Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Plasmodium vivax | phospholipase C-like, putative | 0.0015 | 0.008 | 0.0182 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0074 | 0.2006 | 1 |
Loa Loa (eye worm) | phosphatidylinositol-specific phospholipase C | 0.0016 | 0.011 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.2002 | 0.2002 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.2002 | 0.2002 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0096 | 0.2739 | 0.6222 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0096 | 0.274 | 0.6223 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.0046 | 0.1079 | 0.2452 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0147 | 0.4402 | 1 |
Brugia malayi | ThiF family protein | 0.0047 | 0.1131 | 0.1131 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0147 | 0.4402 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0766 | 0.0766 |
Brugia malayi | Variant SH3 domain containing protein | 0.011 | 0.3185 | 0.3185 |
Loa Loa (eye worm) | acetyltransferase | 0.0318 | 1 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0158 | 0.4773 | 0.4773 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Trypanosoma brucei | beta lactamase | 0.0074 | 0.2006 | 0.4556 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.008 | 0.008 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0074 | 0.2006 | 0.2237 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0147 | 0.4402 | 0.5 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0147 | 0.4402 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0318 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0147 | 0.4402 | 1 |
Plasmodium falciparum | SUMO-activating enzyme subunit 1 | 0.0047 | 0.1131 | 0.2569 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0147 | 0.4402 | 0.4402 |
Trichomonas vaginalis | histone acetyltransferase gcn5, putative | 0.0013 | 0.0003 | 0.0006 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0074 | 0.2002 | 0.2002 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0147 | 0.4402 | 0.4402 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0147 | 0.4402 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0046 | 0.1079 | 0.2452 |
Plasmodium vivax | ubiquitin activating enzyme, putative | 0.0047 | 0.1131 | 0.2569 |
Brugia malayi | phospholipase C homolog | 0.0026 | 0.0452 | 0.0452 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0147 | 0.4402 | 0.4402 |
Echinococcus granulosus | acetylcholinesterase | 0.0074 | 0.2002 | 0.2088 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0085 | 0.2361 | 0.5363 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0147 | 0.4402 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0096 | 0.2739 | 0.6222 |
Echinococcus granulosus | SUMO activating enzyme subunit 1 | 0.0047 | 0.1131 | 0.118 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0096 | 0.2742 | 0.6229 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0085 | 0.2361 | 0.5363 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2742 | 0.2742 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0096 | 0.2742 | 0.6229 |
Schistosoma mansoni | phospholipase C beta | 0.0035 | 0.0736 | 0.0736 |
Brugia malayi | TAZ zinc finger family protein | 0.0228 | 0.7033 | 0.7033 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0096 | 0.2739 | 0.6222 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0147 | 0.4402 | 0.4402 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0147 | 0.4402 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.2002 | 0.2002 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0096 | 0.274 | 0.1855 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0147 | 0.4402 | 0.4402 |
Echinococcus multilocularis | SUMO activating enzyme subunit 1 | 0.0047 | 0.1131 | 0.1131 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0051 | 0.1248 | 0.2835 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0044 | 0.1033 | 0.1033 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0096 | 0.2742 | 0.2742 |
Brugia malayi | Phosphatidylinositol-specific phospholipase C, X domain containing protein | 0.0015 | 0.008 | 0.008 |
Echinococcus granulosus | 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 | 0.0036 | 0.0766 | 0.0799 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.011 | 0.3185 | 0.3185 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0228 | 0.7033 | 0.7033 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0147 | 0.4402 | 0.9152 |
Echinococcus granulosus | CREB binding protein | 0.0143 | 0.4277 | 0.4462 |
Toxoplasma gondii | phosphoinositide phospholipase PIPLC | 0.0016 | 0.011 | 0.025 |
Loa Loa (eye worm) | carboxylesterase | 0.0074 | 0.2002 | 0.2002 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0096 | 0.2742 | 0.2742 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0147 | 0.4402 | 1 |
Trypanosoma cruzi | phosphoinositide-specific phospholipase C, putative | 0.0016 | 0.011 | 0.025 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0147 | 0.4402 | 0.4593 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0096 | 0.2739 | 0.6222 |
