Detailed information for compound 679860

Basic information

Technical information
  • TDR Targets ID: 679860
  • Name: 5-bromo-N-(2-methyl-3-nitrophenyl)furan-2-car boxamide
  • MW: 325.115 | Formula: C12H9BrN2O4
  • H donors: 1 H acceptors: 3 LogP: 3.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(o1)C(=O)Nc1cccc(c1C)[N+](=O)[O-]
  • InChi: 1S/C12H9BrN2O4/c1-7-8(3-2-4-9(7)15(17)18)14-12(16)10-5-6-11(13)19-10/h2-6H,1H3,(H,14,16)
  • InChiKey: UUHPNTORVDFWII-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-bromo-N-(2-methyl-3-nitro-phenyl)furan-2-carboxamide
  • 5-bromo-N-(2-methyl-3-nitrophenyl)-2-furancarboxamide
  • 5-bromo-N-(2-methyl-3-nitro-phenyl)-2-furamide
  • ARONIS000642
  • ST054435
  • AN-329/40744087
  • ZINC00038394

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans short chain dehydrogenase 0.0571 0.6829 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0411 0.0411
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0782 0.8084
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.022 0.0553
Echinococcus granulosus GPCR family 2 0.0034 0.0243 0.0207
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1846 0.4646
Brugia malayi RNA, U transporter 1 0.0079 0.0802 0.2018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.2111 0.2081
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1846 0.4646
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0782 0.1969
Echinococcus multilocularis geminin 0.036 0.4235 0.4213
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0243 0.0207
Schistosoma mansoni hypothetical protein 0.036 0.4235 0.4235
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0017 0.0037 0.0055
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.06 0.1509
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0782 0.1969
Loa Loa (eye worm) hypothetical protein 0.0107 0.1141 0.1141
Echinococcus granulosus muscleblind protein 0.0155 0.1727 0.1696
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0411 0.4051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0587 0.0551
Leishmania major trypanothione reductase 0.0092 0.0959 0.2413
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.022 0.1978
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.06 0.0564
Loa Loa (eye worm) hypothetical protein 0.0155 0.1727 0.1727
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.008 0.1135
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.022 0.1978
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0045 0.0045
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0338 0.3973 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.017 0.017
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.021 0.2408 0.3526
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0114 0.0077
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.06 0.0878
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0782 0.8084
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.022 0.0553
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.022 0.0553
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1846 0.4646
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0726 0.1827
Schistosoma mansoni hypothetical protein 0.0034 0.0243 0.0243
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.022 0.0553
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0106 0.0266
Loa Loa (eye worm) hypothetical protein 0.0044 0.037 0.037
Treponema pallidum NADH oxidase 0.0032 0.022 1
Brugia malayi hypothetical protein 0.0078 0.0782 0.1969
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.9591 0.9589
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.022 0.0553
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1404 0.1404
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.008 0.0201
Trypanosoma brucei trypanothione reductase 0.0092 0.0959 0.2413
Leishmania major hypothetical protein, conserved 0.0016 0.0022 0.0056
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.008 0.0201
Loa Loa (eye worm) glutathione reductase 0.0092 0.0959 0.0959
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.022 0.0322
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3973 1
Brugia malayi RNA binding protein 0.0129 0.1404 0.3535
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0236 0.0346
Mycobacterium tuberculosis Putative ferredoxin reductase 0.021 0.2408 0.3526
Echinococcus granulosus tar DNA binding protein 0.0129 0.1404 0.1372
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3973 1
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0048 0.0411 0.0375
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0336 0.3948 0.5781
Mycobacterium ulcerans epoxide hydrolase EphA 0.0336 0.3948 0.5781
Leishmania major GTP-binding protein, putative 0.0021 0.008 0.0201
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.0959 0.0959
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0236 0.0595
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.06 0.0878
Mycobacterium ulcerans short chain dehydrogenase 0.0017 0.0037 0.0055
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0411 0.1034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.022 0.0553
Schistosoma mansoni zinc finger protein 0.002 0.0077 0.0077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.022 0.0553
Echinococcus multilocularis zinc finger protein 0.002 0.0077 0.0039
Echinococcus granulosus pyruvate kinase 0.0033 0.0236 0.02
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.022 0.5
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0411 0.1034
Trichomonas vaginalis ran, putative 0.0021 0.008 0.0201
Plasmodium falciparum glutathione reductase 0.0092 0.0959 1
Schistosoma mansoni zinc finger protein 0.0016 0.0022 0.0022
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0236 0.1281
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.022 0.0553
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.022 0.0553
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2904 0.7308
Plasmodium falciparum thioredoxin reductase 0.0092 0.0959 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0106 0.0266
Echinococcus granulosus snurportin 1 0.0298 0.3485 0.346
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1404 0.1404
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3973 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0234 0.2696 1
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0048 0.0411 0.085
Schistosoma mansoni hypothetical protein 0.0073 0.0726 0.0726
Brugia malayi glutathione reductase 0.0092 0.0959 0.2413
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0236 0.1281
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0256 0.0219
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.008 0.0201
Loa Loa (eye worm) hypothetical protein 0.0034 0.0243 0.0243
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0236 0.0236
Echinococcus granulosus pyruvate kinase 0.0033 0.0236 0.02
Echinococcus multilocularis synaptic glycoprotein sc2 0.0048 0.0411 0.0375
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0236 0.0595
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.008 0.0043
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.017 0.0429
