Detailed information for compound 682881

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 437.558 | Formula: C23H27N5O2S
  • H donors: 1 H acceptors: 4 LogP: 4.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Nc1cc(C)nc(n1)N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C23H27N5O2S/c1-17-4-8-20(9-5-17)25-22-16-19(3)24-23(26-22)27-12-14-28(15-13-27)31(29,30)21-10-6-18(2)7-11-21/h4-11,16H,12-15H2,1-3H3,(H,24,25,26)
  • InChiKey: CUYMQNKCCBPTJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.003 0.0209 0.0168
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0475 0.1046
Toxoplasma gondii thioredoxin reductase 0.0093 0.1065 0.247
Loa Loa (eye worm) hypothetical protein 0.0029 0.0199 0.0346
Brugia malayi hypothetical protein 0.0133 0.1617 0.2804
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.03 0.388 1
Brugia malayi hydrolase, alpha/beta fold family protein 0.0041 0.0367 0.0629
Entamoeba histolytica hypothetical protein 0.0049 0.0475 0.0498
Echinococcus granulosus L aminoadipate semialdehyde 0.0175 0.2179 0.2179
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.03 0.0148
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0169 0.0308
Schistosoma mansoni hypothetical protein 0.0072 0.078 0.0742
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0739 0.0701
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0049 0.0475 0.0293
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.154 0.154
Plasmodium falciparum thioredoxin reductase 0.0093 0.1065 0.247
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0243 0.0447
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0669 0.1514
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0475 0.0587
Echinococcus multilocularis pyruvate kinase 0.0019 0.0061 0.0061
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0169 0.0169
Echinococcus multilocularis cpg binding protein 0.0033 0.0256 0.0256
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0169 0.0128
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.03 0.0148
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0073 0.0119
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0263 0.0577
Echinococcus granulosus muscleblind protein 0.0163 0.2014 0.2014
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0034 0.0267 0.0841
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0127
Echinococcus granulosus dna polymerase eta 0.002 0.0073 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0743 0.0705
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.2734 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0145 0.027
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0316 0.0316
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0169 0.0308
Leishmania major pyruvate kinase 0.0036 0.03 0.0963
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0169 0.0128
Echinococcus granulosus pyruvate kinase 0.0036 0.03 0.03
Onchocerca volvulus 0.0034 0.0267 0.0096
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0203
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.03 0.0514
Plasmodium falciparum glutathione reductase 0.0093 0.1065 0.247
Onchocerca volvulus Huntingtin homolog 0.0133 0.1617 0.2216
Trichomonas vaginalis set domain proteins, putative 0.0499 0.6573 0.8069
Echinococcus multilocularis lamin dm0 0.0029 0.0206 0.0206
Leishmania major hypothetical protein, conserved 0.0027 0.0169 0.0474
Loa Loa (eye worm) hypothetical protein 0.004 0.0345 0.06
Loa Loa (eye worm) hypothetical protein 0.0133 0.1617 0.2811
Loa Loa (eye worm) hypothetical protein 0.0025 0.0151 0.0263
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0073 0.0079
Brugia malayi hypothetical protein 0.0165 0.204 0.3539
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0235 0.2995 0.7695
Onchocerca volvulus Huntingtin homolog 0.0133 0.1617 0.2216
Loa Loa (eye worm) cytochrome b 0.0323 0.4186 0.7275
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0258 0.0439
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0073 0.0079
Brugia malayi glutathione reductase 0.0093 0.1065 0.1843
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0041 0.0071
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0193 0.0193
Echinococcus multilocularis peregrin 0.003 0.0209 0.0209
Schistosoma mansoni cpg binding protein 0.0033 0.0256 0.0216
Plasmodium vivax SET domain protein, putative 0.0063 0.0669 0.1514
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0386 0.0463
Echinococcus multilocularis dna polymerase kappa 0.002 0.0073 0.0073
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0119
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0243
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0211 0.2675 0.6862
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0128 0.0213
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0316 0.0637
Brugia malayi chromobox protein homolog 3 0.004 0.0345 0.0591
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0628 0.0628
Echinococcus granulosus GPCR family 2 0.0033 0.0258 0.0258
Mycobacterium ulcerans hypothetical protein 0.0025 0.0145 0.0188
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0316 0.0377
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0119
Loa Loa (eye worm) hypothetical protein 0.0027 0.0169 0.0293
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0161 0.199 0.199
Echinococcus multilocularis muscleblind protein 1 0.0163 0.2014 0.2014
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0209 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0669 0.0669
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0016 0.0009
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0243 0.0488
Echinococcus granulosus pyruvate kinase 0.0036 0.03 0.03
