.0989	0.2471
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0144	0.0768	0.1774
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.012	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0156	0.0358
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0117	0.0605	0.1511
Brugia malayi	hypothetical protein	0.0024	0.0052	0.012
Brugia malayi	MAP kinase sur-1	0.0105	0.0534	0.1231
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0057	0.0246	0.0309
Onchocerca volvulus		0.0117	0.0605	0.7196
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0156	0.0358
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0746	0.4376	0.5877
Echinococcus granulosus	microtubule associated protein 2	0.0683	0.4	0.9232
Mycobacterium tuberculosis	Probable lipase LipE	0.0117	0.0605	0.0793
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0156	0.0358
Entamoeba histolytica	Ran family GTPase	0.0023	0.0044	0.0527
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0156	0.0155
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0105	0.0534	0.878
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0057	0.0246	0.0565
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0017	0.0037
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0117	0.0605	0.0793
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0527	0.8673
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0156	0.0358
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0454	0.0453
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0104	0.0527	0.1215
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0083	0.0206
Schistosoma mansoni	hypothetical protein	0.004	0.0147	0.0365
Plasmodium vivax	hypothetical protein, conserved	0.0117	0.0605	1
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0191	0.019
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.0768	0.1919
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0083	0.1129
Echinococcus granulosus	snurportin 1	0.0335	0.1913	0.4414
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.012	0.1749
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.0489	0.1127
Echinococcus granulosus	beta LACTamase domain containing family member	0.0117	0.0605	0.1395
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0058	0.0697
Leishmania major	GTP-binding protein, putative	0.0023	0.0044	0.0457
Trichomonas vaginalis	D-aminoacylase, putative	0.0117	0.0605	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0044	0.0043
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.074	0.1705
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0017	0.0039
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0105	0.0534	0.878
Schistosoma mansoni	ran	0.0023	0.0044	0.0107
Onchocerca volvulus		0.0117	0.0605	0.7196
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0144	0.0768	0.1772
Loa Loa (eye worm)	transcription factor SMAD2	0.0234	0.1307	0.3015
Giardia lamblia	Kinase, CMGC MAPK	0.0105	0.0534	1
Leishmania major	hypothetical protein, conserved	0.0024	0.0052	0.0591
Mycobacterium tuberculosis	Conserved protein	0.0117	0.0605	0.0793
Brugia malayi	MH1 domain containing protein	0.0016	0.0001	0.0002
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0044	0.0457
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0083	0.1129
Trichomonas vaginalis	penicillin-binding protein, putative	0.0117	0.0605	1
Brugia malayi	Inositol-1	0.0036	0.012	0.0277
Brugia malayi	beta-lactamase family protein	0.0117	0.0605	0.1397
Trichomonas vaginalis	D-aminoacylase, putative	0.0117	0.0605	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0083	0.0082
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0044	0.0101
Plasmodium falciparum	phd finger protein, putative	0.003	0.0083	0.8677
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0332	0.0828
Trypanosoma cruzi	hypothetical protein, conserved	0.0117	0.0605	1
Brugia malayi	hypothetical protein	0.0739	0.4333	1
Schistosoma mansoni	hypothetical protein	0.0071	0.0332	0.0828
Schistosoma mansoni	patched 1	0.0042	0.0156	0.0388
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0057	0.0246	0.3891
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.012	0.1749
Brugia malayi	jmjC domain containing protein	0.0036	0.0121	0.0279
Mycobacterium leprae	Probable lipase LipE	0.0117	0.0605	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 676891