TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 553.666 | Formula: C30H35NO7S
H donors: 1 H acceptors: 3 LogP: 4.05 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: CSc1ccc2c(cc1=O)[C@H](CCc1c2c(OC)c(c(c1)OC)OC)NC(=O)C12CCC(C2(C)C)(C(=O)O1)C
InChi: 1S/C30H35NO7S/c1-28(2)29(3)12-13-30(28,38-27(29)34)26(33)31-19-10-8-16-14-21(35-4)24(36-5)25(37-6)23(16)17-9-11-22(39-7)20(32)15-18(17)19/h9,11,14-15,19H,8,10,12-13H2,1-7H3,(H,31,33)/t19-,29?,30?/m0/s1
InChiKey: GYBKEYUKEQTTKB-LFSSYFFGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Tubulin alpha chain	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	peroxisome assembly protein 26	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium berghei	alpha tubulin 2	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania mexicana	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium yoelii	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Entamoeba histolytica	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania braziliensis	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Theileria parva	Tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Entamoeba histolytica	tubulin alpha-1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin subunit TubB	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania braziliensis	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium yoelii	Tubulin/FtsZ family, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Babesia bovis	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	Tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania donovani	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium knowlesi	alpha-tubulin II, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-2/alpha-4 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	peroxisome assembly protein 26	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha-3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Theileria parva	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	tubulin alpha chain - mouse	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	alpha-tubulin isotype 2	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium berghei	alpha tubulin 1	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	Tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium vivax	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium falciparum	alpha tubulin 2	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Babesia bovis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma congolense	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin subunit TubB	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Cryptosporidium parvum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium vivax	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium knowlesi	alpha tubulin, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium falciparum	alpha tubulin 1	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Toxoplasma gondii	alpha-tubulin I, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	ko:K07374 tubulin alpha, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Neospora caninum	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Cryptosporidium hominis	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania mexicana	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma cruzi	alpha tubulin, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Candida albicans	cytoskeletal structural protein	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	ko:K07374 tubulin alpha, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei gambiense	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-1C chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	Tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Toxoplasma gondii	alpha tubulin TUBA1	Get druggable targets OG5_126605	All targets in OG5_126605

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	40.3 %
Schistosoma mansoni	tubulin subunit epsilon	Tubulin alpha chain	451 aa	469 aa	27.9 %
Loa Loa (eye worm)	tubulin beta-1 chain	Tubulin alpha chain	451 aa	437 aa	39.4 %
Giardia lamblia	Gamma tubulin	Tubulin alpha chain	451 aa	467 aa	29.6 %
Echinococcus granulosus	tubulin gamma 1 chain	Tubulin alpha chain	451 aa	455 aa	31.4 %
Babesia bovis	tubulin, putative	Tubulin alpha chain	451 aa	463 aa	20.7 %
Onchocerca volvulus	Regulatory-associated protein of mTOR homolog	Tubulin alpha chain	451 aa	439 aa	76.3 %
Onchocerca volvulus		Tubulin alpha chain	451 aa	438 aa	84.7 %
Trypanosoma brucei	epsilon tubulin	Tubulin alpha chain	451 aa	479 aa	25.5 %
Trypanosoma cruzi	epsilon tubulin, putative	Tubulin alpha chain	451 aa	474 aa	27.4 %
Echinococcus multilocularis	tubulin, beta 4A class IVa	Tubulin alpha chain	451 aa	388 aa	38.9 %
Trichomonas vaginalis	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	422 aa	28.4 %
Schistosoma mansoni	tubulin subunit gamma	Tubulin alpha chain	451 aa	451 aa	31.5 %
Schistosoma mansoni	tubulin subunit beta	Tubulin alpha chain	451 aa	434 aa	40.1 %
Echinococcus multilocularis	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	40.6 %
Entamoeba histolytica	tubulin family protein	Tubulin alpha chain	451 aa	434 aa	39.4 %
Plasmodium falciparum	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	465 aa	25.8 %
Plasmodium vivax	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	429 aa	30.8 %
Plasmodium falciparum	tubulin gamma chain	Tubulin alpha chain	451 aa	431 aa	31.8 %
Neospora caninum	tubulin alpha chain, putative	Tubulin alpha chain	451 aa	436 aa	37.4 %
Onchocerca volvulus	Tyrosine kinase homolog	Tubulin alpha chain	451 aa	439 aa	87.7 %
Leishmania mexicana	beta tubulin	Tubulin alpha chain	451 aa	434 aa	42.4 %
Echinococcus granulosus	tubulin alpha	Tubulin alpha chain	451 aa	433 aa	40.0 %
Dictyostelium discoideum	gamma tubulin	Tubulin alpha chain	451 aa	436 aa	32.8 %
Echinococcus multilocularis	tubulin gamma 1 chain	Tubulin alpha chain	451 aa	455 aa	31.4 %
Drosophila melanogaster	gamma-Tubulin at 23C	Tubulin alpha chain	451 aa	446 aa	32.3 %
Onchocerca volvulus		Tubulin alpha chain	451 aa	434 aa	41.5 %
Onchocerca volvulus	Putative cytochrome c-type heme lyase	Tubulin alpha chain	451 aa	434 aa	39.2 %
Leishmania braziliensis	epsilon tubulin, putative	Tubulin alpha chain	451 aa	469 aa	29.4 %
Onchocerca volvulus		Tubulin alpha chain	451 aa	441 aa	74.4 %
Giardia lamblia	Epsilon tubulin	Tubulin alpha chain	451 aa	457 aa	29.3 %
