Detailed information for compound 701414

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 425.272 | Formula: C17H14BrFN2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(c(c1)F)NS(=O)(=O)c1cc2CCC(=O)N3c2c(c1)CC3
  • InChi: 1S/C17H14BrFN2O3S/c18-12-2-3-15(14(19)9-12)20-25(23,24)13-7-10-1-4-16(22)21-6-5-11(8-13)17(10)21/h2-3,7-9,20H,1,4-6H2
  • InChiKey: GMIXMONQKMIDMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis muscleblind protein 0.0154 0.328 0.328
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.1222 0.1221
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0087 0.0233
Mycobacterium ulcerans hypothetical protein 0.0173 0.3732 0.5829
Brugia malayi Carboxyl transferase domain containing protein 0.008 0.158 0.2363
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0087 0.0119
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0031 0.0468 0.0639
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0316 0.0315
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0316 0.1258
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.1223 0.1223
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0031 0.0468 1
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0316 0.0362
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0807 0.1103
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0087 0.0119
Brugia malayi CXXC zinc finger family protein 0.0031 0.0463 0.0594
Echinococcus multilocularis pyruvate kinase 0.0018 0.0151 0.0151
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0087 0.0233
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0087 0.0233
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0575 0.0575
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0539 0.0715
Schistosoma mansoni cytochrome P450 0.0015 0.0087 0.0087
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0031 0.0468 0.073
Schistosoma mansoni pyruvate carboxylase 0.0031 0.0468 0.0467
Schistosoma mansoni hypothetical protein 0.0047 0.0815 0.0815
Schistosoma mansoni hypothetical protein 0.0139 0.2942 0.2942
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1151 0.1685
Brugia malayi jmjC domain containing protein 0.0036 0.0575 0.0773
Echinococcus granulosus GPCR family 2 0.0064 0.1223 0.1223
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0031 0.0468 0.073
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0539 0.0715
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0208 0.4525 0.4524
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.3327 0.4547
Echinococcus multilocularis pyruvate kinase 0.0027 0.0371 0.0371
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1916 0.2896
Echinococcus granulosus hormone sensitive lipase 0.0208 0.4525 0.4524
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0087 0.0233
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0087 0.0136
Schistosoma mansoni glutaminase 0.0289 0.6402 0.6402
Leishmania major pyruvate kinase 0.0035 0.0539 0.0736
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0087 0.0233
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.1223 0.1799
Echinococcus multilocularis 0.0015 0.0087 0.0087
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.2043 0.2043
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0031 0.0468 0.0467
Mycobacterium leprae putative cytochrome p450 0.0015 0.0087 0.1613
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.1223 0.1223
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0032 0.047 0.0469
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0031 0.0468 0.0467
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0087 0.0233
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1222 0.1908
Trichomonas vaginalis CAMK family protein kinase 0.01 0.2043 0.2839
Schistosoma mansoni hypothetical protein 0.0064 0.1223 0.1223
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.006 0.112 1
Onchocerca volvulus 0.0031 0.0463 0.0401
Loa Loa (eye worm) hypothetical protein 0.0154 0.328 0.5057
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0083 0.1646 0.1646
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0087 0.0233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1916 0.1916
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0087 0.0136
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.006 0.112 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0087 0.0136
Mycobacterium ulcerans pyruvate carboxylase 0.0031 0.0468 0.073
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0087 0.0136
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0087 0.0528
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.5002 0.5002
Loa Loa (eye worm) RNA binding protein 0.0061 0.1151 0.1685
Mycobacterium ulcerans glutaminase 0.0289 0.6402 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.2043 0.2043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1916 0.1916
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.1223 0.1223
Brugia malayi glutaminase DH11.1 0.0289 0.6402 1
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0539 0.0366
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1151 0.1151
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0316 0.0315
Schistosoma mansoni pyruvate kinase 0.0035 0.0539 0.0538
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.2043 0.2793
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0151 0.0916
Trichomonas vaginalis CAMK family protein kinase 0.01 0.2043 0.2839
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0087 0.0233
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1107 0.6722
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1916 0.1916
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0087 0.0136
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0087 0.0136
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0396 0.049
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.4423 0.6866
Loa Loa (eye worm) hypothetical protein 0.0049 0.0864 0.123
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.1223 0.1799
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0316 0.0431
Schistosoma mansoni pyruvate kinase 0.0035 0.0539 0.0538
Trichomonas vaginalis glutaminase, putative 0.0289 0.6402 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.104 0.1421
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0087 0.0136
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.1222 0.742
Brugia malayi RNA binding protein 0.0061 0.1151 0.1685
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1885 0.1885
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0539 0.4809
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0329 0.7316 1
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1151 0.1685
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0301 0.0338
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0087 0.0233
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.127 0.127
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.1222 0.1221
Schistosoma mansoni cpg binding protein 0.0033 0.0504 0.0503
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0298 0.1167
