TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 368.43 | Formula: C20H24N4O3
H donors: 5 H acceptors: 3 LogP: 1.88 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: NCCNc1ccc(c2c1C(=O)c1c(C2=O)cccc1)NCCNCCO
InChi: 1S/C20H24N4O3/c21-7-8-23-15-5-6-16(24-10-9-22-11-12-25)18-17(15)19(26)13-3-1-2-4-14(13)20(18)27/h1-6,22-25H,7-12,21H2
InChiKey: HQUHDZKCORKVGW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin L cysteine protease	0.1148	0.1926	0.1805
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0488	0.0148	0.0148
Onchocerca volvulus	Cathepsin F homolog	0.2091	0.4466	1
Brugia malayi	cathepsin L-like precursor	0.1431	0.2689	0.2579
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1148	0.1926	0.1926
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4146	1	1
Plasmodium vivax	vivapain-2	0.2091	0.4466	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2091	0.4466	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.1148	0.1926	0.4117
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Entamoeba histolytica	cysteine proteinase, putative	0.1148	0.1926	0.4117
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2091	0.4466	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Giardia lamblia	Encystation-specific protease	0.0568	0.0363	0.0707
Toxoplasma gondii	cathepsin B	0.162	0.3195	0.6901
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0699	0.0716	0.0858
Leishmania major	cathepsin L-like protease	0.2091	0.4466	0.4859
Loa Loa (eye worm)	fibroinase	0.2091	0.4466	0.4383
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0699	0.0716	0.1863
Loa Loa (eye worm)	cathepsin B	0.162	0.3195	0.3093
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2091	0.4466	1
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Loa Loa (eye worm)	hypothetical protein	0.1431	0.2689	0.2579
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2091	0.4466	0.4383
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2091	0.4466	1
Entamoeba histolytica	cysteine proteinase, putative	0.1148	0.1926	0.4117
Leishmania major	cathepsin L-like protease	0.2091	0.4466	0.4859
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2091	0.4466	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.2091	0.4466	0.4383
Trypanosoma brucei	cysteine peptidase C (CPC)	0.162	0.3195	0.3266
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0716	0.0762	0.0623
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.066	0.061	0.0469
Loa Loa (eye worm)	ctsf protein	0.2091	0.4466	0.4383
Brugia malayi	Cathepsin L-like precursor	0.2091	0.4466	0.4383
Trypanosoma cruzi	cysteine protease, putative	0.1148	0.1926	0.1805
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1148	0.1926	0.1805
Loa Loa (eye worm)	hypothetical protein	0.1431	0.2689	0.2579
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2091	0.4466	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.162	0.3195	0.7056
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1148	0.1926	0.4117
Onchocerca volvulus		0.2091	0.4466	1
Leishmania major	cathepsin L-like protease	0.2091	0.4466	0.4859
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1431	0.2689	0.5883
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.162	0.3195	0.3195
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0699	0.0716	0.1314
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Brugia malayi	Cathepsin L-like precursor	0.2091	0.4466	0.4383
Plasmodium vivax	unspecified product	0.066	0.061	0.1071
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1431	0.2689	0.2579
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.162	0.3195	0.3093
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0699	0.0716	0.1314
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2091	0.4466	0.4383
Giardia lamblia	Cathepsin B precursor	0.162	0.3195	1
Entamoeba histolytica	cysteine protease, putative	0.2091	0.4466	1
Trypanosoma cruzi	cysteine peptidase, putative	0.2591	0.5812	0.5749
Giardia lamblia	Cathepsin B precursor	0.0716	0.0762	0.2014
Echinococcus granulosus	cathepsin l1	0.1431	0.2689	0.2579
Loa Loa (eye worm)	hypothetical protein	0.066	0.061	0.0469
Toxoplasma gondii	cathepsin CPC1	0.0699	0.0716	0.0858
Echinococcus granulosus	cathepsin b	0.4146	1	1
Echinococcus multilocularis	cathepsin b	0.4146	1	1
Onchocerca volvulus		0.2091	0.4466	1
Toxoplasma gondii	cathepsin CPL	0.2091	0.4466	1
Giardia lamblia	Cathepsin B precursor	0.162	0.3195	1
Onchocerca volvulus		0.2091	0.4466	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0716	0.0762	0.0623
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Trypanosoma cruzi	cruzipain precursor, putative	0.066	0.061	0.0469
Entamoeba histolytica	cysteine proteinase, putative	0.2091	0.4466	1
Trypanosoma cruzi	cysteine peptidase, putative	0.2591	0.5812	0.5749
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2091	0.4466	1
Echinococcus multilocularis	cysteine protease	0.2091	0.4466	0.4383
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1148	0.1926	0.1926