Schistosoma japonicum	ko:K10389 tubulin gamma, putative	Tubulin alpha chain	451 aa	434 aa	31.8 %
Echinococcus multilocularis	tubulin delta chain	Tubulin alpha chain	451 aa	401 aa	22.9 %
Trypanosoma brucei	epsilon tubulin	Tubulin alpha chain	451 aa	478 aa	25.7 %
Schistosoma mansoni	tubulin subunit beta	Tubulin alpha chain	451 aa	435 aa	40.9 %
Cryptosporidium hominis	gamma-tubulin	Tubulin alpha chain	451 aa	443 aa	30.9 %
Cryptosporidium parvum	gamma tubulin	Tubulin alpha chain	451 aa	443 aa	30.9 %
Loa Loa (eye worm)	BEN-1 protein	Tubulin alpha chain	451 aa	434 aa	41.5 %
Plasmodium knowlesi	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	454 aa	26.2 %
Neospora caninum	Beta-tubulin, related	Tubulin alpha chain	451 aa	417 aa	31.4 %
Plasmodium berghei	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	455 aa	27.7 %
Leishmania major	epsilon tubulin, putative	Tubulin alpha chain	451 aa	469 aa	27.5 %
Echinococcus granulosus	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	41.5 %
Leishmania donovani	epsilon tubulin, putative	Tubulin alpha chain	451 aa	471 aa	27.0 %
Brugia malayi	Tubulin beta-1 chain	Tubulin alpha chain	451 aa	434 aa	39.6 %
Leishmania mexicana	epsilon tubulin, putative	Tubulin alpha chain	451 aa	469 aa	27.7 %
Plasmodium yoelii	tubulin gamma chain	Tubulin alpha chain	451 aa	431 aa	31.3 %
Plasmodium yoelii	tubulin beta chain	Tubulin alpha chain	451 aa	455 aa	26.8 %
Theileria parva	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	462 aa	29.7 %
Trypanosoma cruzi	epsilon tubulin, putative	Tubulin alpha chain	451 aa	474 aa	27.4 %
Leishmania infantum	epsilon tubulin, putative	Tubulin alpha chain	451 aa	471 aa	27.0 %
Babesia bovis	tubulin gamma chain	Tubulin alpha chain	451 aa	429 aa	31.7 %
Echinococcus multilocularis	tubulin alpha	Tubulin alpha chain	451 aa	436 aa	40.1 %
Onchocerca volvulus	Putative methyltransferase KIAA1456	Tubulin alpha chain	451 aa	441 aa	31.7 %
Trypanosoma congolense	epsilon tubulin	Tubulin alpha chain	451 aa	472 aa	26.5 %
Plasmodium berghei	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	431 aa	31.1 %
Entamoeba histolytica	tubulin family protein	Tubulin alpha chain	451 aa	434 aa	40.1 %
Echinococcus multilocularis	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	41.5 %
Plasmodium knowlesi	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	429 aa	30.8 %
Entamoeba histolytica	tubulin gamma chain	Tubulin alpha chain	451 aa	434 aa	30.9 %
Trypanosoma brucei	epsilon tubulin	Tubulin alpha chain	451 aa	478 aa	25.7 %
Drosophila melanogaster	beta-Tubulin at 60D	Tubulin alpha chain	451 aa	439 aa	39.2 %
Dictyostelium discoideum	beta tubulin	Tubulin alpha chain	451 aa	443 aa	40.4 %
Echinococcus granulosus	tubulin beta 4A class IVa	Tubulin alpha chain	451 aa	388 aa	38.9 %
Trypanosoma brucei gambiense	epsilon tubulin	Tubulin alpha chain	451 aa	479 aa	25.7 %
Plasmodium vivax	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	458 aa	26.2 %
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	Tubulin alpha chain	451 aa	436 aa	38.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.0047	0.2684	0.809
Echinococcus multilocularis	neuropeptide s receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	neuropeptide receptor	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Echinococcus granulosus	tm gpcr rhodopsin	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0082	0.5272	0.5272
Trypanosoma cruzi	cysteine proteinase, putative	0.0016	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0017	0.037	0.1114
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0255	0.0255
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0016	0.0325	0.0325
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.0748	0.0748
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.057	0.1717
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0022	0.0748	0.0748
Echinococcus multilocularis	g protein coupled receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.5272	0.5272
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.2634	0.2634
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0016	0.0325	0.1211
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0287	0.0287
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0325	0.0076
Brugia malayi	G-protein coupled receptor	0.0082	0.5272	0.5272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0016	0.0325	0.098
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.5272	0.5272
Echinococcus granulosus	g protein coupled receptor	0.0082	0.5272	0.5272
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0082	0.5272	0.5272
Echinococcus granulosus	7tm_1 domain containing protein	0.0082	0.5272	0.5272
Leishmania major	cysteine peptidase A (CPA)	0.0047	0.2684	0.809
Echinococcus multilocularis	tubulin alpha 1C chain	0.0022	0.0748	0.0748
Echinococcus multilocularis	fmrfamide receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	tyrosine protein kinase Srms	0.0015	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.2684	0.4808
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0325	0.098
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0015	0.0287	0.0287
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.2634	0.2634
Entamoeba histolytica	hypothetical protein	0.0016	0.0325	0.1211
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0016	0.0325	0.098
Giardia lamblia	Cathepsin L precursor	0.0016	0.0325	0.098
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0015	0.0287	0.0287
Schistosoma mansoni	biogenic amine receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	tyrosine kinase	0.0015	0.0287	0.0287
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Schistosoma mansoni	histamine h1 receptor	0.0082	0.5272	0.5272
Onchocerca volvulus		0.0082	0.5272	1
Plasmodium vivax	vivapain-3	0.0016	0.0325	0.1211
Trypanosoma brucei	alpha tubulin	0.0022	0.0748	0.2255
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Loa Loa (eye worm)	tubulin alpha chain	0.0022	0.0748	0.0748
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0016	0.0325	0.098
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Brugia malayi	Serotonin receptor	0.0082	0.5272	0.5272
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0325	0.0325
Onchocerca volvulus	Cathepsin F homolog	0.0047	0.2684	0.4808
Schistosoma mansoni	biogenic amine receptor	0.0082	0.5272	0.5272
