Detailed information for compound 68211

Basic information

Technical information
  • TDR Targets ID: 68211
  • Name: 1-(5-methoxy-1H-indol-3-yl)-2-pyridin-4-ylsul fanylethanone
  • MW: 298.36 | Formula: C16H14N2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(c[nH]2)C(=O)CSc1ccncc1
  • InChi: 1S/C16H14N2O2S/c1-20-11-2-3-15-13(8-11)14(9-18-15)16(19)10-21-12-4-6-17-7-5-12/h2-9,18H,10H2,1H3
  • InChiKey: BSAURTVZQVZOFP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(5-methoxy-1H-indol-3-yl)-2-(4-pyridylsulfanyl)ethanone
  • 1-(5-methoxy-1H-indol-3-yl)-2-(4-pyridylthio)ethanone
  • 1-(5-methoxy-1H-indol-3-yl)-2-pyridin-4-ylsulfanyl-ethanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Chromobox protein 3 0.0011 0.0048 0.0063
Brugia malayi glutathione reductase 0.01 0.1687 0.1828
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0166 0.092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0048 0.0218
Onchocerca volvulus 0.003 0.0396 0.6507
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.1687 0.2326
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) 0.055 1 1
Brugia malayi SET domain containing protein 0.0012 0.0059 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0342 0.197
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0481 0.2803
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0077 0.0092
Echinococcus granulosus Chromo domain 0.0011 0.0048 0.0063
Loa Loa (eye worm) glutathione reductase 0.01 0.1687 0.4863
Mycobacterium tuberculosis Probable oxidoreductase 0.0253 0.452 0.4895
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0508 0.9223 1
Brugia malayi Cytochrome P450 family protein 0.0012 0.0064 0.0069
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0311 0.0337
Echinococcus granulosus chromobox protein 1 0.0068 0.1102 0.1519
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0048 0.0106
Plasmodium vivax glutathione reductase, putative 0.01 0.1687 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0048 0.0218
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0048 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0166 0.092
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0045 0.0678 1
Schistosoma mansoni hypothetical protein 0.0192 0.3387 0.4668
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0048 0.0219
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.405 0.4385
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0045 0.0678 0.0723
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0045 0.0678 1
Echinococcus multilocularis Aminotransferase class III 0.0045 0.0678 0.0933
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0166 0.092
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0045 0.0678 0.0723
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0481 0.2803
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.405 0.4385
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0048 0.0052
Toxoplasma gondii thioredoxin reductase 0.01 0.1687 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0481 0.051
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0048 0.0218
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0011 0.0012
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0045 0.0678 0.0723
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0011 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0064 0.0185
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0311 0.0337
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0481 0.2803
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0011 0.0012
Onchocerca volvulus 0.0012 0.0059 0.0813
Echinococcus granulosus ornithine aminotransferase 0.0045 0.0678 0.0933
Trichomonas vaginalis hypothetical protein 0.0011 0.0048 0.0218
Brugia malayi Thioredoxin reductase 0.01 0.1687 0.1828
Brugia malayi CHD4 protein 0.0013 0.0077 0.0084
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0064 0.0316
Echinococcus multilocularis chromobox protein 1 0.0068 0.1102 0.1519
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0481 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0481 0.2803
Brugia malayi Cytochrome P450 family protein 0.0012 0.0064 0.0069
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0045 0.0678 0.0921
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0481 1
Onchocerca volvulus 0.0028 0.0361 0.5925
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0045 0.0678 0.0723
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0508 0.9223 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0048 0.0106
Echinococcus granulosus glutamate synthase 0.0009 0.0011 0.0012
Plasmodium falciparum ornithine aminotransferase 0.0045 0.0678 0.3977
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0218
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0048 0.0063
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0048 0.0051
Loa Loa (eye worm) thioredoxin reductase 0.01 0.1687 0.4863
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0166 0.092
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0064 0.0057
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0361 0.1041
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0011 0.0012
Echinococcus granulosus geminin 0.0192 0.3387 0.4674
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0045 0.0678 0.0667
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0011 0.0012
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0481 0.2799
Plasmodium falciparum thioredoxin reductase 0.01 0.1687 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0048 0.0219
Echinococcus multilocularis ornithine aminotransferase 0.0045 0.0678 0.0933
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0045 0.0678 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0218
