TDR Targets

Basic information

Technical information

TDR Targets ID: 711274
Name: 3-[4-(tert-butylsulfamoyl)phenyl]-1-cyclohexy lurea
MW: 353.48 | Formula: C17H27N3O3S
H donors: 3 H acceptors: 3 LogP: 2.69 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)S(=O)(=O)NC(C)(C)C)NC1CCCCC1
InChi: 1S/C17H27N3O3S/c1-17(2,3)20-24(22,23)15-11-9-14(10-12-15)19-16(21)18-13-7-5-4-6-8-13/h9-13,20H,4-8H2,1-3H3,(H2,18,19,21)
InChiKey: IUDCPBGRHYGRTN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[4-(tert-butylsulfamoyl)phenyl]-1-cyclohexyl-urea
AN-329/42294982
ZINC00677206
MLS000582124
N-(tert-butyl)-4-{[(cyclohexylamino)carbonyl]amino}benzenesulfonamide
SMR000200331
ARONIS006096
STK119846

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cytochrome P450, family 2, subfamily D, polypeptide 6	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 2, subfamily C, polypeptide 9	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 3, subfamily A, polypeptide 4	Starlite/ChEMBL	No references
Homo sapiens	glutaminase	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Trypanosoma brucei gambiense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	CYP4Cod1	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania major	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	cytochrome P450 56	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania braziliensis	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania infantum	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Leishmania donovani	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Trypanosoma congolense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Candida albicans	cytochrome P450 556	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	cytochrome P450	cytochrome P450, family 2, subfamily D, polypeptide 6	497 aa	425 aa	32.0 %
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	cytochrome P450, family 2, subfamily C, polypeptide 9	490 aa	441 aa	21.8 %
Brugia malayi	cytochrome P450	cytochrome P450, family 3, subfamily A, polypeptide 4	502 aa	492 aa	24.2 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Kinase, PLK	0.0092	0.102	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0000099437
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0418	0.1015
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0121	0.0108
Echinococcus multilocularis	dna polymerase eta	0.0045	0.0443	0.0443
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0254	0.0254
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.102	0.102
Trypanosoma cruzi	DNA polymerase eta, putative	0.0032	0.0275	0.0738
Brugia malayi	CXXC zinc finger family protein	0.0057	0.0589	0.148
Schistosoma mansoni	hypothetical protein	0.0011	0.0016	0.0016
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0177	0.0406
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0418	0.1145
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0041	0.0392	0.0392
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0254	0.0254
Schistosoma mansoni	hypothetical protein	0.0345	0.416	0.416
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.102	0.2533
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0013	0.0037	0.0061
Onchocerca volvulus		0.0041	0.0392	0.1422
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0000099437
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0391	0.1069
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0418	0.1015
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Echinococcus multilocularis	Chromo domain	0.0011	0.0016	0.0016
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0121	0.0305
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0254	0.1952
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.072	0.1777
Echinococcus granulosus	chromobox protein 2	0.0011	0.0016	0.0016
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.016	0.0402
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0418	0.1051
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0121	0.0267
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0039	0.0059
Schistosoma mansoni	chromobox protein	0.0011	0.0016	0.0016
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0122	0.1399	0.1399
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0418	0.1015
Plasmodium vivax	SET domain protein, putative	0.003	0.0254	0.4603
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0254	0.0254
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0386	0.1399
Brugia malayi	Valyl-tRNA synthetase	0.0011	0.0016	0.004
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0121	0.0121
Toxoplasma gondii	hypothetical protein	0.0047	0.0467	0.369
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0136	0.0136
Loa Loa (eye worm)	helicase	0.0011	0.0016	0.004
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0068	0.0068
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0418	0.0418
Onchocerca volvulus		0.0043	0.0418	0.1516
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0564	0.1418
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0115	0.0288
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0039	0.0059
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0418	0.0487
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.035	0.0843
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0226	0.0226
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0177	0.0406
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0068	0.0068
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0564	0.0564
Schistosoma mansoni	hypothetical protein	0.0345	0.416	0.416
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0016	0.0016
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.016	0.1438
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0534	0.1475
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0418	0.0487
Mycobacterium ulcerans	lipase LipD	0.0043	0.0418	0.0487
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0115	0.0115
Schistosoma mansoni	kinase	0.0047	0.0458	0.0458
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0169	0.0435
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0254	0.0254
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0177	0.0406
Brugia malayi	glutaminase DH11.1	0.033	0.3979	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0032	0.0275	0.212
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0013	0.0037	0.0061
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.016	0.5
Mycobacterium ulcerans	glutaminase	0.033	0.3979	0.5045
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0418	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.102	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.004
Schistosoma mansoni	hypothetical protein	0.0019	0.0115	0.0115
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.102	0.2858
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0121	0.0121
