Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3056 | 1 | 1 |
Mycobacterium ulcerans | esterase LipC | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0073 | 0.007 | 0.007 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0052 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0073 | 0.007 | 1 |
Mycobacterium leprae | Possible lipase LipU | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.007 | 0.007 |
Echinococcus multilocularis | hormone sensitive lipase | 0.3056 | 1 | 1 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0 | 0.5 |
Leishmania major | ecotin, putative | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0073 | 0.007 | 0.007 |
Trichomonas vaginalis | Esterase, putative | 0.0052 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0073 | 0.007 | 0.007 |
Brugia malayi | Carboxylesterase family protein | 0.0073 | 0.007 | 1 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0052 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0052 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.0161 | 1 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3056 | 1 | 1 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.007 | 0.007 |
Mycobacterium ulcerans | esterase LipW | 0.0052 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3056 | 1 | 1 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0052 | 0 | 0.5 |
Onchocerca volvulus | 0.0052 | 0 | 0.5 | |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0161 | 0.0161 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.3056 | 1 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0052 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 160 nM | Inhibitory concentration for 50% inhibition of HIV-1 reverse transcriptase | ChEMBL. | 10937734 |
IC50 (binding) | = 160 nM | Inhibitory concentration for 50% inhibition of HIV-1 reverse transcriptase | ChEMBL. | 10937734 |
IC90 (binding) | = 19 nM | Inhibitory concentration for 90% inhibition of HIV-1 reverse transcriptase, whole cell based antiviral assay | ChEMBL. | 10937734 |
IC90 (binding) | = 19 nM | Inhibitory concentration for 90% inhibition of HIV-1 reverse transcriptase, whole cell based antiviral assay | ChEMBL. | 10937734 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.