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0243 0.0288
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.0398
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0669 0.0669
Echinococcus multilocularis abhydrolase domain containing protein 0.0041 0.0367 0.0367
Echinococcus multilocularis microtubule associated protein 2 0.0752 1 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0021 0.0028
Echinococcus multilocularis pyruvate kinase 0.0019 0.0061 0.0061
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0235 0.2995 0.7695
Brugia malayi jmjC domain containing protein 0.0027 0.0169 0.0285
Brugia malayi TAR-binding protein 0.0069 0.0743 0.1284
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0145 0.0188
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0073 0.0119
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0243 0.0447
Echinococcus multilocularis musashi 0.0029 0.0206 0.0206
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0243 0.0488
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.03 0.0963
Echinococcus granulosus pyruvate kinase 0.0019 0.0061 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0169 0.0474
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Echinococcus granulosus dna polymerase kappa 0.002 0.0073 0.0073
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0643 0.1452
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0169 0.0169
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0145 0.0167
Giardia lamblia Pyruvate kinase 0.0036 0.03 0.0297
Leishmania major hypothetical protein, conserved 0.0216 0.2734 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.154 0.3852
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0743 0.1292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.063
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0073 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Entamoeba histolytica hypothetical protein 0.0039 0.0339 0.033
Schistosoma mansoni hypothetical protein 0.0446 0.5849 0.5832
Wolbachia endosymbiont of Brugia malayi cytochrome b subunit of the bc complex 0.0323 0.4186 1
Onchocerca volvulus 0.0165 0.204 0.288
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0169 0.0474
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.154 0.3852
Loa Loa (eye worm) hypothetical protein 0.0163 0.2014 0.3501
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.154 0.3904
Leishmania major DNA polymerase kappa, putative 0.002 0.0073 0.0119
Schistosoma mansoni pyruvate kinase 0.0036 0.03 0.026
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0169 0.0169
Schistosoma mansoni inositol monophosphatase 0.0037 0.0316 0.0276
Echinococcus granulosus cytochrome B 0.0323 0.4186 0.4186
Brugia malayi jmjC domain containing protein 0.0027 0.0169 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.063
Brugia malayi hypothetical protein 0.0039 0.0339 0.0581
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0073 0.0119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0475 0.1611
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0175 0.2179 0.3782
Loa Loa (eye worm) hypothetical protein 0.0063 0.0669 0.1162
Giardia lamblia Fructose-bisphosphate aldolase 0.0615 0.8144 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0102 0.1186 0.115
Schistosoma mansoni intermediate filament proteins 0.0029 0.0206 0.0166
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.03 0.0358
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0211 0.2675 0.6862
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0049 0.0475 0.113
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0209 0.0168
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0243 0.0751
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0073 0.0119
Mycobacterium ulcerans pyruvate kinase 0.0036 0.03 0.0597
Loa Loa (eye worm) hypothetical protein 0.0105 0.123 0.2137
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0049 0.0475 0.0587
Toxoplasma gondii apocytochrome b, putative 0.0323 0.4186 1
Schistosoma mansoni hypothetical protein 0.0172 0.2138 0.2106
Schistosoma mansoni microtubule-associated protein tau 0.0752 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0243 0.0751
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0041
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0743 0.0743
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0145 0.0188
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0339 0.0339
Echinococcus multilocularis pyruvate kinase 0.0019 0.0061 0.0061
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0243 0.0488
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0211 0.2675 0.6669
Echinococcus multilocularis lysine specific demethylase 5A 0.01 0.1162 0.1162
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0615 0.8144 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0316 0.0663
Loa Loa (eye worm) hypothetical protein 0.0175 0.2179 0.3788
Plasmodium falciparum glutathione reductase 0.0032 0.0243 0.0488
Brugia malayi intermediate filament protein 0.0029 0.0206 0.0349
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.03 0.0963
Schistosoma mansoni chromobox protein 0.0071 0.0766 0.0728
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0475 0.1046
Echinococcus multilocularis geminin 0.0172 0.2138 0.2138
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0258 0.0258
Loa Loa (eye worm) RNA binding protein 0.0069 0.0743 0.1292
Leishmania major phosphopantetheinyl transferase-like protein 0.0049 0.0475 0.1611
Echinococcus granulosus tar DNA binding protein 0.0069 0.0743 0.0743
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0119
Schistosoma mansoni cpg binding protein 0.0031 0.0232 0.0192