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.057	0.1717
Echinococcus granulosus	alpha tubulin	0.0022	0.0748	0.0748
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0016	0.0325	0.0325
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.2634	0.2634
Brugia malayi	SH2 domain containing protein	0.0015	0.0287	0.0287
Loa Loa (eye worm)	fibroinase	0.0047	0.2684	0.2684
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.2684	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0082	0.5272	0.5272
Brugia malayi	RE15519p	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Brugia malayi	Cathepsin L-like precursor	0.0047	0.2684	0.2684
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0082	0.5272	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0016	0.0325	0.1211
Onchocerca volvulus		0.0082	0.5272	1
Brugia malayi	Tubulin alpha-2 chain	0.0022	0.0748	0.0748
Brugia malayi	Cathepsin L-like precursor	0.0047	0.2684	0.2684
Echinococcus multilocularis	cathepsin b	0.0145	1	1
Brugia malayi	tubulin alpha chain - mouse	0.0022	0.0748	0.0748
Echinococcus granulosus	tm gpcr rhodopsin	0.0082	0.5272	0.5272
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0082	0.5272	0.5272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0082	0.5272	0.5272
Giardia lamblia	Cathepsin L precursor	0.0016	0.0325	0.098
Echinococcus multilocularis	tubulin alpha 3 chain	0.0022	0.0748	0.0748
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0325	0.098
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0015	0.0287	0.0287
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0016	0.0325	0.1211
Echinococcus multilocularis	neuropeptides capa receptor	0.0082	0.5272	0.5272
Brugia malayi	larval opioid receptor	0.0082	0.5272	0.5272
Giardia lamblia	Cysteine protease	0.0016	0.0325	0.098
Leishmania major	cathepsin L-like protease	0.0047	0.2684	0.809
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.0748	0.2255
Brugia malayi	cathepsin L-like cysteine proteinase	0.0016	0.0325	0.0325
Echinococcus granulosus	neuropeptide FF receptor 2	0.0082	0.5272	0.5272
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.0748	0.2255
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.057	0.057
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Giardia lamblia	Hypothetical protein	0.0016	0.0325	0.098
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0056	0.3317	0.3317
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.5272	0.5272
Onchocerca volvulus		0.0082	0.5272	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0082	0.5272	0.5272
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0047	0.2684	0.2684
Schistosoma mansoni	alpha tubulin	0.0022	0.0748	0.0748
Echinococcus granulosus	neuropeptide s receptor	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus granulosus	tubulin alpha chain	0.0022	0.0748	0.0748
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.5272	0.5272
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0082	0.5272	0.5272
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0287	0.0287
Echinococcus multilocularis	G protein coupled receptor 139	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Schistosoma mansoni	tyrosine kinase	0.0015	0.0287	0.0287
Giardia lamblia	Encystation-specific protease	0.0016	0.0325	0.098
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Brugia malayi	Cathepsin L-like precursor	0.0047	0.2684	0.2684
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.2684	0.2684
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Giardia lamblia	Cathepsin B precursor	0.0056	0.3317	1
Plasmodium falciparum	serine repeat antigen 7	0.0016	0.0325	0.1211
Onchocerca volvulus		0.0047	0.2684	0.4808
Plasmodium vivax	vivapain-2	0.0047	0.2684	1
Echinococcus granulosus	neuropeptide Y receptor	0.0082	0.5272	0.5272
Brugia malayi	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0325	0.098
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0016	0.0325	0.1211
Schistosoma mansoni	amine GPCR	0.0082	0.5272	0.5272
Echinococcus granulosus	tubulin alpha 3 chain	0.0022	0.0748	0.0748
Loa Loa (eye worm)	alpha-tubulin	0.0022	0.0748	0.0748
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0082	0.5272	0.5272
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.5272	0.5272
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0017	0.037	0.037
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0287	0.0287
Onchocerca volvulus		0.0082	0.5272	1
Giardia lamblia	Cathepsin L precursor	0.0016	0.0325	0.098
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0287	0.0287
Echinococcus granulosus	peroxisome assembly protein 26	0.0022	0.0748	0.0748
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0325	0.0325
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0287	0.0287
Brugia malayi	protein-tyrosine kinase	0.0015	0.0287	0.0287
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus granulosus	c src tyrosine kinase	0.0015	0.0287	0.0287
Onchocerca volvulus		0.0047	0.2684	0.4808
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.057	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Echinococcus granulosus	g protein coupled receptor	0.0082	0.5272	0.5272
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.2684	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	tubulin alpha 1C chain	0.0022	0.0748	0.0748
Brugia malayi	tubulin alpha-2 chain	0.0022	0.0748	0.0748
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0082	0.5272	0.5272
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.2634	0.2634
Echinococcus multilocularis	sex peptide receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0015	0.0287	0.0287
Echinococcus granulosus	serotonin receptor	0.0082	0.5272	0.5272
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0016	0.0325	0.098
Loa Loa (eye worm)	ctsf protein	0.0047	0.2684	0.2684
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Echinococcus granulosus	Tubulin alpha 1 chain	0.0022	0.0748	0.0748
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0325	0.098
Schistosoma mansoni	neuropeptide f receptor 76f	0.0082	0.5272	0.5272
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Echinococcus granulosus	tm gpcr rhodopsin	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0015	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0099	0.6584	0.6584
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.2634	0.2634
Toxoplasma gondii	cathepsin CPC1	0.0016	0.0325	0.098