Schistosoma mansoni | phospholipase C-like protein 2 plc-L2 | 0.0026 | 0.0452 | 0.0452 |
Plasmodium falciparum | phosphoinositide-specific phospholipase C | 0.0015 | 0.008 | 0.0182 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.0046 | 0.1079 | 0.1079 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0046 | 0.1079 | 0.2452 |
Leishmania major | glyceraldehyde-3-phosphate dehydrogenase-like protein | 0.0096 | 0.274 | 0.6223 |
Echinococcus granulosus | CREB binding protein | 0.0036 | 0.0767 | 0.0801 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0074 | 0.2002 | 0.2002 |
Echinococcus multilocularis | acetylcholinesterase | 0.0074 | 0.2002 | 0.2002 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0208 | 0.0208 |
Brugia malayi | Phosphatidylinositol-specific phospholipase C, X domain containing protein | 0.0016 | 0.011 | 0.011 |
Loa Loa (eye worm) | CBP-B | 0.016 | 0.4836 | 0.4836 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0154 | 0.4624 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0036 | 0.0767 | 0.0767 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0147 | 0.4402 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0096 | 0.2739 | 0.6222 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0096 | 0.274 | 0.6223 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0154 | 0.4624 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0046 | 0.1079 | 0.2452 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0096 | 0.2742 | 0.2861 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1131 | 0.1131 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0147 | 0.4402 | 0.4593 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0228 | 0.7033 | 0.7033 |
Onchocerca volvulus | 0.0036 | 0.0766 | 1 | |
Trypanosoma brucei | phosphoinositide-specific phospholipase C | 0.0016 | 0.011 | 0.025 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0102 | 0.2911 | 0.2911 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2965 | 0.2965 |
Echinococcus multilocularis | CREB binding protein | 0.0036 | 0.0767 | 0.0767 |
Loa Loa (eye worm) | Plcb4 protein | 0.0035 | 0.0736 | 0.0736 |
Leishmania major | phosphatidylinositol-specific phospholipase-like protein | 0.0015 | 0.008 | 0.0182 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0036 | 0.0767 | 0.0767 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0147 | 0.4402 | 0.4402 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.0046 | 0.1079 | 0.2452 |
Echinococcus granulosus | carboxylesterase 5A | 0.0074 | 0.2002 | 0.2088 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0147 | 0.4402 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.2002 | 0.2002 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0147 | 0.4402 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.2002 | 0.2002 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0147 | 0.4402 | 0.4402 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0147 | 0.4402 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0102 | 0.2911 | 0.2911 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0051 | 0.1248 | 0.1248 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.1131 | 0.2569 |
Echinococcus multilocularis | acetylcholinesterase | 0.0074 | 0.2002 | 0.2002 |
Echinococcus granulosus | CREB binding protein | 0.0228 | 0.7033 | 0.7337 |
Onchocerca volvulus | 0.0036 | 0.0766 | 1 | |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0147 | 0.4402 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0306 | 0.9586 | 1 |
Schistosoma mansoni | sumo-1-activating enzyme E1a | 0.0047 | 0.1131 | 0.1131 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0147 | 0.4402 | 1 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0096 | 0.274 | 0.6223 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0318 | 1 | 1 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0147 | 0.4402 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0074 | 0.2002 | 0.2088 |
Trichomonas vaginalis | histone acetyltransferase gcn5, putative | 0.0013 | 0.0003 | 0.0006 |
Leishmania major | phosphoinositide-specific phospholipase C, putative | 0.0015 | 0.008 | 0.0182 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0096 | 0.2742 | 0.2742 |
Echinococcus granulosus | CREB binding protein | 0.0036 | 0.0767 | 0.0801 |
Brugia malayi | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 | 0.0035 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0766 | 0.0766 |
Leishmania major | phospholipase c-like protein | 0.0016 | 0.011 | 0.025 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0096 | 0.2739 | 0.2857 |
Echinococcus multilocularis | 1 phosphatidylinositol 4,5 bisphosphate | 0.0036 | 0.0766 | 0.0766 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC25 (functional) | = 6.6 | Negative inotropy measured as the concentration required to depress contraction in the isolated Langendorff-perfused guinea pig heart by 25% | ChEMBL. | 2943898 |
-Log IC50 (functional) | = 7.8 | In vitro calcium antagonist activity was assessed against calcium induced constriction of potassium-depolarized rat aorta | ChEMBL. | 2943898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.