Echinococcus multilocularis	chromobox protein 1	0.0068	0.072	0.072
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0115	0.0115
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0016	0.0000099437
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0018	0.0105	0.1713
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0177	0.0406
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0115	0.0288
Leishmania major	cytochrome p450-like protein	0.0013	0.0037	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0000099437
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.016	0.0411
Leishmania major	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0024	0.0172	0.0172
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0136	0.0303
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.004
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.016	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1669	0.4195
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0121	0.0108
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.0016	0.0016
Onchocerca volvulus		0.0011	0.0016	0.0057
Echinococcus multilocularis	dnaJ subfamily B	0.0815	1	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0111	0.0111
Brugia malayi	ImpB/MucB/SamB family protein	0.0045	0.0443	0.1113
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0418	0.1051
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.3328	0.4213
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.016	0.0411
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0016	0.0000099438
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0418	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.1606	0.4526
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0121	0.0267
Echinococcus multilocularis	cpg binding protein	0.006	0.0629	0.0629
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0039	0.0059
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0564	0.0564
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0212	0.0496
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0011	0.0016	0.00000000084724
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0564	0.0564
Schistosoma mansoni	cpg binding protein	0.0057	0.0589	0.0589
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0121	0.0121
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0121	0.0301
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0000099437
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.102	0.2858
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.102	0.2533
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0418	0.0487
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.2409	0.6055
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.035	0.1269
Schistosoma mansoni	blooms syndrome DNA helicase	0.0016	0.0082	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0000099437
Trichomonas vaginalis	esterase, putative	0.0043	0.0418	0.1015
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0418	0.1051
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.0169	0.0435
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0121	0.1052
Trypanosoma cruzi	DNA polymerase eta, putative	0.0045	0.0443	0.1216
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0418	0.0487
Leishmania major	DNA polymerase eta, putative	0.0032	0.0275	0.0738
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0121	0.0301
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.016	0.016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0046	0.0086
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0169	0.0435
Onchocerca volvulus		0.0043	0.0418	0.1516
Trypanosoma brucei	PAB1-binding protein , putative	0.0053	0.0534	0.1475
Schistosoma mansoni	hypothetical protein	0.0013	0.0037	0.0037
Leishmania major	mitochondrial DNA polymerase beta	0.0294	0.3528	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0000099437
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0169	0.0424
Brugia malayi	Cytochrome P450 family protein	0.0036	0.0323	0.0813
Schistosoma mansoni	glutaminase	0.033	0.3979	0.3979
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0418	0.7763
Leishmania major	cytochrome p450-like protein	0.0013	0.0037	0.0061
Schistosoma mansoni	hypothetical protein	0.0024	0.0173	0.0173
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0121	0.0305
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0418	0.1145
Schistosoma mansoni	ap endonuclease	0.0023	0.016	0.016
Onchocerca volvulus		0.003	0.0251	0.0912
Schistosoma mansoni	hypothetical protein	0.003	0.0251	0.0251
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0294	0.3528	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0024	0.0172	0.0172
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.016	0.0157
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.102	0.2533
Schistosoma mansoni	chromobox protein	0.0068	0.072	0.072
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0564	0.0564
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0024	0.0177	0.0406
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Plasmodium vivax	ataxin-2 like protein, putative	0.0053	0.0534	1
Brugia malayi	MH2 domain containing protein	0.0144	0.1669	0.4195
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0016	0.0000099438
Loa Loa (eye worm)	glutaminase	0.033	0.3979	1
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0056	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0288
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0418	0.0487
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0039	0.0059
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0254	0.0254
Brugia malayi	beta-lactamase	0.0043	0.0418	0.1051
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0039	0.0059
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0418	0.1051
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0017	0.009	0.0188
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0046	0.0086
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.0169	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.004
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0016	0.00000000084724
Schistosoma mansoni	cpg binding protein	0.006	0.0629	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0389	0.0978
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0011	0.0016	0.0016
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0626	0.1573
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0418	0.1015
Toxoplasma gondii	ABC1 family protein	0.0043	0.0418	0.3292
Echinococcus granulosus	Chromobox protein 3	0.0011	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0000099437
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0000099437
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0294	0.3528	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0418	0.0487
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0418	0.1145
