TDR Targets

Basic information

Technical information

TDR Targets ID: 710761
Name: N-(3-chloro-2-methylphenyl)-4-[(4-methylsulfa nylphenyl)sulfonylamino]benzenesulfonamide
MW: 483.024 | Formula: C20H19ClN2O4S3
H donors: 2 H acceptors: 4 LogP: 4.47 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CSc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)S(=O)(=O)Nc1cccc(c1C)Cl
InChi: 1S/C20H19ClN2O4S3/c1-14-19(21)4-3-5-20(14)23-30(26,27)17-10-6-15(7-11-17)22-29(24,25)18-12-8-16(28-2)9-13-18/h3-13,22-23H,1-2H3
InChiKey: UPFNSHUHZIDBQJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-chloro-2-methyl-phenyl)-4-[(4-methylsulfanylphenyl)sulfonylamino]benzenesulfonamide
N-(3-chloro-2-methylphenyl)-4-[[4-(methylthio)phenyl]sulfonylamino]benzenesulfonamide
N-(3-chloro-2-methyl-phenyl)-4-[[4-(methylthio)phenyl]sulfonylamino]benzenesulfonamide
ZINC02882267

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0089	0.0921	0.0819
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0226	0.0224
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0039	0.0226	0.0452
Brugia malayi	nuclear hormone receptor	0.0039	0.0226	0.0365
Brugia malayi	acetyltransferase, GNAT family protein	0.0152	0.1803	0.448
Onchocerca volvulus		0.0151	0.1785	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0039	0.0226	0.0226
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0039	0.0226	0.0365
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0039	0.0226	0.0224
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0099	0.1061	0.0976
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0039	0.0226	0.0452
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0195	0.039
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	0.067	0.9064	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0039	0.0226	0.0365
Schistosoma mansoni	RAR-like nuclear receptor	0.0039	0.0226	0.0452
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0089	0.0921	0.0819
Onchocerca volvulus	Bile acid receptor homolog	0.0039	0.0226	0.0195
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0226	0.0224
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.0753	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0039	0.0226	0.0452
Schistosoma mansoni	hypothetical protein	0.0033	0.0141	0.0282
Mycobacterium ulcerans	glutaminase	0.0282	0.3625	0.3868
Loa Loa (eye worm)	hypothetical protein	0.0303	0.392	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0379	0.4992	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0194	0.0425
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.0753	1
Echinococcus granulosus	FTZ F1 alpha	0.0039	0.0226	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1785	0.4351
Schistosoma mansoni	retinoic acid receptor RXR	0.0039	0.0226	0.0452
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0035	0.0158	0.0158
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0039	0.0226	0.0224
Loa Loa (eye worm)	acetyltransferase	0.0152	0.1803	0.4399
Schistosoma mansoni	zinc finger protein	0.0024	0.0008	0.0017
Brugia malayi	glutaminase DH11.1	0.0282	0.3625	0.9232
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0141	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0389	0.0657
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0239	0.0338
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0357	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0195	0.0142
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0039	0.0226	0.0226
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0039	0.0226	0.0226
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0039	0.0226	0.0452
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0039	0.0226	0.0495
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0039	0.0226	0.0365
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.0753	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0089	0.0921	0.0819
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0039	0.0226	0.0365
Echinococcus multilocularis	muscleblind protein	0.0303	0.392	0.392
Echinococcus multilocularis	zinc finger protein	0.0024	0.0008	0.0008
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0039	0.0226	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0342	0.0532
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0195	0.0284
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0221	0.0212
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0039	0.0226	0.0452
Brugia malayi	hypothetical protein	0.0037	0.0194	0.0283
Brugia malayi	hypothetical protein	0.0151	0.1785	0.4432
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0324	0.2328
Schistosoma mansoni	glutaminase	0.0282	0.3625	0.7263
Brugia malayi	beta-lactamase family protein	0.0037	0.0195	0.0284
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0239	0.5
Trypanosoma brucei	PAB1-binding protein , putative	0.0077	0.0753	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0145	0.171	0.3752
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0195	0.0142
Echinococcus multilocularis	geminin	0.034	0.4444	0.4444
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0194	0.0194
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0039	0.0226	0.0495
Brugia malayi	glutathione reductase	0.0039	0.0221	0.0353
Brugia malayi	ecdysteroid receptor	0.0039	0.0226	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0195	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0226	0.0224
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.0324	0.0379
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0039	0.0226	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0357	0.0572
Echinococcus multilocularis	tumor protein p63	0.0349	0.4558	0.4558
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0039	0.0226	0.0365
Toxoplasma gondii	thioredoxin reductase	0.0039	0.0221	0.0472
Schistosoma mansoni	hypothetical protein	0.0035	0.0158	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0314	0.0459
Brugia malayi	Bromodomain containing protein	0.0081	0.081	0.1888
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0194	0.0389
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0039	0.0226	0.0495
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0039	0.0226	0.0452
Echinococcus multilocularis	muscleblind protein 1	0.0303	0.392	0.392
Brugia malayi	beta-lactamase	0.0037	0.0195	0.0284
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0152	0.1803	0.1803
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0324	0.2328
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0039	0.0226	0.0226
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0221	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0226	0.0224
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0221	0.0212
Leishmania major	hypothetical protein, conserved	0.0077	0.0753	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0099	0.1061	0.0976