Echinococcus granulosus	cathepsin l1	0.2091	0.4466	0.4383
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1148	0.1926	0.1805
Loa Loa (eye worm)	hypothetical protein	0.2091	0.4466	0.4383
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2091	0.4466	0.4383
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Leishmania major	cysteine peptidase A (CPA)	0.2091	0.4466	0.4859
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1431	0.2689	0.5883
Giardia lamblia	Cathepsin B precursor	0.162	0.3195	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2091	0.4466	1
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2091	0.4466	1
Trypanosoma cruzi	cysteine peptidase, putative	0.2091	0.4466	0.4383
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.4146	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.1148	0.1926	0.1805
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Brugia malayi	Cathepsin L-like precursor	0.1431	0.2689	0.2579
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0488	0.0148	0.0148
Leishmania major	cathepsin L-like protease	0.2591	0.5812	1
Onchocerca volvulus		0.2091	0.4466	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0568	0.0363	0.0499
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0716	0.0762	0.1421
Brugia malayi	Cathepsin L-like precursor	0.066	0.061	0.0469
Onchocerca volvulus	Cathepsin L homolog	0.2091	0.4466	1
Plasmodium vivax	vivapain-2	0.2091	0.4466	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4146	1	1
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2091	0.4466	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4146	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0488	0.0148	0.0148
Entamoeba histolytica	cysteine proteinase, putative	0.1148	0.1926	0.4117
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2091	0.4466	0.4383
Loa Loa (eye worm)	hypothetical protein	0.4146	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0568	0.0363	0.0707
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Leishmania major	cathepsin L-like protease	0.2091	0.4466	0.4859
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Entamoeba histolytica	cysteine proteinase, putative	0.1431	0.2689	0.5883
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0488	0.0148	0.0148
Echinococcus multilocularis	cysteine protease	0.2091	0.4466	0.4383
Leishmania major	cathepsin L-like protease	0.2591	0.5812	1
Brugia malayi	Cathepsin L-like precursor	0.2091	0.4466	0.4383
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Loa Loa (eye worm)	hypothetical protein	0.066	0.061	0.0469
Echinococcus granulosus	cysteine protease	0.1148	0.1926	0.1805
Echinococcus multilocularis	cathepsin L cysteine protease	0.2091	0.4466	0.4383
Echinococcus multilocularis	cathepsin L	0.1148	0.1926	0.1805
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1148	0.1926	0.4117
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0568	0.0363	0.0499
Plasmodium vivax	unspecified product	0.1148	0.1926	0.4117
Echinococcus granulosus	cathepsin L	0.1148	0.1926	0.1805
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2091	0.4466	0.4383
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2091	0.4466	0.4383
Entamoeba histolytica	cysteine proteinase, putative	0.1148	0.1926	0.4117
Schistosoma mansoni	cathepsin F (C01 family)	0.2091	0.4466	0.4466
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0716	0.0762	0.0623
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2091	0.4466	1
Echinococcus multilocularis	cathepsin b	0.4146	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1931	0.4034	0.3944
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Leishmania major	cathepsin L-like protease	0.2091	0.4466	0.4859
Onchocerca volvulus		0.2091	0.4466	1
Schistosoma mansoni	cathepsin F (C01 family)	0.2091	0.4466	0.4466
Loa Loa (eye worm)	hypothetical protein	0.066	0.061	0.0469
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0619	0.05	0.0816
Brugia malayi	Cathepsin L-like precursor	0.2091	0.4466	0.4383
Entamoeba histolytica	cysteine proteinase 2	0.1148	0.1926	0.4117
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0699	0.0716	0.1314
Onchocerca volvulus		0.2091	0.4466	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Brugia malayi	Papain family cysteine protease containing protein	0.1148	0.1926	0.1805
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0488	0.0148	0.0148
Schistosoma mansoni	cathepsin B (C01 family)	0.0488	0.0148	0.0148
Trypanosoma cruzi	cysteine proteinase, putative	0.1148	0.1926	0.1805
Trypanosoma cruzi	cysteine peptidase, putative	0.2591	0.5812	0.5749
Schistosoma mansoni	cathepsin S (C01 family)	0.0488	0.0148	0.0148
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0488	0.0148	0.0148
Brugia malayi	cathepsin F-like cysteine proteinase	0.066	0.061	0.0469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0716	0.0762	0.1421
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0568	0.0363	0.0707
