TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 563.044 | Formula: C30H31ClN4O5
H donors: 3 H acceptors: 6 LogP: 5.39 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: CCCCc1nc(c(n1Cc1ccc(cc1)NC(=O)[C@@H](n1cccc1C(=O)O)Cc1ccccc1)CC(=O)O)Cl
InChi: 1S/C30H31ClN4O5/c1-2-3-11-26-33-28(31)24(18-27(36)37)35(26)19-21-12-14-22(15-13-21)32-29(38)25(17-20-8-5-4-6-9-20)34-16-7-10-23(34)30(39)40/h4-10,12-16,25H,2-3,11,17-19H2,1H3,(H,32,38)(H,36,37)(H,39,40)/t25-/m0/s1
InChiKey: FXJKNRYTYKTBIU-VWLOTQADSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Type-1B angiotensin II receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	growth hormone secretagogue receptor type 1	Type-1B angiotensin II receptor	359 aa	343 aa	23.0 %
Echinococcus granulosus	neuropeptide receptor	Type-1B angiotensin II receptor	359 aa	317 aa	24.6 %
Echinococcus multilocularis	allatostatin A receptor	Type-1B angiotensin II receptor	359 aa	342 aa	26.6 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Type-1B angiotensin II receptor	359 aa	323 aa	25.7 %
Onchocerca volvulus		Type-1B angiotensin II receptor	359 aa	309 aa	18.8 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Type-1B angiotensin II receptor	359 aa	300 aa	21.0 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Type-1B angiotensin II receptor	359 aa	346 aa	18.2 %
Brugia malayi	putative neuropeptide receptor NPR1	Type-1B angiotensin II receptor	359 aa	295 aa	27.1 %
Loa Loa (eye worm)	neuropeptide F receptor	Type-1B angiotensin II receptor	359 aa	344 aa	23.5 %
Onchocerca volvulus		Type-1B angiotensin II receptor	359 aa	350 aa	24.0 %
Loa Loa (eye worm)	hypothetical protein	Type-1B angiotensin II receptor	359 aa	329 aa	24.0 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Type-1B angiotensin II receptor	359 aa	365 aa	20.0 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Type-1B angiotensin II receptor	359 aa	307 aa	22.1 %
Onchocerca volvulus		Type-1B angiotensin II receptor	359 aa	355 aa	23.9 %
Onchocerca volvulus		Type-1B angiotensin II receptor	359 aa	292 aa	24.7 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Type-1B angiotensin II receptor	359 aa	366 aa	19.7 %
Onchocerca volvulus		Type-1B angiotensin II receptor	359 aa	386 aa	24.4 %
Onchocerca volvulus		Type-1B angiotensin II receptor	359 aa	314 aa	25.2 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Type-1B angiotensin II receptor	359 aa	354 aa	20.6 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Type-1B angiotensin II receptor	359 aa	350 aa	23.1 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Type-1B angiotensin II receptor	359 aa	307 aa	24.1 %
Brugia malayi	ORL1-like opioid receptor	Type-1B angiotensin II receptor	359 aa	314 aa	20.4 %
Schistosoma mansoni	opsin-like receptor	Type-1B angiotensin II receptor	359 aa	299 aa	25.8 %
Echinococcus granulosus	allatostatin A receptor	Type-1B angiotensin II receptor	359 aa	342 aa	27.2 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Type-1B angiotensin II receptor	359 aa	325 aa	20.9 %
Echinococcus multilocularis	neuropeptide receptor	Type-1B angiotensin II receptor	359 aa	317 aa	24.9 %
Brugia malayi	GnHR receptor homolog	Type-1B angiotensin II receptor	359 aa	357 aa	20.4 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Type-1B angiotensin II receptor	359 aa	363 aa	23.7 %
Onchocerca volvulus		Type-1B angiotensin II receptor	359 aa	305 aa	24.9 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Type-1B angiotensin II receptor	359 aa	363 aa	23.4 %
Loa Loa (eye worm)	hypothetical protein	Type-1B angiotensin II receptor	359 aa	308 aa	27.6 %
Echinococcus granulosus	tm gpcr rhodopsin	Type-1B angiotensin II receptor	359 aa	300 aa	21.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine protease, putative	0.0395	0.2339	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0472	0.2995	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0395	0.2339	0.2304
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0239	0.1016	0.0716
Onchocerca volvulus	Cathepsin F homolog	0.0395	0.2339	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0395	0.2339	0.6923
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1297	1	1
Plasmodium vivax	RNA helicase-1, putative	0.0239	0.1016	0.1035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0239	0.1016	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0395	0.2339	0.6923
Giardia lamblia	Cathepsin B precursor	0.0472	0.2995	1
Toxoplasma gondii	cathepsin B	0.0472	0.2995	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0395	0.2339	0.6923
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0239	0.1016	0.0975