Echinococcus granulosus	thioredoxin glutathione reductase	0.004	0.0228	0.0501
Mycobacterium tuberculosis	Probable oxidoreductase	0.0099	0.1061	0.0976
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0357	0.0572
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0195	0.0427
Brugia malayi	Bromodomain containing protein	0.0043	0.0279	0.0505
Onchocerca volvulus		0.0051	0.0389	0.1223
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0324	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0226	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0303	0.392	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0099	0.1061	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0039	0.0226	0.0224
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0194	0.0194
Brugia malayi	Muscleblind-like protein	0.0303	0.392	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0039	0.0226	0.0495
Brugia malayi	Thioredoxin reductase	0.0039	0.0221	0.0353
Loa Loa (eye worm)	transcription factor SMAD2	0.024	0.3035	0.7657
Schistosoma mansoni	hypothetical protein	0.034	0.4444	0.8902
Onchocerca volvulus	Protein ultraspiracle homolog	0.0039	0.0226	0.0195
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0195	0.039
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0389	0.0779
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0039	0.0226	0.0224
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0195	0.0142
Brugia malayi	beta-lactamase family protein	0.0037	0.0195	0.0284
Echinococcus granulosus	muscleblind protein	0.0303	0.392	0.86
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0065	0.0588	0.1291
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0039	0.0226	0.0495
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0357	0.0707
Mycobacterium tuberculosis	Probable dehydrogenase	0.0089	0.0921	0.0819
Brugia malayi	Nuclear hormone receptor-like 1	0.0039	0.0226	0.0365
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0039	0.0226	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0195	0.0142
Echinococcus granulosus	geminin	0.034	0.4444	0.9749
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0039	0.0226	0.0452
Schistosoma mansoni	nuclear hormone receptor	0.0039	0.0226	0.0452
Schistosoma mansoni	hypothetical protein	0.0037	0.0194	0.0389
Schistosoma mansoni	thyroid hormone receptor	0.0039	0.0226	0.0452
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0039	0.0226	0.0226
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0039	0.0226	0.0495
Echinococcus multilocularis	FTZ F1 alpha	0.0039	0.0226	0.0226
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0039	0.0226	0.0224
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0039	0.0226	0.0224
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0324	0.2328
Trypanosoma brucei	trypanothione reductase	0.0039	0.0221	0.0472
Brugia malayi	hypothetical protein	0.0077	0.0753	0.174
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0195	0.0142
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0221	0.0472
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0039	0.0226	0.0495
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.0324	0.0379
Brugia malayi	MH2 domain containing protein	0.024	0.3035	0.7691
Loa Loa (eye worm)	glutaminase 2	0.0282	0.3625	0.922
Brugia malayi	Steroid receptor seven-up type 2	0.0039	0.0226	0.0365
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0039	0.0226	0.0365
Brugia malayi	hypothetical protein	0.005	0.037	0.0743
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0039	0.0226	0.0365
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0039	0.0226	0.0495
Brugia malayi	photoreceptor-specific nuclear receptor	0.0039	0.0226	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0226	0.0224
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0065	0.0588	0.0588
Leishmania major	trypanothione reductase	0.0039	0.0221	0.0472
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0039	0.0226	0.0365
Schistosoma mansoni	thyroid hormone receptor	0.0039	0.0226	0.0452
Mycobacterium tuberculosis	Probable reductase	0.0089	0.0921	0.0819
Echinococcus granulosus	tumor protein p63	0.0349	0.4558	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0226	0.0224
Toxoplasma gondii	LsmAD domain-containing protein	0.0077	0.0753	1
Schistosoma mansoni	hypothetical protein	0.034	0.4444	0.8902
Brugia malayi	steroid hormone receptor	0.0039	0.0226	0.0365
Echinococcus multilocularis	ecdysone induced protein 78C	0.0039	0.0226	0.0226
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0035	0.0158	0.0346
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0039	0.0226	0.0224
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0039	0.0226	0.0226
Schistosoma mansoni	coup transcription factor	0.0039	0.0226	0.0452
Loa Loa (eye worm)	MH2 domain-containing protein	0.024	0.3035	0.7657
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0195	0.0142
Schistosoma mansoni	bromodomain containing protein	0.0069	0.064	0.1282
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	0.067	0.9064	1
Brugia malayi	nuclear receptor NHR-88	0.0039	0.0226	0.0365
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0194	0.0426
Trichomonas vaginalis	glutaminase, putative	0.0282	0.3625	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0039	0.0226	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0753	0.1619
Echinococcus multilocularis	thioredoxin glutathione reductase	0.004	0.0228	0.0228
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.0239	1
Loa Loa (eye worm)	steroid hormone receptor	0.0039	0.0226	0.0224
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0152	0.1803	0.3613
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0237	0.2999	0.3162
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0089	0.0921	0.8393
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0039	0.0221	0.003
Onchocerca volvulus		0.0039	0.0226	0.0195
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.0753	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0089	0.0921	0.0819
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0195	0.0142
Loa Loa (eye worm)	glutaminase	0.0282	0.3625	0.922
Loa Loa (eye worm)	hypothetical protein	0.004	0.0229	0.0233
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0039	0.0226	0.0365
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0221	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0226	0.0224
Plasmodium vivax	ataxin-2 like protein, putative	0.0077	0.0753	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0039	0.0226	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0696	0.147
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0039	0.0226	0.0365
Echinococcus granulosus	zinc finger protein	0.0024	0.0008	0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 710761