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0011 0.0012
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.405 0.4385
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0011 0.0012
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0045 0.0678 0.0667
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0481 0.2803
Trypanosoma brucei trypanothione reductase 0.01 0.1687 1
Echinococcus multilocularis glutamate synthase 0.0009 0.0011 0.0012
Schistosoma mansoni chromobox protein 0.0011 0.0048 0.0051
Entamoeba histolytica hypothetical protein 0.0011 0.0048 0.0106
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0253 0.452 0.4514
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0548 0.32
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0138
Brugia malayi Ribonuclease 2-5A family protein 0.0196 0.3468 0.376
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0048 0.0219
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0048 0.0219
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0048 0.0219
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0166 0.092
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.1687 0.1819
Loa Loa (eye worm) helicase 0.0011 0.0048 0.0138
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0064 0.0316
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0011 0.0032
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0481 0.0649
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0011 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0102 0.0544
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0045 0.0678 0.0723
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0481 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0481 0.2803
Echinococcus granulosus chromobox protein 2 0.0011 0.0048 0.0063
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0077 0.0223
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0064 0.0185
Brugia malayi hypothetical protein 0.0011 0.0048 0.0052
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.405 0.4385
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0032
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0481 0.2803
Echinococcus multilocularis cpg binding protein 0.003 0.0391 0.0537
Echinococcus granulosus cpg binding protein 0.003 0.0391 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0111 0.0595
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0011 0.0012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0826 0.4864
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0166 0.092
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0048 0.0218
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0481 0.051
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0481 0.2803
Mycobacterium ulcerans L-lysine aminotransferase 0.0508 0.9223 1
Trichomonas vaginalis serine threonine-protein kinase, putative 0.01 0.1689 1
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1102 0.6502
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0048 0.0219
Onchocerca volvulus 0.0011 0.0048 0.062
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0196 0.3468 0.4786
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0166 0.092
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0602 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0396 0.114
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) 0.055 1 1
Schistosoma mansoni chromobox protein 0.0068 0.1102 0.1509
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0048 0.0106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0048 0.0218
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0011 0.0012
Echinococcus multilocularis ornithine aminotransferase 0.0045 0.0678 0.0933
Leishmania major trypanothione reductase 0.01 0.1687 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0481 0.2803
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1102 0.6502
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0048 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0218
Echinococcus multilocularis chromobox protein 2 0.0011 0.0048 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0048 0.0219
Plasmodium falciparum glutathione reductase 0.01 0.1687 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0481 0.051
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0011 0.0012
Echinococcus granulosus chromobox protein 1 0.0068 0.1102 0.1519
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0481 0.7048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0481 0.2803
Brugia malayi Heterochromatin protein 1 0.0068 0.1102 0.1195
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0048 0.0218
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0048 0.0052
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0481 0.2803
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0011 0.0048 0.0051
Schistosoma mansoni cpg binding protein 0.003 0.0391 0.0525
Echinococcus multilocularis geminin 0.0192 0.3387 0.4674
Loa Loa (eye worm) hypothetical protein 0.0038 0.0548 0.1581
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.1687 0.2326
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0045 0.0678 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0218
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0138
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0481 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0342 0.197
Plasmodium vivax thioredoxin reductase, putative 0.01 0.1687 1
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0064 0.0185
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0138
Treponema pallidum NADH oxidase 0.0035 0.0481 0.047
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.405 0.4044
Entamoeba histolytica hypothetical protein 0.0011 0.0048 0.0106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0166 0.092