Loa Loa (eye worm) hypothetical protein 0.0072 0.078 0.1355
Echinococcus multilocularis pyruvate kinase 0.0036 0.03 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Schistosoma mansoni hypothetical protein 0.0172 0.2138 0.2106
Echinococcus granulosus phd:f box containing protein 0.0027 0.0169 0.0169
Entamoeba histolytica hypothetical protein 0.0039 0.0339 0.033
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0217
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0743 0.0705
Brugia malayi Heterochromatin protein 1 0.0071 0.0766 0.1324
Plasmodium vivax glutathione reductase, putative 0.0093 0.1065 0.247
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0175 0.2179 0.2147
Echinococcus multilocularis GPCR, family 2 0.0033 0.0258 0.0258
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0041 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Echinococcus granulosus pyruvate kinase 0.0019 0.0061 0.0061
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0316 0.102
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0169 0.0169
Leishmania major pyruvate kinase 0.0036 0.03 0.0963
Onchocerca volvulus 0.0175 0.2179 0.3099
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0345 0.0413
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0217
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0169 0.0128
Mycobacterium tuberculosis Probable oxidoreductase 0.0235 0.2995 0.7695
Echinococcus multilocularis lamin 0.0029 0.0206 0.0206
Loa Loa (eye worm) inositol-1 0.0037 0.0316 0.0549
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0209 0.0404
Onchocerca volvulus 0.0075 0.0825 0.0973
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.2734 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0206 0.0358
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.03 0.0105
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0258 0.0448
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.154 0.3616
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0169 0.0474
Giardia lamblia DINP protein human, muc B family 0.002 0.0073 0.0016
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0243 0.0751
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0211 0.2675 0.6862
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0636 0.1105
Brugia malayi PHD-finger family protein 0.003 0.0209 0.0354
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0366 0.0366
Loa Loa (eye worm) hydrolase 0.0041 0.0367 0.0638
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0316 0.0377
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0169 0.0128
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0169 0.0308
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0217
Brugia malayi cytochrome b 0.0323 0.4186 0.7273
Plasmodium falciparum pyruvate kinase 0.0036 0.03 0.0626
Schistosoma mansoni jumonji/arid domain-containing protein 0.0102 0.1186 0.115
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0206 0.0358
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0061 0.0063
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0209 0.0404
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0316 0.102
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.03 0.388 1
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0217
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0243 0.0488
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0345 0.0218
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0316 0.0316
Echinococcus granulosus dnaJ subfamily B 0.0446 0.5849 0.5849
Brugia malayi jmjC domain containing protein 0.0027 0.0169 0.0285
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0209 0.0209
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.03 0.0626
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0188 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Loa Loa (eye worm) pyruvate kinase 0.0036 0.03 0.0522
Schistosoma mansoni hydrolase 0.0041 0.0367 0.0327
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0073 0.0084
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0049 0.0475 0.1055
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0243 0.0288
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0073 0.0119
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0243 0.0751
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0743 0.0705
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0169 0.0169
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.154 0.5566
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0049 0.0475 1
Schistosoma mansoni lamin 0.0029 0.0206 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0016 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0073 0.0118
Trypanosoma brucei trypanothione reductase 0.0093 0.1065 0.3802
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0151 0.0097
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0766 0.093
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0258 0.0258
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0243 0.0751
Echinococcus granulosus cpg binding protein 0.0033 0.0256 0.0256
Brugia malayi isocitrate dehydrogenase 0.0017 0.0041 0.0062
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0243 0.0488
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0145 0.0385
Echinococcus multilocularis dna polymerase eta 0.002 0.0073 0.0073
Echinococcus granulosus lamin dm0 0.0029 0.0206 0.0206
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0041
Loa Loa (eye worm) pyruvate kinase 0.0036 0.03 0.0522
Echinococcus granulosus abhydrolase domain containing protein 0.0041 0.0367 0.0367
Echinococcus granulosus pyruvate kinase 0.0019 0.0061 0.0061
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0243 0.0527