Leishmania major	cathepsin L-like protease	0.0395	0.2339	0.6686
Giardia lamblia	Cathepsin B precursor	0.0472	0.2995	1
Leishmania major	cathepsin L-like protease	0.0395	0.2339	0.6686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Brugia malayi	Papain family cysteine protease containing protein	0.0221	0.0864	0.0864
Echinococcus granulosus	cathepsin b	0.1297	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Echinococcus multilocularis	cathepsin L cysteine protease	0.0395	0.2339	0.2304
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Onchocerca volvulus		0.0395	0.2339	1
Loa Loa (eye worm)	hypothetical protein	0.0491	0.3152	0.3152
Onchocerca volvulus		0.0395	0.2339	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0395	0.2339	0.1615
Onchocerca volvulus		0.0395	0.2339	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0277	0.1333	0.2203
Brugia malayi	Papain family cysteine protease containing protein	0.0221	0.0864	0.0864
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0171	0.0439	0.0439
Onchocerca volvulus		0.0395	0.2339	1
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0239	0.1016	0.0975
Brugia malayi	Cathepsin L-like precursor	0.0277	0.1333	0.1333
Echinococcus multilocularis	cathepsin L	0.0221	0.0864	0.0821
Loa Loa (eye worm)	fibroinase	0.0395	0.2339	0.2339
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1297	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0395	0.2339	0.1615
Brugia malayi	Trypsin family protein	0.0171	0.0439	0.0439
Schistosoma mansoni	cathepsin F (C01 family)	0.0277	0.1333	0.1333
Leishmania major	cathepsin L-like protease	0.0395	0.2339	0.6686
Echinococcus multilocularis	cathepsin b	0.1297	1	1
Echinococcus multilocularis	cysteine protease	0.0395	0.2339	0.2304
Onchocerca volvulus		0.0277	0.1333	0.4705
Brugia malayi	Cathepsin L-like precursor	0.0395	0.2339	0.2339
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0395	0.2339	0.6923
Brugia malayi	cathepsin L-like precursor	0.0277	0.1333	0.1333
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0395	0.2339	0.6923
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0395	0.2339	0.6923
Entamoeba histolytica	cysteine proteinase, putative	0.0395	0.2339	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0221	0.0864	0.0864
Onchocerca volvulus		0.0395	0.2339	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0395	0.2339	0.6923
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0472	0.2995	1
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0239	0.1016	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0395	0.2339	0.2339
Leishmania major	cathepsin L-like protease	0.0395	0.2339	0.6686
Brugia malayi	Cathepsin L-like precursor	0.0395	0.2339	0.2339
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0395	0.2339	0.2339
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0395	0.2339	0.6923
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0239	0.1016	0.0167
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0239	0.1016	0.1035
Loa Loa (eye worm)	hypothetical protein	0.0277	0.1333	0.1333
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0125	0.0046	0.0046
Brugia malayi	Cathepsin L-like precursor	0.0277	0.1333	0.1333
Entamoeba histolytica	cysteine proteinase, putative	0.0395	0.2339	1
Loa Loa (eye worm)	cathepsin B	0.0472	0.2995	0.2995
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0491	0.3152	0.3152
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0239	0.1016	0.1035
Schistosoma mansoni	cathepsin F (C01 family)	0.0395	0.2339	0.2339
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0277	0.1333	0.2203
Giardia lamblia	Cathepsin B precursor	0.0472	0.2995	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0395	0.2339	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Leishmania major	cysteine peptidase A (CPA)	0.0395	0.2339	0.6686
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0239	0.1016	0.0975
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0239	0.1016	0.1016
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0439	0.0439
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Toxoplasma gondii	cathepsin CPL	0.0395	0.2339	0.6686
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0395	0.2339	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0125	0.0046	0.0046
Plasmodium vivax	vivapain-2	0.0395	0.2339	1
Loa Loa (eye worm)	hypothetical protein	0.0277	0.1333	0.1333
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0239	0.1016	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0277	0.1333	0.1333