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0087 0.0233
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0539 0.0715
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0301 0.041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1916 0.1916
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1151 0.1151
Trypanosoma cruzi acetyl-CoA carboxylase 0.0051 0.0921 0.1259
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1151 0.1151
Giardia lamblia PHD finger protein 15 0.0028 0.0396 0.1667
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0316 0.1916
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0087 0.0136
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0316 0.0362
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0316 0.0362
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0087 0.0136
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0396 0.2407
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.1017 0.1472
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0807 0.1103
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0087 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.01 0.2043 0.2839
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0031 0.0468 0.1252
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0083 0.1646 0.1646
Loa Loa (eye worm) hypothetical protein 0.0228 0.5002 0.7783
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0807 0.1103
Loa Loa (eye worm) hypothetical protein 0.0203 0.4423 0.6866
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.4423 0.6866
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0087 0.0233
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1222 0.1908
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0087 0.0136
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0087 0.0233
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.1222 0.3273
Brugia malayi Cytochrome P450 family protein 0.0024 0.0301 0.0338
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0208 0.4525 0.4524
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.008 0.158 0.2363
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0151 0.1348
Brugia malayi PHD-finger family protein 0.0028 0.0396 0.049
Schistosoma mansoni survival motor neuron protein 0.0047 0.0815 0.0815
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0087 0.0087
Brugia malayi Muscleblind-like protein 0.0154 0.328 0.5057
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0575 0.0575
Echinococcus multilocularis dnaJ subfamily B 0.0446 1 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0539 0.0715
Loa Loa (eye worm) hypothetical protein 0.0139 0.2942 0.4521
Echinococcus multilocularis peregrin 0.0028 0.0396 0.0396
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0539 1
Chlamydia trachomatis pyruvate kinase 0.0035 0.0539 1
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0031 0.0468 0.073
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0316 0.0315
Schistosoma mansoni cpg binding protein 0.0031 0.0463 0.0462
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0156 0.3327 0.4547
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1916 0.1916
Trypanosoma brucei acetyl-CoA carboxylase 0.0083 0.1646 0.225
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1444 0.1444
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.3732 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0463 0.0594
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0208 0.4525 0.4524
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.2043 0.2793
Brugia malayi Cytochrome P450 family protein 0.0055 0.1017 0.1472
Echinococcus multilocularis GPCR, family 2 0.0064 0.1223 0.1223
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0539 0.0366
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0087 0.0136
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0316 0.0315
Giardia lamblia Kinase, PLK 0.01 0.2043 1
Echinococcus multilocularis pyruvate kinase 0.0035 0.0539 0.0538
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1222 0.1221
Loa Loa (eye worm) glutaminase 2 0.0289 0.6402 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.2043 0.3098
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0575 0.0773
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0539 0.0736
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0329 0.7316 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0301 0.0338
Brugia malayi Latrophilin receptor protein 2 0.0064 0.1223 0.1799
Schistosoma mansoni pyruvate kinase 0.0018 0.0151 0.0151
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0575 0.0575
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0539 0.0736
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0083 0.1646 1
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0539 0.3271
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1151 0.1151
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0881 0.093
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0539 0.0863
Echinococcus multilocularis muscleblind protein 1 0.0154 0.328 0.328
Trichomonas vaginalis CAMK family protein kinase 0.01 0.2043 0.2839
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0539 0.0736
Schistosoma mansoni hypothetical protein 0.0028 0.0396 0.0396
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1222 0.1908
Brugia malayi jmjC domain containing protein 0.0093 0.1885 0.2847
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0087 0.0136
Leishmania major pyruvate kinase 0.0035 0.0539 0.0736
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0396 0.0396
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0087 0.0233
Brugia malayi MH2 domain containing protein 0.0123 0.257 0.3932
Toxoplasma gondii hypothetical protein 0.0053 0.0964 0.5854
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.5002 0.5002
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0031 0.0468 0.0639
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0301 0.0469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1916 0.1916
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0301 0.041
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0316 0.0431
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.1223 0.1223
Echinococcus granulosus pyruvate kinase 0.0018 0.0151 0.0151
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0087 0.0119
Leishmania major acetyl-CoA carboxylase, putative 0.0083 0.1646 0.225
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.3327 0.4547
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0176 0.0141
Loa Loa (eye worm) hypothetical protein 0.0154 0.328 0.5057
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.2043 0.2793
Echinococcus granulosus cpg binding protein 0.0033 0.0504 0.0503
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0083 0.1646 1
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0316 0.1258
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1885 0.1885
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.1222 0.1669
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0087 0.0136