Brugia malayi	Cathepsin L-like precursor	0.2091	0.4466	0.4383
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Loa Loa (eye worm)	cysteine protease	0.2091	0.4466	0.4383
Schistosoma mansoni	cathepsin C	0.0488	0.0148	0.0148
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.066	0.061	0.0469
Onchocerca volvulus		0.2091	0.4466	1
Schistosoma mansoni	cathepsin s	0.066	0.061	0.061
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0488	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.1431	0.2689	0.2579
Trypanosoma cruzi	cruzipain precursor, putative	0.2591	0.5812	0.5749
Leishmania major	cathepsin L-like protease	0.2591	0.5812	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2091	0.4466	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2091	0.4466	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0988	0.1493	0.1365
Schistosoma mansoni	cathepsin F (C01 family)	0.1431	0.2689	0.2689
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0488	0.0148	0.0148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Plasmodium vivax	vivapain-3	0.1148	0.1926	0.4117
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0699	0.0716	0.1314
Plasmodium vivax	vivapain-1	0.1148	0.1926	0.4117
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Echinococcus granulosus	cathepsin b	0.4146	1	1
Entamoeba histolytica	cysteine protease, putative	0.1148	0.1926	0.4117
Onchocerca volvulus		0.1431	0.2689	0.5883
Brugia malayi	Papain family cysteine protease containing protein	0.2091	0.4466	0.4383
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0716	0.0762	0.1421
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2591	0.5812	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.4146	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.066	0.061	0.0469
Brugia malayi	Papain family cysteine protease containing protein	0.1148	0.1926	0.1805
Brugia malayi	Cathepsin L-like precursor	0.2091	0.4466	0.4383
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2091	0.4466	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1148	0.1926	0.4117
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0716	0.0762	0.1421
Entamoeba histolytica	cysteine proteinase, putative	0.2091	0.4466	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1148	0.1926	0.1926
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0699	0.0716	0.0716
Onchocerca volvulus	Cathepsin L homolog	0.2091	0.4466	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2091	0.4466	1
Brugia malayi	Cathepsin L-like precursor	0.1431	0.2689	0.2579

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 2.38 ug ml-1	Concentration required to inhibit the growth of L1210 leukemia cells	ChEMBL.	2754697
ED50 (functional)	= 2.38 ug ml-1	Concentration required to inhibit the growth of L1210 leukemia cells	ChEMBL.	2754697
Survival (functional)	= 5	Survivors of CDF1 mice on day 4 after 1st injection of compound 40 at mg/kg in seven mice; 5/7	ChEMBL.	2754697
Survival (functional)	= 7	Survivors of CDF1 mice on day 4 after 1st injection of compound at 20 mg/kg in seven mice; 7/7	ChEMBL.	2754697
Survival (functional)	= 7	Survivors of CDF1 mice on day 4 after 1st injection of compound at 10 mg/kg in seven mice; 7/7	ChEMBL.	2754697
Survival (functional)	= 7	Survivors of CDF1 mice on day 4 after 1st injection of compound at 5 mg/kg in seven mice; 7/7	ChEMBL.	2754697
Survival (functional)	= 7	Survivors of CDF1 mice on day 4 after 1st injection of compound at 2.5 mg/kg in seven mice; 7/7	ChEMBL.	2754697
Survival (functional)	= 7	Survivors of CDF1 mice on day 4 after 1st injection of compound at 1.25 mg/kg in seven mice; 7/7	ChEMBL.	2754697
T/C (functional)	= 80 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 40 mg/kg	ChEMBL.	2754697
T/C (functional)	= 80 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 40 mg/kg	ChEMBL.	2754697
T/C (functional)	= 170 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 1.25 mg/kg	ChEMBL.	2754697
T/C (functional)	= 170 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 1.25 mg/kg	ChEMBL.	2754697
T/C (functional)	= 180 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 2.5 mg/kg	ChEMBL.	2754697
T/C (functional)	= 180 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 2.5 mg/kg	ChEMBL.	2754697
T/C (functional)	= 200 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 5 mg/kg	ChEMBL.	2754697
T/C (functional)	= 200 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 5 mg/kg	ChEMBL.	2754697
T/C (functional)	= 300 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 20 mg/kg	ChEMBL.	2754697
T/C (functional)	= 300 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 10 mg/kg	ChEMBL.	2754697
T/C (functional)	= 300 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 20 mg/kg	ChEMBL.	2754697
T/C (functional)	= 300 %	Percent ratio of the medium survival time for P388 murine leukemia in CDF1 mice at 10 mg/kg	ChEMBL.	2754697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 67868