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2684	0.2684
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0325	0.098
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.4225	0.4225
Loa Loa (eye worm)	TK protein kinase	0.0015	0.0287	0.0287
Echinococcus multilocularis	tubulin alpha 1C chain	0.0022	0.0748	0.0748
Echinococcus granulosus	G protein coupled receptor 139	0.0082	0.5272	0.5272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Echinococcus granulosus	Tubulin alpha 1 chain	0.0022	0.0748	0.0748
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0082	0.5272	0.5272
Toxoplasma gondii	cathepsin B	0.0056	0.3317	1
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0287	0.0287
Echinococcus granulosus	neuropeptide receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	tyrosine kinase	0.0015	0.0287	0.0287
Plasmodium falciparum	serine repeat antigen 4	0.0016	0.0325	0.1211
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0325	0.098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Echinococcus granulosus	GPCR family 2	0.0031	0.1487	0.1487
Brugia malayi	cathepsin L-like precursor	0.0047	0.2684	0.2684
Echinococcus granulosus	cathepsin L	0.0016	0.0325	0.0325
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0022	0.0748	0.0748
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	fmrfamide receptor	0.0082	0.5272	0.5272
Brugia malayi	neuropeptide F receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.2634	0.2634
Echinococcus multilocularis	cathepsin L	0.0016	0.0325	0.0325
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	1	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.057	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0082	0.5272	0.5272
Trypanosoma brucei	alpha tubulin	0.0022	0.0748	0.2255
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0015	0.0255	0.0768
Onchocerca volvulus		0.0082	0.5272	1
Loa Loa (eye worm)	TYRA-2 protein	0.0082	0.5272	0.5272
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0325	0.0325
Schistosoma mansoni	alpha tubulin	0.0022	0.0748	0.0748
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.057	0.2123
Echinococcus multilocularis	fmrfamide receptor	0.0082	0.5272	0.5272
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0022	0.0748	0.2255
Brugia malayi	putative neuropeptide receptor	0.0082	0.5272	0.5272
Brugia malayi	cathepsin F-like cysteine proteinase	0.0016	0.0325	0.0325
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.0748	0.2255
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0082	0.5272	0.5272
Trypanosoma brucei	alpha tubulin	0.0022	0.0748	0.2255
Plasmodium vivax	tubulin alpha chain, putative	0.0022	0.0748	0.2787
Brugia malayi	hypothetical protein	0.0015	0.0287	0.0287
Schistosoma mansoni	opsin-like receptor	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.2684	0.809
Echinococcus granulosus	cathepsin L	0.0016	0.0325	0.0325
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.057	0.5
Entamoeba histolytica	cysteine proteinase 2	0.0016	0.0325	0.1211
Brugia malayi	G protein-coupled receptor	0.0082	0.5272	0.5272
Onchocerca volvulus		0.0082	0.5272	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0015	0.0287	0.0287
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0022	0.0748	0.2255
Echinococcus granulosus	7TM GPCR rhodopsin	0.0082	0.5272	0.5272
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Brugia malayi	G-protein coupled receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	tyrosine kinase	0.0015	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0145	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0015	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0325	0.0325
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	serotonin receptor	0.0082	0.5272	0.5272
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0325	0.098
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.6584	0.6584
Brugia malayi	hypothetical protein	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Trypanosoma brucei	alpha tubulin	0.0022	0.0748	0.2255
Giardia lamblia	Cathepsin B precursor	0.0016	0.0325	0.098
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0015	0.0287	0.0287
Loa Loa (eye worm)	tubulin alpha chain	0.0022	0.0748	0.0748
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0016	0.0325	0.098
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0016	0.0325	0.0325
Schistosoma mansoni	alpha tubulin	0.0022	0.0748	0.0748
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0082	0.5272	0.5272
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0016	0.0325	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1487	0.1487
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0082	0.5272	0.5272
Entamoeba histolytica	cysteine proteinase 1, putative	0.0016	0.0325	0.1211
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0325	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0016	0.0325	0.0325
Leishmania major	cathepsin L-like protease	0.0047	0.2684	0.809
Schistosoma mansoni	amine GPCR	0.0082	0.5272	0.5272
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0082	0.5272	0.5272
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0082	0.5272	0.5272
Giardia lamblia	Cysteine protease	0.0016	0.0325	0.098
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0015	0.0287	0.0287
Onchocerca volvulus		0.0082	0.5272	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.2684	0.2684
Giardia lamblia	Alpha-tubulin	0.0022	0.0748	0.2255
Schistosoma mansoni	amine GPCR	0.0082	0.5272	0.5272
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Echinococcus multilocularis	hypothetical protein	0.0022	0.0748	0.0748
Echinococcus multilocularis	tyrosine protein kinase shark	0.0015	0.0287	0.0287
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0016	0.0325	0.1211
Brugia malayi	alpha-tubulin	0.0022	0.0748	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0287	0.0287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2684	0.2684
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0145	1	1
Echinococcus granulosus	tubulin subunit TubB	0.0022	0.0748	0.0748
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.1487	0.1487
Brugia malayi	hypothetical protein	0.0082	0.5272	0.5272
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	1	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.057	0.057
Brugia malayi	Dopamine receptor	0.0082	0.5272	0.5272
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.2684	0.2684