Echinococcus granulosus lysine specific demethylase 5A 0.0102 0.1186 0.1186
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0386 0.0463
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0145 0.0188
Onchocerca volvulus 0.0031 0.0232 0.0041
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0439 0.5753 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0243 0.0488
Schistosoma mansoni cytochrome b 0.0323 0.4186 0.4162
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.03 0.0148
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0161 0.199 0.199
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0243 0.0414
Brugia malayi jmjC domain containing protein 0.0027 0.0169 0.0285
Schistosoma mansoni inositol monophosphatase 0.0037 0.0316 0.0276
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0061 0.0063
Loa Loa (eye worm) hypothetical protein 0.0027 0.0169 0.0293
Plasmodium vivax JmjC domain containing protein 0.0027 0.0169 0.0308
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0243 0.0226
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0339 0.0299
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.123 0.213
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0206 0.0358
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0073 0.0073
Entamoeba histolytica hypothetical protein 0.0039 0.0339 0.033
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0073 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0243
Echinococcus multilocularis L aminoadipate semialdehyde 0.0175 0.2179 0.2179
Brugia malayi Muscleblind-like protein 0.0163 0.2014 0.3495
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0232 0.0403
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0316 0.102
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0235 0.2995 0.7554
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.154 0.1505
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.123 0.2137
Echinococcus multilocularis chromobox protein 1 0.0071 0.0766 0.0766
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.1065 0.2667
Mycobacterium tuberculosis Probable reductase 0.0211 0.2675 0.6862
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0169 0.0293
Treponema pallidum fructose-bisphosphate aldolase 0.0615 0.8144 1
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0169 0.0169
Onchocerca volvulus Alhambra homolog 0.003 0.0209 0.0004
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0209 0.0363
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0076 0.0035
Echinococcus multilocularis pyruvate kinase 0.0029 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.003 0.0209 0.0363
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0061 0.0047
Trypanosoma brucei unspecified product 0.002 0.0073 0.0119
Schistosoma mansoni hypothetical protein 0.0039 0.0339 0.0299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Echinococcus multilocularis chromobox protein 1 0.0071 0.0766 0.0766
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0193 0.0193
Loa Loa (eye worm) pyruvate kinase 0.0036 0.03 0.0522
Schistosoma mansoni lamin 0.0029 0.0206 0.0166
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.03 0.0963
Giardia lamblia PHD finger protein 15 0.003 0.0209 0.0183
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0316 0.0377
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0073 0.0119
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.154 0.154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0145 0.0385
Plasmodium vivax cytochrome b 0.0323 0.4186 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.03 0.388 1
Echinococcus granulosus lamin 0.0029 0.0206 0.0206
Schistosoma mansoni pyruvate kinase 0.0019 0.0061 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.0102 0.1186 0.2061
Plasmodium falciparum thioredoxin reductase 0.0032 0.0243 0.0488
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0743 0.1284
Loa Loa (eye worm) hypothetical protein 0.0036 0.03 0.0522
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0316 0.0301
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.1065 0.247
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0073 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0169 0.0293
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0169 0.0169
Brugia malayi RNA binding protein 0.0069 0.0743 0.1284
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0339 0.0339
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0316 0.102
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Plasmodium falciparum epoxide hydrolase 1 0.0041 0.0367 0.0786
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0669 0.0669
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0447
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0316 0.0184
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0243 0.0751
Echinococcus granulosus intermediate filament protein 0.0029 0.0206 0.0206
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.5849 0.5849
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0386 0.0282
Brugia malayi Thioredoxin reductase 0.0093 0.1065 0.1843
Entamoeba histolytica hypothetical protein 0.0039 0.0339 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0766 0.1331
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.063
Trypanosoma brucei hypothetical protein, conserved 0.0216 0.2734 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0049 0.0475 0.1046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Loa Loa (eye worm) hypothetical protein 0.0033 0.0258 0.0448
Schistosoma mansoni cpg binding protein 0.0033 0.0256 0.0216
Leishmania major DNA polymerase eta, putative 0.002 0.0073 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0345 0.0413
