Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | deoxyhypusine synthase | 0.007 | 0.7022 | 0.6077 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0082 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0082 | 1 | 1 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.007 | 0.7022 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0082 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0082 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0073 | 0.7743 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0082 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0082 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0082 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0082 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0073 | 0.7743 | 1 |
Schistosoma mansoni | deoxyhypusine synthase | 0.007 | 0.7022 | 0.7022 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0082 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0082 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0041 | 0.0151 | 0.0151 |
Chlamydia trachomatis | sulfite reductase | 0.0051 | 0.2407 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0082 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0082 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0082 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0073 | 0.7743 | 0.2424 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0082 | 1 | 1 |
Brugia malayi | deoxyhypusine synthase | 0.007 | 0.7022 | 0.6077 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0082 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0082 | 1 | 1 |
Echinococcus multilocularis | deoxyhypusine synthase | 0.007 | 0.7022 | 0.6077 |
Trypanosoma cruzi | p450 reductase, putative | 0.0082 | 1 | 1 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.007 | 0.7022 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0082 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | deoxyhypusine synthase | 0.007 | 0.7022 | 0.6077 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0073 | 0.7743 | 0.2424 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0051 | 0.2407 | 0.2407 |
Toxoplasma gondii | deoxyhypusine synthase | 0.007 | 0.7022 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0073 | 0.7743 | 0.2424 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0082 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.