Giardia lamblia	Cathepsin B precursor	0.0056	0.3317	1
Plasmodium vivax	unspecified product	0.0016	0.0325	0.1211
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.2684	0.809
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.5272	0.5272
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0016	0.0325	0.0325
Schistosoma mansoni	neuropeptide F-like receptor	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.6584	0.6584
Toxoplasma gondii	exonuclease III APE	0.0019	0.057	0.1717
Echinococcus granulosus	dro:myosuppressin receptor	0.0082	0.5272	0.5272
Giardia lamblia	Cathepsin B precursor	0.0056	0.3317	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.057	0.057
Echinococcus granulosus	tyrosine kinase	0.0015	0.0287	0.0287
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.1487	0.1487
Schistosoma mansoni	hypothetical protein	0.0031	0.1487	0.1487
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.0748	0.0748
Echinococcus multilocularis	g protein coupled receptor	0.0082	0.5272	0.5272
Onchocerca volvulus		0.0082	0.5272	1
Giardia lamblia	Cathepsin L-like protease	0.0016	0.0325	0.098
Loa Loa (eye worm)	tubulin alpha 2	0.0017	0.037	0.037
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0015	0.0287	0.0287
Schistosoma mansoni	neuropeptide receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	cathepsin b	0.0145	1	1
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Schistosoma mansoni	hypothetical protein	0.0031	0.1487	0.1487
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0016	0.0325	0.0325
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.2684	0.809
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0325	0.0325
Plasmodium falciparum	serine repeat antigen 5	0.0016	0.0325	0.1211
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0015	0.0287	0.0287
Brugia malayi	Tubulin alpha chain	0.0022	0.0748	0.0748
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0325	0.098
Echinococcus granulosus	cathepsin L cysteine protease	0.0016	0.0325	0.0325
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0082	0.5272	0.5272
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0082	0.5272	0.5272
Brugia malayi	Cathepsin L-like precursor	0.0047	0.2684	0.2684
Loa Loa (eye worm)	cathepsin B	0.0056	0.3317	0.3317
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0016	0.0325	0.098
Echinococcus multilocularis	c src tyrosine kinase	0.0015	0.0287	0.0287
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0016	0.0325	0.0325
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0082	0.5272	0.5272
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0016	0.0325	0.1211
Brugia malayi	SRC-1	0.0015	0.0287	0.0287
Echinococcus multilocularis	somatostatin receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	g protein coupled receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0022	0.0748	0.0748
Leishmania major	cathepsin L-like protease	0.0047	0.2684	0.809
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.2634	0.2634
Brugia malayi	Cathepsin L-like precursor	0.0047	0.2684	0.2684
Plasmodium vivax	vivapain-1	0.0016	0.0325	0.1211
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Brugia malayi	hypothetical protein	0.0082	0.5272	0.5272
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0016	0.0325	0.1211
Brugia malayi	putative neuropeptide receptor NPR1	0.0082	0.5272	0.5272
Echinococcus multilocularis	orexin receptor type 2	0.0082	0.5272	0.5272
Schistosoma mansoni	cathepsin S (C01 family)	0.0016	0.0325	0.0325
Schistosoma mansoni	hypothetical protein	0.0082	0.5272	0.5272
Toxoplasma gondii	cathepsin CPL	0.0047	0.2684	0.809
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0082	0.5272	0.5272
Brugia malayi	hypothetical protein	0.0082	0.5272	0.5272
Giardia lamblia	Cathepsin L precursor	0.0016	0.0325	0.098
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0015	0.0287	0.0287
Brugia malayi	Dopamine receptor protein 1	0.0082	0.5272	0.5272
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0015	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Onchocerca volvulus		0.0082	0.5272	1
Schistosoma mansoni	tubulin subunit alpha	0.0022	0.0748	0.0748
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0016	0.0325	0.1211
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.057	0.2123
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0325	0.1211
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0015	0.0287	0.0287
Schistosoma mansoni	hypothetical protein	0.0068	0.4225	0.4225
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0287	0.0287
Leishmania major	cathepsin L-like protease	0.0047	0.2684	0.809
Echinococcus multilocularis	cathepsin L	0.0016	0.0325	0.0325
Plasmodium vivax	serine-repeat antigen (SERA)	0.0016	0.0325	0.1211
Echinococcus multilocularis	dro:myosuppressin receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	neuropeptides capa receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	amine GPCR	0.0082	0.5272	0.5272
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Toxoplasma gondii	alpha-tubulin I, putative	0.0022	0.0748	0.2255
Loa Loa (eye worm)	alpha-tubulin	0.0022	0.0748	0.0748
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0047	0.2684	0.2684
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0016	0.0325	0.098
Echinococcus granulosus	sex peptide receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	cathepsin l1	0.0047	0.2684	0.2684
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.2684	0.809
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.057	0.5
Giardia lamblia	Cysteine protease	0.0016	0.0325	0.098
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0082	0.5272	0.5272
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0082	0.5272	1
Leishmania major	cathepsin L-like protease	0.0047	0.2684	0.809
Onchocerca volvulus		0.0047	0.2684	0.4808
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0056	0.3317	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0016	0.0325	0.0325
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.1487	0.1487
Onchocerca volvulus		0.0082	0.5272	1
Brugia malayi	Cathepsin L-like precursor	0.0047	0.2684	0.2684
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Schistosoma mansoni	tyrosine kinase	0.0015	0.0287	0.0287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Schistosoma mansoni	tubulin subunit alpha	0.0022	0.0748	0.0748