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0145 0.0145
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0751
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.154 0.3852
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.1065 0.3802
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0073 0.0118
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0061 0.0047
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0258 0.0258
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.078 0.1348
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0073 0.0073
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.03 0.0358
Loa Loa (eye worm) glutathione reductase 0.0093 0.1065 0.1851
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.03 0.0676
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0743 0.0705
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0766 0.093
Echinococcus multilocularis muscleblind protein 0.0163 0.2014 0.2014
Brugia malayi Pre-SET motif family protein 0.0063 0.0669 0.1154
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0206 0.0349
Brugia malayi Bromodomain containing protein 0.003 0.0209 0.0354
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0743 0.1292
Trypanosoma brucei pyruvate kinase 1 0.0036 0.03 0.0963
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0145 0.0385
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0151 0.0263
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0061 0.0047
Mycobacterium tuberculosis Conserved protein 0.0025 0.0145 0.027
Brugia malayi CXXC zinc finger family protein 0.0031 0.0232 0.0394
Onchocerca volvulus 0.0031 0.0229 0.0036
Schistosoma mansoni pyruvate kinase 0.0036 0.03 0.026
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.03 0.0514
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Brugia malayi Pre-SET motif family protein 0.0439 0.5753 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.154 0.1505
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0041 0.0041
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0258 0.0258
Brugia malayi jmjC domain containing protein 0.0102 0.1186 0.2054
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0169 0.0293
Echinococcus granulosus peregrin 0.003 0.0209 0.0209
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0243 0.0751
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.1072 0.1072
Toxoplasma gondii cytochrome b 0.0323 0.4186 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0243 0.0751
Plasmodium falciparum cytochrome b 0.0323 0.4186 1
Onchocerca volvulus 0.0499 0.6573 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0727 0.1263
Brugia malayi Inositol-1 0.0037 0.0316 0.054
Mycobacterium tuberculosis Probable dehydrogenase 0.0211 0.2675 0.6862
Loa Loa (eye worm) hypothetical protein 0.0133 0.1617 0.2811
Echinococcus granulosus geminin 0.0172 0.2138 0.2138
Loa Loa (eye worm) hypothetical protein 0.0163 0.2014 0.3501
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0073 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.0825 0.0787
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0366 0.0366
Chlamydia trachomatis pyruvate kinase 0.0036 0.03 0.2467
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0188 0.022
Loa Loa (eye worm) hypothetical protein 0.0165 0.204 0.3545
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0049 0.0475 0.1055
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0169 0.0128
Schistosoma mansoni chromobox protein 0.0071 0.0766 0.0728
Schistosoma mansoni DNA polymerase eta 0.002 0.0073 0.0032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.8144 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0145 0.0188
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0128 0.0213
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.1072 0.1072
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0021 0.0037
Schistosoma mansoni cytochrome b 0.0323 0.4186 0.4162
Plasmodium falciparum phd finger protein, putative 0.003 0.0209 0.0404
Echinococcus multilocularis pyruvate kinase 0.0036 0.03 0.03
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Echinococcus granulosus chromobox protein 1 0.0071 0.0766 0.0766
Brugia malayi jmjC domain containing protein 0.0161 0.199 0.3452
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0243 0.0751
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0211 0.2675 0.6862
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0041 0.0041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0258 0.0439
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0049 0.0475 0.1046
Leishmania major trypanothione reductase 0.0093 0.1065 0.3802
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0073 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.123 0.213
Schistosoma mansoni jumonji domain containing protein 0.0141 0.172 0.1686
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0615 0.8144 1
Echinococcus granulosus chromobox protein 1 0.0071 0.0766 0.0766
Plasmodium vivax hypothetical protein, conserved 0.003 0.0209 0.0404
Leishmania major hypothetical protein, conserved 0.0041 0.0367 0.121
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.01 0.0164
Plasmodium vivax pyruvate kinase, putative 0.0036 0.03 0.0626
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0145 0.0145
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.1065 0.1851
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0073 0.0127
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0041 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0743 0.0705

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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