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0113 0.0113
Plasmodium falciparum polyprenol reductase, putative 0.0048 0.0411 0.4051
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0243 0.0613
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.1141 0.1141
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.008 0.0201
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0236 0.0595
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0114 0.0077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.2111 0.5312
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0106 0.0266
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0236 0.0236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0045 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0571 0.6829 1
Schistosoma mansoni hypothetical protein 0.0035 0.0256 0.0256
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.008 0.0201
Toxoplasma gondii thioredoxin reductase 0.0092 0.0959 0.2413
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.3485 0.3485
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.022 0.0553
Loa Loa (eye worm) hypothetical protein 0.0155 0.1727 0.1727
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3973 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.008 0.046
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0045 0.0007
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0052 0.0052
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0338 0.3973 1
Schistosoma mansoni bromodomain containing protein 0.0066 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0045
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0236 0.1281
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1846 0.4646
Entamoeba histolytica hypothetical protein 0.0023 0.0106 0.0066
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0045 0.0007
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0782 0.8084
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.021 0.2408 0.3526
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.1141 0.2873
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.06 0.06
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0236 0.0236
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2904 0.7308
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1404 0.1404
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0338 0.3973 1
Brugia malayi Thioredoxin reductase 0.0092 0.0959 0.2413
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.022 0.5
Plasmodium vivax importin-beta 2, putative 0.0028 0.017 0.1442
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0243 0.0207
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0116 0.0291
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0236 0.0595
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.2904 0.7308
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.022 0.0553
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0045 0.0007
Echinococcus granulosus geminin 0.036 0.4235 0.4213
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0048 0.0411 0.0375
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.008 0.008
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.021 0.2408 0.8932
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0236 0.0595
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0243 0.0613
Schistosoma mansoni hypothetical protein 0.0034 0.0243 0.0243
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0045 0.0045
Plasmodium falciparum thioredoxin reductase 0.0032 0.022 0.1978
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.06 0.06
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.0959 0.0925
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.1404 0.1404
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0048 0.0411 0.1034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0243 0.0207
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.022 0.0183
Echinococcus granulosus importin subunit beta 1 0.0028 0.017 0.0133
Schistosoma mansoni hypothetical protein 0.0021 0.009 0.009
Leishmania major importin beta-1 subunit, putative 0.0023 0.0106 0.0266
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0256 0.0219
Loa Loa (eye worm) hypothetical protein 0.0048 0.0411 0.0411
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.022 0.0322
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.022 0.022
Echinococcus multilocularis pyruvate kinase 0.0033 0.0236 0.02
Mycobacterium ulcerans hypothetical protein 0.0338 0.3973 0.5818
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0017 0.0037 0.0139
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.06 0.0878
Schistosoma mansoni ran 0.0021 0.008 0.008
Echinococcus multilocularis pyruvate kinase 0.0026 0.015 0.0113
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1955 0.492
Plasmodium falciparum glutathione reductase 0.0032 0.022 0.1978
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.022 0.0553
Loa Loa (eye worm) hypothetical protein 0.0073 0.0726 0.0726
Brugia malayi Synaptic glycoprotein SC2 0.0048 0.0411 0.1034
Schistosoma mansoni ran 0.0021 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0078 0.0782 0.0782
Echinococcus granulosus zinc finger protein 0.002 0.0077 0.0039
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0048 0.0411 0.0411
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0048 0.0411 0.085
Brugia malayi hypothetical protein 0.005 0.0444 0.1117
Echinococcus multilocularis hormone sensitive lipase 0.083 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.2111 0.2081
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0048 0.0411 0.1034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0113 0.0113
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.1141 0.2873
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0048 0.0411 0.1034
Loa Loa (eye worm) hypothetical protein 0.0338 0.3973 0.3973
Brugia malayi PHD-finger family protein 0.0026 0.0144 0.0363
Giardia lamblia Pyruvate kinase 0.0033 0.0236 0.5329
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0236 0.0595
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.2111 0.2111
Mycobacterium tuberculosis Probable dehydrogenase 0.021 0.2408 0.3526
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.083 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.0959 0.0925
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.009 0.009
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0236 0.0346
Echinococcus multilocularis importin subunit beta 1 0.0028 0.017 0.0133
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0243 0.0207
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.2904 0.2904
Echinococcus multilocularis pyruvate kinase 0.0033 0.0236 0.02
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.022 0.0322
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0236 0.2159
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.2111 0.2081
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.022 0.0183
Brugia malayi TAR-binding protein 0.0129 0.1404 0.3535
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.022 0.0322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0045 0.0045