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0418	0.0487
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Loa Loa (eye worm)	glutaminase 2	0.033	0.3979	1
Onchocerca volvulus		0.0043	0.0418	0.1516
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0626	0.1573
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0102	0.0218
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.102	0.2533
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0418	0.0418
Schistosoma mansoni	caspase-7 (C14 family)	0.003	0.0251	0.0251
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.035	0.0843
Brugia malayi	hypothetical protein	0.0053	0.0534	0.1342
Echinococcus granulosus	chromobox protein 1	0.0068	0.072	0.072
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.004
Onchocerca volvulus		0.0232	0.2757	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.004
Echinococcus multilocularis	chromobox protein 2	0.0011	0.0016	0.0016
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0386	0.0934
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0386	0.0934
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0169	0.0424
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0418	0.0487
Schistosoma mansoni	cytochrome P450	0.0013	0.0037	0.0037
Trichomonas vaginalis	helicase, putative	0.0013	0.0039	0.0059
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0013	0.0037	0.0061
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.102	0.102
Brugia malayi	cytochrome P450	0.0013	0.0037	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.004
Brugia malayi	hypothetical protein	0.0034	0.0301	0.0758
Loa Loa (eye worm)	cytochrome P450	0.0013	0.0037	0.0094
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.0534	1
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0136	0.0136
Schistosoma mansoni	hypothetical protein	0.0815	1	1
Echinococcus multilocularis		0.0013	0.0037	0.0037
Toxoplasma gondii	LsmAD domain-containing protein	0.0053	0.0534	0.4241
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Leishmania major	DNA polymerase eta, putative	0.0045	0.0443	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0443	0.1113
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0121	0.0301
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0121	0.0108
Echinococcus granulosus	caspase 2	0.003	0.0251	0.0251
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0169	0.0424
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.005	0.0282
Loa Loa (eye worm)	cytochrome P450 family protein	0.0036	0.0323	0.0813
Schistosoma mansoni	hypothetical protein	0.0019	0.0115	0.0115
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0389	0.0978
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.016	0.016
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0039	0.0059
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0564	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0024
Echinococcus granulosus	cpg binding protein	0.006	0.0629	0.0629
Brugia malayi	Heterochromatin protein 1	0.0068	0.072	0.181
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.0169	0.0168
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0418	0.1015
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.102	0.2858
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0068	0.0068
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0564	0.1418
Loa Loa (eye worm)	hypothetical protein	0.003	0.0251	0.0632
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0057	0.0589	0.148
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0136	0.0342
Brugia malayi	CHD4 protein	0.0014	0.0056	0.0142
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.016	0.0411
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.102	0.3699
Trypanosoma brucei	polo-like protein kinase	0.0092	0.102	0.2858
Schistosoma mansoni	ap endonuclease	0.0023	0.016	0.016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0046	0.0086
Brugia malayi	Pre-SET motif family protein	0.003	0.0254	0.0639
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0564	0.0564
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.0534	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.016	0.2785
Trypanosoma brucei	DNA polymerase eta, putative	0.0045	0.0443	0.1216
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0115	0.0288
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0011	0.0016	0.0016
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0391	0.1069
Loa Loa (eye worm)	hypothetical protein	0.003	0.0248	0.0623
Leishmania major	hypothetical protein, conserved	0.0043	0.0418	0.1145
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1669	0.4195
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0418	0.1051
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0391	0.1069
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0111	0.0279
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0418	0.0487
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0016	0.0016
Onchocerca volvulus		0.0057	0.0589	0.2135
Leishmania major	cytochrome p450-like protein	0.0023	0.0169	0.0435
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0011	0.0016	0.004
Brugia malayi	hypothetical protein	0.0011	0.0016	0.004
Trypanosoma brucei	unspecified product	0.002	0.0121	0.0301
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0504	0.1389
Schistosoma mansoni	DNA polymerase eta	0.0045	0.0443	0.0443
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0014	0.0052	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0418	0.1051
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0391	0.1069
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0418	0.0487
Loa Loa (eye worm)	hypothetical protein	0.006	0.0626	0.1573
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0169	0.0424
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0418	0.0487
Trypanosoma brucei	unspecified product	0.0014	0.0046	0.0086
Onchocerca volvulus		0.003	0.0248	0.0899
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0418	0.1051
Onchocerca volvulus		0.0011	0.0016	0.0057
Echinococcus granulosus	dna polymerase eta	0.0045	0.0443	0.0443
Brugia malayi	beta-lactamase family protein	0.0043	0.0418	0.1051
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0177	0.0406
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.2757	0.6916
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.102	0.2563
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.072	0.181
Trypanosoma brucei	unspecified product	0.0014	0.0046	0.0086
Brugia malayi	M-phase phosphoprotein, mpp8	0.0011	0.0016	0.004
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0418	0.0487
Brugia malayi	Cell death protein 3 precursor	0.003	0.0251	0.0632
Mycobacterium ulcerans	hypothetical protein	0.0155	0.1801	0.2257
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0418	0.0418
Echinococcus granulosus	GPCR family 2	0.0019	0.0115	0.0115
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0115	0.0115