Brugia malayi hypothetical protein 0.0228 0.5002 0.7783
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0396 0.3539
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0301 0.041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0135 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0087 0.0233
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0087 0.0233
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0396 0.0396
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0087 0.0136
Leishmania major mitochondrial DNA polymerase beta 0.0329 0.7316 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0087 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1916 0.1916
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0653 0.0652
Plasmodium falciparum phd finger protein, putative 0.0028 0.0396 0.3539
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1916 0.2896
Leishmania major cytochrome p450-like protein 0.0024 0.0301 0.041
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0539 0.0863
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.2043 1
Schistosoma mansoni cpg binding protein 0.0033 0.0504 0.0503
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0031 0.0468 0.0639
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0087 0.0233
Echinococcus granulosus jumonji domain containing protein 0.004 0.0653 0.0652
Echinococcus granulosus pyruvate kinase 0.0035 0.0539 0.0538
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0031 0.0468 0.8679
Loa Loa (eye worm) hypothetical protein 0.0035 0.0539 0.0715
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0087 0.0136
Echinococcus multilocularis pyruvate kinase 0.0035 0.0539 0.0538
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0539 0.0863
Trichomonas vaginalis CAMK family protein kinase 0.01 0.2043 0.2839
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0087 0.1613
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0087 0.0233
Echinococcus multilocularis cpg binding protein 0.0033 0.0504 0.0503
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0031 0.0468 0.0639
Echinococcus granulosus muscleblind protein 0.0154 0.328 0.328
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0333
Schistosoma mansoni hypothetical protein 0.0015 0.0087 0.0087
Loa Loa (eye worm) glutaminase 0.0289 0.6402 1
Echinococcus multilocularis hormone sensitive lipase 0.0208 0.4525 0.4524
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0316 0.2818
Schistosoma mansoni hypothetical protein 0.0064 0.1223 0.1223
Echinococcus multilocularis pyruvate kinase 0.0018 0.0151 0.0151
Schistosoma mansoni kinase 0.0051 0.0912 0.0912
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0087 0.0233
Giardia lamblia Pyruvate kinase 0.0018 0.0151 0.0425
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0539 0.0715
Giardia lamblia Pyruvate kinase 0.0035 0.0539 0.2386
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0316 0.0315
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0316 0.0431
Loa Loa (eye worm) hypothetical protein 0.0208 0.4525 0.7027
Leishmania major carboxylase, putative 0.0031 0.0468 0.0639
Leishmania major cytochrome p450-like protein 0.0015 0.0087 0.0119
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0539 0.0841
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0316 0.2818
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0087 0.0233
Echinococcus granulosus pyruvate kinase 0.0018 0.0151 0.0151
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0087 0.0119
Brugia malayi Cytochrome P450 family protein 0.0024 0.0301 0.0338
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1093 0.1593
Loa Loa (eye worm) hypothetical protein 0.0064 0.1223 0.1799
Echinococcus granulosus pyruvate kinase 0.0035 0.0539 0.0538
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1222 0.1221
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0031 0.0468 0.0639
Trichomonas vaginalis CAMK family protein kinase 0.01 0.2043 0.2839
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.257 0.3932
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0329 0.7316 1
Schistosoma mansoni hypothetical protein 0.0064 0.1223 0.1223
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0032 0.047 0.0469
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0087 0.0136
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.2043 1
Schistosoma mansoni hypothetical protein 0.0446 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0807 0.1103
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0087 0.0233
Plasmodium falciparum pyruvate kinase 0.0035 0.0539 0.4809
Schistosoma mansoni hypothetical protein 0.0064 0.1223 0.1223
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.4423 0.6866
Echinococcus granulosus pyruvate kinase 0.0018 0.0151 0.0151
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0396 0.2407
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1151 0.1151
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0087 0.0136
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0539 0.0736
Onchocerca volvulus 0.0047 0.0815 0.2542
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0815 0.1153
Trypanosoma brucei polo-like protein kinase 0.01 0.2043 0.2793
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0301 0.0338
Brugia malayi Bromodomain containing protein 0.0028 0.0396 0.049
Echinococcus granulosus tar DNA binding protein 0.0061 0.1151 0.1151
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0539 0.1443
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0087 0.0136
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1151 0.1685
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0881 0.093
Trichomonas vaginalis CAMK family protein kinase 0.01 0.2043 0.2839
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0298 0.0333
Brugia malayi TAR-binding protein 0.0061 0.1151 0.1685
Echinococcus multilocularis pyruvate kinase 0.0018 0.0151 0.0151
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0031 0.0468 0.1252
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0396 0.0396
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.2043 0.3098
Trypanosoma brucei unspecified product 0.0021 0.0219 0.0299
Schistosoma mansoni acetyl-CoA carboxylase 0.0083 0.1646 0.1646
Echinococcus granulosus peregrin 0.0028 0.0396 0.0396
Leishmania major cytochrome p450-like protein 0.0015 0.0087 0.0119
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.257 0.3932
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1151 0.1151
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0087 0.0136
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0151 0.1348
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.2942 0.4521
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0534 0.0534
Toxoplasma gondii pyruvate carboxylase 0.0031 0.0468 0.2839
Loa Loa (eye worm) hypothetical protein 0.0028 0.0396 0.049
Chlamydia trachomatis biotin carboxylase 0.0029 0.0401 0.744
Schistosoma mansoni serine/threonine protein kinase 0.01 0.2043 0.2043

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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