TDR Targets

Basic information

Technical information

TDR Targets ID: 680234
Name: 5-iodo-2-methoxy-N-(phenylmethyl)benzenesulfo namide
MW: 403.235 | Formula: C14H14INO3S
H donors: 1 H acceptors: 2 LogP: 3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1S(=O)(=O)NCc1ccccc1)I
InChi: 1S/C14H14INO3S/c1-19-13-8-7-12(15)9-14(13)20(17,18)16-10-11-5-3-2-4-6-11/h2-9,16H,10H2,1H3
InChiKey: FKLVDGOHHALLIW-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-(benzyl)-5-iodo-2-methoxy-benzenesulfonamide
AP-263/40918024
N-benzyl-5-iodo-2-methoxybenzenesulfonamide
ZINC01156522

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.3287	0.2799
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.1985	0.5
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.1985	0.1402
Entamoeba histolytica	recQ family DNA helicase	0.0011	0.0039	0.0039
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.1985	0.4699
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0021	0.1021	0.0367
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.1021	0.0367
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0114	1	1
Echinococcus granulosus	bloom syndrome protein	0.0021	0.1021	0.0367
Schistosoma mansoni	chromatin regulatory protein sir2	0.0017	0.0678	0.0678
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.1021	0.0367
Schistosoma mansoni	chromatin regulatory protein sir2	0.0017	0.0678	0.0678
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.3287	0.3261
Loa Loa (eye worm)	transcriptional regulator	0.0017	0.0678	0.0642
Schistosoma mansoni	6-phosphofructokinase	0.0114	1	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0054	0.4224	0.3804
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.1021	0.0367
Brugia malayi	6-phosphofructokinase	0.0114	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.1985	0.1402
Giardia lamblia	Sgs1 DNA helicase, putative	0.0021	0.1021	0.0965
Toxoplasma gondii	histone deacetylase SIR2-like	0.0017	0.0678	0.1606
Loa Loa (eye worm)	sirtuin 4	0.0017	0.0678	0.0642
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	1	1
Entamoeba histolytica	recQ family helicase, putative	0.0021	0.1021	0.1021
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0031	0.1985	0.1954
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0054	0.4224	0.4202
Brugia malayi	6-phosphofructokinase	0.0114	1	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0114	1	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0039	0.0092
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.1985	0.4699
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0017	0.0678	0.0678
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0054	0.4224	1
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0054	0.4224	0.4224
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0021	0.1021	0.0367
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.3287	0.3287
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0039	0.00000000082886
Entamoeba histolytica	phosphofructokinase, putative	0.0114	1	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0114	1	1
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.1021	0.0367
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.3287	0.2799
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.1021	0.0367
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.1021	0.0367
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.1021	0.0986
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0114	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	1	1
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0017	0.0678	0.0642
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.3287	0.2799
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.1985	0.1402
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.3287	0.2799
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0054	0.4224	0.3804
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0054	0.4224	0.3804
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0021	0.1021	0.0367
Schistosoma mansoni	DNA helicase recq1	0.0021	0.1021	0.1021
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.1021	0.0965
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0054	0.4224	0.3804
Schistosoma mansoni	chromatin regulatory protein sir2	0.0017	0.0678	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0678	0.0642
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.1985	0.3685
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.1985	0.4699
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0017	0.0678	0.0678
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.1021	0.0367
Entamoeba histolytica	phosphofructokinase, putative	0.0114	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.1985	0.1402
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.1021	0.2416
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.1985	0.1402
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.1985	0.3685
Schistosoma mansoni	chromatin regulatory protein sir2	0.0017	0.0678	0.0678
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0017	0.0678	0.0678
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	1	1
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0054	0.4224	0.3804
Loa Loa (eye worm)	transcriptional regulator	0.0017	0.0678	0.0642
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.3287	0.3287
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.1985	0.4699
Leishmania major	ATP-dependent phosphofructokinase	0.0114	1	1
Schistosoma mansoni	6-phosphofructokinase	0.0114	1	1
Loa Loa (eye worm)	transcriptional regulator	0.0017	0.0678	0.0642
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.1021	0.0367
Loa Loa (eye worm)	phosphofructokinase	0.0114	1	1
Schistosoma mansoni	chromatin regulatory protein sir2	0.0054	0.4224	0.4224
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0054	0.4224	1
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0011	0.0039	0.0092
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0017	0.0678	0.0642
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.3287	0.3287
Echinococcus granulosus	6 phosphofructokinase	0.0114	1	1
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.1985	0.5
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0021	0.1021	0.0986
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0054	0.4224	0.4202
Schistosoma mansoni	chromatin regulatory protein sir2	0.0017	0.0678	0.0678
Entamoeba histolytica	hypothetical protein, conserved	0.0017	0.0678	0.0678
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.1985	0.3685
Schistosoma mansoni	chromatin regulatory protein sir2	0.0017	0.0678	0.0678
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.3287	0.2799
Loa Loa (eye worm)	6-phosphofructokinase	0.0114	1	1
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.1021	0.0367
Schistosoma mansoni	blooms syndrome DNA helicase	0.0011	0.0039	0.0039
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.1985	0.1985
Loa Loa (eye worm)	hypothetical protein	0.0021	0.1021	0.0986
Plasmodium vivax	hypothetical protein, conserved	0.0017	0.0678	0.1606
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0021	0.1021	0.0367
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0114	1	1
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0114	1	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0114	1	1
Toxoplasma gondii	histone deacetylase SIR2	0.0054	0.4224	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.1985	0.1402
Echinococcus multilocularis	6 phosphofructokinase	0.0114	1	1
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0021	0.1021	0.0965
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0054	0.4224	1
Entamoeba histolytica	phosphofructokinase, putative	0.0114	1	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0054	0.4224	0.3804
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.1985	0.4699
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.1985	0.1402
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.1021	0.2416
Schistosoma mansoni	DNA helicase recq5	0.0021	0.1021	0.1021
Loa Loa (eye worm)	RecQ helicase	0.0021	0.1021	0.0986

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 680234