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0234 0.2696 0.3948
Trypanosoma cruzi ISWI complex protein 0.0016 0.0022 0.0056
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0782 0.1969
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.06 0.0878
Loa Loa (eye worm) hypothetical protein 0.0073 0.0727 0.0727
Leishmania major hypothetical protein, conserved 0.0078 0.0782 0.1969
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.022 0.1978
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2111 0.2111
Schistosoma mansoni importin beta-1 0.0028 0.017 0.017
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0236 0.0877
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.022 0.1978
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.2111 0.2081
Mycobacterium tuberculosis Probable oxidoreductase 0.0234 0.2696 0.3948
Leishmania major pyruvate kinase 0.0033 0.0236 0.0595
Echinococcus granulosus synaptic glycoprotein sc2 0.0048 0.0411 0.0375
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2904 0.7308
Entamoeba histolytica hypothetical protein 0.0048 0.0411 0.085
Schistosoma mansoni hypothetical protein 0.0034 0.0243 0.0243
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.083 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.017 0.0429
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.022 0.0553
Onchocerca volvulus 0.0048 0.0411 0.2225
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.036 0.4235 0.4235
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2111 0.2111
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0411 0.4051
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.083 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0285 0.0248
Schistosoma mansoni pyruvate kinase 0.0017 0.0037 0.0037
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.022 0.0553
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.021 0.2408 0.3526
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0048 0.0411 0.0411
Plasmodium vivax glutathione reductase, putative 0.0092 0.0959 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1846 0.4646
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.1404 0.3535
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1404 0.1404
Echinococcus multilocularis snurportin 1 0.0298 0.3485 0.346
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0236 0.0595
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0338 0.3973 1
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1955 0.492
Loa Loa (eye worm) TAR-binding protein 0.0129 0.1404 0.1404
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.06 0.1509
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0048 0.0411 0.1034
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.0411 0.1034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0236 0.0236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.022 0.0553
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0236 0.0595
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2904 0.7308
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1846 0.4646
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.022 0.0553
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.022 0.0553
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.022 0.0553
Schistosoma mansoni pyruvate kinase 0.0033 0.0236 0.0236
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.06 0.0564
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0234 0.2696 0.3948
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.008 0.046
Chlamydia trachomatis pyruvate kinase 0.0033 0.0236 1
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0338 0.3973 1
Brugia malayi Bromodomain containing protein 0.0078 0.0781 0.1966
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0587 0.0551
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2111 0.2111
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0243 0.0243
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2904 0.7308
Plasmodium vivax polyprenol reductase, putative 0.0048 0.0411 0.4051
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.022 0.0553
Echinococcus multilocularis muscleblind protein 0.0155 0.1727 0.1696
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0782 0.1969
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0316
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.022 0.0553
Plasmodium falciparum importin beta, putative 0.0028 0.017 0.1442
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.0959 0.1404
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0411 0.1034
Loa Loa (eye worm) hypothetical protein 0.0042 0.0346 0.0346
Loa Loa (eye worm) RNA binding protein 0.0129 0.1404 0.1404
Brugia malayi Bromodomain containing protein 0.004 0.0315 0.0792
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0048 0.0411 0.1034
Mycobacterium tuberculosis Probable reductase 0.021 0.2408 0.3526
Echinococcus multilocularis GPCR, family 2 0.0034 0.0243 0.0207
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0236 0.0595
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.008 0.0043
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0285 0.0248
Giardia lamblia Synaptic glycoprotein SC2 0.0048 0.0411 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0106 0.0266
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0116 0.0291
Schistosoma mansoni pyruvate kinase 0.0033 0.0236 0.0236
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0045 0.0007
Trypanosoma brucei ISWI complex protein 0.0016 0.0022 0.0056
Loa Loa (eye worm) hypothetical protein 0.083 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1846 0.4646
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0411 0.1034
Leishmania major pyruvate kinase 0.0033 0.0236 0.0595
Brugia malayi Muscleblind-like protein 0.0155 0.1727 0.4346
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.022 0.0553
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.1846 1
Schistosoma mansoni hypothetical protein 0.0034 0.0243 0.0243
Echinococcus multilocularis tar DNA binding protein 0.0129 0.1404 0.1372
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.022 0.0553
Echinococcus multilocularis muscleblind protein 1 0.0155 0.1727 0.1696
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.0959 1
Trypanosoma cruzi ISWI complex protein 0.0016 0.0022 0.0056
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3973 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.022 0.4881
Plasmodium falciparum pyruvate kinase 0.0033 0.0236 0.2159
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0113 0.0084
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.0959 0.2413
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0037 0.0094
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.017 0.0429
Schistosoma mansoni hypothetical protein 0.0298 0.3485 0.3485
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1404 0.1404
Brugia malayi Importin beta-1 subunit 0.0028 0.017 0.0429
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2904 0.7308

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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