Plasmodium vivax	vivapain-2	0.0395	0.2339	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0395	0.2339	0.2304
Brugia malayi	Cathepsin L-like precursor	0.0395	0.2339	0.2339
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Echinococcus granulosus	cathepsin L	0.0221	0.0864	0.0821
Echinococcus granulosus	cathepsin b	0.1297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0395	0.2339	0.6923
Echinococcus granulosus	cathepsin l1	0.0277	0.1333	0.1293
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0221	0.0864	0.0864
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Schistosoma mansoni	cathepsin F (C01 family)	0.0395	0.2339	0.2339
Onchocerca volvulus	Cathepsin L homolog	0.0395	0.2339	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0221	0.0864	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0439	0.0439
Onchocerca volvulus		0.0395	0.2339	1
Loa Loa (eye worm)	cysteine protease	0.0395	0.2339	0.2339
Brugia malayi	Cathepsin L-like precursor	0.0395	0.2339	0.2339
Trypanosoma cruzi	cysteine peptidase, putative	0.0395	0.2339	0.1615
Trypanosoma cruzi	cruzipain precursor, putative	0.0395	0.2339	0.1615
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0395	0.2339	0.2304
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0239	0.1016	0.0716
Loa Loa (eye worm)	ctsf protein	0.0395	0.2339	0.2339
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1016	0.1016
Brugia malayi	Papain family cysteine protease containing protein	0.0395	0.2339	0.2339
Leishmania major	cathepsin L-like protease	0.0395	0.2339	0.6686
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.2995	0.2995
Echinococcus granulosus	cysteine protease	0.0221	0.0864	0.0821
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0221	0.0864	0.0864
Leishmania major	cathepsin L-like protease	0.0395	0.2339	0.6686
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0395	0.2339	1
Treponema pallidum	ATP-dependent RNA helicase	0.0239	0.1016	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0395	0.2339	0.2339
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0277	0.1333	0.0514
Leishmania major	cathepsin L-like protease	0.0395	0.2339	0.6686
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0472	0.2995	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0395	0.2339	0.1615
Entamoeba histolytica	cysteine proteinase, putative	0.0277	0.1333	0.3182
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0239	0.1016	0.3037
Loa Loa (eye worm)	hypothetical protein	0.1297	1	1
Brugia malayi	eukaryotic initiation factor 4A	0.0239	0.1016	0.1016
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0239	0.1016	0.0716
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0239	0.1016	0.1016
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0395	0.2339	0.6923
Echinococcus multilocularis	cathepsin b	0.1297	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0395	0.2339	0.6923
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0277	0.1333	0.1333
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0491	0.3152	0.3152
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Leishmania major	cathepsin L-like protease	0.0395	0.2339	0.6686
Echinococcus multilocularis	cysteine protease	0.0395	0.2339	0.2304
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0395	0.2339	0.6923
Brugia malayi	Cathepsin L-like precursor	0.0395	0.2339	0.2339
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1297	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1297	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0395	0.2339	0.6923
Onchocerca volvulus		0.0395	0.2339	1
Brugia malayi	Cathepsin L-like precursor	0.0395	0.2339	0.2339
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0239	0.1016	0.0716
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0472	0.2995	0.2332
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0395	0.2339	0.2304
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0171	0.0439	0.0439
Onchocerca volvulus	Cathepsin L homolog	0.0395	0.2339	1
Echinococcus granulosus	cathepsin l1	0.0395	0.2339	0.2304
Echinococcus multilocularis	cathepsin L cysteine protease	0.0395	0.2339	0.2304

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.027 uM	Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.	ChEMBL.	8510101
IC50 (binding)	= 0.027 uM	Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.	ChEMBL.	8510101
IC50 (functional)	= 0.52 uM	Inhibition of Angiotensin II induced contraction of isolated rabbit aortic rings	ChEMBL.	8510101

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL297653

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 68586