Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Alcohol dehydrogenase | Starlite/ChEMBL | References |
Homo sapiens | alcohol dehydrogenase 1B (class I), beta polypeptide | Starlite/ChEMBL | References |
Homo sapiens | alcohol dehydrogenase 1C (class I), gamma polypeptide | Starlite/ChEMBL | References |
Homo sapiens | alcohol dehydrogenase 1A (class I), alpha polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.031 | 0.8696 | 0.8612 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0043 | 0.061 | 0.5 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0043 | 0.061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0135 | 0.0135 |
Onchocerca volvulus | 0.0043 | 0.061 | 0.061 | |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0353 | 1 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0353 | 1 | 1 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0043 | 0.061 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.061 | 0.061 |
Leishmania major | oxidoreductase-like protein | 0.0043 | 0.061 | 1 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0353 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0043 | 0.061 | 0.5 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0043 | 0.061 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0043 | 0.061 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0043 | 0.061 | 1 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0353 | 1 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0043 | 0.061 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0353 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.061 | 0.061 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0353 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0043 | 0.061 | 0.0481 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0043 | 0.061 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0043 | 0.061 | 0.0481 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0043 | 0.061 | 0.0481 |
Mycobacterium ulcerans | oxidoreductase | 0.0043 | 0.061 | 0.0481 |
Mycobacterium ulcerans | polyketide synthase | 0.0043 | 0.061 | 0.0481 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0027 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | acyl carrier protein | 0.0027 | 0.0135 | 0.0135 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0043 | 0.061 | 1 |
Leishmania major | d-xylulose reductase, putative | 0.0043 | 0.061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.061 | 0.061 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0027 | 0.0135 | 0.0135 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0043 | 0.061 | 0.061 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0043 | 0.061 | 0.0481 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0043 | 0.061 | 1 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0353 | 1 | 1 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0043 | 0.061 | 0.0481 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0043 | 0.061 | 0.5 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0353 | 1 | 1 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0353 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0043 | 0.061 | 0.5 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0043 | 0.061 | 1 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0043 | 0.061 | 1 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0353 | 1 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0043 | 0.061 | 1 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0043 | 0.061 | 0.0481 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0043 | 0.061 | 0.0481 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0043 | 0.061 | 1 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0353 | 1 | 1 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0043 | 0.061 | 0.0481 |
Leishmania major | quinone oxidoreductase, putative | 0.0043 | 0.061 | 1 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.031 | 0.8696 | 0.8612 |
Mycobacterium ulcerans | dehydrogenase | 0.0043 | 0.061 | 0.0481 |
Leishmania major | oxidoreductase, putative | 0.0043 | 0.061 | 1 |
Schistosoma mansoni | zinc binding dehydrogenase | 0.0043 | 0.061 | 0.061 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0043 | 0.061 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0043 | 0.061 | 1 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0043 | 0.061 | 1 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0043 | 0.061 | 0.0481 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0043 | 0.061 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0043 | 0.061 | 0.061 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0043 | 0.061 | 0.0481 |
Onchocerca volvulus | 0.0027 | 0.0135 | 0.0135 | |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0027 | 0.0135 | 0.0135 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0043 | 0.061 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.9 uM | Inhibition of human alcohol dehydrogenase alpha activity | ChEMBL. | 9572895 |
Ki (binding) | = 3.9 uM | Inhibition of human alcohol dehydrogenase alpha activity | ChEMBL. | 9572895 |
Ki (binding) | = 7.3 uM | Inhibition of human alcohol dehydrogenase beta 1 activity | ChEMBL. | 9572895 |
Ki (binding) | = 7.3 uM | Inhibition of human alcohol dehydrogenase beta 1 activity | ChEMBL. | 9572895 |
Ki (binding) | = 7.6 uM | Inhibition of horse liver alcohol dehydrogenase activity | ChEMBL. | 9572895 |
Ki (binding) | = 7.6 uM | Inhibition of horse liver alcohol dehydrogenase activity | ChEMBL. | 9572895 |
Ki (binding) | = 13 uM | Inhibition of human alcohol dehydrogenase gamma2 activity | ChEMBL. | 9572895 |
Ki (binding) | = 13 uM | Inhibition of human alcohol dehydrogenase gamma2 activity | ChEMBL. | 9572895 |
Ki (binding) | = 28 uM | Inhibition of human alcohol dehydrogenase sigma activity | ChEMBL. | 9572895 |
Ki (binding) | = 28 uM | Inhibition of human alcohol dehydrogenase sigma activity | ChEMBL. | 9572895 |
Ki (binding) | = 150 uM | Inhibition of human alcohol dehydrogenase pi activity | ChEMBL. | 9572895 |
Ki (binding) | = 150 uM | Inhibition of human alcohol dehydrogenase pi activity | ChEMBL. | 9572895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.