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0048 0.0052
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0048 0.0219
Onchocerca volvulus 0.0011 0.0048 0.062
Schistosoma mansoni cpg binding protein 0.003 0.0391 0.0525
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1102 0.3178
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0048 0.0052
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0048 0.0051
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0602 0.352
Brugia malayi Protein cec-1. 0.0011 0.0048 0.0052
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0045 0.0678 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1701 0.2336
Entamoeba histolytica protein kinase, putative 0.0196 0.3468 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0059 0.0066
Echinococcus multilocularis dnaJ subfamily B 0.04 0.7244 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0548 0.9091
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0481 0.2803
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0138
Mycobacterium tuberculosis Probable reductase 0.0228 0.405 0.4385
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0481 0.7048
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0602 0.352
Echinococcus multilocularis chromobox protein 1 0.0068 0.1102 0.1519
Plasmodium falciparum glutathione reductase 0.0035 0.0481 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.01 0.1689 1
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0045 0.0678 0.0723
Echinococcus multilocularis Chromo domain 0.0011 0.0048 0.0063
Mycobacterium tuberculosis Probable aminotransferase 0.0045 0.0678 0.0723
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0481 0.7048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0481 0.2803
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0111 0.0595
Schistosoma mansoni hypothetical protein 0.04 0.7244 1
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0045 0.0678 0.0667
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0138
Leishmania major cytochrome p450-like protein 0.0012 0.0064 0.0316
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0481 0.2803
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0253 0.452 0.4895
Mycobacterium ulcerans acetylornithine aminotransferase 0.0045 0.0678 0.0723
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0944 0.129
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0481 0.2799
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0481 0.2803
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0011 0.0012
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0481 0.0521
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0253 0.452 0.4895
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0064 0.0316
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0077 0.0104
Plasmodium vivax ornithine aminotransferase, putative 0.0045 0.0678 0.3977
Brugia malayi chromobox protein homolog 3 0.0038 0.0548 0.0594
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0481 0.2803
Brugia malayi glutamate synthase 0.0009 0.0011 0.0012
Schistosoma mansoni chromobox protein 0.0068 0.1102 0.1509
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0045 0.0678 0.3977
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0481 0.051
Entamoeba histolytica protein kinase, putative 0.0196 0.3468 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0218
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0481 0.2803
Mycobacterium ulcerans hypothetical protein 0.0045 0.0678 0.0723
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0048 0.0219
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0481 0.0661
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0481 0.0661
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0138
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0011 0.0012
Echinococcus granulosus dnaJ subfamily B 0.04 0.7244 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0481 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0481 0.2803
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0045 0.0678 0.0723
Schistosoma mansoni chromobox protein 0.0011 0.0048 0.0051
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0011 0.0012
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0077 0.0104
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0011 0.0012
Brugia malayi CXXC zinc finger family protein 0.0028 0.0361 0.0391
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.405 0.4385
Echinococcus granulosus Aminotransferase class III 0.0045 0.0678 0.0933
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0048 0.0063
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.1687 1
Plasmodium falciparum thioredoxin reductase 0.0035 0.0481 0.2803
Loa Loa (eye worm) IRE protein kinase 0.0196 0.3468 1
Schistosoma mansoni hypothetical protein 0.0192 0.3387 0.4668
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0548 0.32
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0045 0.0678 0.3971
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0196 0.3468 0.4786
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0138
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0048 0.0063
Schistosoma mansoni cpg binding protein 0.0028 0.0361 0.0484
Entamoeba histolytica hypothetical protein 0.0011 0.0048 0.0106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0481 0.2803

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 32 uM Inhibitory activity of the compound against (IMPDH) inosine 5'-monophosphate dehydrogenase ChEMBL. 12729643
IC50 (binding) = 32 uM Inhibitory activity of the compound against (IMPDH) inosine 5'-monophosphate dehydrogenase ChEMBL. 12729643

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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