Echinococcus multilocularis	neuropeptide receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.2684	0.2684
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0015	0.0287	0.0287
Echinococcus multilocularis	neuropeptide receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0068	0.4225	0.4225
Brugia malayi	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus multilocularis	peroxisome assembly protein 26	0.0022	0.0748	0.0748
Echinococcus multilocularis	cathepsin b	0.0145	1	1
Giardia lamblia	Cysteine protease	0.0016	0.0325	0.098
Brugia malayi	hypothetical protein	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0016	0.0325	0.098
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0016	0.0325	0.1211
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.0748	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Brugia malayi	hypothetical protein	0.0082	0.5272	0.5272
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	amine GPCR	0.0082	0.5272	0.5272
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0015	0.0287	0.0287
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.0748	0.2255
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0016	0.0325	0.1211
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	g protein coupled receptor	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.2684	0.809
Loa Loa (eye worm)	SRC-1	0.0015	0.0287	0.0287
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0082	0.5272	0.5272
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0016	0.0325	0.1211
Onchocerca volvulus		0.0047	0.2684	0.4808
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0082	0.5272	0.5272
Brugia malayi	hypothetical protein	0.0082	0.5272	0.5272
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.2684	0.2684
Echinococcus multilocularis	tubulin alpha 3 chain	0.0022	0.0748	0.0748
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0287	0.0287
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.2634	0.2634
Schistosoma mansoni	cathepsin B (C01 family)	0.0016	0.0325	0.0325
Plasmodium falciparum	serine repeat antigen 2	0.0016	0.0325	0.1211
Onchocerca volvulus		0.0047	0.2684	0.4808
Schistosoma mansoni	neuropeptide receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	tyrosine protein kinase shark	0.0015	0.0287	0.0287
Echinococcus granulosus	orexin receptor type 2	0.0082	0.5272	0.5272
Echinococcus granulosus	tyrosine kinase	0.0015	0.0287	0.0287
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.2684	0.809
Toxoplasma gondii	alpha tubulin TUBA1	0.0022	0.0748	0.2255
Echinococcus granulosus	tubulin alpha chain	0.0022	0.0748	0.0748
Plasmodium falciparum	alpha tubulin 1	0.0022	0.0748	0.2787
Echinococcus multilocularis	cysteine protease	0.0047	0.2684	0.2684
Brugia malayi	Tyrosine-protein kinase abl-1	0.0015	0.0287	0.0287
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0016	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0325	0.098
Schistosoma mansoni	growth hormone secretagogue receptor	0.0082	0.5272	0.5272
Brugia malayi	hypothetical protein	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Brugia malayi	GnHR receptor homolog	0.0082	0.5272	0.5272
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.1487	0.1487
Echinococcus granulosus	tubulin alpha 3 chain	0.0022	0.0748	0.0748
Brugia malayi	fibroinase precursor	0.0016	0.0325	0.0325
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Loa Loa (eye worm)	G-protein coupled receptor	0.0082	0.5272	0.5272
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0022	0.0748	0.2255
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0016	0.0325	0.098
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	1	1
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2684	0.2684
Echinococcus granulosus	biogenic amine 5HT receptor	0.0082	0.5272	0.5272
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0047	0.2684	0.2684
Plasmodium vivax	tubulin alpha chain, putative	0.0022	0.0748	0.2787
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0082	0.5272	0.5272
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0015	0.0287	0.0287
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0016	0.0325	0.098
Brugia malayi	Dopamine receptor protein 2	0.0082	0.5272	0.5272
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.057	0.1717
Schistosoma mansoni	myosin xvIII	0.0082	0.5272	0.5272
Echinococcus multilocularis	GPCR, family 2	0.0031	0.1487	0.1487
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0325	0.0325
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0325	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2684	0.2684
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.1487	0.1487
Schistosoma mansoni	hypothetical protein	0.0031	0.1487	0.1487
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Trypanosoma cruzi	cruzipain precursor, putative	0.0047	0.2684	0.2684
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.2684	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.2684	0.2684
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Echinococcus multilocularis	allatostatin A receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0082	0.5272	0.5272
Trypanosoma cruzi	major cysteine proteinase, putative	0.0016	0.0325	0.0325
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.057	0.057
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Schistosoma mansoni	hypothetical protein	0.0082	0.5272	0.5272
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0325	0.098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Giardia lamblia	Cathepsin B precursor	0.0016	0.0325	0.098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Brugia malayi	SH2 domain containing protein	0.0015	0.0287	0.0287
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0287	0.0287
Giardia lamblia	Cathepsin L precursor	0.0016	0.0325	0.098
Brugia malayi	sulfakinin receptor protein	0.0082	0.5272	0.5272
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Plasmodium vivax	vivapain-2	0.0047	0.2684	1
Schistosoma mansoni	opsin-like receptor	0.0082	0.5272	0.5272
Brugia malayi	Cathepsin L-like precursor	0.0047	0.2684	0.2684
Brugia malayi	neuropeptide F receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.2684	0.2684
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0016	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0016	0.0325	0.0325
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0047	0.2684	0.2684