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0039	0.0059
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.072	0.1777
Leishmania major	hypothetical protein, conserved	0.0053	0.0534	0.1475
Brugia malayi	chromobox protein homolog 3	0.0038	0.035	0.088
Onchocerca volvulus	Cell death protein 3 homolog	0.003	0.0251	0.0912
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0534	0.1475
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.003	0.0251	0.0632
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0418	0.0487
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0626	0.1573
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.016	0.0431
Echinococcus granulosus	cytochrome P450 2K1	0.0013	0.0037	0.0037
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0024	0.0177	0.0406
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.1606	0.4526
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.016	0.2785
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0011	0.0016	0.00000000035927
Schistosoma mansoni	hypothetical protein	0.0019	0.0115	0.0115
Brugia malayi	Protein cec-1.	0.0011	0.0016	0.004
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.016	0.0411
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0039	0.0059
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0013	0.0037	0.0061
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0564	0.0564
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0108	0.0272
Schistosoma mansoni	hypothetical protein	0.0041	0.0389	0.0389
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0024	0.0177	0.0406
Echinococcus granulosus	apoptotic protease activating factor 1	0.003	0.0251	0.0251
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0155	0.1801	0.2257
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0013	0.0037	0.0175
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0016	0.0000099437
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	0.0642	0.785	1
Trichomonas vaginalis	glutaminase, putative	0.033	0.3979	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0534	0.1342
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0084	0.021
Echinococcus multilocularis	geminin	0.0345	0.416	0.416
Trichomonas vaginalis	Heterochromatin protein, putative	0.0011	0.0016	0.0000099437
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.102	0.102
Brugia malayi	Pre-SET motif family protein	0.0204	0.2409	0.6055
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.0016	0.004
Schistosoma mansoni	chromobox protein	0.0011	0.0016	0.0016
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0294	0.3528	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0121	0.0121
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0121	0.0301
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Echinococcus granulosus	Chromo domain	0.0011	0.0016	0.0016
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0136	0.0342
Brugia malayi	beta-lactamase family protein	0.0043	0.0418	0.1051
Brugia malayi	SET domain containing protein	0.0013	0.0045	0.0112
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.016	0.0364
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	0.0642	0.785	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0111	0.0111
Trichomonas vaginalis	hypothetical protein	0.0011	0.0016	0.0000099437
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0418	0.0487
Schistosoma mansoni	hypothetical protein	0.0019	0.0115	0.0115
Echinococcus multilocularis	caspase 2	0.003	0.0251	0.0251
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.102	0.2533
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.004
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0016	0.0000099438
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0013	0.0037	0.0061
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0102	0.0218
Echinococcus multilocularis	apoptotic protease activating factor 1	0.003	0.0251	0.0251
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0212	0.0496
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.102	0.2533
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0418	0.1051
Loa Loa (eye worm)	hypothetical protein	0.0038	0.035	0.088
Echinococcus granulosus	geminin	0.0345	0.416	0.416
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0056	0.0056
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0014	0.0056	0.0056
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0121	0.0301
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.0443	0.1079
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.016	0.0157
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.0443	0.1079
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0121	0.0108
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0014	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0418	0.1051
Loa Loa (eye worm)	hypothetical protein	0.003	0.0254	0.0639
Schistosoma mansoni	chromobox protein	0.0068	0.072	0.072
Echinococcus granulosus	chromobox protein 1	0.0068	0.072	0.072
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.016	0.0402
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.1606	0.4526
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0092	0.102	1
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0016	0.0000099437
Toxoplasma gondii	exonuclease III APE	0.0023	0.016	0.1181
Schistosoma mansoni	cpg binding protein	0.006	0.0629	0.0629
Echinococcus granulosus	dna polymerase kappa	0.002	0.0121	0.0121
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0121	0.0121
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0136	0.0303
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0039	0.0059
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.016	0.0364
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0418	0.0418
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.102	0.2533
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0109	0.1238	1
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0037	0.0094
Schistosoma mansoni	hypothetical protein	0.0024	0.0172	0.0172
Brugia malayi	hypothetical protein	0.003	0.0251	0.0632
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0254	0.0254
Echinococcus multilocularis	chromobox protein 1	0.0068	0.072	0.072
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0115	0.0115

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 17.7827941 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 19.95262315 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 19.95262315 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 25.11886432 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
Potency (functional)	0.8913 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.3323 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.081 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1586264
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 711274