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0022	0.0748	0.0748
Echinococcus granulosus	tubulin alpha 1C chain	0.0022	0.0748	0.0748
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.057	0.1717
Echinococcus granulosus	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0016	0.0325	0.1211
Echinococcus granulosus	neuropeptide Y receptor	0.0082	0.5272	0.5272
Onchocerca volvulus		0.0082	0.5272	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0022	0.0748	0.2787
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.057	0.057
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Onchocerca volvulus		0.0047	0.2684	0.4808
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0047	0.2684	0.2684
Schistosoma mansoni	cathepsin C	0.0016	0.0325	0.0325
Echinococcus granulosus	Tubulin alpha 1 chain	0.0022	0.0748	0.0748
Onchocerca volvulus		0.0082	0.5272	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus granulosus	allatostatin A receptor	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0325	0.0325
Brugia malayi	Cathepsin L-like precursor	0.0047	0.2684	0.2684
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0056	0.3317	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0015	0.0287	0.0287
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0325	0.0325
Loa Loa (eye worm)	cysteine protease	0.0047	0.2684	0.2684
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Echinococcus multilocularis	cysteine protease	0.0047	0.2684	0.2684
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0047	0.2684	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0016	0.0325	0.0325
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0287	0.0287
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0082	0.5272	0.5272
Schistosoma mansoni	opsin-like receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0015	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Brugia malayi	Tubulin alpha-2 chain	0.0022	0.0748	0.0748
Onchocerca volvulus		0.0082	0.5272	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Onchocerca volvulus		0.0082	0.5272	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0082	0.5272	0.5272
Leishmania major	cathepsin L-like protease	0.0047	0.2684	0.809
Echinococcus granulosus	neuropeptides capa receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.2684	0.2684
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0016	0.0325	0.0325
Giardia lamblia	Cathepsin L-like protease	0.0016	0.0325	0.098
Giardia lamblia	Alpha-tubulin	0.0022	0.0748	0.2255
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Schistosoma mansoni	hypothetical protein	0.0031	0.1487	0.1487
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.0748	0.0748
Schistosoma mansoni	neuropeptide F-like receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	neuropeptide receptor A26	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0015	0.0287	0.0287
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0016	0.0325	0.1211
Echinococcus granulosus	biogenic amine 5HT receptor	0.0082	0.5272	0.5272
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0287	0.0287
Echinococcus granulosus	tyrosine protein kinase Blk	0.0015	0.0287	0.0287
Echinococcus granulosus	tubulin alpha chain	0.0022	0.0748	0.0748
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0016	0.0325	0.0325
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.057	0.2123
Plasmodium falciparum	serine repeat antigen 3	0.0016	0.0325	0.1211
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0047	0.2684	0.2684
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.2684	0.2684
Giardia lamblia	Hypothetical protein	0.0016	0.0325	0.098
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.2684	0.809
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0287	0.0287
Echinococcus granulosus	somatostatin receptor	0.0082	0.5272	0.5272
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.6584	0.6584
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0016	0.0325	0.098
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0287	0.0287
Echinococcus granulosus	cysteine protease	0.0016	0.0325	0.0325
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0016	0.0325	0.0325
Echinococcus granulosus	g-protein coupled receptor	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Echinococcus multilocularis	serotonin receptor	0.0082	0.5272	0.5272
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0017	0.037	0.037
Trypanosoma cruzi	cysteine protease, putative	0.0016	0.0325	0.0325
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0015	0.0287	0.0287
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0015	0.0287	0.0287
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0056	0.3317	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0022	0.0748	0.2787
Onchocerca volvulus		0.0082	0.5272	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0082	0.5272	0.5272
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.057	0.057
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0015	0.0287	0.0287
Echinococcus granulosus	cathepsin l1	0.0047	0.2684	0.2684
Giardia lamblia	Cathepsin B precursor	0.0016	0.0325	0.098
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	tubulin subunit TubB	0.0022	0.0748	0.0748
Echinococcus granulosus	cathepsin b	0.0145	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0015	0.0287	0.0287
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Brugia malayi	ORL1-like opioid receptor	0.0082	0.5272	0.5272
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.0748	0.2255
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0016	0.0325	0.098
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0325	0.0325
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0056	0.3317	0.3317
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0015	0.0287	0.0287
Brugia malayi	Serotonin receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	neuropeptide receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	tubulin alpha chain	0.0022	0.0748	0.0748
Schistosoma mansoni	adenoreceptor	0.0082	0.5272	0.5272
Echinococcus granulosus	hypothetical protein	0.0082	0.5272	0.5272
Leishmania major	alpha tubulin	0.0022	0.0748	0.2255
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.2634	0.2634
Brugia malayi	Melatonin receptor type 1A	0.0082	0.5272	0.5272
Onchocerca volvulus		0.0016	0.0325	0.0076
Entamoeba histolytica	cysteine protease, putative	0.0047	0.2684	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.1487	0.1487
Leishmania major	cathepsin L-like protease	0.0047	0.2684	0.809
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0325	0.098
Plasmodium falciparum	alpha tubulin 2	0.0022	0.0748	0.2787
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.2684	0.809
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0325	0.0325
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0047	0.2684	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0145	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0082	0.5272	0.5272
Schistosoma mansoni	tubulin subunit alpha	0.0022	0.0748	0.0748
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0015	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0015	0.0287	0.1071
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0082	0.5272	0.5272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Loa Loa (eye worm)	neuropeptide F receptor	0.0082	0.5272	0.5272
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Onchocerca volvulus		0.0047	0.2684	0.4808
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.5272	0.5272
Plasmodium falciparum	serine repeat antigen 1	0.0016	0.0325	0.1211
Onchocerca volvulus		0.0082	0.5272	1
Schistosoma mansoni	ap endonuclease	0.0019	0.057	0.057
Echinococcus multilocularis	neuropeptide receptor A26	0.0082	0.5272	0.5272
Toxoplasma gondii	cathepsin CPC2	0.0016	0.0325	0.098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.2684	0.809
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0287	0.0287
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0016	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0016	0.0325	0.098
Echinococcus multilocularis	neuropeptides capa receptor	0.0082	0.5272	0.5272
Trypanosoma cruzi	major cysteine proteinase, putative	0.0016	0.0325	0.0325
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0325	0.098
Brugia malayi	cathepsin L precursor	0.0016	0.0325	0.0325
Loa Loa (eye worm)	TK/ABL protein kinase	0.0015	0.0287	0.0287
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0047	0.2684	0.2684
Plasmodium falciparum	serine repeat antigen 8	0.0016	0.0325	0.1211
Schistosoma mansoni	neuropeptide receptor	0.0082	0.5272	0.5272
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0016	0.0325	0.098
Echinococcus multilocularis	neuropeptide Y receptor	0.0082	0.5272	0.5272
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0082	0.5272	0.5272
Onchocerca volvulus		0.0047	0.2684	0.4808
Onchocerca volvulus	Cathepsin L homolog	0.0047	0.2684	0.4808
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0047	0.2684	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0325	0.0325
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0016	0.0325	0.1211
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Schistosoma mansoni	hypothetical protein	0.0082	0.5272	0.5272
Brugia malayi	AKH receptor	0.0082	0.5272	0.5272
Giardia lamblia	Cathepsin B precursor	0.0016	0.0325	0.098
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0016	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0082	0.5272	0.5272
Loa Loa (eye worm)	tubulin alpha 2	0.0017	0.037	0.037
Schistosoma mansoni	tyrosine kinase	0.0015	0.0287	0.0287
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0016	0.0325	0.1211
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.2684	0.809
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0015	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0748	0.0748
Loa Loa (eye worm)	TK/FER protein kinase	0.0015	0.0287	0.0287
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0082	0.5272	0.5272
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.2684	0.2684
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Giardia lamblia	Cathepsin B precursor	0.0016	0.0325	0.098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0016	0.0325	0.098
Schistosoma mansoni	ap endonuclease	0.0019	0.057	0.057
Trypanosoma cruzi	alpha tubulin, putative	0.0022	0.0748	0.0748
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.0748	0.0748
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.1487	0.1487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0325	0.098
Echinococcus multilocularis	g-protein coupled receptor	0.0082	0.5272	0.5272
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Loa Loa (eye worm)	G-protein coupled receptor	0.0082	0.5272	0.5272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.2684	0.809
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0325	0.1211
Plasmodium vivax	unspecified product	0.0016	0.0325	0.1211
Brugia malayi	G protein-coupled receptor F59B2.13	0.0082	0.5272	0.5272
Brugia malayi	follicle stimulating hormone receptor	0.0082	0.5272	0.5272
Echinococcus granulosus	tubulin alpha chain	0.0022	0.0748	0.0748
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0015	0.0287	0.0287
Echinococcus multilocularis	tyrosine kinase	0.0015	0.0287	0.0287
Plasmodium vivax	serine-repeat antigen (SERA)	0.0016	0.0325	0.1211
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0015	0.0287	0.0287
Trypanosoma cruzi	cysteine proteinase, putative	0.0016	0.0325	0.0325
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.057	0.1717
Onchocerca volvulus		0.0082	0.5272	1
Giardia lamblia	Cathepsin L precursor	0.0016	0.0325	0.098
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0325	0.1211
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0047	0.2684	0.809
Schistosoma mansoni	biogenic amine receptor	0.0082	0.5272	0.5272
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0015	0.0287	0.0287
Plasmodium falciparum	serine repeat antigen 6	0.0016	0.0325	0.1211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0047	0.2684	0.809
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272
Echinococcus multilocularis	cathepsin L cysteine protease	0.0047	0.2684	0.2684
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0082	0.5272	0.5272
Plasmodium falciparum	serine repeat antigen 9	0.0016	0.0325	0.1211
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.0748	0.2255
Loa Loa (eye worm)	hypothetical protein	0.0082	0.5272	0.5272

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.62	Inhibition of tubulin polymerization interacting at the colchicine binding site.	ChEMBL.	10649972
Log IC50 (binding)	= 5.62	Inhibition of tubulin polymerization interacting at the colchicine binding site.	ChEMBL.	10649972

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 71085